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Steve mcgee

Sabine Topka, Joseph Vijai, Michael F Walsh, Lauren Jacobs, Ann Maria, Danylo Villano, Pragna Gaddam, Gang Wu, Rose B McGee, Emily Quinn, Hiroto Inaba, Christine Hartford, Ching-Hon Pui, Alberto Pappo, Michael Edmonson, Michael Y Zhang, Polina Stepensky, Peter Steinherz, Kasmintan Schrader, Anne Lincoln, James Bussel, Steve M Lipkin, Yehuda Goldgur, Mira Harit, Zsofia K Stadler, Charles Mullighan, Michael Weintraub, Akiko Shimamura, Jinghui Zhang, James R Downing, Kim E Nichols, Kenneth Offit
Somatic mutations affecting ETV6 often occur in acute lymphoblastic leukemia (ALL), the most common childhood malignancy. The genetic factors that predispose to ALL remain poorly understood. Here we identify a novel germline ETV6 p. L349P mutation in a kindred affected by thrombocytopenia and ALL. A second ETV6 p. N385fs mutation was identified in an unrelated kindred characterized by thrombocytopenia, ALL and secondary myelodysplasia/acute myeloid leukemia. Leukemic cells from the proband in the second kindred showed deletion of wild type ETV6 with retention of the ETV6 p...
June 2015: PLoS Genetics
Ahrathy Selathurai, Greg M Kowalski, Micah L Burch, Patricio Sepulveda, Steve Risis, Robert S Lee-Young, Severine Lamon, Peter J Meikle, Amanda J Genders, Sean L McGee, Matthew J Watt, Aaron P Russell, Matthew Frank, Suzanne Jackowski, Mark A Febbraio, Clinton R Bruce
Accumulation of diacylglycerol (DG) in muscle is thought to cause insulin resistance. DG is a precursor for phospholipids, thus phospholipid synthesis could be involved in regulating muscle DG. Little is known about the interaction between phospholipid and DG in muscle; therefore, we examined whether disrupting muscle phospholipid synthesis, specifically phosphatidylethanolamine (PtdEtn), would influence muscle DG content and insulin sensitivity. Muscle PtdEtn synthesis was disrupted by deleting CTP:phosphoethanolamine cytidylyltransferase (ECT), the rate-limiting enzyme in the CDP-ethanolamine pathway, a major route for PtdEtn production...
May 5, 2015: Cell Metabolism
John Wityak, Kevin F McGee, Michael P Conlon, Ren Hua Song, Bryan C Duffy, Brent Clayton, Michael Lynch, Gwen Wang, Emily Freeman, James Haber, Douglas B Kitchen, David D Manning, Jiffry Ismail, Yuri Khmelnitsky, Peter Michels, Jeff Webster, Macarena Irigoyen, Michele Luche, Monica Hultman, Mei Bai, IokTeng D Kuok, Ryan Newell, Marieke Lamers, Philip Leonard, Dawn Yates, Kim Matthews, Lynette Ongeri, Steve Clifton, Tania Mead, Susan Deupree, Pat Wheelan, Kathy Lyons, Claire Wilson, Alex Kiselyov, Leticia Toledo-Sherman, Maria Beconi, Ignacio Muñoz-Sanjuan, Jonathan Bard, Celia Dominguez
Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. Using in vitro ADME profiling data, 9t was identified as possessing favorable permeability and a low potential for efflux, but it was rapidly cleared in liver microsomal incubations. In a mouse pharmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by high plasma clearance...
April 9, 2015: Journal of Medicinal Chemistry
Nancy M McGee, Gene Reeder, Timothy S Regan, J D Kleinke, Steve Arnold
BACKGROUND: Patients, payers, public health researchers, medical economists, and policymakers have all called for aggressive deployment of information technologies to support the management of health records and prescriptions. In response, payers of all types have been making investments in electronic systems. OBJECTIVES: To understand, analyze, and quantify current private payer involvement in electronic personal health records and electronic prescribing development and implementation...
September 2009: American Health & Drug Benefits
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W Gribble, Grace Q Alba, Merrill Ayres, Timothy J Carlson, Ada Chen, Xiaoqi Chen, Robert Cho, Richard V Connors, Michael DeGraffenreid, Jeffrey T Deignan, Jason Duquette, Pingchen Fan, Benjamin Fisher, Jiasheng Fu, Justin N Huard, Jacob Kaizerman, Kathleen S Keegan, Cong Li, Kexue Li, Yunxiao Li, Lingming Liang, Wen Liu, Sarah E Lively, Mei-Chu Lo, Ji Ma, Dustin L McMinn, Jeffrey T Mihalic, Kriti Modi, Rachel Ngo, Kanaka Pattabiraman, Derek E Piper, Christophe Queva, Mark L Ragains, Julia Suchomel, Steve Thibault, Nigel Walker, Xiaodong Wang, Zhulun Wang, Malgorzata Wanska, Paul M Wehn, Margaret F Weidner, Alex J Zhang, Xiaoning Zhao, Alexander Kamb, Dineli Wickramasinghe, Kang Dai, Lawrence R McGee, Julio C Medina
We describe the structural optimization of a lead compound 1 that exhibits dual inhibitory activities against FLT3 and CDK4. A series of pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine derivatives was synthesized, and SAR analysis, using cell-based assays, led to the discovery of 28 (AMG 925), a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date. Compound 28 inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb(+)) and U937 (FLT3(WT)) and induced cell death in MOLM13 (FLT3(ITD)) and even in MOLM13 (FLT3(ITD, D835Y)), which exhibits resistance to a number of FLT3 inhibitors currently under clinical development...
