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https://www.readbyqxmd.com/read/29146714/reasons-causes-and-identity
#1
Andrew McGee
No abstract text is available yet for this article.
November 16, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29144510/characterizing-reduced-coverage-regions-through-comparison-of-exome-and-genome-sequencing-data-across-10-centers
#2
Rashesh V Sanghvi, Christian J Buhay, Bradford C Powell, Ellen A Tsai, Michael O Dorschner, Celine S Hong, Matthew S Lebo, Ariella Sasson, David S Hanna, Sean McGee, Kevin M Bowling, Gregory M Cooper, David E Gray, Robert J Lonigro, Andrew Dunford, Christine A Brennan, Carrie Cibulskis, Kimberly Walker, Mauricio O Carneiro, Joshua Sailsbery, Lucia A Hindorff, Dan R Robinson, Avni Santani, Mahdi Sarmady, Heidi L Rehm, Leslie G Biesecker, Deborah A Nickerson, Carolyn M Hutter, Levi Garraway, Donna M Muzny, Nikhil Wagle
PurposeAs massively parallel sequencing is increasingly being used for clinical decision making, it has become critical to understand parameters that affect sequencing quality and to establish methods for measuring and reporting clinical sequencing standards. In this report, we propose a definition for reduced coverage regions and describe a set of standards for variant calling in clinical sequencing applications.MethodsTo enable sequencing centers to assess the regions of poor sequencing quality in their own data, we optimized and used a tool (ExCID) to identify reduced coverage loci within genes or regions of particular interest...
November 16, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29122296/a-case-of-neuromyelitis-optica-spectrum-disorder-presenting-with-undiagnosed-sjogren-s-syndrome-and-a-single-atypical-tumefactive-lesion-a-diagnostic-challenge
#3
EDITORIAL
Jeanie C McGee, Alireza Minagar
No abstract text is available yet for this article.
November 1, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29109123/a-protective-function-of-il-22bp-in-ischemia-reperfusion-and-acetaminophen-induced-liver-injury
#4
Dörte Kleinschmidt, Anastasios D Giannou, Heather M McGee, Jan Kempski, Babett Steglich, Francis Jessica Huber, Thomas Michael Ernst, Ahmad Mustafa Shiri, Claudia Wegscheid, Elena Tasika, Peter Hübener, Philipp Huber, Tanja Bedke, Niklas Steffens, Theodora Agalioti, Tobias Fuchs, Jill Noll, Hannelore Lotter, Gisa Tiegs, Ansgar W Lohse, Jonathan H Axelrod, Eithan Galun, Richard A Flavell, Nicola Gagliani, Samuel Huber
Acute liver injury can be secondary to a variety of causes, including infections, intoxication, and ischemia. All of these insults induce hepatocyte death and subsequent inflammation, which can make acute liver injury a life-threatening event. IL-22 is a dual natured cytokine which has context-dependent protective and pathogenic properties during tissue damage. Accordingly, IL-22 was shown to promote liver regeneration upon acute liver damage. However, other studies suggest pathogenic properties of IL-22 during chronic liver injury...
November 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29108644/mesh-sutured-repairs-of-contaminated-incisional-hernias
#5
Gregory A Dumanian, Steven T Lanier, Jason M Souza, Mimi Wu Young, Alexei S Mlodinow, Anne-Marie Boller, Kyle H Mueller, Amy L Halverson, Michael F McGee, Jonah J Stulberg
BACKGROUND: We sought to evaluate the results of a new mesh sutured repair technique for closure of contaminated incisional hernias. METHODS: 48 patients with contaminated hernias 5 cm wide or greater by CT scan were closed with mesh sutures. Surgical site occurrence, infections, and hernia recurrence were compared to similar patient series reported in the literature. RESULTS: Of the 48 patients, 20 had clean-contaminated wounds, 16 had contaminated wounds, and 12 were infected...
October 25, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29102163/assessing-the-cerebral-gray-matter-volume-in-response-to-fingolimod-therapy-in-multiple-sclerosis-a-more-analytic-view
#6
EDITORIAL
Jeanie C McGee, Alireza Minagar
No abstract text is available yet for this article.
