keyword
MENU ▼
Read by QxMD icon Read
search

Mcgee

keyword
https://www.readbyqxmd.com/read/28732171/using-metagenomics-to-show-the-efficacy-of-forest-restoration-in-the-new-jersey-pine-barrens
#1
William D Eaton, Shadi Shokralla, Kathleen M McGee, Mehrdad Hajibabaei
The Franklin Parker Preserve within the New Jersey Pine Barrens contains 5,000 acres of wetlands habitat, including old-growth Atlantic White Cedar (or AWC; Chamaecyparis thyoides) swamps, cranberry bogs, and former cranberry bogs undergoing restoration into AWC forests. This study showed that the C-use efficiency was greater in the old-growth AWC soils than in soils from 8-year old mid-stage restored AWC stands, which were greater than found in soil from 4-year old AWC stands-the latter two stands being restored from long-term cranberry bogs...
July 21, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28730525/identification-of-a-seed-coat-specific-promoter-fragment-from-the-arabidopsis-mucilage-modified4-gene
#2
Gillian H Dean, Zhaoqing Jin, Lin Shi, Elahe Esfandiari, Robert McGee, Kylie Nabata, Tiffany Lee, Ljerka Kunst, Tamara L Western, George W Haughn
The Arabidopsis seed coat-specific promoter fragment described is an important tool for basic and applied research in Brassicaceae species. During differentiation, the epidermal cells of the Arabidopsis seed coat produce and secrete large quantities of mucilage. On hydration of mature seeds, this mucilage becomes easily accessible as it is extruded to form a tightly attached halo at the seed surface. Mucilage is composed mainly of pectin, and also contains the key cell wall components cellulose, hemicellulose, and proteins, making it a valuable model for studying numerous aspects of cell wall biology...
July 20, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28727234/kynurenine-a-tryptophan-metabolite-that-accumulates-with-age-induces-bone-loss
#3
Mona El Refaey, Meghan E McGee-Lawrence, Sadanand Fulzele, Eileen J Kennedy, Wendy B Bollag, Mohammed Elsalanty, Qing Zhong, Ke-Hong Ding, Nathaniel G Bendzunas, Xing-Ming Shi, Jianrui Xu, William D Hill, Maribeth H Johnson, Monte Hunter, Jessica L Pierce, Kanglun Yu, Mark W Hamrick, Carlos M Isales
Age-dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase in the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants and are anabolic for bone and that they may potentially play a protective role in an aging environment. We hypothesized that upon oxidation the aromatic amino acids would not only lose their anabolic effects but also potentially become a catabolic byproduct...
July 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28724936/an-engineered-protein-antagonist-of-k-ras-b-raf-interaction
#4
Monique J Kauke, Michael W Traxlmayr, Jillian A Parker, Jonathan D Kiefer, Ryan Knihtila, John McGee, Greg Verdine, Carla Mattos, K Dane Wittrup
Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferential binding to K-Ras G12D. This is the first reported inhibitor to achieve nanomolar affinity while exhibiting specificity for mutant over wild type (WT) K-Ras. Crystal structures of the protein R11.1.6 in complex with K-Ras WT and K-Ras G12D offer insight into the structural basis for specificity, highlighting differences in the switch I conformation as the major defining element in the higher affinity interaction...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716912/sialylation-on-o-glycans-protects-platelets-from-clearance-by-liver-kupffer-cells
#5
Yun Li, Jianxin Fu, Yun Ling, Tadayuki Yago, J Michael McDaniel, Jianhua Song, Xia Bai, Yuji Kondo, Yannan Qin, Christopher Hoover, Samuel McGee, Bojing Shao, Zhenghui Liu, Roberto Sonon, Parastoo Azadi, Jamey D Marth, Rodger P McEver, Changgeng Ruan, Lijun Xia
Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-glycans). However, the biological importance of O-glycans in platelet clearance is unclear. Here, we generated mice with a hematopoietic cell-specific loss of O-glycans (HC C1galt1(-/-) ). These mice lack O-glycans on platelets and exhibit reduced peripheral platelet numbers. Platelets from HC C1galt1(-/-) mice show reduced levels of α-2,3-linked sialic acids and increased accumulation in the liver relative to wild-type platelets...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28712078/effects-based-spatial-assessment-of-contaminated-estuarine-sediments-from-bear-creek-baltimore-harbor-md-usa
#6
Sharon E Hartzell, Michael A Unger, Beth L McGee, Lance T Yonkos
Estuarine sediments in regions with prolonged histories of industrial activity are often laden to significant depths with complex contaminant mixtures, including trace metals and persistent organic pollutants. Given the complexity of assessing risks from multi-contaminant exposures, the direct measurement of impacts to biological receptors is central to characterizing contaminated sediment sites. Though biological consequences are less commonly assessed at depth, laboratory-based toxicity testing of subsurface sediments can be used to delineate the scope of contamination at impacted sites...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28711389/population-genetic-structure-antibiotic-resistance-capsule-switching-and-evolution-of-invasive-pneumococci-before-conjugate-vaccination-in-malawi
#7
Chrispin Chaguza, Jennifer E Cornick, Cheryl P Andam, Rebecca A Gladstone, Maaike Alaerts, Patrick Musicha, Chikondi Peno, Naor Bar-Zeev, Arox W Kamng'ona, Anmol M Kiran, Chisomo L Msefula, Lesley McGee, Robert F Breiman, Aras Kadioglu, Neil French, Robert S Heyderman, William P Hanage, Stephen D Bentley, Dean B Everett
INTRODUCTION: Pneumococcal infections cause a high death toll in Sub Saharan Africa (SSA) but the recently rolled out pneumococcal conjugate vaccines (PCV) will reduce the disease burden. To better understand the population impact of these vaccines, comprehensive analysis of large collections of pneumococcal isolates sampled prior to vaccination is required. Here we present a population genomic study of the invasive pneumococcal isolates sampled before the implementation of PCV13 in Malawi...
