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https://www.readbyqxmd.com/read/29668046/black-cohosh-extracts-and-powders-induce-micronuclei-a-biomarker-of-genetic-damage-in-human-cells
#1
Stephanie L Smith-Roe, Carol D Swartz, Kim G Shepard, Steven M Bryce, Stephen D Dertinger, Suramya Waidyanatha, Grace E Kissling, Scott S Auerbach, Kristine L Witt
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant increases in micronucleated erythrocytes in peripheral blood of female Wistar Han rats and B6C3F1/N mice administered 15-1,000 mg BCE/kg/day by gavage for 90 days. These animals also developed a dose-dependent nonregenerative macrocytic anemia characterized by clinical changes consistent with megaloblastic anemia...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29667916/fiscal-impact-of-smoking-cessation-in-thailand-a-government-perspective-cost-benefit-analysis
#2
Mark P Connolly, Nikolaos Kotsopoulos, Pichaya Suthipinijtham, Suthat Rungruanghiranya
We evaluate the broader public economic consequences of investments in smoking cessation that change lifetime productivity, which can influence future government tax revenue and social transfer costs and health care spending. The analysis applies a government perspective framework for assessing the intergenerational relationships between morbidity and mortality and lifetime tax revenue and social transfers received. Applying smoking prevalence in Thailand, a cohort model was developed for smoker and former smokers to estimate impact on lifetime direct taxes and tobacco taxes paid...
April 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29667878/safety-challenges-and-improvement-strategies-of-ethnic-minority-construction-workers-a-case-study-in-hong-kong
#3
Chunlin Wu, Xiaowei Luo, Tao Wang, Yue Wang, Bibek Sapkota
Due to cultural differences, ethnic minority construction workers are more difficult to manage and more vulnerable to accidents. This study aims to identify the major barriers faced by ethnic minority workers from their own perspectives and determine potential strategies to enhance safety climate of construction projects, thus ultimately improve their safety performance. A survey with modified Nordic safety climate questionnaire was conducted in a certain sub-contractor in Hong Kong. In-depth interviews, status quo description, major challenge investigation and safety knowledge tests were carried as well...
April 18, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29667877/practices-and-values-regarding-milk-consumption-among-pre-schoolers-in-bangkok
#4
Jomkwan Yothasamut, Laura Camfield, Michael Pfeil
PURPOSE: Thai government agencies and the business sector have been promoting milk consumption. Considering the robust and continual movements by those actors to promote milk consumption among children in Thailand at the national level, this study aims to investigate milk-consumption practices and values towards milk consumption at pre-school, family and individual levels. METHODS: This cross-sectional qualitative study employs observation and interview methods, along with the Ecological System Theory as a framework...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29667835/oxygen-release-induced-chemomechanical-breakdown-of-layered-cathode-materials
#5
Linqin Mu, Ruoqian Lin, Rong Xu, Lili Han, Sihao Xia, Dimosthenis Sokaras, James Steiner, Tsu-Chien Weng, Dennis Nordlund, Marca M Doeff, Yijin Liu, Kejie Zhao, Huolin L Xin, Feng Lin
Chemical and mechanical properties interplay on the nanometric scale and collectively govern the functionalities of battery materials. Understanding the relationship between the two can inform the design of battery materials with optimal chemomechanical properties for long-life lithium batteries. Herein, we report a mechanism of nanoscale mechanical breakdown in layered oxide cathode materials, originating from oxygen release at high states of charge under thermal abuse conditions. We observe that the mechanical breakdown of charged Li1-xNi0...
April 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29667385/chance-of-reimbursement-for-add-on-therapies-in-poland-and-in-the-world-review-of-the-reimbursement-recommendations
#6
Ewa Borowiack, Magdalena Marzec, Anna Nowotarska, Joanna Jarosz, Agata Orkisz, Patrycja Prząda-Machno
INTRODUCTION: Oncology drugs combined with standard therapies (so-called add-on therapies, e.g. bevacizumab, palbociclib) often receive negative recommendations regarding the legitimacy of public financing, issued by government agencies responsible for their assessment, i.e. health technology assessment agencies. The aim of the study was to estimate the scale of the problem related to the reimbursement of add-on therapies used in the treatment of breast and genitourinary cancers in Poland and in the world...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667238/diet-quality-and-10-year-healthcare-costs-by-bmi-categories-in-the-mid-age-cohort-of-the-australian-longitudinal-study-on-women-s-health
#7
A Patterson, A Hure, T Burrows, J Jackson, C Collins
BACKGROUND: Better diets, as evaluated by diet quality indices, are associated with lower rates of morbidity and mortality. Although governments and researchers alike recognise the burden that obesity incurs for increased healthcare spending, there is insufficient evidence for the role of diet quality on healthcare costs. METHODS: Diet quality was assessed by the Australian Recommended Food Score (ARFS) for 6328 women aged 50-55 years from the Australian Longitudinal Study on Women's Health...
