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Stephen mcgee

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https://www.readbyqxmd.com/read/27821148/understanding-pneumococcal-serotype-1-biology-through-population-genomic-analysis
#1
Chrispin Chaguza, Jennifer E Cornick, Simon R Harris, Cheryl P Andam, Laura Bricio-Moreno, Marie Yang, Feyruz Yalcin, Sani Ousmane, Shanil Govindpersad, Madikay Senghore, Chinelo Ebruke, Mignon Du Plessis, Anmol M Kiran, Gerd Pluschke, Betuel Sigauque, Lesley McGee, Keith P Klugman, Paul Turner, Jukka Corander, Julian Parkhill, Jean-Marc Collard, Martin Antonio, Anne von Gottberg, Robert S Heyderman, Neil French, Aras Kadioglu, William P Hanage, Dean B Everett, Stephen D Bentley
BACKGROUND: Pneumococcus kills over one million children annually and over 90 % of these deaths occur in low-income countries especially in Sub-Saharan Africa (SSA) where HIV exacerbates the disease burden. In SSA, serotype 1 pneumococci particularly the endemic ST217 clone, causes majority of the pneumococcal disease burden. To understand the evolution of the virulent ST217 clone, we analysed ST217 whole genomes from isolates sampled from African and Asian countries. METHODS: We analysed 226 whole genome sequences from the ST217 lineage sampled from 9 African and 4 Asian countries...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27554445/characterization-of-3-3-dimethyl-substituted-n-aryl-piperidines-as-potent-microsomal-prostaglandin-e-synthase-1-inhibitors
#2
Steven L Kuklish, Stephen Antonysamy, Shobha N Bhattachar, Srinivasan Chandrasekhar, Matthew J Fisher, Adrian J Fretland, Karen Gooding, Anita Harvey, Norman E Hughes, John G Luz, Peter R Manninen, James E McGee, Antonio Navarro, Bryan H Norman, Katherine M Partridge, Steven J Quimby, Matthew A Schiffler, Ashley V Sloan, Alan M Warshawsky, Jeremy S York, Xiao-Peng Yu
Here we report on novel, potent 3,3-dimethyl substituted N-aryl piperidine inhibitors of microsomal prostaglandin E synthases-1(mPGES-1). Example 14 potently inhibited PGE2 synthesis in an ex vivo human whole blood (HWB) assay with an IC50 of 7nM. In addition, 14 had no activity in human COX-1 or COX-2 assays at 30μM, and failed to inhibit human mPGES-2 at 62.5μM in a microsomal prep assay. These data are consistent with selective mPGES-1-mediated reduction of PGE2. In dog, 14 had oral bioavailability (74%), clearance (3...
October 1, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27130160/huwe1-mutations-in-juberg-marsidi-and-brooks-syndromes-the-results-of-an-x-chromosome-exome-sequencing-study
#3
Michael J Friez, Susan Sklower Brooks, Roger E Stevenson, Michael Field, Monica J Basehore, Lesley C Adès, Courtney Sebold, Stephen McGee, Samantha Saxon, Cindy Skinner, Maria E Craig, Lucy Murray, Richard J Simensen, Ying Yzu Yap, Marie A Shaw, Alison Gardner, Mark Corbett, Raman Kumar, Matthias Bosshard, Barbara van Loon, Patrick S Tarpey, Fatima Abidi, Jozef Gecz, Charles E Schwartz
BACKGROUND: X linked intellectual disability (XLID) syndromes account for a substantial number of males with ID. Much progress has been made in identifying the genetic cause in many of the syndromes described 20-40 years ago. Next generation sequencing (NGS) has contributed to the rapid discovery of XLID genes and identifying novel mutations in known XLID genes for many of these syndromes. METHODS: 2 NGS approaches were employed to identify mutations in X linked genes in families with XLID disorders...
