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https://www.readbyqxmd.com/read/28526298/regulation-of-the-glycerol-transporter-aquaporin-3-by-histone-deacetylase-3-and-p53-in-keratinocytes
#1
Vivek Choudhary, Lawrence O Olala, Karen Kagha, Zhi-Qiang Pan, Xunsheng Chen, Rong Yang, Abigail Cline, Inas Helwa, Lauren Marshall, Ismail Kaddour-Djebbar, Meghan E McGee-Lawrence, Wendy B Bollag
Aquaporin-3 (AQP3), a water and glycerol channel, plays an important role in epidermal function, with studies demonstrating its involvement in keratinocyte proliferation, differentiation and migration and epidermal wound healing and barrier repair. Increasing speculation about the use of histone deacetylase (HDAC) inhibitors to treat skin diseases led us to investigate HDAC's role in the regulation of AQP3. The broad-spectrum HDAC inhibitor, suberolyanilide hydroxamic acid (SAHA) induced AQP3 mRNA and protein expression in a dose- and time-dependent manner in normal keratinocytes...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28523465/development-and-validation-of-a-cross-country-hospital-patient-quality-of-care-assessment-tool-in-europe
#2
Amanda Villiers-Tuthill, Karolina Doulougeri, Hannah McGee, Anthony Montgomery, Efharis Panagopoulou, Karen Morgan
BACKGROUND: Patient perceptions of quality of care (QoC) are directly linked with patient safety and clinical effectiveness. We need patient-designed QoC instruments that work across languages and countries to optimise studies across systems in this area. Few QoC measurement tools exist that assess all aspects of QoC from the patient perspective. This paper describes the development and validation of a comprehensive measure to assess patient perceptions of QoC that incorporates technical and interpersonal aspects of care and is grounded in the established Institute of Medicine (IOM) QoC framework...
May 18, 2017: Patient
https://www.readbyqxmd.com/read/28518018/penicillin-resistance-of-nonvaccine-type-pneumococcus-before-and-after-pcv13-introduction-united-states
#3
Cheryl P Andam, Colin J Worby, Ryan Gierke, Lesley McGee, Tamara Pilishvili, William P Hanage
Introduction of 13-valent pneumococcal conjugate vaccine in the United States was not associated with a significant change in prevalence of penicillin resistance in nonvaccine type serotypes because of the variable success of highly resistant serotypes. Differences in regional serotype distribution and serotype-specific resistance contributed to geographic heterogeneity of penicillin resistance.
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28516866/invasive-serotype-35b-pneumococci-including-an-expanding-serotype-switch-lineage-united-states-2015-2016
#4
Sopio Chochua, Benjamin J Metcalf, Zhongya Li, Hollis Walker, Theresa Tran, Lesley McGee, Bernard Beall
We used whole-genome sequencing to characterize 199 nonvaccine serotype 35B pneumococcal strains that caused invasive pneumococcal disease (IPD) in the United States during 2015-2016 and related these findings to previous serotype 35B IPD data obtained by Active Bacterial Core surveillance. Penicillin-nonsusceptible 35B IPD increased during post-pneumococcal 7-valent conjugate vaccine years (2001-2009) and increased further after implementation of pneumococcal 13-valent conjugate vaccine in 2010. This increase was caused primarily by the 35B/sequence type (ST) 558 lineage...
June 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28503311/a-community-resource-for-exploring-and-utilizing-genetic-diversity-in-the-usda-pea-single-plant-plus-collection
#5
William L Holdsworth, Elodie Gazave, Peng Cheng, James R Myers, Michael A Gore, Clarice J Coyne, Rebecca J McGee, Michael Mazourek
Globally, pea (Pisum sativum L.) is an important temperate legume crop for food, feed and fodder, and many breeding programs develop cultivars adapted to these end-uses. In order to assist pea development efforts, we assembled the USDA Pea Single Plant Plus Collection (PSPPC), which contains 431 P. sativum accessions with morphological, geographic and taxonomic diversity. The collection was characterized genetically in order to maximize its value for trait mapping and genomics-assisted breeding. To that end, we used genotyping-by-sequencing-a cost-effective method for de novo single-nucleotide polymorphism (SNP) marker discovery-to generate 66 591 high-quality SNPs...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28502785/car-t-cell-therapy-for-lung-cancer-and-malignant-pleural-mesothelioma
#6
REVIEW
Masha Zeltsman, Jordan Dozier, Erin McGee, Daniel Ngai, Prasad S Adusumilli
Immunotherapy is a promising field that harnesses the power of the immune system as a therapeutic agent for cancer treatment. Beneficial outcomes shown in patients with non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM) with relatively higher tumor-infiltrating T cells, combined with impressive responses obtained in a cohort of patients with NSCLC following checkpoint blockade therapy, lays a strong foundation to promote effector immune responses in these patients. One such approach being investigated is administration of tumor antigen-targeted T cells with transduction of a chimeric antigen receptor (CAR)...