April 24, 2014: Journal of Medicinal Chemistry
Madeleine Didsbury, Richard G McGee, Allison Tong, Jonathan C Craig, Jeremy R Chapman, Steve Chadban, Germaine Wong
BACKGROUND: Exercise training is effective in improving the cardiovascular risk profiles of nontransplanted patients, but the health benefits and potential harms of routine exercise training after solid organ transplantation are unclear. This study aims to assess the health benefits and harms of supervised exercise training programs in solid organ recipients. METHODS: We systematically reviewed all randomized controlled trials (RCTs) comparing the outcomes of exercise training programs in solid organ recipients against standard care...
March 15, 2013: Transplantation
Nadine Norton, Duanxiang Li, Mark J Rieder, Jill D Siegfried, Evadnie Rampersaud, Stephan Züchner, Steve Mangos, Jorge Gonzalez-Quintana, Libin Wang, Sean McGee, Jochen Reiser, Eden Martin, Deborah A Nickerson, Ray E Hershberger
Dilated cardiomyopathy commonly causes heart failure and is the most frequent precipitating cause of heart transplantation. Familial dilated cardiomyopathy has been shown to be caused by rare variant mutations in more than 30 genes but only ~35% of its genetic cause has been identified, principally by using linkage-based or candidate gene discovery approaches. In a multigenerational family with autosomal dominant transmission, we employed whole-exome sequencing in a proband and three of his affected family members, and genome-wide copy number variation in the proband and his affected father and unaffected mother...
March 11, 2011: American Journal of Human Genetics
Joseph A Trunzo, Benjamin K Poulose, Michael F McGee, Mehrdad Nikfarjam, Steve J Schomisch, Raymond P Onders, Judy Jin, Amitabh Chak, Jeffrey L Ponsky, Jeffrey M Marks
BACKGROUND: Evaluation of a potential source for abdominal sepsis in a critically ill patient can be challenging. With flexible endoscopy readily available in this setting, we sought to evaluate the diagnostic efficacy of a transgastric natural orifice transluminal endoscopic surgery (NOTES) peritoneoscopy vs. laparoscopic exploration in the identification of intra-abdominal pathology in a porcine model. METHODS: In this acute study, 15 pigs were randomized to demonstrate 0 to 4 pathologic lesions: small bowel ischemia (SBI), small bowel perforation (SBP), colon perforation (CP), and gangrenous cholecystitis (GC)...
October 2010: Surgical Endoscopy
Joseph A Trunzo, Michael F McGee, Leandro T Cavazzola, Steve Schomisch, Mehrdad Nikfarjam, Jessica Bailey, Tripurari Mishra, Benjamin K Poulose, Young-Joon Lee, Jeffrey L Ponsky, Jeffrey M Marks
BACKGROUND: The immunologic and physiologic effects of natural orifice translumenal endoscopic surgery (NOTES) versus traditional surgical approaches are poorly understood. Previous investigations have shown that NOTES and laparoscopy share similar inflammatory cytokine profiles except for a possible late-phase tissue necrosis factor-alpha (TNF-alpha) depression with NOTES. The local peritoneal reaction and immunomodulatory influence of pneumoperitoneum agents in NOTES also are not known and may play an important role in altering the physiologic insult induced by NOTES...
July 2010: Surgical Endoscopy
Judy Jin, Gabriela Voskerician, Shawn A Hunter, Michael F McGee, Leandro T Cavazzola, Steve Schomisch, Karem Harth, Michael J Rosen
BACKGROUND: Even with the advent of bioresorbable barriers, complications due to visceral adhesions following surgery continue to occur. The use of a homologous adhesive barrier such as human peritoneal membrane (HPM) could prevent adhesions formation and enhance wound healing. This study evaluates HPM as an effective adhesive barrier in a porcine model simulating a ventral hernia procedure. MATERIALS AND METHODS: Through a midline laparotomy, meshes (10 cmx10 cm) were sewn onto the intact peritoneum of a pig, on each side of a midline incision in superior and inferior positions (4 randomized meshes/pig, n=9 pigs)...
October 2009: Journal of Surgical Research
Steve Kremer, Mickey C Smith
No abstract text is available yet for this article.
2008: Pharmacy in History
Christina P Williams, Michael J Rosen, Judy Jin, Michael F McGee, Steve J Schomisch, Jeffery Ponsky
Abdominal fascial closure after midline laparotomy can be time-consuming and inaccurate and is a common time for needle-stick injuries. The SuturTek 360 degrees Fascial Closure Device (FCD) is designed to provide a secure fascial closure while reducing the risk of needle-stick injury. To date, the accuracy and efficacy of the fascial closure obtained with this device have never been objectively determined. Ten pigs averaging 18 kg were killed and underwent a midline laparotomy. Idealized suture locations were premarked through the fascia...