October 13, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29098083/an-analysis-of-3-year-outcomes-following-canaloplasty-for-the-treatment-of-open-angle-glaucoma
#7
Mahmoud A Khaimi, Justin D Dvorak, Kai Ding
Purpose: To report 3-year results investigating the safety and efficacy of canaloplasty for open-angle glaucoma. Setting: University of Oklahoma, Dean McGee Eye Institute, Oklahoma, United States of America. Design: Nonrandomized single-center retrospective chart review. Methods: Adult open-angle glaucoma eyes underwent canaloplasty or combined cataract-canaloplasty surgery. A tensioning suture was placed into Schlemm's canal in all eyes...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29094273/nativity-as-a-determinant-of-health-disparities-among-children
#8
Sasha A McGee, Luz Claudio
Nativity is not often considered in the study of health disparities. We conducted a cross-sectional, parent-reported survey of demographics, socioeconomic characteristics, healthcare access, and health conditions in New York City schoolchildren (n = 9029). US-born children with US-born parents (US/US) had higher socioeconomic status, better access to healthcare, and reported higher rates of disease diagnoses compared to US-born children with immigrant parents and to immigrant children. Dental cavities were the only condition in which US/US children reported lower prevalence...
November 1, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29084043/partnerships-between-a-university-affiliated-clinic-and-community-based-organizations-to-reach-black-men-who-have-sex-with-men-for-prep-care
#9
Meredith E Clement, N Lance Okeke, Terry Munn, Miguel Hunter, Kareem Alexis, Amy Corneli, Arlene C Seña, Kara McGee, Mehri S McKellar
No abstract text is available yet for this article.
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29074637/mr-elastography-analysis-of-glioma-stiffness-and-idh1-mutation-status
#10
K M Pepin, K P McGee, A Arani, D S Lake, K J Glaser, A Manduca, I F Parney, R L Ehman, J Huston
BACKGROUND AND PURPOSE: Our aim was to noninvasively evaluate gliomas with MR elastography to characterize the relationship of tumor stiffness with tumor grade and mutations in the isocitrate dehydrogenase 1 (IDH1) gene. MATERIALS AND METHODS: Tumor stiffness properties were prospectively quantified in 18 patients (mean age, 42 years; 6 women) with histologically proved gliomas using MR elastography from 2014 to 2016. Images were acquired on a 3T MR imaging unit with a vibration frequency of 60 Hz...
October 26, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29056422/the-effect-of-antipyretics-on-immune-response-and-fever-following-receipt-of-inactivated-influenza-vaccine-in-young-children
#11
Emmanuel B Walter, Christoph P Hornik, Lisa Grohskopf, Charles E McGee, Christopher A Todd, Oidda I Museru, Lynn Harrington, Karen R Broder
BACKGROUND: Antipyretics reduce fever following childhood vaccinations; after inactivated influenza vaccine (IIV) they might ameliorate fever and thereby decrease febrile seizure risk, but also possibly blunt the immune response. We assessed the effect of antipyretics on immune responses and fever following IIV in children ages 6 through 47 months. METHODS: Over the course of three seasons, one hundred forty-two children, receiving either a single or the first of 2 recommended doses of IIV, were randomized to receive either oral acetaminophen suspension (n = 59) or placebo (n = 59) (double-blinded) or ibuprofen (n = 24) (open-label) immediately following IIV and every 4-8 h thereafter for 24 h...
October 19, 2017: Vaccine
https://www.readbyqxmd.com/read/29053714/atopic-asthmatic-immune-phenotypes-associated-with-airway-microbiota-and-airway-obstruction
#12
Benjamin A Turturice, Halvor S McGee, Brian Oliver, Melissa Baraket, Brian T Nguyen, Christian Ascoli, Ravi Ranjan, Asha Rani, David L Perkins, Patricia W Finn
BACKGROUND: Differences in asthma severity may be related to inflammation in the airways. The lower airway microbiota has been associated with clinical features such as airway obstruction, symptom control, and response to corticosteroids. OBJECTIVE: To assess the relationship between local airway inflammation, severity of disease, and the lower airway microbiota in atopic asthmatics. METHODS: A cohort of young adult, atopic asthmatics with intermittent or mild/moderate persistent symptoms (n = 13) were assessed via bronchoscopy, lavage, and spirometry...
2017: PloS One
https://www.readbyqxmd.com/read/29053141/loss-of-bim-increases-mitochondrial-oxygen-consumption-and-lipid-oxidation-reduces-adiposity-and-improves-insulin-sensitivity-in-mice
#13
Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners suggest an additional function not directly linked to apoptosis regulation. To identify such a function, we studied mice lacking the BH3-only protein BIM. BIM(-/-) cells had a higher mitochondrial oxygen consumption rate that was associated with higher mitochondrial complex IV activity. The consequences of increased oxygen consumption in BIM(-/-) mice were significantly lower body weights, reduced adiposity and lower hepatic lipid content...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29049046/determination-of-death-in-donation-after-circulatory-death-an-ethical-propriety
#14
Andrew McGee, Dale Gardiner, Paul Murphy
PURPOSE OF REVIEW: The recently developed donation after circulatory death (DCD) heart transplant technique, pioneered by Papworth Hospital in the UK, involves the use of extracorporeal perfusion technologies to restart the donor heart in situ and thereby restore the donor's own circulation, after first isolating the donor's cerebral circulation. By restoring the circulation in the deceased donor, even if the cerebral circulation is excluded, the Papworth technique challenges the acceptability of death determination in DCD...
