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Metamizole

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https://www.readbyqxmd.com/read/29136265/generalized-bullous-fixed-drug-eruption-following-metamizole-re-exposure-a-medical-error-analytic-case-study
#1
Peter Elsner, Maja Mockenhaupt
No abstract text is available yet for this article.
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29127905/dissolution-studies-of-metamizole-sodium-and-pseudoephedrine-sulphate-dosage-forms-comparison-and-correlation-of-electronic-tongue-results-with-reference-studies
#2
Małgorzata Wesoły, Marcin Zabadaj, Krzysztof Cal, Patrycja Ciosek-Skibińska, Wojciech Wróblewski
This work reports a critical evaluation of the results of the release of active substances (APIs) from novel pharmaceutical formulations provided by an electronic tongue system (ET). Detailed dissolution studies of modified-release granules used in pharmacotherapy containing metamizole sodium and pseudoephedrine sulphate were carried out. The impact of the dissolution-modifying excipients (carmellose sodium and hypromellose) on the dissolution process as well as on the outcomes of the sensor array of ion-selective electrodes was investigated...
November 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29107589/metamizole-and-platelet-inhibition-by-aspirin-following-on-pump-coronary-artery-bypass-grafting
#3
Mirosław Wilczyński, Maciej T Wybraniec, Marek Sanak, Joanna Góral, Katarzyna Mizia-Stec
OBJECTIVE: The purpose of the study was to evaluate the impact of intravenous metamizole on platelet inhibition by aspirin in patients with coronary artery disease early after on-pump coronary artery bypass grafting (CABG). DESIGN: Prospective, single-blind, randomized trial. SETTING: Tertiary referal hospital. PARTICIPANTS: The study comprised 43 patients with multivessel coronary artery disease undergoing CABG. INTERVENTIONS: Patients were randomized to postoperative intravenous metamizole ± opioids (study group; n = 23) or opioids alone (control group; n = 20)...
June 7, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29055450/management-of-infusion-related-reactions-associated-with-alemtuzumab-in-patients-with-multiple-sclerosis
#4
Saša Šega-Jazbec, Barbara Barun, Alenka Horvat Ledinek, Višnja Fabekovac, Magdalena Krbot Skorić, Mario Habek
OBJECTIVE: Infusion-associated reactions (IARs) occur in >90% patients with multiple sclerosis (MS) treated with alemtuzumab. We aimed to study the frequency of IARs at 2 sites using 5 days of steroids (1g/day of IV methylprednisolone), but otherwise distinct protocols. METHODS: This was retrospective chart review of 38 consecutive MS patients who were treated with alemtuzumab from June 2015 till February 2017 at Department of Neurology, University Hospital Center Zagreb, Croatia and Department of Neurology, University Medical Center Ljubljana, Slovenia...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29024184/the-use-of-dipyrone-metamizol-as-an-analgesic-in-children-what-is-the-evidence-a-review
#5
REVIEW
Thomas G de Leeuw, Maaike Dirckx, Antonia Gonzalez Candel, Gail P Scoones, Frank J P M Huygen, Saskia N de Wildt
Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. Due to a possible risk of agranulocytosis with the use of dipyrone, it has been banned in a number of countries. The most commonly used data for the use of dipyrone are related to adults. Information relating to the use of dipyrone in children is scarce. Given the potential added value of dipyrone in the treatment of pain, a review of the literature was conducted to obtain more insight into the analgesic efficacy of dipyrone in children as well as the safety of dipyrone in terms of adverse events...
December 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28960668/inhibitory-effects-of-some-drugs-on-carbonic-anhydrase-enzyme-purified-from-kangal-akkaraman-sheep-in-sivas-turkey
#6
Ümit M Koçyiğit, Sevgi Durna Daştan, Parham Taslimi, Taner Daştan, İlhami Gülçin
In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of preparation of the hemolysate and conducting the Sepharose-4B-tyrosine-sulfanilamide affinity gel chromatography in having specific activity of 11626 EU mg(-1) , yield of 14.40%, and 242.76-fold purification. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis was performed to assess the enzyme purity and a single band was observed...