December 2008: Surgical Innovation
B Joseph Elmunzer, Steve J Schomisch, Joseph A Trunzo, Benjamin K Poulose, Conor P Delaney, Michael F McGee, Ashley L Faulx, Jeffrey M Marks, Jeffrey L Ponsky, Amitabh Chak
BACKGROUND: Most natural orifice transluminal endoscopic surgery (NOTES) procedures have been performed through the anterior stomach wall, based on the established safety of PEG placement. This approach does not afford mechanically efficient access to all anatomic areas of interest. OBJECTIVE: To assess the utility of EUS in identifying safe alternate access sites for NOTES. DESIGN: Nonsurvival animal experiment. METHODS: Thirty-two EUS-guided access procedures were performed through the antrum, the posterior stomach wall, or the rectum of 12 pigs...
January 2009: Gastrointestinal Endoscopy
Michael F McGee, Jeffrey M Marks, Raymond P Onders, Amitabh Chak, Michael J Rosen, Christina P Williams, Judy Jin, Steve J Schomisch, Jeffrey L Ponsky et al.
BACKGROUND: Obtaining reliable closure of transvisceral defects currently limits natural orifice transluminal endoscopic surgery (NOTES). PEG tubes are potential means of managing NOTES gastrotomies. OBJECTIVE: To determine the efficacy of PEG closure after NOTES. DESIGN: An experimental animal study. SETTING: A laboratory. INTERVENTIONS: The pigs received gastric lavage with saline solution, chloramphenicol, or no lavage, and then underwent transgastric NOTES peritoneoscopy...
August 2008: Gastrointestinal Endoscopy
Michael F McGee, Steve J Schomisch, Jeffrey M Marks, Conor P Delaney, Judy Jin, Christina Williams, Amitabh Chak, David T Matteson, Jamie Andrews, Jeffrey L Ponsky
BACKGROUND: Natural orifice translumenal endoscopic surgery (NOTES) allows access to the peritoneal cavity without skin incisions. Contamination of the peritoneal cavity by enteric contents may render NOTES more physiologically and immunologically invasive than previously thought. Measurement of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) is a validated method to quantify surgical stress. The physiologic and immunologic impact of NOTES is unknown...
March 2008: Surgery
Michael F McGee, Jeffrey M Marks, Judy Jin, Christina Williams, Amitabh Chak, Steve J Schomisch, Jamie Andrews, Shoichi Okada, Jeffrey L Ponsky
Obtaining endolumenal closure of hollow visceral defects may complement conventional, incision-based, surgical alternatives and benefit the experimental field of natural orifice translumenal endoscopic surgery (NOTES). Endoscopic tissue plicating devices (TPD) represent a promising closure technology; however, the long-term integrity of resultant closures is uncertain. Swine (n=10) underwent survival transgastric NOTES peritoneoscopy procedures with TPD gastrotomy closure while device performance and closure integrity were evaluated...
January 2008: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Michael J Rosen, Christina Williams, Judy Jin, Michael F McGee, Steve Schomisch, Jeffrey Marks, Jeffrey Ponsky
BACKGROUND: The ideal surgical treatment for complicated ventral hernias remains elusive. Traditional component separation provides local advancement of native tissue for tension-free closure without prosthetic materials. This technique requires an extensive subcutaneous dissection with division of perforating vessels predisposing to skin-flap necrosis and complicated wound infections. A minimally invasive component separation may decrease wound complication rates; however, the adequacy of the myofascial advancement has not been studied...
September 2007: American Journal of Surgery
Raymond P Onders, Michael F McGee, Jeffrey Marks, Amitabh Chak, Michael J Rosen, Anthony Ignagni, Ashley Faulx, Steve Schomisch, Jeffrey Ponsky
BACKGROUND: Autopsy studies confirm that many intensive care unit (ICU) patients die from unrecognized sources of abdominal sepsis or ischemia. Computed tomography (CT) scans can be of limited use for these diagnoses and difficult to obtain in critically ill patients who require significant support for transport. Bedside laparoscopy has been described but still is cumbersome to perform. Bedside flexible endoscopy as a diagnostic tool or for placement of gastrostomy tubes is a standard ICU procedure...
April 2007: Surgical Endoscopy
Peter B Cotton, Patrick Connor, Daniel McGee, Paul Jowell, Nick Nickl, Steve Schutz, Joseph Leung, John Lee, Eric Libby
BACKGROUND: The medical profession, payers, and patients are interested increasingly in the quality of endoscopic procedures, including colonoscopy. The American Society for Gastrointestinal Endoscopy has recommended "report cards" by which endoscopists may keep track of certain key elements of their practice including indications, findings, duration, technical end points, complications, and patient satisfaction. METHODS: The GI-Trac endoscopy reporting database includes many of the data points recommended by ASGE for report cards...
March 2003: Gastrointestinal Endoscopy
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