2016: BMJ Open
https://www.readbyqxmd.com/read/27001799/multistate-outbreak-of-respiratory-infections-among-unaccompanied-children-june-2014-july-2014
#4
Sara Tomczyk, Carmen S Arriola, Bernard Beall, Alvaro Benitez, Stephen R Benoit, LaShondra Berman, Joseph Bresee, Maria da Gloria Carvalho, Amanda Cohn, Kristen Cross, Maureen H Diaz, Louise K Francois Watkins, Ryan Gierke, Jose E Hagan, Aaron M Harris, Seema Jain, Lindsay Kim, Miwako Kobayashi, Stephen Lindstrom, Lesley McGee, Meredith McMorrow, Benjamin L Metcalf, Matthew R Moore, Iaci Moura, W Allan Nix, Edith Nyangoma, M Steven Oberste, Sonja J Olsen, Fabiana Pimenta, Christina Socias, Kathleen Thurman, Jessica Waller, Stephen H Waterman, Matthew Westercamp, Melinda Wharton, Cynthia G Whitney, Jonas M Winchell, Bernard Wolff, Curi Kim
BACKGROUND: From January 2014-July 2014, more than 46 000 unaccompanied children (UC) from Central America crossed the US-Mexico border. In June-July, UC aged 9-17 years in 4 shelters and 1 processing center in 4 states were hospitalized with acute respiratory illness. We conducted a multistate investigation to interrupt disease transmission. METHODS: Medical charts were abstracted for hospitalized UC. Nonhospitalized UC with influenza-like illness were interviewed, and nasopharyngeal and oropharyngeal swabs were collected to detect respiratory pathogens...
July 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26962082/phylogenetic-analysis-of-invasive-serotype-1-pneumococcus-in-south-africa-1989-to-2013
#5
Mignon du Plessis, Mushal Allam, Stefano Tempia, Nicole Wolter, Linda de Gouveia, Claire von Mollendorf, Keith A Jolley, Nontombi Mbelle, Jeannette Wadula, Jennifer E Cornick, Dean B Everett, Lesley McGee, Robert F Breiman, Rebecca A Gladstone, Stephen D Bentley, Keith P Klugman, Anne von Gottberg
Serotype 1 is an important cause of invasive pneumococcal disease in South Africa and has declined following the introduction of the 13-valent pneumococcal conjugate vaccine in 2011. We genetically characterized 912 invasive serotype 1 isolates from 1989 to 2013. Simpson's diversity index (D) and recombination ratios were calculated. Factors associated with sequence types (STs) were assessed. Clonal complex 217 represented 96% (872/912) of the sampled isolates. Following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), ST diversity increased in children <5 years (D, 0...
May 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26818398/long-term-toxicity-of-naturally-occurring-asbestos-in-male-fischer-344-rats
#6
Jaime M Cyphert, Marie A McGee, Abraham Nyska, Mette C Schladweiler, Urmila P Kodavanti, Stephen H Gavett
Naturally occurring asbestos (NOA) fibers are found in geologic deposits that may be disturbed by mining, earthworks, or natural processes, resulting in adverse health risks to exposed individuals. The toxicities of Libby amphibole and NOA samples including Sumas Mountain chrysotile (SM), El Dorado tremolite (ED), and Ontario ferroactinolite cleavage fragments (ON) were compared in male Fischer 344 (F344) rats 15 mo after exposure. Rat-respirable fractions of LA and SM displayed greater mean lengths and aspect ratios than ED and ON...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/26509889/technological-memory-aid-use-by-people-with-acquired-brain-injury
#7
Matthew Jamieson, Breda Cullen, Marilyn McGee-Lennon, Stephen Brewster, Jonathan Evans
Evans, Wilson, Needham, and Brentnall ( 2003 ) investigated memory aid use by people with acquired brain injury (ABI) and found little use of technological memory aids. The present study aims to investigate use of technological and other memory aids and strategies 10 years on, and investigate what predicts use. People with ABI and self-reported memory impairments (n = 81) completed a survey containing a memory aid checklist, demographic questions and memory questionnaires. Chi-square analysis showed that 10 of 18 memory aids and strategies were used by significantly more people in the current sample than in Evans et al...
October 28, 2015: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/26479704/ameliorating-spinal-cord-injury-in-an-animal-model-with-mechanical-tissue-resuscitation
#8
Zhen-Lin Zheng, Michael J Morykwas, Stephen Tatter, Stan Gordon, Maria McGee, Heather Green, Louis C Argenta
BACKGROUND: Traumatic spinal cord injury (SCI) is a major worldwide cause of mortality and disability with limited treatment options. Previous research applying controlled negative pressure to traumatic brain injury in rat and swine models resulted in smaller injuries and more rapid recovery. OBJECTIVE: To examine the effects of the application of a controlled vacuum (mechanical tissue resuscitation [MTR]) to SCI in a rat model under several magnitudes of vacuum...
