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https://www.readbyqxmd.com/read/29445307/sleep-problems-during-the-menopausal-transition-prevalence-impact-and-management-challenges
#1
REVIEW
Fiona C Baker, Massimiliano de Zambotti, Ian M Colrain, Bei Bei
A substantial number of women experience sleep difficulties in the approach to menopause and beyond, with 26% experiencing severe symptoms that impact daytime functioning, qualifying them for a diagnosis of insomnia. Here, we review both self-report and polysomnographic evidence for sleep difficulties in the context of the menopausal transition, considering severity of sleep complaints and links between hot flashes (HFs) and depression with poor sleep. Longitudinal population-based studies show that sleep difficulties are uniquely linked with menopausal stage and changes in follicle-stimulating hormone and estradiol, over and above the effects of age...
2018: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29433404/the-characteristics-of-hypoactive-sexual-desire-disorder-in-korean-women-who-visited-a-community-based-gynaecology-hospital-for-sexual-dysfunction
#2
Ho Ju Yun, Hyun Hee Cho
This cross-sectional study analysed the characteristics of HSDD (hypoactive sexual desire disorder) in Korean women. Two hundred and seventeen women seen for sexual dysfunction were assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised (DMS IV-TR) and the Female Sexual Function Index (FSFI). A diagnosis of HSDD was more common in women in their 40 s (56%), who had previously undergone surgery for a feeling of 'wide vagina'. Both too much or too little sexual activity caused HSDD...
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29429422/the-role-of-sleep-difficulties-in-the-vasomotor-menopausal-symptoms-and-depressed-mood-relationships-an-international-pooled-analysis-of-eight-studies-in-the-interlace-consortium
#3
Hsin-Fang Chung, Nirmala Pandeya, Annette J Dobson, Diana Kuh, Eric J Brunner, Sybil L Crawford, Nancy E Avis, Ellen B Gold, Ellen S Mitchell, Nancy F Woods, Joyce T Bromberger, Rebecca C Thurston, Hadine Joffe, Toyoko Yoshizawa, Debra Anderson, Gita D Mishra
BACKGROUND: Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions. METHODS: A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49-51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity)...
February 12, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29410721/i-ching-balance-acupuncture-treatment-of-migraines-insomnia-and-depression-in-a-post-ovariectomy-patient-receiving-hormone-replacement-therapy
#4
Arkady Kotlyar
Introduction: Surgical menopause is associated with symptoms that can affect a woman's quality of life (QoL) significantly. These symptoms include migraines, insomnia, and depression. Case: A 45-year-old Caucasian female presented at an acupuncture clinic. Fourteen years prior, she had been diagnosed with ovarian carcinoma, underwent ovariectomy, and was prescribed hormone replacement therapy. Deteriorating QoL caused her to seek acupuncture for migraines, insomnia, and depression. The outcomes sought for treatment of this case included intensity, duration, and frequency of migraines, insomnia, and depression, as well as her QoL...
February 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29400073/oral-hormonal-therapy-with-ethinylestradiol-levonorgestrel-improves-insulin-resistance-obesity-and-glycogen-synthase-kinase-3-independent-of-circulating-mineralocorticoid-in-estrogen-deficient-rats
#5
Oluwaseun Aremu Adeyanju, Olaniyi Soetan, Ayodele Soladoye, Lawrence A Aderemi Olatunji
Estrogen deficiency has been associated with increased cardiovascular diseases (CVD) and recent clinical trials of standard formulations of hormonal therapies have not demonstrated consistent beneficial effects. Estrogen-progestin therapy has been used as exogenous estrogen to normalise depressed estrogen level during menopause. Ovariectomized rodents mimic estrogen-deficient state in that they develop cardiometabolic dysfunction, including insulin resistance (IR).We therefore hypothesized that hormonal therapy with combined oral contraceptive steroids, ethinylestradiol/levonorgestrel (EEL) improves IR, obesity and glycogen synthase kinase-3 (GSK-3) through reduction in circulating mineralocorticoid level in ovariectomized rats...
February 3, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29381662/association-between-hiv-status-and-psychological-symptoms-in-perimenopausal-women
#6
Sara E Looby, Christina Psaros, Greer Raggio, Corinne Rivard, Laura Smeaton, Jan Shifren, Steven Grinspoon, Hadine Joffe
OBJECTIVE: HIV-infected women are burdened by depression and anxiety, which may impact adherence to antiretroviral therapy and overall quality of life. Yet, little is known about the scope of psychological symptoms in the growing number of HIV-infected women reaching menopause, when affective symptoms are more prevalent in the general population. We conducted a longitudinal study to compare affective symptoms between perimenopausal HIV-infected and non-HIV-infected women. METHODS: The Center for Epidemiologic Studies Depression Scale (CES-D), and the Generalized Anxiety Disorder scale (GAD-7) were completed at baseline and 12 months among 33 HIV-infected and 33 non-HIV-infected perimenopausal women matched by race, age, menstrual patterns, and BMI...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29380646/a-simple-risk-score-based-on-sleep-quality-for-predicting-depressive-symptoms-in-menopausal-women-a-multicenter-study
#7
Yanwei Zheng, Yang Zhou, Jieping Zhu, Qi Hua, Minfang Tao
OBJECTIVE: We aim to establish a simple risk score based on sleep quality for predicting depressive symptoms in menopausal women through a cross-sectional investigation. MATERIALS AND METHODS: A total of 705 Chinese women aged 40-60 years were included in this cross-sectional investigation of a self-report questionnaire from the Physical Examination Center at Shanghai Jiao Tong University Affiliated Sixth People's Hospital. Depressive symptoms and sleep quality were evaluated using self-rating depressive symptom scale (SDS)and the Pittsburgh Sleep Quality Index (PSQI), respectively...