July 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28687609/deguelin-exerts-potent-nematocidal-activity-via-the-mitochondrial-respiratory-chain
#8
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan R E Ansell, Gillian M Fisher, Katherine T Andrews, Bill C H Chang, Martin A M Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively and potently inhibits the motility and development of nematodes, which supports its potential as a lead candidate for drug development. Furthermore, we demonstrate that deguelin treatment significantly increases gene transcription that is associated with energy metabolism, particularly oxidative phosphorylation and mito-ribosomal protein production before inhibiting motility...
July 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28684932/preoperative-considerations-for-the-ostomate
#9
REVIEW
Molly A Wasserman, Michael F McGee
Intestinal stomas significantly impact patients' quality of life. Stoma-related complications are common, but even without complications, patients are faced with new challenges in stoma management and daily activities. Preoperative patient education and stoma site marking, in conjunction with conscientious surgical stewardship, are key to patient satisfaction and successful operative outcomes.
July 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28684930/the-plight-of-the-ostomate
#10
Michael F McGee
No abstract text is available yet for this article.
July 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28684929/michael-f-mcgee-md-facs-fascrs
#11
Scott R Steele
No abstract text is available yet for this article.
July 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28681992/outcomes-and-patterns-of-failure-of-sarcomatoid-carcinoma-of-the-larynx-the-mayo-clinic-experience
#12
Mauricio E Gamez, Elizabeth Jeans, Michael L Hinni, Eric Moore, Geoffrey Young, Daniel Ma, Lisa McGee, Matthew R Buras, Samir H Patel
OBJECTIVES/HYPOTHESIS: Sarcomatoid carcinoma is a rare variant of squamous cell carcinoma of the head and neck. No consensus exists on its management. Our aim was to present our outcomes. STUDY DESIGN: Retrospective study. Median follow-up 45 months. METHODS: There were 38 patients with pathologically confirmed sarcomatoid carcinoma of the larynx treated at the Mayo Clinic from 1990 to 2014. Statistical analysis of overall survival (OS), progression-free survival (PFS), and local control (LC) were conducted using the Kaplan-Meier method...
July 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28674117/genetic-counselor-recommendations-for-cancer-predisposition-evaluation-and-surveillance-in-the-pediatric-oncology-patient
#13
REVIEW
Harriet Druker, Kristin Zelley, Rose B McGee, Sarah R Scollon, Wendy K Kohlmann, Katherine A Schneider, Kami Wolfe Schneider
As the understanding of the genetic etiology of childhood cancers increases, the need for the involvement of experts familiar with the provision of genetic counseling for this population is paramount. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in which international experts in pediatric cancer predisposition met to establish surveillance guidelines for children with cancer predisposition. Identifying for whom, when, why, and how these cancer predisposition surveillance guidelines should be implemented is essential...
July 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28667254/quantity-of-alcohol-drinking-positively-correlates-with-serum-levels-of-endotoxin-and-markers-of-monocyte-activation
#14
Suthat Liangpunsakul, Evelyn Toh, Ruth A Ross, Laura E Heathers, Kristina Chandler, AdePeju Oshodi, Breann McGee, Elizabeth Modlik, Tobyn Linton, Darrin Mangiacarne, Claudie Jimenez, X Charlie Dong, Li Wang, Wanzhu Tu, David E Nelson
It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 controls). Time Line Follow-Back questionnaire was used to quantify the amount of alcohol consumed. Serum LPS, sCD14, and sCD163 were measured. Peripheral blood mononuclear cells (PBMCs) were also isolated. Compared to controls, ED had higher total drinks in the past 30 days, higher levels of LPS, sCD14 and sCD163...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666762/the-impact-of-baseline-edmonton-symptom-assessment-scale-scores-on-treatment-and-survival-in-patients-with-advanced-non-small-cell-lung-cancer
#15
Sharon F McGee, Tinghua Zhang, Hannah Jonker, Scott A Laurie, Glen Goss, Garth Nicholas, Khalid Albaimani, Paul Wheatley-Price
BACKGROUND: Palliative systemic therapy is frequently underutilized in patients with advanced non-small-cell lung cancer (NSCLC), for many reasons. The aim of this study was to identify patient-reported factors that may predict for treatment decisions and survival in advanced NSCLC, using the Edmonton Symptom Assessment Scale (ESAS), which is a self-reported questionnaire that quantifies symptom burden by asking patients to rate the severity of 9 common symptoms. PATIENTS AND METHODS: With ethics approval, we analyzed ESAS scores at initial oncology consultation for 461 patients with advanced NSCLC seen at The Ottawa Hospital Cancer Centre from 2009 to 2012...
