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https://www.readbyqxmd.com/read/28448128/total-chemical-synthesis-and-folding-of-all-l-and-all-d-variants-of-oncogenic-kras-g12v
#1
Adam Marc Levinson, John H McGee, Andrew G Roberts, Gardner Creech, Ting Wang, Michael T Peterson, Ronald C Hendrickson, Gregory L Verdine, Samuel J Danishefsky
The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered 'undruggable' due to its high affinity for GTP and its lack of hydrophobic binding pockets. Herein, we report a total chemical synthesis of all-L- and all-D-amino acid biotinylated variants of oncogenic mutant KRas(G12V)...
April 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28445679/response-to-a-comprehensive-nutrition-focused-quality-improvement-program-reduces-30-day-readmissions-and-length-of-stay-in-hospitalized-patients
#2
Ursula Mary McGee, Hannah Ruth Cole, Rachael Catherine Barlow
No abstract text is available yet for this article.
May 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28432504/3t-mri-of-the-knee-with-optimised-isotropic-3d-sequences-accurate-delineation-of-intra-articular-pathology-without-prolonged-acquisition-times
#3
Osamah M Abdulaal, Louise Rainford, Peter MacMahon, Eoin Kavanagh, Marie Galligan, James Cashman, Allison McGee
OBJECTIVES: To investigate optimised isotropic 3D turbo spin echo (TSE) and gradient echo (GRE)-based pulse sequences for visualisation of articular cartilage lesions within the knee joint. METHODS: Optimisation of experimental imaging sequences was completed using healthy volunteers (n=16) with a 3-Tesla (3T) MRI scanner. Imaging of patients with knee cartilage abnormalities (n=57) was then performed. Acquired sequences included 3D proton density-weighted (PDW) TSE (SPACE) with and without fat-suppression (FS), and T2*W GRE (TrueFISP) sequences, with acquisition times of 6:51, 6:32 and 5:35 min, respectively...
April 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28427394/erratum-to-obesity-and-type-2-diabetes-have-additive-effects-on-left-ventricular-remodelling-in-normotensive-patients-a-cross-sectional-study
#4
Kirstie A De Jong, Juliane K Czeczor, Smithamol Sithara, Kevin McEwen, Gary D Lopaschuk, Alan Appelbe, Kimberly Cukier, Mark Kotowicz, Sean L McGee
No abstract text is available yet for this article.
April 20, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28425328/the-use-of-a-smartwatch-as-a-prompting-device-for-people-with-acquired-brain-injury-a-single-case-experimental-design-study
#5
Matthew Jamieson, Mattia Monastra, Graeme Gillies, Rumen Manolov, Breda Cullen, Marilyn McGee-Lennon, Stephen Brewster, Jonathan Evans
Prompting-based memory compensation is a potential application for smartwatches. This study investigated the usability and efficacy of a Moto360 smartwatch as a memory aid. Four community dwelling adults with memory difficulties following acquired brain injury (ABI) were included in an A-B-A single case experimental design study. Performance of everyday memory tasks was tested over six weeks with the smartwatch and software provided during weeks three and four. Participants were asked to use their usual memory aids and strategies during the control phases (weeks 1-2, 5-6)...
April 20, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28424245/oral-nutrition-in-children-with-bronchiolitis-on-high-flow-nasal-cannula-is-well-tolerated
#6
Anthony Alexander Sochet, Jessica Ann McGee, Tessie Wazeerah October
OBJECTIVES: To determine the incidence of aspiration-related respiratory failure and nutrition interruptions in children with bronchiolitis on high-flow nasal cannula (HFNC) receiving enteral nutrition. METHODS: We performed a single-center, prospective, observational cohort study within a 313-bed tertiary medical center from January through December 2015. We included term children 1 month to 2 years of age without comorbid bacterial pneumonia or chronic medical conditions who were diagnosed with bronchiolitis while receiving HFNC and enteral nutrition...
April 19, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28392480/network-analysis-reveals-a-signaling-regulatory-loop-in-pik3ca-mutated-breast-predicting-survival-outcome
#7
Shauna R McGee, Chabane Tibiche, Mark Trifiro, Edwin Wang
Mutated genes are rarely common even in the same pathological type between cancer patients and as such, it has been very challenging to interpret genome sequencing data and difficult to predict clinical outcomes. PIK3CA is one of a few genes whose mutations are relatively popular in tumors. For example, more than 46.6% of luminal-A breast cancer samples have PIK3CA mutated, whereas only 35.5% of all breast cancer samples contain PIK3CA mutations. To understand the function of PIK3CA mutations in luminal A breast cancer, we applied our recently proposed cancer hallmark network framework to investigate the network motifs in the PIK3CA-mutated luminal A tumors...