April 17, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/29667210/pastoral-power-and-the-promotion-of-self-care
#8
Lorelei Jones
In many countries government policy is becoming increasingly reliant on citizens taking greater responsibility for their health and wellbeing and limiting their consumption of public services. In this paper I develop Foucauldian perspectives on the work required to create and maintain responsibilised subjects, focusing on the role of 'pastors' - specialists, experts and therapists who promote desirable subjectivities (Waring and Latif ). Drawing from ethnographic research, I consider how government policies for the promotion of self-care within the English healthcare system not only place increased emphasis on patients taking responsibility for their own health and wellbeing, but also seek to constitute new pastoral subjectivities as responsible for conducting the conduct of patients...
April 17, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29667158/obesity-prevention-and-management-strategies-in-canada-shifting-paradigms-and-putting-people-first
#9
REVIEW
Arya M Sharma, Ximena Ramos Salas
PURPOSE OF REVIEW: The purpose of this study was to review public and private sector obesity policies in Canada and to make recommendations for future evidence-based obesity prevention and management strategies. RECENT FINDINGS: Synthesis of obesity prevention and management policies and research studies are presented in three primary themes: (1) Increased awareness about the impact of weight bias and obesity stigma in Canada; (2) Inadequate government obesity prevention and management policies and strategies; and (3) Lack of comprehensive private sector obesity prevention and management policies...
April 17, 2018: Current Obesity Reports
https://www.readbyqxmd.com/read/29667102/body-size-and-tube-voltage-dependent-guiding-equations-for-optimal-selection-of-image-acquisition-parameters-in-clinical-x-ray-imaging
#10
Xiaoming Zheng
The purpose of this work was to present body size and tube voltage-dependent equations for optimal selection of image acquisition parameters in guiding clinical X-ray imaging. The dose output of X-ray tubes was expressed as a function of the image acquisition parameters of tube voltage (kVp), tube current-exposure time product (mAs), and body size (d). Dose power (n) to kVp was determined to be a linear function of body size in an earlier phantom study. Tube voltage-dependent attenuation coefficients of water were used to determine the kVp effect on the depth dose of X-rays from the body's entrance surface...
April 17, 2018: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29667070/differences-in-use-of-government-subsidised-mental-health-services-by-men-and-women-with-psychological-distress-a-study-of-229-628-australians-aged-45-years-and-over
#11
Xenia Dolja-Gore, Deborah Loxton, Catherine D'Este, Fiona Blyth, Julie Byles
This study examined factors associated with use of government subsidised mental health services by 229,628 men and women from the Sax Institute's 45 and Up Study. Logistical regression models assessed use of mental health services by gender and according to level of psychological distress. Approximately equal proportion of men and women had high psychological distress scores (approximately 7%) but only 7% of these men and 11% of these women used services. Use was associated with predisposing (younger age and higher education), enabling (private health insurance) and need factors (higher psychological distress scores)...
April 17, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29667069/the-versatile-role-of-exosomes-in-cancer-progression-diagnostic-and-therapeutic-implications
#12
REVIEW
Vignesh Sundararajan, Fazlul H Sarkar, Thamil Selvee Ramasamy
BACKGROUND: Recent advances in cancer biology have highlighted the relevance of exosomes and nanovesicles as carriers of genetic and biological messages between cancer cells and their immediate and/or distant environments. It has been found that these molecular cues may play significant roles in cancer progression and metastasis. Cancer cells secrete exosomes containing diverse molecules that can be transferred to recipient cells and/or vice versa to induce a plethora of biological processes, including angiogenesis, metastasis formation, therapeutic resistance, epithelial-mesenchymal transition and epigenetic/stemness (re)programming...
April 17, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29667063/allocating-on-coal-consumption-and-co-2-emission-from-fair-and-efficient-perspective-empirical-analysis-on-provincial-panel-data-of-china
#13
Bang-Jun Wang, Jia-Lu Zhao, Yan-Fang Wu, Chao-Qun Zhu, Yin-Nan He, Yi-Xi Wei
This paper considers a problem of how to allocate resource effectively and equitably among provinces. To address the problem, a total factor resource input-oriented data envelopment analysis (DEA) model is used to evaluate the energy and environmental efficiency for 30 provinces in China during 2009-2013 in this paper. Based on the evaluation results, from efficient and fair perspective, a revised DEA-based resource allocation model is established. It is worth pointing out that the model takes the input orientation and output orientation into account at the same time and can be used to allocate coal consumption and carbon emission by 2020 for 30 provinces in China...
