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https://www.readbyqxmd.com/read/28100596/genomic-epidemiology-of-penicillin-non-susceptible-pneumococci-with-non-vaccine-serotypes-causing-invasive-disease-in-the-usa
#1
Cheryl P Andam, Patrick K Mitchell, Alanna Callendrello, Qiuzhi Chang, Jukka Corander, Chrispin Chaguza, Lesley McGee, Bernard W Beall, William P Hanage
Conjugate vaccination against seven pneumococcal serotypes (PCV7) reduced disease prevalence due to antibiotic resistant strains throughout the 2000s; however, disease caused by resistant non-vaccine type (NVT) strains increased. Some of these emerging strains were derived from vaccine types (VT) that had changed their capsule by recombination. The introduction of vaccine targeting 13 serotypes (PCV13) in 2010 has led to concern that this scenario will repeat itself. We generated high quality draft genomes from 265 isolates of NVT pneumococci not susceptible to penicillin (PNSP) in 2009 and compared them with 581 isolates from 2012-2013, collected by the Active Bacterial Core surveillance (ABCs) of the Centers for Disease Control and Prevention (CDC)...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#2
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28086953/student-and-faculty-perceptions-on-the-rapid-scale-up-of-medical-students-in-ethiopia
#3
Brittney S Mengistu, Holly Vins, Caitrin M Kelly, Daphne R McGee, Jennifer O Spicer, Miliard Derbew, Abebe Bekele, Damen Haile Mariam, Carlos Del Rio, Henry M Blumberg, Dawn L Comeau
BACKGROUND: Ethiopia is a country of over 94 million people that has a severe physician shortage with approximately only 2.5 physicians per 100,000 persons. Recently, the Ethiopian government implemented a "flood and retain" initiative to rapidly increase the quantity of physicians in Ethiopia. Consequently, medical student enrollment at Addis Ababa University (AAU) School of Medicine increased from 100 to approximately 300-400 students per class. This study evaluated the impact of the rapid scale-up in the number of medical students on the quality of medical education at AAU and the impact of the U...
January 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28079949/a-11-steps-total-synthesis-of-magellanine-through-a-gold-i-catalyzed-dehydro-diels-alder-reaction
#4
Philippe McGee, Geneviève Bétournay, Francis Barabé, Louis Barriault
We have developed an innovative strategy for the formation of angular carbocycles via a gold(I)-catalyzed dehydro Diels-Alder reaction. This transformation provides rapid access to a variety of complex angular cores in excellent diastereoselectivities and high yields. The usefulness of this Au(I) -catalyzed cycloaddition was further demonstrated by accomplishing a 11-steps total synthesis of (±)-magellanine.
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28072594/genetics-consultation-rates-following-a-diagnosis-of-high-grade-serous-ovarian-carcinoma-in-the-canadian-province-of-ontario
#5
Jacob McGee, Karen Panabaker, Sean Leonard, Peter Ainsworth, Laurie Elit, Salimah Z Shariff
OBJECTIVE: In 2001, the province of Ontario expanded cancer genetic testing eligibility to include all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. The aim of this study was to determine the proportion of women who attended genetics counseling for consideration of BRCA1/2 gene analysis. We also sought to examine if regional differences in consultation rate exist across administrative health regions in the province of Ontario. METHODS: We identified all women with a pathological diagnosis of HGSC in the province of Ontario between 1997 until 2011...
January 9, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28069681/clinical-practice-guidelines-for-sustained-neuromuscular-blockade-in-the-adult-critically-ill-patient-2016-update-executive-summary
#6
Michael J Murray, Heidi F DeBlock, Brian L Erstad, Anthony W Gray, Judith Jacobi, Ché J Jordan, William T McGee, Claire McManus, Maureen O Meade, Sean A Nix, Andrew J Patterson, Karen Sands, Richard M Pino, Ann N Tescher, Richard Arbour, Bram Rochwerg, Catherine Friederich Murray, Sangeeta Mehta
No abstract text is available yet for this article.
January 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28048248/su-f-t-44-a-comparison-of-the-pre-plan-intra-operative-plan-and-post-implant-dosimetry-for-a-prostate-implant-case-using-prefabricated-linear-polymer-encapsulated-pd-103
#7
R Sheu, A Powers, H McGee, R Stock, Y Lo
PURPOSE: To investigate the reproducibility and limitations of Pd-103 prostate brachytherapy using fixed length linear sources (CivaString). METHODS: An LDR prostate brachytherapy case which was preplanned on MR images with prefabricated linear polymer-encapsulated Pd-103 sources (CivaString) was studied and compared with ultrasound based intra-operative planning and CT based post-implant dosimetry. We evaluated the following parameters among the three studies: prostate geometry (volume and cross sectional area), needle position and alignment deviations, and dosimetry parameters (D90)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034637/image-based-gradient-non-linearity-characterization-to-determine-higher-order-spherical-harmonic-coefficients-for-improved-spatial-position-accuracy-in-magnetic-resonance-imaging
#8
Paul T Weavers, Shengzhen Tao, Joshua D Trzasko, Yunhong Shu, Erik J Tryggestad, Jeffrey L Gunter, Kiaran P McGee, Daniel V Litwiller, Ken-Pin Hwang, Matt A Bernstein
PURPOSE: Spatial position accuracy in magnetic resonance imaging (MRI) is an important concern for a variety of applications, including radiation therapy planning, surgical planning, and longitudinal studies of morphologic changes to study neurodegenerative diseases. Spatial accuracy is strongly influenced by gradient linearity. This work presents a method for characterizing the gradient non-linearity fields on a per-system basis, and using this information to provide improved and higher-order (9th vs...