April 6, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/28390556/an-investigation-of-saudi-arabian-mr-radiographers-knowledge-and%C3%A2-confidence-in-relation-to-mr-image-quality-related-errors
#8
W Alsharif, M Davis, A McGee, L Rainford
OBJECTIVE: To investigate MR radiographers' current knowledge base and confidence level in relation to quality-related errors within MR images. METHOD: Thirty-five MR radiographers within 16 MRI departments in the Kingdom of Saudi Arabia (KSA) independently reviewed a prepared set of 25 MR images, naming the error, specifying the error-correction strategy, scoring how confident they were in recognising this error and suggesting a correction strategy by using a scale of 1-100...
May 2017: Radiography
https://www.readbyqxmd.com/read/28382658/regional-assessment-of-in-vivo-myocardial-stiffness-using-3d-magnetic-resonance-elastography-in-a-porcine-model-of-myocardial-infarction
#9
Shivaram P Arunachalam, Arvin Arani, Francis Baffour, Joseph A Rysavy, Phillip J Rossman, Kevin J Glaser, David S Lake, Joshua D Trzasko, Armando Manduca, Kiaran P McGee, Richard L Ehman, Philip A Araoz
PURPOSE: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. METHODS: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery...
April 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28369907/who-is-and-isn-t-having-babies-with-down-syndrome-in-western-sydney-a-ten-year-hospital-cohort-study
#10
Rebecca M Moses, James H W Brown, Dale C Wright, Hayley Diplock, Sarah J Melov, Therese Mary McGee
BACKGROUND: Screening for Down syndrome (DS) is a key component of antenatal care, recommended to be universally offered to women irrespective of age or background. Despite this, the diagnosis of DS is often not made until the neonatal period. AIMS: To retrospectively describe and compare the differences in populations with an antenatal diagnosis (AD) and neonatal diagnosis (ND) of DS and to explore why an antenatal diagnosis was not made. MATERIALS AND METHODS: The cohorts were women cared for at Westmead Hospital whose pregnancy received a diagnosis of DS between 2006 and 2015...
March 29, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28350313/improving-the-reach-of-the-national-diabetes-prevention-program-within-a-health-disparities-population-a-bronx-new-york-pilot-project-crossing-health-and-community-based-sectors
#11
Robert Morrow, Lisa Ferretti, Chris Norwood, Douglas Reich, Erica Chito-Childs, Phillip McCallion, Jose Tiburcio, Eleanor McGee, Jose A Lopez
INTRODUCTION: Diabetes affects upward of 30% of South Bronx residents. The Centers for Disease Control and Prevention's National Diabetes Prevention Program (NDPP) reduces risk of progression to diabetes, yet implementation has been elusive within health disparities populations. METHODS: This community-based, collaborative project piloted the NDPP in the South Bronx and evaluated implementation challenges and enablers. The New York State training group prepared community peer lifestyle coaches recruited by a community organization...
October 2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/28349564/emerging-roles-for-the-amyloid-precursor-protein-and-derived-peptides-in-the-regulation-of-cellular-and-systemic-metabolism
#12
REVIEW
Juliane K Czeczor, Sean L McGee
The amyloid precursor protein (APP) is a transmembrane protein that can be cleaved by proteases through two different pathways to yield a number of small peptides, each with distinct physiological properties and functions. It has been extensively studied in the context of Alzheimer's disease, with the APP-derived amyloid beta (Aβ) peptide being a major constituent of the amyloid plaques observed in this disease. It has been known for some time that APP can regulate neuronal metabolism, however this review will examine evidence that APP and its peptides can also regulate key metabolic processes such as insulin action, lipid synthesis and storage and mitochondrial function in peripheral tissues...
March 28, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28346091/a-high-throughput-screening-model-of-the-tumor-microenvironment-for-ovarian-cancer-cell-growth
#13
Madhu Lal-Nag, Lauren McGee, Rajarshi Guha, Ernst Lengyel, Hilary A Kenny, Marc Ferrer
The tumor microenvironment plays an important role in the processes of tumor growth, metastasis, and drug resistance. We have used a multilayered 3D primary cell culture model that reproduces the human ovarian cancer metastatic microenvironment to study the effect of the microenvironment on the pharmacological responses of different classes of drugs on cancer cell proliferation. A collection of oncology drugs was screened to identify compounds that inhibited the proliferation of ovarian cancer cells growing as monolayers or forming spheroids, on plastic and on a 3D microenvironment culture model of the omentum metastatic site, and also cells already in preformed spheroids...
January 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28333320/cross-resistance-to-lincosamides-streptogramins-a-and-pleuromutilins-in-streptococcus-agalactiae-isolates-from-the-usa
#14
Paulina A Hawkins, Caitlin S Law, Benjamin J Metcalf, Sopio Chochua, Delois M Jackson, Lars F Westblade, Robert Jerris, Bernard W Beall, Lesley McGee
Background: Streptococcus agalactiae (Group B Streptococcus, GBS) is a leading cause of meningitis, sepsis and pneumonia in neonates in the United States. GBS also causes invasive disease in older infants, pregnant women, children and young adults with underlying medical conditions, and older adults. Resistance to lincosamides in the absence of erythromycin resistance is rare in GBS, but has been previously reported in clinical isolates, both on its own or in combination with resistance to streptogramins A and pleuromutilins (L/LSA/LSAP phenotypes)...
