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Ronald Donelson

Jonathan N Pruneda, F Donelson Smith, Angela Daurie, Danielle L Swaney, Judit Villén, John D Scott, Andrew W Stadnyk, Isolde Le Trong, Ronald E Stenkamp, Rachel E Klevit, John R Rohde, Peter S Brzovic
Pathogenic bacteria introduce effector proteins directly into the cytosol of eukaryotic cells to promote invasion and colonization. OspG, a Shigella spp. effector kinase, plays a role in this process by helping to suppress the host inflammatory response. OspG has been reported to bind host E2 ubiquitin-conjugating enzymes activated with ubiquitin (E2~Ub), a key enzyme complex in ubiquitin transfer pathways. A co-crystal structure of the OspG/UbcH5c~Ub complex reveals that complex formation has important ramifications for the activity of both OspG and the UbcH5c~Ub conjugate...
March 3, 2014: EMBO Journal
Ronald Donelson, Audrey Long, Kevin Spratt, Tak Fung
OBJECTIVE: To determine whether outcomes from treatment determined by subjects' directional preference (ie, reduction in back and/or leg pain, by performing a single direction of repeated end-range lumbar movement) would vary based on pain duration, location, or neurologic status. DESIGN: A secondary analysis of data from a multicenter randomized clinical trial. SETTING: Eleven physical therapy departments or clinics in 5 countries, with referrals for both acute and chronic low back pain...
September 2012: PM & R: the Journal of Injury, Function, and Rehabilitation
Ronald Donelson, Greg McIntosh, Hamilton Hall
OBJECTIVE: To determine the frequency and the characteristics of low back pain (LBP) recurrences. The research questions were as follows: (1) Are LBP recurrences common? (2) Do episodes worsen with multiple recurrences? (3) Does pain change location in any recognizable pattern during an episode? DESIGN: Single-page self-administered questionnaire. SETTING: Thirty clinical practices (primary care, physical therapy, chiropractic, and surgical spine) in North America and Europe...
June 2012: PM & R: the Journal of Injury, Function, and Rehabilitation
Ronald Donelson
Despite its classic clinical presentation, and even when confirmed by compatible imaging findings of a herniated disc, the radiculopathy diagnosis provides only limited assistance for making decisions about treatment. The 2003 Medicare data revealed an eightfold variation in the rates of lumbar laminectomy and discectomy across geographic regions. In an effort to address this uncertainty in care, this article describes the management paradigm known as Mechanical Diagnosis and Therapy and its usefulness in decision-making for patients with lumbar radiculopathies, and reviews the relevant literature...
February 2011: Physical Medicine and Rehabilitation Clinics of North America
Ronald Donelson
PURPOSE/OBJECTIVES: To convey a valuable and greatly misunderstood paradigm for evaluating and treating low back pain (LBP) and its extensive scientific evidence. PRIMARY PRACTICE SETTING(S): Low back pain is a highly prevalent and very expensive health dilemma. But by using a paradigm called Mechanical Diagnosis and Therapy (a.k.a. McKenzie methods), it is now possible to identify a very large LBP subgroup whose pain is rapidly reversible, meaning that it can often be eliminated quickly, with return to full function using a single, patient-specific direction of simple, yet precise, end-range low back exercises and some posture modifications...
March 2008: Professional Case Management
Stephen May, Ronald Donelson
The management of chronic low back pain (CLBP) has proven to be very challenging in North America, as evidenced by its mounting socioeconomic burden. Choosing among available nonsurgical therapies can be overwhelming for many stakeholders, including patients, health providers, policy makers, and third-party payers. Although all parties share a common goal and wish to use limited health-care resources to support interventions most likely to result in clinically meaningful improvements, there is often uncertainty about the most appropriate intervention for a particular patient...
January 2008: Spine Journal: Official Journal of the North American Spine Society
Brian E Udermann, Kevin F Spratt, Ronald G Donelson, John Mayer, James E Graves, John Tillotson
BACKGROUND CONTEXT: This study was prompted by 1) the almost universal use of patient education as an initial or at least an ancillary step in the treatment of patients presenting with low back pain, 2) the relative dearth of studies evaluating the effectiveness of patient education and 3) the complete lack of support in the few existing studies for the efficacy of education in improving patients' long-term health status. PURPOSE: A feasibility study to evaluate the efficacy of an individualized biomechanical treatment educational booklet to effect improvement in health status...
July 2004: Spine Journal: Official Journal of the North American Spine Society
F Todd Wetzel, Ronald Donelson
BACKGROUND CONTEXT: The selection of appropriate patients for lumbar disc surgery is a challenging task involving a highly variable, multifactorial decision process complicated by a lack of reliable, validated clinical signs and imaging findings. Recently, multiple studies have demonstrated the reliability and diagnostic utility of a standardized form of spinal assessment using repeated end-range test movements while monitoring patterns of pain response (McKenzie assessment). PURPOSE: It is the aim of this article to evaluate the utility of this assessment system and its literature support in the selection of candidates for surgery for disc-related pain...
March 2003: Spine Journal: Official Journal of the North American Spine Society
Tom Mayer, Peter Polatin, Barry Smith, Robert Gatchel, David Fardon, Stanley Herring, Charlotte Smith, Ronald Donelson, David Wong
No abstract text is available yet for this article.
May 2003: Spine Journal: Official Journal of the North American Spine Society
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