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https://www.readbyqxmd.com/read/28323991/whole-body-vibration-mimics-the-metabolic-effects-of-exercise-in-male-leptin-receptor-deficient-mice
#1
Meghan E McGee-Lawrence, Karl H Wenger, Sudipta Misra, Catherine L Davis, Norman K Pollock, Mohammed Elsalanty, Kehong Ding, Carlos M Isales, Mark W Hamrick, Joanna R Erion, Marlena Wosiski-Kuhn, Phonepasong Arounleut, Mark P Mattson, Roy G Cutler, Jack C Yu, Alexis M Stranahan
Whole-body vibration has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether whole-body vibration recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wildtype (Wt) and leptin receptor deficient (db/db) mice to daily treadmill exercise or whole-body vibration for three months. Body weights were analyzed and compared with Wt and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following treadmill exercise or whole-body vibration...
March 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28314588/risk-of-breast-cancer-after-a-diagnosis-of-ovarian-cancer-in-brca-mutation-carriers-is-preventive-mastectomy-warranted
#2
Jacob McGee, Vasily Giannakeas, Beth Karlan, Jan Lubinski, Jacek Gronwald, Barry Rosen, John McLaughlin, Harvey Risch, Ping Sun, William D Foulkes, Susan L Neuhausen, Joanne Kotsopoulos, Steven A Narod
OBJECTIVE: Preventive breast surgery and MRI screening are offered to unaffected BRCA mutation carriers. The clinical benefit of these two modalities has not been evaluated among mutation carriers with a history of ovarian cancer. Thus, we sought to determine whether or not BRCA mutation carriers with ovarian cancer would benefit from preventive mastectomy or from MRI screening. METHODS: First, the annual mortality rate for ovarian cancer patients was estimated for a cohort of 178 BRCA mutation carriers from Ontario, Canada...
March 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28304110/perceptions-of-health-among-black-adults-living-in-a-diverse-urban-community
#3
Dahnika Sachs, Jill N Peltzer, Jerrihlyn L McGee
OBJECTIVE: The Robert Wood Johnson Foundation's culture of health initiative advocates for making health a shared value. Health cannot be a shared value without an understanding of how health is defined and perceived. The purpose of this qualitative descriptive study was to examine community members' perceptions of health and influencing factors, including health care services. DESIGN AND SAMPLE: Data were collected through a purposive sample of nine focus groups with 52 participants who were primarily Black (94%) and female (65%)...
March 17, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28301453/investigation-of-salmonella-enteritidis-outbreak-associated-with-truffle-oil-district-of-columbia-2015
#4
S Janet Kuramoto-Crawford, Sasha McGee, Keith Li, Andrew K Hennenfent, Kossia Dassie, Jhetari T Carney, Arian Gibson, Ivory Cooper, Morris Blaylock, Reginald Blackwell, Angela Fields, John Davies-Cole
On September 8, 2015, the District of Columbia Department of Health (DCDOH) received a call from a person who reported experiencing gastrointestinal illness after eating at a District of Columbia (DC) restaurant with multiple locations throughout the United States (restaurant A). Later the same day, a local emergency department notified DCDOH to report four persons with gastrointestinal illness, all of whom had eaten at restaurant A during August 30-September 5. Two patients had laboratory-confirmed Salmonella group D by stool culture...
March 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28298153/exploring-drug-dosing-regimens-in-vitro-using-real-time-3d-spheroid-tumor-growth-assays
#5
Madhu Lal-Nag, Lauren McGee, Steven A Titus, Kyle Brimacombe, Sam Michael, Gurusingham Sittampalam, Marc Ferrer
Two-dimensional monolayer cell proliferation assays for cancer drug discovery have made the implementation of large-scale screens feasible but only seem to reflect a simplified view that oncogenes or tumor suppressor genes are the genetic drivers of cancer cell proliferation. However, there is now increased evidence that the cellular and physiological context in which these oncogenic events occur play a key role in how they drive tumor growth in vivo and, therefore, in how tumors respond to drug treatments...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28296137/percutaneous-peripheral-nerve-stimulation-for-the-treatment-of-chronic-low-back-pain-two-clinical-case-reports-of-sustained-pain-relief
#6
Leonardo Kapural, Christopher A Gilmore, John Chae, Richard L Rauck, Steven P Cohen, Michael F Saulino, Amorn Wongsarnpigoon, Meredith J McGee, Joseph W Boggs
As the leading cause of disability among U.S. adults, chronic low back pain (LBP) is one sof the most prevalent and challenging musculoskeletal conditions. Neuromodulation provides an opportunity to reduce or eliminate the use of opioids to treat chronic LBP, but the cost and invasiveness of existing methods have limited its broad adoption, especially earlier in the treatment continuum. The present case report details the results of a novel method of short-term percutaneous peripheral nerve stimulation (PNS) in 2 subjects with chronic LBP...
