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https://www.readbyqxmd.com/read/29656382/opioid-prescriptions-in-older-medicare-beneficiaries-after-the-2014-federal-rescheduling-of-hydrocodone-products
#1
Yong-Fang Kuo, Mukaila A Raji, Victor Liaw, Jacques Baillargeon, James S Goodwin
OBJECTIVES: To examine how an October 2014 Drug Enforcement Administration policy reclassified hydrocodone product from schedule III to II has affected older adults, who are among the largest consumers of prescription opioids in the United States. DESIGN: Retrospective cohort study. SETTING: United States. PARTICIPANTS: A 20% sample of Medicare Part D beneficiaries aged 65 and older from 2013 through 2015 (> 2,500,000 beneficiaries each year) MEASUREMENTS: From January 2013 to December 2015, we calculated the monthly prevalence of opioid prescriptions and the prevalence of individuals who received prescriptions for a 90-day supply or longer (prolonged), as well as hospitalizations related to opioid toxicity in 2013 and 2015...
April 14, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29613851/an-innovative-solution-to-detect-classify-and-report-illicit-online-marketing-and-sales-of-controlled-substances-via-twitter-project-finalist-at-hhs-opioid-code-a-thon
#2
Tim Mackey, Janani Kalyanam, Josh Klugman, Ella Kuzmenko, Rashmi Gupta
BACKGROUND: On December 6-7, 2017, the U.S. Department of Health and Human Services hosted its first Code-a-Thon event aimed at leveraging technology and data-driven solutions to help combat the opioid epidemic. Authors, comprised of an interdisciplinary team from academia, the private sector, and the U.S. Centers for Disease Control and Prevention, participated in the Code-a-Thon as part of the "Prevention" track. OBJECTIVE: To develop and deploy a methodology using machine learning to accurately detect the marketing and sale of opioids by illicit online sellers via Twitter as part of participation at the HHS Opioid Code-a-Thon event...
March 27, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29610897/association-between-us-state-medical-cannabis-laws-and-opioid-prescribing-in-the-medicare-part-d-population
#3
Ashley C Bradford, W David Bradford, Amanda Abraham, Grace Bagwell Adams
Importance: Opioid-related mortality increased by 15.6% from 2014 to 2015 and increased almost 320% between 2000 and 2015. Recent research finds that the use of all pain medications (opioid and nonopioid collectively) decreases in Medicare Part D and Medicaid populations when states approve medical cannabis laws (MCLs). The association between MCLs and opioid prescriptions is not well understood. Objective: To examine the association between prescribing patterns for opioids in Medicare Part D and the implementation of state MCLs...
April 2, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29608639/transition-to-nonopioid-analgesia-does-not-impair-pain-control-after-major-aesthetic-plastic-surgery
#4
Thu-Hoai C Nguyen, Nicholas F Lombana, Dmitry Zavlin, Clayton L Moliver
Background: Multimodal analgesic protocols are increasingly favored over traditional opioid regimens due to decreased adverse side effects and reduced opioid consumption. Concomitant use of selective cyclooxygenase (COX)-2 inhibitor celecoxib and anticonvulsant gabapentin have been proposed to adequately control acute postoperative pain. Objectives: To determine efficacy of postoperative pain control using nonopioid pain regimen vs traditional opioids for all aesthetic plastic surgery procedures...
March 28, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29604365/effects-of-ceftriaxone-on-hydrocodone-seeking-behavior-and-glial-glutamate-transporters-in-p-rats
#5
Fahad S Alshehri, Alqassem Y Hakami, Yusuf S Althobaiti, Youssef Sari
Hydrocodone (HYD) is one of the most widely prescribed opioid analgesic drugs. Several neurotransmitters are involved in opioids relapse. Among these neurotransmitters, glutamate is suggested to be involved in opioid dependence and relapse. Glutamate is regulated by several glutamate transporters, including glutamate transporter 1 (GLT-1) and cystine/glutamate transporter (xCT). In this study, we investigated the effects of ceftriaxone (CEF) (200 mg/kg, i.p.), known to upregulate GLT-1 and xCT, on reinstatement to HYD (5 mg/kg, i...
March 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29584496/evaluating-drugged-driving-effects-of-exemplar-pain-and-anxiety-medications
#6
Timothy L Brown, Gary Milavetz, Gary Gaffney, Andrew Spurgin
OBJECTIVE: Distracted and drug-influenced driving presents a major risk for traffic safety morbidity and mortality. As part of an ongoing research program, we examined the effects of a commonly prescribed combination of medications for pain relief: alprazolam, a benzodiazepine, and a hydrocodone preparation, a combination opiate and acetaminophen, on a simulated driving protocol. METHODS: Utilizing a within-subjects design, we recruited 8 healthy experienced drivers without major physical and psychological histories...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29582394/comparative-rates-of-mortality-and-serious-adverse-effects-among-commonly-prescribed-opioid-analgesics
#7
David L Murphy, Jacob A Lebin, Stevan G Severtson, Heather A Olsen, Nabarun Dasgupta, Richard C Dart
INTRODUCTION: The epidemic of prescription opioid overdose and mortality parallels the dispensing rates of prescription opioids, and the availability of increasingly potent opioid analgesics. OBJECTIVE: The common assumption that more potent opioid analgesics are associated with higher rates of adverse outcomes has not been adequately substantiated. We compared the rate of serious adverse events among commonly prescribed opioid analgesics of varying potency. METHODS: Serious adverse events (SAEs; defined as death, major medical effect, or hospitalization) resulting from exposure to tablets containing seven opioid analgesics (oxycodone, hydrocodone, morphine, hydromorphone, oxymorphone, tapentadol, and tramadol) captured by the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS® ) System Poison Center Program were evaluated from 2010 through 2016...