June 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28658293/green-design-of-a-paper-test-card-for-urinary-iodine-analysis
#16
Nicholas M Myers, Ivan C Leung, Sean W McGee, Kathleen Eggleson, Marya Lieberman
When young children do not receive adequate amounts of the micronutrient iodine in their diet, their growth and cognitive development can be impaired. Nearly every country in the world has programs in place to track iodine intake and provide supplemental iodine if needed, usually in the form of fortified salt. The iodine nutrition status of a population can be tracked by monitoring iodine levels in urine samples to see if the median value falls in the range of 100-300 micrograms of iodine per liter of urine (μg I/L), which indicates adequate or more than adequate iodine nutrition...
2017: PloS One
https://www.readbyqxmd.com/read/28656529/il-22-enhances-tnf-%C3%AE-and-il-1-induced-cxcl8-responses-by-intestinal-epithelial-cell-lines
#17
Rebecca S Young, Brody M Wiles, Dennis W McGee
IL-22 is known to induce intestinal epithelial cells (IECs) to produce the chemokine CXCL8. However, IECs exist in a cytokine network during mucosal inflammation, such that IL-22 must act in concert with potent pro-inflammatory cytokines like TNF-α and IL-1. Our studies show that IL-22 alone increased CXCL8 secretion from HT-29 cells, but the levels were minimal compared to that of the cells treated with TNF-α or IL-1 only. More significantly, co-stimulation with IL-22 and TNF-α enhanced both CXCL8 secretion and mRNA levels well over that of TNF-α stimulation alone...
June 27, 2017: Inflammation
https://www.readbyqxmd.com/read/28636433/immunogenicity-of-ags-004-dendritic-cell-therapy-in-patients-treated-during-acute-hiv-infection
#18
Cynthia L Gay, Mark A DeBenedette, Irina Y Tcherepanova, Alicia Gamble, Whitney E Lewis, Anna B Cope, JoAnn D Kuruc, Kara S McGee, Mary F Kearney, John M Coffin, Nancie M Archin, Charles B Hicks, Joseph J Eron, Charles A Nicolette, David M Margolis
AGS-004 consists of matured autologous dendritic cells co-electroporated with in vitro transcribed RNA encoding autologous HIV antigens. In an open-label, single arm sub-study of AGS-004-003, AGS-004 was administered monthly to suppressed participants who started antiretroviral therapy (ART) during acute HIV infection. HIV-1 specific T cell responses were measured by multicolor flow cytometry after 3-4 doses. The frequency of resting CD4(+) T-cell infection (RCI) was measured by quantitative viral outgrowth assay...
June 21, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28633682/effect-of-space-allowance-and-floor-type-on-performance-welfare-and-physiological-measurements-of-finishing-beef-heifers
#19
M P Keane, M McGee, E G O'Riordan, A K Kelly, B Earley
Accommodating cattle indoors during the winter is widely practiced throughout Europe. There is currently no legislation surrounding the space allowance and floor type that should be provided to cattle during this time, however, concerns have been raised regarding the type of housing systems currently in use. The objective of the study was to investigate the effect of space allowance and floor type on performance and welfare of finishing beef heifers. Continental crossbred heifers (n=240: mean initial live; weight, 504 (SD 35...
June 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28620008/pten-dicer1-fh-and-their-associated-tumor-susceptibility-syndromes-clinical-features-genetics-and-surveillance-recommendations-in-childhood
#20
REVIEW
Kris Ann P Schultz, Surya P Rednam, Junne Kamihara, Leslie Doros, Maria Isabel Achatz, Jonathan D Wasserman, Lisa R Diller, Laurence Brugières, Harriet Druker, Katherine A Schneider, Rose B McGee, William D Foulkes
PTEN hamartoma tumor syndrome (PHTS), DICER1 syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome are pleiotropic tumor predisposition syndromes that include benign and malignant neoplasms affecting adults and children. PHTS includes several disorders with shared and distinct clinical features. These are associated with elevated lifetime risk of breast, thyroid, endometrial, colorectal, and renal cancers as well as melanoma. Thyroid cancer represents the predominant cancer risk under age 20 years...
June 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
keyword
keyword
25100
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"