March 14, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28292636/who-we-are-and-what-we-can-become-an-analysis-of-professional-identity-formation-in-ir
#7
Eric J Keller, Katherine A McGee, Scott A Resnick, Scott O Trerotola, Karim Valji, Matthew S Johnson, Jeremy D Collins, Robert L Vogelzang
PURPOSE: To characterize the unique experiences, values, and perspectives of interventional radiology (IR) fellows. MATERIALS AND METHODS: Sixteen fellows from 4 US vascular and IR programs were interviewed within 2 months of beginning and 2-3 months following their 2015-2016 fellowships about patient interactions, training experiences, and views of IR and other specialties. Interviews were systematically analyzed for dominant themes by using constructivist grounded theory...
March 11, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28291487/physical-screening-predictors-for-success-in-completing-air-force-phase-ii-air-liaison-officer-aptitude-assessment
#8
John Christopher McGee, Eric Wilson, Haley Barela, Sharon Blum
OBJECTIVES: Air Liaison Officer Aptitude Assessment (AAA) attrition is often associated with a lack of candidate physical preparation. The Functional Movement Screen, Tactical Fitness Assessment, and fitness metrics were collected (n = 29 candidates) to determine what physical factors could predict a candidate s success in completing AAA. METHODS: Between-group comparisons were made between candidates completing AAA versus those who did not (p < 0.05). Upper 50% thresholds were established for all variables with R(2) < 0...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291447/an-orthopedic-performance-improvement-initiative-at-a-small-military-treatment-facility
#9
John Christopher McGee, Christopher G Bise, Joel M Stevens
OBJECTIVES: The scientific literature demonstrates a cost-benefit associated with early access to physical therapy. The purpose of this case study is to report the results of an orthopedic performance improvement initiative (OPII) at a small military treatment facility (approximately 4.5K active duty beneficiaries). The OPII was introduced to (1) limit variation by ensuring that all active duty orthopedic consults were audited ensuring proper timing of appropriate services and (2) establish contractual agreement for shared resources with the U...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288774/intravenous-vs-intraosseous-access-and-return-of-spontaneous-circulation-during-out-of-hospital-cardiac-arrest
#10
Brian Clemency, Kaori Tanaka, Paul May, Johanna Innes, Sara Zagroba, Jacqueline Blaszak, David Hostler, Derek Cooney, Kevin McGee, Heather Lindstrom
INTRODUCTION: Guidelines endorse intravenous (IV) and intraosseous (IO) medication administration for cardiac arrest treatment. Limited clinical evidence supports this recommendation. A multiagency, retrospective study was performed to determine the association between parenteral access type and return of spontaneous circulation (ROSC) in out of hospital cardiac arrest. METHODS: This was a structured, retrospective chart review of emergency medical services (EMS) records from three agencies...
February 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28283078/distortion-product-otoacoustic-emissions-in-young-adult-and-geriatric-cats
#11
George M Strain, Kain A McGee
Recordings of distortion product otoacoustic emissions (DPOAEs) were taken from 15 geriatric cats (mean age ± standard deviation, SD, 13.6 ± 2.7 years; range 10.2-19.4 years) and 12 young adult control cats (mean ± SD 4.6 ± 0.5 years; range 3.4-5 years) to identify frequency-specific age-related changes in cochlear responses. Recordings were performed for primary frequencies from 2 to 12 kHz in 2 kHz increments. Cats were considered to be geriatric > 11.9 ± 1.9 years of age...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28274387/experiences-and-perceptions-of-the-united-states-ebola-active-monitoring-program-results-from-a-survey-of-former-persons-under-monitoring-in-washington-dc
#12
A Hennenfent, S McGee, K Dassie, J Grant, K Li, K Zamore, J Davies-Cole, F Johnson-Clarke
OBJECTIVES: To assess Former Persons Under Monitoring (FPUM)s' experiences and perceptions of the United States (US) Ebola Active Monitoring Program. STUDY DESIGN: Retrospective assessment survey of FPUM. METHODS: An electronic survey was distributed to FPUMs monitored in Washington, DC, during October 2014-September 2015 (n = 830). RESULTS: Most FPUMs (>70%) had a favourable perception of the program. Less than 5% avoided future travel or participation in outbreak response activities as a result of their monitoring experience...
March 2017: Public Health
https://www.readbyqxmd.com/read/28259352/study-of-socs-gene-family-expression-profile-in-ms-patients-another-step-forward
#13
EDITORIAL
Jeanie C McGee, Alireza Minagar
No abstract text is available yet for this article.
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28258188/lysine-post-translational-modification-of-glyceraldehyde-3-phosphate-dehydrogenase-regulates-hepatic-and-systemic-metabolism
#14
Simon T Bond, Kirsten F Howlett, Greg M Kowalski, Shaun Mason, Timothy Connor, Adrian Cooper, Victor Streltsov, Clinton R Bruce, Ken R Walder, Sean L McGee
Reciprocal regulation of hepatic glycolysis and gluconeogenesis contributes to systemic metabolic homeostasis. Recent evidence from lower order organisms has found that reversible post-translational modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), particularly acetylation, contributes to the reciprocal regulation of glycolysis/gluconeogenesis. However, whether this occurs in mammalian hepatocytes in vitro or in vivo is unknown. Several proteomics studies have identified 4 lysine residues in critical regions of mammalian GAPDH that are altered by multiple post-translational modifications...