March 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28323991/whole-body-vibration-mimics-the-metabolic-effects-of-exercise-in-male-leptin-receptor-deficient-mice
#15
Meghan E McGee-Lawrence, Karl H Wenger, Sudipta Misra, Catherine L Davis, Norman K Pollock, Mohammed Elsalanty, Kehong Ding, Carlos M Isales, Mark W Hamrick, Joanna R Erion, Marlena Wosiski-Kuhn, Phonepasong Arounleut, Mark P Mattson, Roy G Cutler, Jack C Yu, Alexis M Stranahan
Whole-body vibration has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether whole-body vibration recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wildtype (Wt) and leptin receptor deficient (db/db) mice to daily treadmill exercise or whole-body vibration for three months. Body weights were analyzed and compared with Wt and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following treadmill exercise or whole-body vibration...
March 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28321819/the-perceptual-basis-of-vast-space
#16
Roberta L Klatzky, William B Thompson, Jeanine K Stefanucci, Devin Gill, D Kevin McGee
"Vast" is a word often applied to environmental terrain that is perceived to have large spatial extent. This judgment is made even at viewing distances where traditional metric depth cues are not useful. This paper explores the perceptual basis of vast experience, including reliability and visual precursors. Experiment 1 demonstrated strong agreement in ratings of the spatial extent of two-dimensional (2D) scene images by participants in two countries under very different viewing conditions. Image categories labeled "vast" often exemplified scene attributes of ruggedness and openness (Oliva & Torralba, 2001)...
March 20, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28320830/exercise-and-the-skeletal-muscle-epigenome
#17
Sean L McGee, Ken R Walder
An acute bout of exercise is sufficient to induce changes in skeletal muscle gene expression that are ultimately responsible for the adaptive responses to exercise. Although much research has described the intracellular signaling responses to exercise that are linked to transcriptional regulation, the epigenetic mechanisms involved are only just emerging. This review will provide an overview of epigenetic mechanisms and what is known in the context of exercise. Additionally, we will explore potential interactions between metabolism during exercise and epigenetic regulation, which serves as a framework for potential areas for future research...
March 20, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28314588/risk-of-breast-cancer-after-a-diagnosis-of-ovarian-cancer-in-brca-mutation-carriers-is-preventive-mastectomy-warranted
#18
Jacob McGee, Vasily Giannakeas, Beth Karlan, Jan Lubinski, Jacek Gronwald, Barry Rosen, John McLaughlin, Harvey Risch, Ping Sun, William D Foulkes, Susan L Neuhausen, Joanne Kotsopoulos, Steven A Narod
OBJECTIVE: Preventive breast surgery and MRI screening are offered to unaffected BRCA mutation carriers. The clinical benefit of these two modalities has not been evaluated among mutation carriers with a history of ovarian cancer. Thus, we sought to determine whether or not BRCA mutation carriers with ovarian cancer would benefit from preventive mastectomy or from MRI screening. METHODS: First, the annual mortality rate for ovarian cancer patients was estimated for a cohort of 178 BRCA mutation carriers from Ontario, Canada...
March 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28304110/perceptions-of-health-among-black-adults-living-in-a-diverse-urban-community
#19
Dahnika Sachs, Jill N Peltzer, Jerrihlyn L McGee
OBJECTIVE: The Robert Wood Johnson Foundation's culture of health initiative advocates for making health a shared value. Health cannot be a shared value without an understanding of how health is defined and perceived. The purpose of this qualitative descriptive study was to examine community members' perceptions of health and influencing factors, including health care services. DESIGN AND SAMPLE: Data were collected through a purposive sample of nine focus groups with 52 participants who were primarily Black (94%) and female (65%)...
March 17, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28301453/investigation-of-salmonella-enteritidis-outbreak-associated-with-truffle-oil-district-of-columbia-2015
#20
S Janet Kuramoto-Crawford, Sasha McGee, Keith Li, Andrew K Hennenfent, Kossia Dassie, Jhetari T Carney, Arian Gibson, Ivory Cooper, Morris Blaylock, Reginald Blackwell, Angela Fields, John Davies-Cole
On September 8, 2015, the District of Columbia Department of Health (DCDOH) received a call from a person who reported experiencing gastrointestinal illness after eating at a District of Columbia (DC) restaurant with multiple locations throughout the United States (restaurant A). Later the same day, a local emergency department notified DCDOH to report four persons with gastrointestinal illness, all of whom had eaten at restaurant A during August 30-September 5. Two patients had laboratory-confirmed Salmonella group D by stool culture...
March 17, 2017: MMWR. Morbidity and Mortality Weekly Report
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