April 26, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28498895/acute-illness-among-surfers-after-exposure-to-seawater-in-dry-and-wet-weather-conditions
#7
Benjamin F Arnold, Kenneth C Schiff, Ayse Ercumen, Jade Benjamin-Chung, Joshua A Steele, John F Griffith, Steven J Steinberg, Paul Smith, Charles D McGee, Richard Wilson, Chad Nelsen, Stephen B Weisberg, John M Colford
Rainstorms increase levels of fecal indicator bacteria in urban coastal waters, but it is unknown whether exposure to seawater after rainstorms increases rates of acute illness. Our objective was to provide the first estimates of rates of acute illness after seawater exposure during both dry- and wet-weather periods and to determine the relationship between levels of indicator bacteria and illness among surfers, a population with a high potential for exposure after rain. We enrolled 654 surfers in San Diego, California, and followed them longitudinally during the 2013-2014 and 2014-2015 winters (33,377 days of observation, 10,081 surf sessions)...
May 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28487541/germline-samd9-mutation-in-siblings-with-monosomy-7-and-myelodysplastic-syndrome
#8
J R Schwartz, S Wang, J Ma, T Lamprecht, M Walsh, G Song, S C Raimondi, G Wu, M F Walsh, R B McGee, C Kesserwan, K E Nichols, B E Cauff, R C Ribeiro, M Wlodarski, J M Klco
Leukemia accepted article preview online, 10 May 2017. doi:10.1038/leu.2017.142.
May 10, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28475561/adverse-event-rates-change-favorably-over-time-for-patients-bridged-with-the-heartware-left-ventricular-assist-device
#9
Simon Maltais, Keith D Aaronson, Jeffrey J Teuteberg, Mark S Slaughter, Samer S Najjar, Valluvan Jeevanandam, Duc T Pham, Ed McGee, Katrin Leadley, Robert L Kormos
The HeartWare Ventricular Assist System (HVAD) provides significant improvements in survival and quality of life, and here, we seek to evaluate temporal differences in the adverse event (AE) rates. Patients (n = 382) in the ADVANCE bridge-to-transplant and continued access protocol trial were assessed for bleeding, cardiac arrhythmia, infection, ischemic and hemorrhagic stroke, and right heart failure during predetermined time periods (≤30, >30-180, >180-365, >365-730, >730-1,095 days) after HVAD implant...
May 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28473925/unintended-sunburn-a-potential-target-for-sun-protection-messages
#10
Geraldine F H McLeod, Anthony I Reeder, Andrew R Gray, Rob McGee
New Zealand (NZ) has the highest melanoma incidence rate in the world. Primary prevention efforts focus on reducing sunburn incidence and increasing sun protective practices in the population. However, sunburn from excessive ultraviolet radiation (UVR) remains common. To reduce sunburn incidence, it is important to examine those individuals who experience unintended sunburn. This study aims to use data from the NZ Triennial Sun Protection Survey to describe respondents who were not intending to tan but were sunburnt after outdoor UVR exposure...
2017: Journal of Skin Cancer
https://www.readbyqxmd.com/read/28467564/precollege-programs-an-innovative-way-to-introduce-nursing-to-college-bound-students
#11
Helen Frances Baker, Blake Tyler McGee
No abstract text is available yet for this article.
May 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28464950/illumina-miseq-16s-amplicon-sequence-analysis-of-bovine-respiratory-disease-associated-bacteria-in-lung-and-mediastinal-lymph-node-tissue
#12
Dayle Johnston, Bernadette Earley, Paul Cormican, Gerard Murray, David Anthony Kenny, Sinead Mary Waters, Mark McGee, Alan Kieran Kelly, Matthew Sean McCabe
BACKGROUND: Bovine respiratory disease (BRD) is caused by growth of single or multiple species of pathogenic bacteria in lung tissue following stress and/or viral infection. Next generation sequencing of 16S ribosomal RNA gene PCR amplicons (NGS 16S amplicon analysis) is a powerful culture-independent open reference method that has recently been used to increase understanding of BRD-associated bacteria in the upper respiratory tract of BRD cattle. However, it has not yet been used to examine the microbiome of the bovine lower respiratory tract...
May 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28464793/icover-an-interactive-visualization-tool-for-verification-and-refinement-of-metagenomic-bins
#13
Bertjan Broeksema, Magdalena Calusinska, Fintan McGee, Klaas Winter, Francesco Bongiovanni, Xavier Goux, Paul Wilmes, Philippe Delfosse, Mohammad Ghoniem
BACKGROUND: Recent advances in high-throughput sequencing allow for much deeper exploitation of natural and engineered microbial communities, and to unravel so-called "microbial dark matter" (microbes that until now have evaded cultivation). Metagenomic analyses result in a large number of genomic fragments (contigs) that need to be grouped (binned) in order to reconstruct draft microbial genomes. While several contig binning algorithms have been developed in the past 2 years, they often lack consensus...