January 30, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29354617/depression-and-quality-of-life-among-postmenopausal-women-in-bangladesh-a-cross-sectional-study
#8
Mamun Ibn Bashar, Kawsar Ahmed, Muhammad Shahin Uddin, Farzana Ahmed, Abdullah-Al Emran, Aditi Chakraborty
Objectives: The aims of the research are to examine the problems of abnormal menopausal women: the relationship between depression and menopausal-specific quality of life (MENQOL)-symptoms among postmenopausal women; the association of MENQOL-symptoms between pre- and postmenopausal female society in Bangladeshi real community. Methods: This cross sectional study was conducted on 435 women of Tangail, aged (≥ 17) years, using a structured questionnaire where is inaacluded the information of MENQOL and one of the main outcomes "depression" is measured by beck depression inventory...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29354615/effect-of-phytoestrogen-on-depression-and-anxiety-in-menopausal-women-a-systematic-review
#9
Abolfazl Fattah
Objectives: In this systematic review, the effectiveness of herbal medicines in improving depression and anxiety in menopausal women was assessed. Methods: Three following databases were individually searched: MEDLINE (1966-March 2017), SCOPUS (1990-March 2017), and the Cochrane Library (Cochrane Central Register of Controlled Trials; 2017). Results: A total of 9 trials were included in this systematic review. Overall, soy was found to have a beneficial effect...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29354614/role-identification-of-passiflora-incarnata-linnaeus-a-mini-review
#10
REVIEW
Mijin Kim, Hee-Sook Lim, Hae-Hyeog Lee, Tae-Hee Kim
Some species of traditional herbal medicine has a history of use, most traditional natural herbs have been used for various diseases such as diabetes, hypertension, and obesity. Among them, Passiflora incarnata L. is a traditional natural medicine, flowers as well as berries, roots, and leaves have been used as a medicine. It has been used as a natural medicine for the treatment of insomnia and anxiety for a longtime in Europe, and it has been used primarily for sedation tea in North America. Moreover, Passiflora incarnata L...
December 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/29345506/effects-of-physical-and-depressive-symptoms-on-the-sexual-life-of-turkish-women-in-the-climacteric-period
#11
E Yanikkerem, A Göker, Ö Çakır, N Esmeray
OBJECTIVE: To assess the effects of physical and depressive symptoms on the sexual life of women in the climacteric period. METHODS: This study was conducted with 572 women at a university hospital. The Beck Depression Inventory (BDI), Menopause Rating Scale (MRS) and Female Sexual Function Index (FSFI) were used to evaluate depressive symptoms, intensity of menopausal symptoms and sexual function. RESULTS: Sexual dysfunction and depressive symptoms were determined in 86...
January 18, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29332222/efficacy-of-crocus-sativus-saffron-in-treatment-of-major-depressive-disorder-associated-with-post-menopausal-hot-flashes-a-double-blind-randomized-placebo-controlled-trial
#12
Ladan Kashani, Sophia Esalatmanesh, Farzaneh Eftekhari, Samrand Salimi, Tahereh Foroughifar, Farnaz Etesam, Hamideh Safiaghdam, Ehsan Moazen-Zadeh, Shahin Akhondzadeh
PURPOSE: Due to concerns regarding the side effects of hormone therapy, many studies have focused on the development of non-hormonal agents for treatment of hot flashes. The aim of this study was to evaluate the efficacy and safety of saffron (stigma of Crocus sativus) in treatment of major depressive disorder associated with post-menopausal hot flashes. METHODS: Sixty women with post-menopausal hot flashes participated in this study. The patients randomly received either saffron (30 mg/day, 15 mg twice per day) or placebo for 6 weeks...
January 13, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29331929/sex-related-differential-response-to-dexamethasone-in-endocrine-and-immune-measures-in-depressed-in-patients-and-healthy-controls
#13
Carina Rampp, Andreas Eichelkraut, Johanna Best, Darina Czamara, Monika Rex-Haffner, Manfred Uhr, Elisabeth B Binder, Andreas Menke
Although sex differences in major depression have been reported repeatedly, the underlying mechanisms are still disputed. The rapidly changing gonadal steroid concentrations of the postpartum period or during menopause have been shown to be associated with depressive symptoms and to modulate the hypothalamic-pituitary-adrenal (HPA)-axis, which is implicated in depression. The sample comprised of 128 depressed in-patients (36.7% women) and 166 healthy controls (30.0% women). Blood was collected at baseline (at 6pm) and then 3 h as well as 21 h after ingestion of 1...