June 2016: Neurosurgery
https://www.readbyqxmd.com/read/26363404/strain-features-and-distributions-in-pneumococci-from-children-with-invasive-disease-before-and-after-13-valent-conjugate-vaccine-implementation-in-the-usa
#9
B J Metcalf, R E Gertz, R A Gladstone, H Walker, L K Sherwood, D Jackson, Z Li, C Law, P A Hawkins, S Chochua, M Sheth, N Rayamajhi, S D Bentley, L Kim, C G Whitney, L McGee, B Beall
The effect of second-generation pneumococcal conjugate vaccines on invasive pneumococcal disease (IPD) strain distributions have not yet been well described. We analysed IPD isolates recovered from children aged <5 years through Active Bacterial Core surveillance before (2008-2009; n = 828) and after (2011-2013; n = 600) 13-valent pneumococcal conjugate vaccine (PCV13) implementation. We employed conventional testing, PCR/electrospray ionization mass spectrometry and whole genome sequence (WGS) analysis to identify serotypes, resistance features, genotypes, and pilus types...
January 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26123971/loving-nature-from-the-inside-out-a-biophilia-matrix-identification-strategy-for-designers
#10
Beth McGee, Anna Marshall-Baker
OBJECTIVE: The development of the Biophilic Design Matrix (BDM) was to aid designers or other specialists in identifying and quantifying biophilic features through a visual inventory of interior spaces. BACKGROUND: With mounting evidence to support the healing attributes of biophilic environments, we propose a method to identify biophilic content within interior spaces. Such a strategy offers much promise to the advancement of restorative environments. METHODS: The BDM was based on Stephen Kellert's biophilic design attribute list and modified to be appropriate for interior environments, specifically children's healthcare spaces...
2015: HERD
https://www.readbyqxmd.com/read/25710269/differential-effects-of-particulate-matter-upwind-and-downwind-of-an-urban-freeway-in-an-allergic-mouse-model
#11
Marie A McGee, Ali S Kamal, John K McGee, Charles E Wood, Janice A Dye, Q Todd Krantz, Matthew S Landis, M Ian Gilmour, Stephen H Gavett
Near-road exposure to air pollutants has been associated with decreased lung function and other adverse health effects in susceptible populations. This study was designed to investigate whether different types of near-road particulate matter (PM) contribute to exacerbation of allergic asthma. Samples of upwind and downwind coarse, fine, and ultrafine PM were collected using a wind direction-actuated ChemVol sampler at a single site 100 m from Interstate-96 in Detroit, MI during winter 2010/2011. Upwind PM was enriched in crustal and wood combustion sources while downwind PM was dominated by traffic sources...
March 17, 2015: Environmental Science & Technology
https://www.readbyqxmd.com/read/25480686/global-phylogenomic-analysis-of-nonencapsulated-streptococcus-pneumoniae-reveals-a-deep-branching-classic-lineage-that-is-distinct-from-multiple-sporadic-lineages
#12
Markus Hilty, Daniel Wüthrich, Susannah J Salter, Hansjürg Engel, Samuel Campbell, Raquel Sá-Leão, Hermínia de Lencastre, Peter Hermans, Ewa Sadowy, Paul Turner, Claire Chewapreecha, Mathew Diggle, Gerd Pluschke, Lesley McGee, Özgen Köseoğlu Eser, Donald E Low, Heidi Smith-Vaughan, Andrea Endimiani, Marianne Küffer, Mélanie Dupasquier, Emmanuel Beaudoing, Johann Weber, Rémy Bruggmann, William P Hanage, Julian Parkhill, Lucy J Hathaway, Kathrin Mühlemann, Stephen D Bentley
The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated S. pneumoniae (non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if non-Ec-Sp evolve sporadically, if they have high antibiotic nonsusceptiblity rates and a unique, specific gene content. Here, whole-genome sequencing of 131 non-Ec-Sp isolates sourced from 17 different locations around the world was performed...