May 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28459754/rehabilitation-after-medial-patellofemoral-ligament-reconstruction
#14
Terrence G McGee, Andrew J Cosgarea, Kevin McLaughlin, Miho Tanaka, Ken Johnson
Patellar instability resulting from subluxation or dislocation is a painful and commonly recurring condition. Retinacular restraints control patellar tracking, limiting the movement of the patella in the trochlear groove. The medial patellofemoral ligament (MPFL) is considered the main soft tissue stabilizer against lateral displacement. Few studies of patellar instability discuss rehabilitation after MPFL reconstruction. In this review, we discuss the phases of rehabilitation after MPFL reconstruction, typical interventions by rehabilitation specialists, and patient-specific guidelines for return to prior level of function...
June 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28459303/positive-psychological-assessment-and-early-stage-dementia
#15
Jocelyn Shealy McGee, Holly Carlson Zhao, Dennis R Myers, Steffi Marotzke Kim
OBJECTIVES: There are no known positive psychological (PP) measures adapted/validated for use with people in the early stages of dementia. Objectives were to: (1) develop/pilot an accessible protocol for administering PP measures in this population; 2) examine their psychometric properties; and (3) provide preliminary observations about how people with early-stage dementia perceive various aspects of PP as it pertains to living with dementia. METHODS: Five PP measures were adapted/administered to 36 people with early-stage dementia...
March 9, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28457691/measuring-intrinsic-hand-strength-in-healthy-adults-the-accuracy-intrarater-and-inter-rater-reliability-of-the-rotterdam-intrinsic-hand-myometer
#16
Corey McGee
STUDY DESIGN: Clinical measurement study. INTRODUCTION: Measuring the isometric strength generated during isolated hand joint motions is a challenging feat. The Rotterdam Intrinsic Hand Myometer (RIHM; med.engineers, Rotterdam, Netherlands) permits measurement of isolated movements of the hand. To date, there is limited evidence on the inter-rater reliability and limited adult normative data of RIHM. Given that multiple raters, often with varying degrees of experience, are needed to collect normative data, inter-rater reliability testing and a comparison of novice and experienced raters are needed...
April 28, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28457577/proton-beam-radiotherapy-as-part-of-comprehensive-regional-nodal-irradiation-for-locally-advanced-breast-cancer
#17
Vivek Verma, Zaid Iftekaruddin, Nida Badar, William Hartsell, John Han-Chih Chang, Vinai Gondi, Mark Pankuch, Ming Gao, Stacey Schmidt, Darren Kaplan, Lisa McGee
PURPOSE: This study evaluates acute toxicity outcomes in breast cancer patients treated with adjuvant proton beam therapy (PBT). METHODS: From 2011 to 2016, 91 patients (93 cancers) were treated with adjuvant PBT targeting the intact breast/chest wall and comprehensive regional nodes including the axilla, supraclavicular fossa, and internal mammary lymph nodes. Toxicity was recorded weekly during treatment, one month following treatment, and then every 6months according to the Common Terminology Criteria for Adverse Events (CTCAE) v4...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28448128/total-chemical-synthesis-and-folding-of-all-l-and-all-d-variants-of-oncogenic-kras-g12v
#18
Adam M Levinson, John H McGee, Andrew G Roberts, Gardner S Creech, Ting Wang, Michael T Peterson, Ronald C Hendrickson, Gregory L Verdine, Samuel J Danishefsky
The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered "undruggable" due to its high affinity for GTP and its lack of hydrophobic binding pockets. Herein, we report a total chemical synthesis of all-l- and all-d-amino acid biotinylated variants of oncogenic mutant KRas(G12V)...
May 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28445679/response-to-a-comprehensive-nutrition-focused-quality-improvement-program-reduces-30-day-readmissions-and-length-of-stay-in-hospitalized-patients
#19
Ursula Mary McGee, Hannah Ruth Cole, Rachael Catherine Barlow
No abstract text is available yet for this article.
May 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28432504/3t-mri-of-the-knee-with-optimised-isotropic-3d-sequences-accurate-delineation-of-intra-articular-pathology-without-prolonged-acquisition-times
#20
Osamah M Abdulaal, Louise Rainford, Peter MacMahon, Eoin Kavanagh, Marie Galligan, James Cashman, Allison McGee
OBJECTIVES: To investigate optimised isotropic 3D turbo spin echo (TSE) and gradient echo (GRE)-based pulse sequences for visualisation of articular cartilage lesions within the knee joint. METHODS: Optimisation of experimental imaging sequences was completed using healthy volunteers (n=16) with a 3-Tesla (3T) MRI scanner. Imaging of patients with knee cartilage abnormalities (n=57) was then performed. Acquired sequences included 3D proton density-weighted (PDW) TSE (SPACE) with and without fat-suppression (FS), and T2*W GRE (TrueFISP) sequences, with acquisition times of 6:51, 6:32 and 5:35 min, respectively...
April 21, 2017: European Radiology
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