December 27, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28034522/comparison-of-two-methodologies-for-the-enrichment-of-mononuclear-cells-from-thawed-cord-blood-products-the-automated-sepax-system-versus-the-manual-ficoll-method
#9
Indreshpal Kaur, Jane M Zulovich, Marissa Gonzalez, Kara M McGee, Nirmali Ponweera, Daljit Thandi, Enrique F Alvarez, Kathy Annandale, Frank Flagge, Katayoun Rezvani, Elizabeth Shpall
BACKGROUND AIMS: Umbilical cord blood (CB) is being used as a source of hematopoietic stem cells (HSCs) and immune cells to treat many disorders. Because these cells are present in low numbers in CB, investigators have developed strategies to expand HSCs and other immune cells such as natural killer (NK) cells. The initial step in this process is to enrich mononuclear cells (MNCs) while depleting unwanted cells. The manual method of MNC enrichment is routinely used by many centers; however, it is an open system, time-consuming and operator dependent...
December 26, 2016: Cytotherapy
https://www.readbyqxmd.com/read/28032366/permanence-can-be-defended
#10
Andrew Mcgee, Dale Gardiner
In donation after the circulatory-respiratory determination of death (DCDD), the dead donor rule requires that the donor be dead before organ procurement can proceed. Under the relevant limb of the Uniform Determination of Death Act 1981 (USA), a person is dead when the cessation of circulatory-respiratory function is 'irreversible'. Critics of current practice in DCDD have argued that the donor is not dead at the time organs are procured, and so the procurement of organs from these donors violates the dead donor rule...
December 28, 2016: Bioethics
https://www.readbyqxmd.com/read/28029333/biochemical-and-organoleptic-characteristics-of-muscle-from-early-and-late-maturing-bulls-in-different-production-systems
#11
G B Mezgebo, F J Monahan, M McGee, E G O'Riordan, B Picard, R I Richardson, A P Moloney
In grass-based beef production systems (PS), early maturing (EM) breed types may be preferable to late maturing (LM) breed types in achieving adequate carcass fat cover. Biochemical and organoleptic characteristics of muscle from suckler bulls were investigated in EM and LM (n=28/breed) assigned to one of two PS (ad libitum concentrates and grass silage to slaughter (C) or ad libitum silage plus 2 kg concentrate daily during winter followed by 99 days at pasture and then an indoor finishing period on C (GSPC)) in a 2 breed type×2 PS factorial arrangement of treatments...
December 28, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28027668/social-determinants-of-health-and-retention-in-hiv-care-in-a-clinical-cohort-in-ontario-canada
#12
Beth Rachlis, Ann N Burchell, Sandra Gardner, Lucia Light, Janet Raboud, Tony Antoniou, Jean Bacon, Anita Benoit, Curtis Cooper, Claire Kendall, Mona Loutfy, Wendy Wobeser, Frank McGee, Anita Rachlis, Sean B Rourke
: Continuous HIV care supports antiretroviral therapy initiation and adherence, and prolongs survival. We investigated the association of social determinants of health (SDH) and subsequent retention in HIV care in a clinical cohort in Ontario, Canada. The Ontario HIV Treatment Network Cohort Study is a multi-site cohort of patients at 10 HIV clinics. Data were collected from medical charts, interviews, and via record linkage with the provincial public health laboratory for viral load tests...
December 27, 2016: AIDS Care
https://www.readbyqxmd.com/read/28027044/evaluation-of-hand-forces-during-a-joint-protection-strategy-for-women-with-hand-osteoarthritis
#13
Corey McGee, Virgil Mathiowetz
OBJECTIVE: We evaluated whether a joint-protection strategy changes the mechanics of opening a sealed jar. METHOD: Thirty-one adult women with hand osteoarthritis attempted to open a "sealed" jar instrument when using and not using nonskid material. Grip force, torque, success, and pain were recorded for each trial. RESULTS: Participants used less grip force when twisting with their left hand. The greatest torque and success, yet the least amount of grip force across time, and pain was noted when the left hand turned the lid, the jar was held vertically, the right hand supported the base, and nonskid material was used...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28009809/dietary-fiber-analysis-of-four-pulses-using-aoac-2011-25-implications-for-human-health
#14
Yiran Chen, Rebecca McGee, George Vandemark, Mark Brick, Henry J Thompson
Chickpeas, common beans, dry peas, and lentils are pulse crops that have been a cornerstone of the human diet since the inception of agriculture. However, the displacement of pulses from the diet by low fiber protein alternatives has resulted in a pervasive deficiency referred to as the dietary fiber gap. Using an analytical method American Association of Analytical Chemists (AOAC) 2011.25 that conforms to the Codex Alimentarius Commission consensus definition for dietary fiber, the fiber content of these pulse crops was evaluated in seed types used for commercial production...