December 2014: Genome Biology and Evolution
https://www.readbyqxmd.com/read/25454615/a-multi-institutional-prospective-trial-in-the-usa-confirms-that-the-4kscore-accurately-identifies-men-with-high-grade-prostate-cancer
#13
MULTICENTER STUDY
Dipen J Parekh, Sanoj Punnen, Daniel D Sjoberg, Scott W Asroff, James L Bailen, James S Cochran, Raoul Concepcion, Richard D David, Kenneth B Deck, Igor Dumbadze, Michael Gambla, Michael S Grable, Ralph J Henderson, Lawrence Karsh, Evan B Krisch, Timothy D Langford, Daniel W Lin, Shawn M McGee, John J Munoz, Christopher M Pieczonka, Kimberley Rieger-Christ, Daniel R Saltzstein, John W Scott, Neal D Shore, Paul R Sieber, Todd M Waldmann, Fredrick N Wolk, Stephen M Zappala
BACKGROUND: The 4Kscore combines measurement of four kallikreins in blood with clinical information as a measure of the probability of significant (Gleason ≥7) prostate cancer (PCa) before prostate biopsy. OBJECTIVE: To perform the first prospective evaluation of the 4Kscore in predicting Gleason ≥7 PCa in the USA. DESIGN, SETTING, AND PARTICIPANTS: Prospective enrollment of 1012 men scheduled for prostate biopsy, regardless of prostate-specific antigen level or clinical findings, was conducted at 26 US urology centers between October 2013 and April 2014...
September 2015: European Urology
https://www.readbyqxmd.com/read/24957517/variable-recombination-dynamics-during-the-emergence-transmission-and-disarming-of-a-multidrug-resistant-pneumococcal-clone
#14
Nicholas J Croucher, William P Hanage, Simon R Harris, Lesley McGee, Mark van der Linden, Herminia de Lencastre, Raquel Sá-Leão, Jae-Hoon Song, Kwan Soo Ko, Bernard Beall, Keith P Klugman, Julian Parkhill, Alexander Tomasz, Karl G Kristinsson, Stephen D Bentley
BACKGROUND: Pneumococcal β-lactam resistance was first detected in Iceland in the late 1980s, and subsequently peaked at almost 25% of clinical isolates in the mid-1990s largely due to the spread of the internationally-disseminated multidrug-resistant PMEN2 (or Spain6B-2) clone of Streptococcus pneumoniae. RESULTS: Whole genome sequencing of an international collection of 189 isolates estimated that PMEN2 emerged around the late 1960s, developing resistance through multiple homologous recombinations and the acquisition of a Tn5253-type integrative and conjugative element (ICE)...
2014: BMC Biology
https://www.readbyqxmd.com/read/24924585/truncating-mutations-in-lrp4-lead-to-a-prenatal-lethal-form-of-cenani-lenz-syndrome
#15
Amanda S Lindy, Caleb P Bupp, Stephen J McGee, Erin Steed, Roger E Stevenson, Monica J Basehore, Michael J Friez
Cenani-Lenz syndrome (CLS) is an autosomal recessive skeletal dysplasia that results in malformations of the distal limb, renal anomalies, and characteristic facies. In 2010, this condition was found to be caused by mutations in LRP4, a member of the low-density lipoprotein family of receptors. LRP4 has been shown to antagonize LRP5/LRP6 activation of WNT and β-catenin signaling. Loss of LRP4 function leads to excessive Wnt and β-catenin signaling in the limb bud, which causes abnormal limb development. The large majority of patients with CLS reported in the literature have splicing and missense mutations, which result in syndactyly, oligodactyly, and minor renal malformations...
September 2014: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/24916661/evidence-for-soft-selective-sweeps-in-the-evolution-of-pneumococcal-multidrug-resistance-and-vaccine-escape
#16
Nicholas J Croucher, Claire Chewapreecha, William P Hanage, Simon R Harris, Lesley McGee, Mark van der Linden, Jae-Hoon Song, Kwan Soo Ko, Herminia de Lencastre, Claudia Turner, Fan Yang, Raquel Sá-Leão, Bernard Beall, Keith P Klugman, Julian Parkhill, Paul Turner, Stephen D Bentley
The multidrug-resistant Streptococcus pneumoniae Taiwan(19F)-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, "vaccine escape" PMEN14 isolates with a 19A serotype became an increasingly important cause of disease post-PCV7. Whole genome sequencing was used to characterize the recent evolution of 173 pneumococci of, or related to, PMEN14. This suggested that PMEN14 is a single lineage that originated in the late 1980s in parallel with the acquisition of multiple resistances by close relatives...