March 26, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29579266/time-dependent-postmortem-redistribution-of-opioids-in-blood-and-alternative-matrices
#8
Lana Brockbals, Sandra N Staeheli, Dominic Gascho, Lars C Ebert, Thomas Kraemer, Andrea E Steuer
Forensic postmortem case interpretation can be challenging, in particular due to postmortem redistribution (PMR) phenomena. Recent studies have shown that computed tomography (CT)-guided collection of biopsy samples using a robotic arm (virtobot) provides a valuable tool for systematic studies on time-dependent PMR. Utilizing this strategy, several cases involving opioid use such as methadone, fentanyl, tramadol, codeine, oxycodone and hydrocodone were evaluated for time-dependent concentration changes and potential redistribution mechanisms...
March 20, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29560071/by-default-the-effect-of-prepopulated-prescription-quantities-on-opioid-prescribing-in-the-emergency-department
#9
Jamie R Santistevan, Brian R Sharp, Azita G Hamedani, Scott Fruhan, Andrew W Lee, Brian W Patterson
Introduction: Opioid prescribing patterns have come under increasing scrutiny with the recent rise in opioid prescriptions, opioid misuse and abuse, and opioid-related adverse events. To date, there have been limited studies on the effect of default tablet quantities as part of emergency department (ED) electronic order entry. Our goal was to evaluate opioid prescribing patterns before and after the removal of a default quantity of 20 tablets from ED electronic order entry. Methods: We performed a retrospective observational study at a single academic, urban ED with 58,000 annual visits...
March 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29559326/canadian-trends-in-carpal-tunnel-surgery
#10
Blair Peters, Jennifer L Giuffre
PURPOSE: Treatment patterns of carpal tunnel surgery by members of the American Society of Surgery of the Hand (ASSH) have recently been published. The majority of cases in this study were performed in the general operating room with intravenous (IV) sedation or a Bier block. Patients were most commonly prescribed hydrocodone for postoperative pain. The majority of carpal tunnel releases at our center are performed under local anesthesia alone, with plain acetaminophen (Tylenol) or codeine prescribed for postoperative pain...
March 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29554298/development-of-a-quantitative-lc-ms-ms-assay-for-codeine-morphine-6-acetylmorphine-hydrocodone-hydromorphone-oxycodone-and-oxymorphone-in-neat-oral-fluid
#11
Megan Grabenauer, Katherine N Moore, Nichole D Bynum, Robert M White, John M Mitchell, Eugene D Hayes, Ronald Flegel
Recent advances in analytical capabilities allowing for the identification and quantification of drugs and metabolites in small volumes at low concentrations have made oral fluid a viable matrix for drug testing. Oral fluid is an attractive matrix option due to its relative ease of collection, reduced privacy concerns for observed collections and difficulty to adulterate. The work presented here details the development and validation of a liquid chromatography tandem mass spectrometry (LC-MS-MS) method for the quantification of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone and oxymorphone in neat oral fluid...
March 15, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29551331/trends-in-medical-use-of-opioids-in-the-u-s-2006-2016
#12
Brian J Piper, Dipam T Shah, Olapeju M Simoyan, Kenneth L McCall, Stephanie D Nichols
INTRODUCTION: The U.S. is experiencing an opioid epidemic which is at least partially iatrogenic and fueled by both prescription and illicit misuse. This study provides a nationwide examination of opioid distribution patterns during the last decade. METHODS: Data were obtained from the U.S. Drug Enforcement Administration's Automation of Reports and Consolidated Orders System for 2006-2016. Analyses include quantities of ten opioids legally dispensed nationwide by weight and converted to Morphine Milligram Equivalents...
March 9, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29509867/effect-of-opioid-vs-nonopioid-medications-on-pain-related-function-in-patients-with-chronic-back-pain-or-hip-or-knee-osteoarthritis-pain-the-space-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Erin E Krebs, Amy Gravely, Sean Nugent, Agnes C Jensen, Beth DeRonne, Elizabeth S Goldsmith, Kurt Kroenke, Matthew J Bair, Siamak Noorbaloochi
Importance: Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain. Objective: To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects. Design, Setting, and Participants: Pragmatic, 12-month, randomized trial with masked outcome assessment. Patients were recruited from Veterans Affairs primary care clinics from June 2013 through December 2015; follow-up was completed December 2016...