December 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27983709/no-ifs-no-butts-compliance-with-smoking-cessation-in-secondary-care-guidance-nice-ph48-by-providers-of-cancer-therapies-radiotherapy-and-chemotherapy-in-the-uk
#15
Daniel Hutton, Ivan Gee, Ciara E McGee, Rebecca Mellor
Background: Legislation preventing smoking in public places was introduced in England in July 2007. Since then, smoke-free policies have been extended to the majority of hospitals including those providing cancer therapies. Whilst studies have been conducted on the impact and effectiveness of hospital smoke-free policy in the UK and other countries, there have not been any studies with a focus on cancer care providers. Cancer patients are a priority group for smoking cessation and support and this study aimed to examine implementation of the National Institute Clinical Excellence (NICE) guidance (PH48) in acute cancer care trusts in the UK...
December 15, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27965865/cultural-adaptation-of-a-children-s-weight-management-programme-for-bangladeshi-and-pakistani-families-in-the-uk-a-cluster-randomised-feasibility-study-protocol
#16
Miranda Pallan, Tania Griffin, Emma Lancashire, Kiya Hurley, Jacqueline Blissett, Emma Frew, Paramjit Gill, Laura Griffith, Karla Hemming, Kate Jolly, Eleanor McGee, Charlene Mulhern, Jayne Parry, Janice L Thompson, Peymane Adab
BACKGROUND: Group-based children's weight management programmes are widely available in the UK and evidence shows that these are effective in the short-term. No programmes have been specifically developed to meet the cultural requirements of UK minority ethnic communities. South Asian children are a high-risk group for obesity and its consequences; therefore, the study aim is to adapt an existing weight management programme for children aged 4-11 years and their families to ensure cultural relevance to Pakistani and Bangladeshi communities, and undertake a feasibility study of the adapted programme...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27957509/characteristics-and-pharmacodynamics-of-severe-neuroinflammation-in-a-child-with-neurolupus
#17
Michael R Pranzatelli, Nathan R McGee, Zeng Y Wang, Brajesh K Agrawal
No abstract text is available yet for this article.
March 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27943503/invasive-fungal-infection-after-heart-transplantation-a-seven-year-single-center-experience
#18
Ignacio A Echenique, Michael P Angarone, Robert A Gordon, Jonathan Rich, Allen S Anderson, Edwin C McGee, Travis O Abicht, Joseph Kang, Valentina Stosor
BACKGROUND: Invasive fungal infections (IFIs) are an infrequent but major complication of heart-transplantation (HT). We sought to describe the epidemiology at our institution. METHODS: A prospective cohort study of 159 HT recipients was performed from June 2005 to December 2012. IFIs were defined by European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. RESULTS: By univariate analysis, Hispanic ethnicity/race was associated with IFI (P=0...
December 10, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27942227/aquagenic-urticaria-diagnostic-and-management-challenges
#19
REVIEW
Robert Rothbaum, Jean S McGee
Aquagenic urticaria (AU) is a rare inducible form of physical urticaria, which occurs in response to cutaneous exposure to water, including sweat and tears. Patients present with characteristic 1-3 mm folliculocentric wheals with surrounding 1-3 cm erythematous flares within 20-30 minutes following skin contact with water. In rare cases, there are concomitant systemic symptoms, such as wheezing or shortness of breath. The pathogenesis of AU is poorly understood at this time, and it appears to be mediated in both a histamine-dependent and independent manner...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27940551/management-of-alcohol-misuse-in-patients-with-liver-diseases
#20
Jennifer L Peng, Milan Prakash Patel, Breann McGee, Tiebing Liang, Kristina Chandler, Sucharat Tayarachakul, Sean O'Connor, Suthat Liangpunsakul
Excessive alcohol use not only causes alcoholic liver disease (ALD) but also increases the risk of liver-related mortality in patients who already have other chronic liver diseases. Screening for alcohol misuse or alcohol use disorder (AUD) among patients with underlying liver disease is essential. This clinical review covers what is known about ALD, the impact of alcohol in patients with underlying liver diseases, current management of alcohol misuse and AUD, and the management of alcohol misuse and AUD specifically in patients with liver diseases...
December 9, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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