January 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29326058/sleep-architecture-is-altered-in-the-reserpine-induced-fibromyalgia-model-in-ovariectomized-rats
#14
Alberto Hernandez-Leon, Alonso Fernández-Guasti, Adrián Martínez, Francisco Pellicer, María Eva González-Trujano
Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome with various concomitant symptoms like sleep disorders. FM patients are mainly women and menopause might play an important role in the altered processing of somatosensory information. Adverse effects and moderated efficacy of drugs promote treatment discontinuation by patients. Animal models of FM report pain and depression-like behaviors, but none of them have explored sleep disturbance as possible marker in the preclinic diagnostic. The aim of this study was to investigate alterations of the sleep architecture in the reserpine (RES)-induced FM model in ovarectomized (OVX) rats...
January 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29322180/should-hormone-therapy-be-used-to-prevent-depressive-symptoms-during-the-menopause-transition
#15
Hadine Joffe, Martha Hickey
No abstract text is available yet for this article.
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29322164/efficacy-of-transdermal-estradiol-and-micronized-progesterone-in-the-prevention-of-depressive-symptoms-in-the-menopause-transition-a-randomized-clinical-trial
#16
Jennifer L Gordon, David R Rubinow, Tory A Eisenlohr-Moul, Kai Xia, Peter J Schmidt, Susan S Girdler
Importance: The menopause transition and early postmenopausal period are associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. Although a few studies suggest that hormone therapy can effectively manage existing depression during this time, to our knowledge, there have been no studies testing whether hormone therapy can prevent the onset of perimenopausal and early postmenopausal depressive symptoms. Objective: To examine the efficacy of transdermal estradiol plus intermittent micronized progesterone (TE+IMP) in preventing depressive symptom onset among initially euthymic perimenopausal and early postmenopausal women...
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29290217/variation-in-symptoms-of-depression-and-anxiety-in-midlife-women-by-menopausal-status
#17
Stephanie Mulhall, Ross Andel, Kaarin J Anstey
OBJECTIVES: To examine the association between menopausal status and the risk of symptoms of depression and anxiety in a community-based sample of Australian midlife women. STUDY DESIGN: Female participants (mean age 50.6±1.5) who were premenopausal (n=237), perimenopausal (n=249) or naturally postmenopausal (n=225) were drawn from the Personality and Total Health (PATH) Through Life Project, a longitudinal study. MAIN OUTCOME MEASURES: Symptoms of depression and anxiety were measured using the Goldberg Depression Scale and Goldberg Anxiety Scale...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29250741/everolimus-induced-mood-changes-in-breast-cancer-patients-a-case-control-study
#18
Olivier Mir, Alexandre Salvador, Sarah Dauchy, Stanislas Ropert, Cédric Lemogne, Raphaël Gaillard
Introduction The PI3K/Akt/mTOR pathway plays a critical role in cancer cell growth, proliferation and angiogenesis, but also in brain homeostasis and the pathophysiology of mood disorders. The impact of the mTOR inhibitor everolimus on the mood of breast cancer patients is unknown. Materials and methods Consecutive, post-menopausal metastatic breast cancer patients receiving hormone therapy +/- everolimus were prospectively followed-up using the Beck Depression Inventory (BDI) and the MADRS (Montgomery and Asberg Depression Rating Scale) questionnaires...
December 18, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29248436/estrogen-signaling-in-the-medial-amygdala-decreases-emotional-stress-responses-and-obesity-in-ovariectomized-rats
#19
Christina M Estrada, Valentina Ghisays, Elizabeth T Nguyen, Jody L Caldwell, Joshua Streicher, Matia B Solomon
Declining estradiol (E2), as occurs during menopause, increases risk for obesity and psychopathology (i.e., depression, anxiety). E2 modulates mood and energy homeostasis via binding to estrogen receptors (ER) in the brain. The often comorbid and bidirectional relationship between mood and metabolic disorders suggests shared hormonal and/or brain networks. The medial amygdala (MeA) is abundant in ERs and regulates mood, endocrine, and metabolic stress responses; therefore we tested the hypothesis that E2 in the MeA mitigates emotional and metabolic dysfunction in a rodent model of surgical menopause...
December 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29231609/-manual-acupuncture-versus-electroacupuncture-for-menopausal-syndrome-a-randomized-controlled-trial
#20
Caiyuzhu Wen, Yafei Liu, Xiaoli Pan, Zhen Mao, Li Zhou, Hongxing Zhang
OBJECTIVE: To compare the clinical therapeutic effects and safety on menopausal symptoms between manual acupuncture (MA) and electroacupuncture (EA). METHODS: Fifty patients were randomized into an MA group (25 cases) and an EA group (25 cases). In the MA group, the regular needling technique and pseudo-EA were used at Guanyuan (CV 4), Zigong (EX-CA 1), Tianshu (ST 25) and Sanyinjiao (SP 6). In the EA group, the acupoints were the same as the MA group and stimulated with EA and pseudo-MA (no manipulation applied in treatment), with disperse-dense wave, 10 Hz/50 Hz, 0...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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