September 28, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28946059/pregabalin-as-adjunct-in-a-multimodal-pain-therapy-after-traumatic-foot-amputation-a-case-report-of-a-4-year-old-girl
#7
Stephanie Wössner, Kirsten Weber, Anna C Steinbeck, Markus Oberhauser, Matthias Feuerecker
BACKGROUND AND PURPOSE: The purpose of this case report is to describe a multimodal pain therapeutic concept including the adjunct use of pregabalin in a 4.5 year-old child after forefoot amputation. Phantom limb pain and sensation is a complex pain syndrome that is difficult to treat and prevent. 70-75% of all children develop such a pain syndrome after amputation. We describe here a paediatric patient who underwent forefoot amputation following traumatic foot injury and received multimodal pain therapy including pregabalin...
September 22, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28943040/treatment-of-musculo-skeletal-pain-in-haemophilia
#8
REVIEW
E Carlos Rodriguez-Merchan
Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of F VIII/IX. In acute haemarthroses pain treatment must continue until total disappearance (checked by ultrasonography) and include haematologic treatment, short-term rest of the involved joint, cryotherapy, joint aspiration and analgesic medication (paracetamol in mild pain, metamizole for more intense pain, and in a few precise patients, soft opioids such as codeine or tramadol)...
September 19, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28771890/metamizole-use-during-first-trimester-a-prospective-observational-cohort-study-on-pregnancy-outcome
#9
Katarina Dathe, Stephanie Padberg, Stefanie Hultzsch, Katja Meixner, Tatjana Tissen-Diabaté, Reinhard Meister, Evelin Beck, Christof Schaefer
INTRODUCTION: The analgesic metamizole (dipyrone) is not recommended during pregnancy due to limited experience. In several countries, metamizole has no market authorization because of agranulocytosis as a rare but severe adverse effect. However, in others, metamizole is available and widely used as a pain reliever, and its use occurs also during pregnancy, often followed by fears of potential teratogenic risk. METHODS: This prospective observational cohort study compared pregnancy outcomes of 446 women exposed with metamizole in the first trimester with a randomly selected control cohort comprising 887 women not exposed to metamizole...
October 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28718026/solid-phase-extraction-of-multi-class-pharmaceuticals-from-environmental-water-samples-onto-modified-multi-walled-carbon-nanotubes-followed-by-lc-ms-ms
#10
Bojana Lalović, Tatjana Đurkić, Marija Vukčević, Ivona Janković-Častvan, Ana Kalijadis, Zoran Laušević, Mila Laušević
In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634963/leucopenia-associated-with-metamizole-a-case-control-study
#11
Lea Blaser, Hala Hassna, Sarah Hofmann, Andreas Holbro, Manuel Haschke, Alexandra Rätz Bravo, Andreas Zeller, Stephan Krähenbühl, Anne Taegtmeyer
AIMS OF THE STUDY: The aim of this study was to identify possible risk factors for the development of leucopenia associated with metamizole use. METHODS: A retrospective case-control study was performed. Cases of metamizole-associated leucopenia managed at a single centre (2005-2013) were characterised and compared with matched controls who took metamizole without developing complications. RESULTS: Fifty-seven cases and 139 controls were identified...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28580612/utility-of-basophil-activation-testing-to-assess-perioperative-anaphylactic-reactions-in-real-world-practice
#12
Bernadette Eberlein, Sibylle Wigand, Heidrun Lewald, Eberhard Kochs, Johannes Ring, Tilo Biedermann, Ulf Darsow
INTRODUCTION: Perioperative anaphylactic reactions due to drugs and substances associated with general anesthesia can potentially be life-threatening. The objective of this study was to investigate the significance of the basophil activation test (BAT) for allergy diagnosis work up. METHODS: A total of 14 patients (5 men, 9 women; mean age: 57.8 years) with clinical records of anaphylactic reactions under general anesthesia were studied by means of anesthesia records, skin and serological tests...