March 6, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29489736/current-state-of-the-opioid-epidemic-as-it-pertains-to-pediatric-orthopaedics-from-the-advocacy-committee-of-the-pediatric-orthopaedic-society-of-north-america
#14
Ellen M Raney, Harold J P van Bosse, Kevin G Shea, Joshua M Abzug, Richard M Schwend
INTRODUCTION: The opioid epidemic in the United States has reached crisis proportions. Urgent response is needed. Hydrocodone in combination with acetaminophen is the most prescribed drug in the United States. The most common source of opioids available for misuse is the unused portions of postoperative prescriptions. Among high school seniors, 80% of those who reported nonmedical use of prescription opioids previously had legitimate prescriptions but recreationally used leftover doses...
February 27, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29478889/opioid-prescribing-behavior-of-interventional-radiologists-across-the-united-states
#15
Andrew B Rosenkrantz, J David Prologo, Wenyi Wang, Danny R Hughes, Zachary L Bercu, Richard Duszak
PURPOSE: To study opioid prescribing behavior of US interventional radiologists (IRs). METHODS: Using Medicare Physician and Other Supplier Public Use File claims, we identified 2,133 radiologists whose practice in 2015 comprised predominantly interventional radiology. Cross-linking the Medicare Part D Prescriber File, their opioid prescription writing behavior was characterized. RESULTS: Most (52.2%) IRs wrote 10 or fewer prescriptions total for Medicare beneficiaries...
February 22, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29460670/opioid-prescribing-patterns-among-otolaryngologists
#16
Marissa A Schwartz, James G Naples, Chia-Ling Kuo, Todd E Falcone
Objectives To evaluate national trends in opioid prescribing patterns by otolaryngologists for postoperative pain control after common otolaryngologic procedures. Study Design Cross-sectional; survey. Subjects and Methods A survey to determine opioid prescribing patterns for the treatment of postoperative pain following common otolaryngologic procedures was distributed to all members of the American Academy of Otolaryngology-Head and Neck Surgery. Results The most common pain medication prescribed for adults postoperatively was hydrocodone-acetaminophen (73%), followed by oxycodone-acetaminophen (39%)...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29446449/opioid-prescribing-patterns-among-otolaryngologists-crucial-insights-among-the-medicare-population
#17
Peter F Svider, Khashayar Arianpour, Eric Guo, Elana Folbe, Giancarlo Zuliani, Hosheng Lin, Jean Anderson Eloy, Adam J Folbe
OBJECTIVES/HYPOTHESIS: There has been growing recognition of the roles prescription drug misuse and diversion play in facilitating the ongoing opioid epidemic. Our objective was to evaluate opioid prescription patterns among practicing otolaryngologists. STUDY DESIGN: Retrospective review of a CMS database. METHODS: Medicare Part D beneficiary data (2015) were accessed for a list of otolaryngologists. Opioid prescription rates, amount, and supply were calculated...
February 15, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29419590/extended-release-liposomal-bupivacaine-injection-exparel-for-early-postoperative-pain-control-following-pharyngoplasty
#18
Kristopher M Day, Narayanan M Nair, Devan Griner, Larry A Sargent
BACKGROUND: Liposomal bupivacaine (LB, Exparel) is a long-acting local anesthetic reported to decrease postoperative. The authors demonstrate the first safe use of LB in pediatric patients with improved pain control following pharyngoplasty. METHODS: Retrospective case-control of all the patients who underwent pharyngoplasty at a tertiary craniofacial center from March 2010 to June 2016. Treatment group (TG) administered 1.3% LB and 0.5% bupivacaine and 1:200,000 epinephrine...
February 6, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29378623/patient-perspectives-of-transitioning-from-prescription-opioids-to-heroin-and-the-role-of-route-of-administration
#19
Laura B Monico, Shannon Gwin Mitchell
BACKGROUND: As the availability of prescription opioids decreases and the availability of heroin increases, some prescription opioid users are transitioning to heroin. This study seeks to explore factors associated with respondents' transition from prescription opioid use to heroin. METHODS: In-depth, semi-structured qualitative interviews (n = 20) were conducted with buprenorphine patients in an opioid treatment program. Respondents were predominantly White (n = 13) and male (n = 13), with a range of treatment tenure (4 days to 2 years)...
January 29, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29322813/opioid-drug-poisonings-in-ohio-adolescents-and-young-adults-2002-2014
#20
Sarah Caupp, Janine Steffan, Junxin Shi, Krista K Wheeler, Henry A Spiller, Marcel J Casavant, Henry Xiang
CONTEXT: Opioids represent a drug class that adolescents and young adults intentionally misuse and abuse. When taken on their own or with other substances in this manner, opioids pose an increased risk of overdose and potential death. OBJECTIVE: To determine trends of opioid drug poisonings among adolescents and young adults in Ohio from 2002 to 2014 using Poison Control Center (PCC) data. METHODS: Data were obtained from Ohio PCCs from 2002 to 2014 for opioid drug poisonings amongst 10-29 year olds...
January 11, 2018: Clinical Toxicology
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