April 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666605/can-a-proper-t-cell-development-occur-in-an-altered-thymic-epithelium-lessons-from-ephb-deficient-thymi
#14
Juan José Muñoz, Javier García-Ceca, Sara Montero-Herradón, Beatriz Sánchez Del Collado, David Alfaro, Agustín Zapata
For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype of mutant mice deficient in several Ephs and ephrins B has been determined. Remarkably, thymic stroma in these animals exhibits important defects that appear early in ontogeny but little alterations in the proportions of distinct lymphoid cell populations...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29666504/no-prophylactic-antibiotic-use-for-young-children-s-intussusception-with-low-risk-infection-after-successful-air-enema-reduction
#15
Yuan Zhang, Wen Zou, Lemeng Ren, Yinghui Zhang, Zhaohui Sun, Huandi Liu, Qian Liu, Chunfeng Si, Hongying Jia
The Chinese government has issued the policy of promulgating the clinical use of antibacterial drugs since 2011. Prophylactic antibiotic use is a challenging problem among young children with intussusception after successful air enema reduction. There were limited data regarding the clinical value of prophylactic antibiotics for intussusception with low-risk infections. A retrospective non-randomized comparative study was conducted among 188 young children with intussusception after successful air enema reduction between January 1, 2011 and December 30, 2013...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666322/genetic-control-of-yellow-vein-mosaic-virus-disease-tolerance-in-abelmoschus-esculentus-l-moench
#16
Pushparani Senjam, Bijoy Kumar Senapati, Arup Chattopadhyay, Subrata Dutta
Okra's (Abelmoschus esculentus (L.) Moench) commercial cultivation is threatened in the tropics due to high incidence of yellow vein mosaic virus (YVMV) disease. Okra geneticists across the world tried to understand the inheritance pattern of YVMV disease tolerance without much success. Therefore, the inheritance pattern of YVMV disease in okra was revisited by employing sixgenerations (P₁, P₂, F₁, F₂, BC₁ and BC₂) of four selected crosses (one tolerant × tolerant, two tolerant × susceptible and one susceptible × susceptible) using two tolerant (BCO-1 and Lal Bhendi) and two susceptible (Japanese Jhar Bhendi and PAN 2127) genotypes...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666271/desynchronization-of-slow-oscillations-in-the-basal-ganglia-during-natural-sleep
#17
Aviv D Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666239/individuals-institutions-and-innovation-in-the-debates-of-the-french-revolution
#18
Alexander T J Barron, Jenny Huang, Rebecca L Spang, Simon DeDeo
The French Revolution brought principles of "liberty, equality, fraternity" to bear on the day-to-day challenges of governing what was then the largest country in Europe. Its experiments provided a model for future revolutions and democracies across the globe, but this first modern revolution had no model to follow. Using reconstructed transcripts of debates held in the Revolution's first parliament, we present a quantitative analysis of how this body managed innovation. We use information theory to track the creation, transmission, and destruction of word-use patterns across over 40,000 speeches and a thousand speakers...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666215/control-of-pancreatic-%C3%AE-cell-bioenergetics
#19
REVIEW
Charles Affourtit, Ben Alberts, Jonathan Barlow, Jane E Carré, Anthony G Wynne
The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual as it implies that ATP flux is governed, to a significant extent, by ATP supply, while it is predominantly demand-driven in other cell types. Metabolic control is generally shared between different processes, but potential control of ATP consumption over β-cell bioenergetics has been largely ignored to date...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29666145/development-of-sustainable-community-paramedicine-programmes-a-case-study-in-pennsylvania
#20
Yuan-Han Huang, Linlin Ma, Luke A Sabljak, Zachary A Puhala
BACKGROUND: Community paramedicine (CP) models have been applied across rural and urban communities in support of healthcare delivery systems for nearly two decades. However, there is still insufficient information regarding the development of sustainable CP programmes. This study explores the strategies used by active CP programmes and investigates their operational statuses, community demographics, financial models and challenges for programme development. METHODS: A series of interviews was conducted with four CP programmes in Pennsylvania, USA, which are affiliated with a local government, a health system, an ambulance service and an emergency medical service, respectively...
April 17, 2018: Emergency Medicine Journal: EMJ
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