June 5, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28574391/non-steroidal-anti-inflammatory-drugs-s-antinociception-mediated-by-the-opioid-mechanism-in-the-nucleus-raphe-magnus
#13
T Gorgiladze, I Nozadze, E Abzianidze, M Tsagareli
It has been established that the midbrain periaqueductal gray matter (PAG) and rostral ventro-medial medulla (RVM) are involved in the descending pain control system. The latter involves the midline nucleus raphe magnus (NRM) and adjacent reticular formation. These brain structures are is one of important parts of CNS circuit that controls nociceptive transmission at the level of spinal cord. Here we report that microinjection of commonly used non-steroidal anti-inflammatory drugs (NSAIDs), diclofenac, ketorolac, metamizol, and xefocam into the NRM produces strong antinociception which is mediated by the opioid mechanism...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28560554/continuous-local-analgesia-is-effective-in-postoperative-pain-treatment-after-medium-and-large-incisional-hernia-repair
#14
M C Gherghinescu, C Copotoiu, A E Lazar, D Popa, S S Mogoanta, C Molnar
INTRODUCTION: Incisional hernias are a frequent complication of laparotomy. Open surgery is still an option for the treatment of incisional hernias with medium and large wall defects. Major opioids are routinely used in the treatment of postoperative pain, with several side effects. Continuous local analgesia can be effective in postoperative pain management after various surgical interventions. However, very few reports exist on its application in incisional hernias. PURPOSE: We assessed the effectiveness of ropivacaine in reducing the need for systemic analgesics in postoperative pain management related to these interventions...
October 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28500511/-metamizole-something-to-think-about
#15
T Dingermann
No abstract text is available yet for this article.
June 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28375983/postoperative-administration-of-metamizole-for-one-single-day-a-retrospective-cohort-study
#16
Stefan van Beek, Seppe Koopman, Robert J Stolker, Markus Klimek
No abstract text is available yet for this article.
May 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28317195/patch-testing-in-the-investigation-of-non-immediate-cutaneous-adverse-drug-reactions-to-metamizole
#17
André Pinho, Luís Santiago, Margarida Gonçalo
No abstract text is available yet for this article.
April 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28306590/the-use-of-dipyrone-in-the-icu-is-associated-with-acute-kidney-injury-a-retrospective-cohort-analysis
#18
Thomas Stueber, Laura Buessecker, Andreas Leffler, Hans-Jörg Gillmann
BACKGROUND: Use of dipyrone (metamizole) in perioperative and ICU pain therapy remains controversial due to a lack of solid evidence weighing dipyrone benefit against its potential life-threatening complications. Although dipyrone has known analgesic and antipyretic properties, its mechanisms of actions are incompletely understood. Although dipyrone effects on renal vasodilator prostaglandin synthesis are documented, little is known about its potential renal side effects, especially in the critical care environment...
March 16, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28294366/antihyperalgesic-effects-of-indomethacin-ketorolac-and-metamizole-in-rats-effects-of-metformin
#19
Crystell Guadalupe Guzmán-Priego, Roberto Méndez-Mena, Manuel Alfonso Baños-González, Claudia Ivonne Araiza-Saldaña, Gabriela Castañeda-Corral, Jorge Elías Torres-López
Preclinical Research Metformin-dependent mechanisms have been implicated in the antinociceptive effect of some non-steroidal anti-inflammatory drugs (NSAIDs). In this study, the effect of local peripheral or systemic administration of metformin on the local peripheral or systemic antinociception induced by indomethacin, ketorolac and metamizole was assessed in the rat carrageenan-induced thermal hyperalgesia model. Rats were injected with carrageenan (1%, 50 µl) into the right hindpaw which reduced paw withdrawal latency, a measure of thermal hyperalgesia...
March 2017: Drug Development Research
https://www.readbyqxmd.com/read/28293792/bilateral-sagittal-split-osteotomy-parameters-and-correlations-of-postoperative-pain-management
#20
Gregor F Raschke, Winfried Meissner, Andre Peisker, Gabriel Djedovic, Ulrich Rieger, Arndt Guentsch, Marta Gomez Dammeier, Stefan Schultze-Mosgau
OBJECTIVES: Postoperative pain management is of utmost interest for patients undergoing orthognathic surgery. Currently, there is a lack of information regarding process and outcome parameters of postoperative pain management after bilateral sagittal split osteotomy. MATERIALS AND METHODS: In a prospective clinical study, 31 adults were evaluated on the first postoperative day following bilateral sagittal split osteotomy using the standardized questionnaire of the Germany-wide project Quality Improvement in Postoperative Pain Management (QUIPS)...
March 14, 2017: Clinical Oral Investigations
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