March 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28257899/short-read-whole-genome-sequencing-for-determination-of-antimicrobial-resistance-mechanisms-and-capsular-serotypes-of-current-invasive-streptococcus-agalactiae-recovered-in-the-united-states
#15
Benjamin J Metcalf, Sopio Chochua, Robert E Gertz, Paulina A Hawkins, Jessica Ricaldi, Zhongya Li, Hollis Walker, Theresa Tran, Joy Rivers, Saundra Mathis, Delois Jackson, Anita Glennen, Ruth Lynfield, Lesley McGee, Bernard Beall
OBJECTIVES: Our objective was to evaluate and exploit a whole genome sequence (WGS) bioinformatics pipeline for predicting antimicrobial resistance and capsular serotypes from invasive group B streptococci (iGBS). METHODS: For 1975 iGBS recovered during 2015 from CDC's Active Bacterial Core surveillance, we compared pipeline predictions to broth dilution testing. Fifty-six isolates from earlier surveillance were included for testing β-lactams.. Conventional serotyping was compared to WGS-based assignments for 302 isolates...
February 28, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28252484/ventrogluteal-site-injections-in-the-mental-health-setting-a-comprehensive-educational-program
#16
Helen McGee
Adoption of the ventrogluteal site for intramuscular injections has been limited in mental health settings despite its decreased risk of sciatic nerve injury and its promotion as best practice among student nurses. At a center for addiction and mental health in Toronto, Canada, registered practical nurses followed a competency checklist in a simulation setting and then observed and administered supervised ventrogluteal injections in clinical settings. This article describes the comprehensive educational program and its outcomes in practice...
March 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28251869/a-taxonomy-of-visualization-tasks-for-the-analysis-of-biological-pathway-data
#17
Paul Murray, Fintan McGee, Angus G Forbes
BACKGROUND: Understanding complicated networks of interactions and chemical components is essential to solving contemporary problems in modern biology, especially in domains such as cancer and systems research. In these domains, biological pathway data is used to represent chains of interactions that occur within a given biological process. Visual representations can help researchers understand, interact with, and reason about these complex pathways in a number of ways. At the same time, these datasets offer unique challenges for visualization, due to their complexity and heterogeneity...
February 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28236336/cardiac-mr-elastography-for-quantitative-assessment-of-elevated-myocardial-stiffness-in-cardiac-amyloidosis
#18
Arvin Arani, Shivaram P Arunachalam, Ian C Y Chang, Francis Baffour, Phillip J Rossman, Kevin J Glaser, Joshua D Trzasko, Kiaran P McGee, Armando Manduca, Martha Grogan, Angela Dispenzieri, Richard L Ehman, Philip A Araoz
PURPOSE: To evaluate if cardiac magnetic resonance elastography (MRE) can measure increased stiffness in patients with cardiac amyloidosis. Myocardial tissue stiffness plays an important role in cardiac function. A noninvasive quantitative imaging technique capable of measuring myocardial stiffness could aid in disease diagnosis, therapy monitoring, and disease prognostic strategies. We recently developed a high-frequency cardiac MRE technique capable of making noninvasive stiffness measurements...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28230908/probiotics-for-people-with-hepatic-encephalopathy
#19
REVIEW
Rohan Dalal, Richard G McGee, Stephen M Riordan, Angela C Webster
BACKGROUND: Hepatic encephalopathy is a disorder of brain function as a result of liver failure or portosystemic shunt or both. Both hepatic encephalopathy (clinically overt) and minimal hepatic encephalopathy (not clinically overt) significantly impair patient's quality of life and daily functioning, and represent a significant burden on healthcare resources. Probiotics are live micro-organisms, which when administered in adequate amounts, may confer a health benefit on the host. OBJECTIVES: To determine the beneficial and harmful effects of probiotics in any dosage, compared with placebo or no intervention, or with any other treatment for people with any grade of acute or chronic hepatic encephalopathy...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28228473/violence-related-ambulance-call-outs-in-the-north-west-of-england-a-cross-sectional-analysis-of-nature-extent-and-relationships-to-temporal-celebratory-and-sporting-events
#20
Zara Quigg, Ciara McGee, Karen Hughes, Simon Russell, Mark A Bellis
OBJECTIVE: The aim of this study was to explore the potential of ambulance call-out data in understanding violence to inform about prevention activity. METHOD: This cross-sectional (2013-2015) study examined the nature, extent and characteristics of violence-related ambulance call-outs (n=15 687) across North West England and relationships with temporal, celebratory and sporting events. RESULTS: The majority of call-outs were for men, with a mean age of 33 years...
February 21, 2017: Emergency Medicine Journal: EMJ
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