July 2014: Genome Biology and Evolution
https://www.readbyqxmd.com/read/24805811/alpha-thalassemia-intellectual-disability-variable-phenotypic-expression-among-males-with-a-recurrent-nonsense-mutation%C3%A2-%C3%A2-c-109c-t-p-r37x
#17
REVIEW
M J Basehore, R Michaelson-Cohen, E Levy-Lahad, C Sismani, L M Bird, M J Friez, T Walsh, F Abidi, L Holloway, C Skinner, S McGee, A Alexandrou, M Syrrou, P C Patsalis, G Raymond, T Wang, C E Schwartz, M-C King, R E Stevenson
Alpha-thalassemia intellectual disability, one of the recognizable X-linked disability syndromes, is characterized by short stature, microcephaly, distinctive facies, hypotonic appearance, cardiac and genital anomalies, and marked skewing of X-inactivation in female carriers. With the advent of next generation sequencing, mutations have been identified that result in less severe phenotypes lacking one or more of these phenotypic manifestations. Here we report five unrelated kindreds in which a c.109C>T (p...
May 2015: Clinical Genetics
https://www.readbyqxmd.com/read/24776951/effect-of-submarine-groundwater-discharge-on-bacterial-indicators-and-swimmer-health-at-avalon-beach-ca-usa
#18
Vincent M Yau, Kenneth C Schiff, Benjamin F Arnold, John F Griffith, Joshua S Gruber, Catherine C Wright, Timothy J Wade, Susan Burns, Jacqueline M Hayes, Charles McGee, Mark Gold, Yiping Cao, Alexandria B Boehm, Stephen B Weisberg, John M Colford
Use of fecal indicator bacteria (FIB) for monitoring beach water quality is based on their co-occurrence with human pathogens, a relationship that can be dramatically altered by fate and transport processes after leaving the human intestine. We conducted a prospective cohort study at Avalon Beach, California (USA), where the indicator relationship is potentially affected by the discharge of sewage-contaminated groundwater and by solar radiation levels at this shallow, relatively quiescent beach. The goals of this study were to determine: 1) if swimmers exposed to marine water were at higher risk of illness than non-swimmers; 2) if FIB measured in marine water were associated with swimmer illness, and; 3) if the associations between FIB and swimmer health were modified by either submarine groundwater discharge or solar radiation levels...
August 1, 2014: Water Research
https://www.readbyqxmd.com/read/24618796/mechanical-tissue-resuscitation-at-the-site-of-traumatic-brain-injuries-reduces-the-volume-of-injury-and-hemorrhage-in-a-swine-model
#19
Zhen-lin Zheng, Michael Morykwas, Douglas Campbell, Maria McGee, Charlotte Hollingsworth, Farren Adams, Jennifer Mays, Stephen Tatter, Louis Argenta
BACKGROUND: Traumatic brain injuries (TBIs) continue to be a devastating problem with limited treatment options. Previous research applying controlled vacuum to TBI in a rat model resulted in smaller injuries and more rapid recovery. OBJECTIVE: To examine the effects of the application of a controlled vacuum (mechanical tissue resuscitation) to TBI in a large-animal model. The magnitude of vacuum, length of application, and length of delay between injury and the application of mechanical tissue resuscitation were investigated...
August 2014: Neurosurgery
https://www.readbyqxmd.com/read/24391550/the-contribution-of-%C3%AE-subunit-containing-gabaa-receptors-to-phasic-and-tonic-conductance-changes-in-cerebellum-thalamus-and-neocortex
#20
Zhiwen Ye, Thomas P McGee, Catriona M Houston, Stephen G Brickley
We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In cerebellar granule cells, an enhancement of the tonic conductance was observed for DS2 and the orthosteric agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol). As expected, DS2 did not alter the properties of GABAA receptor-mediated inhibitory postsynaptic synaptic conductances (IPSCs) supporting a purely extrasynaptic role for δ-GABAARs in cerebellar granule cells...
2013: Frontiers in Neural Circuits
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