October 18, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29049023/the-future-of-graduate-and-postdoctoral-training-in-the-biosciences
#15
Peter Hitchcock, Ambika Mathur, Jabbar Bennett, Patricia Cameron, Christine Chow, Philip Clifford, Robert Duvoisin, Andrew Feig, Kevin Finneran, Diane M Klotz, Richard McGee, Mary O'Riordan, Christine Pfund, Christopher Pickett, Nancy Schwartz, Nancy E Street, Elizabeth Watkins, Jonathan Wiest, David Engelke
This article summarizes the outcomes of the second national conference on the Future of Bioscience Graduate and Postdoctoral Training. Five topics were addressed during the conference: diversity in leadership positions; mentoring; modernizing the curriculum; experiential learning; and the need for better data on trainees. The goal of the conference was to develop a consensus around these five topics and to recommend policies that can be implemented by academic and research institutions and federal funding agencies in the United States...
October 19, 2017: ELife
https://www.readbyqxmd.com/read/29029274/mutation-driven-parallel-evolution-during-viral-adaptation
#16
Andrew M Sackman, Lindsey W McGee, Anneliese J Morrison, Jessica Pierce, Jeremy Anisman, Hunter Hamilton, Stephanie Sanderbeck, Cayla Newman, Darin R Rokyta
Convergent evolution has been demonstrated across all levels of biological organization, from parallel nucleotide substitutions to convergent evolution of complex phenotypes, but whether instances of convergence are the result of selection repeatedly finding the same optimal solution to a recurring problem or are the product of mutational biases remains unsettled. We generated 20 replicate lineages allowed to fix a single mutation from each of four bacteriophage genotypes under identical selective regimes to test for parallel changes within and across genotypes at the levels of mutational effect distributions and gene, protein, amino acid, and nucleotide changes...
September 27, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28991699/microglial-macrophage-markers-chi3l1-scd14-and-scd163-in-csf-and-serum-of-pediatric-inflammatory-and-non-inflammatory-neurological-disorders-a-case-control-study-and-reference-ranges
#17
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee
OBJECTIVE: To assess the role of microglia and macrophages in neuroinflammatory disorders in children via biomarkers, and establish control reference ranges. METHODS: In an IRB-approved case-control study of 98 children, the concentrations of CSF/serum CHI3L1, sCD14, and sCD163 were measured by ELISA. Groups were controls (non-inflammatory neurological disorders, NIND, n=37), opsoclonus-myoclonus syndrome (OMS, n=37), and other inflammatory neurological disorders (OIND, n=24)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28990872/a-comparison-of-the-influence-of-anticipated-death-trajectory-and-personal-values-on-end-of-life-care-preferences-a-qualitative-analysis
#18
Katherine P Supiano, Nancy McGee, Kara B Dassel, Rebecca Utz
OBJECTIVES: We examined anticipated preferences for end-of-life (EOL) care in healthy older adults in the context of various terminal disease scenarios to explore the relationship between personal values and diseases and conditions that would influence EOL care choices. METHODS: Qualitative Descriptive Analysis was used to derive themes and the relationship between EOL preference themes and personal value themes in 365 respondents in a national sample of healthy older adults who completed a survey on their anticipated preferences for end-of-life (EOL) care...
August 17, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28980223/erratum-to-effects-based-spatial-assessment-of-contaminated-estuarine-sediments-from-bear-creek-baltimore-harbor-md-usa
#19
Sharon E Hartzell, Michael A Unger, Beth L McGee, Lance T Yonkos
The original publication of this paper contains an error. The correct image of figure 5 is shown in this paper.
October 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28978485/an-essential-role-for-the-tetraspanin-lhfpl4-in-the-cell-type-specific-targeting-and-clustering-of-synaptic-gabaa-receptors
#20
Elizabeth C Davenport, Valentina Pendolino, Georgina Kontou, Thomas P McGee, David F Sheehan, Guillermo López-Doménech, Mark Farrant, Josef T Kittler
Inhibitory synaptic transmission requires the targeting and stabilization of GABAA receptors (GABAARs) at synapses. The mechanisms responsible remain poorly understood, and roles for transmembrane accessory proteins have not been established. Using molecular, imaging, and electrophysiological approaches, we identify the tetraspanin LHFPL4 as a critical regulator of postsynaptic GABAAR clustering in hippocampal pyramidal neurons. LHFPL4 interacts tightly with GABAAR subunits and is selectively enriched at inhibitory synapses...
October 3, 2017: Cell Reports
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