Shamil Haroon, Krishnarajah Nirantharakumar, Sarah E Hughes, Anuradhaa Subramanian, Olalekan Lee Aiyegbusi, Elin Haf Davies, Puja Myles, Tim Williams, Grace Turner, Joht Singh Chandan, Christel McMullan, Janet Lord, David C Wraith, Kirsty McGee, Alastair K Denniston, Thomas Taverner, Louise J Jackson, Elizabeth Sapey, George Gkoutos, Krishna Gokhale, Edward Leggett, Clare Iles, Christopher Frost, Gary McNamara, Amy Bamford, Tom Marshall, Dawit T Zemedikun, Gary Price, Steven Marwaha, Nikita Simms-Williams, Kirsty Brown, Anita Walker, Karen Jones, Karen Matthews, Jennifer Camaradou, Michael Saint-Cricq, Sumita Kumar, Yvonne Alder, David E Stanton, Lisa Agyen, Megan Baber, Hannah Blaize, Melanie Calvert
INTRODUCTION: Individuals with COVID-19 frequently experience symptoms and impaired quality of life beyond 4-12 weeks, commonly referred to as Long COVID. Whether Long COVID is one or several distinct syndromes is unknown. Establishing the evidence base for appropriate therapies is needed. We aim to evaluate the symptom burden and underlying pathophysiology of Long COVID syndromes in non-hospitalised individuals and evaluate potential therapies. METHODS AND ANALYSIS: A cohort of 4000 non-hospitalised individuals with a past COVID-19 diagnosis and 1000 matched controls will be selected from anonymised primary care records from the Clinical Practice Research Datalink, and invited by their general practitioners to participate on a digital platform (Atom5)...
April 26, 2022: BMJ Open