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Menopausal depression

Xiangyan Ruan, Yamei Cui, Juan Du, Fengyu Jin, Alfred Otto Mueck
INTRODUCTION: The climacteric symptoms during peri- and postmenopause have not been extensively studied in China. To further understanding of the characteristics of Chinese women during their menopausal transition, the aim of the study was to compare the prevalence and severity of climacteric symptoms of peri- and postmenopausal Chinese women. METHODS: The retrospective descriptive study was carried out in perimenopausal and postmenopausal women from 20 provinces of China who visited Beijing Obstetrics & Gynecology hospital during 2008-2015...
October 21, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
R Sood, C Kuhle, E Kapoor, J Rullo, J Thielen, K Frohmader, K Mara, D Schroeder, S Faubion
OBJECTIVES: To assess the association between the type of symptom and women's self-reported view of menopause. METHODS: The study was conducted at Mayo Clinic, Rochester MN, between January 2006 and October 2014. Women aged 40-64 were included. Data from 1420 women were analyzed in a cross-sectional design. The Menopause Health Questionnaire was used for symptom assessment. Odds ratios (ORs) and population attributable risk (PAR) (OR × percent frequency) were calculated for each symptom...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
Lola Corzo, Susana Rodríguez, Ramón Alejo, Lucía Fernández-Novoa, Gjumrakch Aliev, Ramón Cacabelos
Menopause is a natural event in women´s lives leading to the cessation of menstruation and the reproductive function due to loss of the ovarian follicular function. Menopause-derived estrogen deprivation and related endocrine factors are linked to some symptoms of middle-aged women, such as hot flashes, aches, joint pain, stiffness, depressed mood, bone degeneration, nutritional dysfunction, or difficulty to maintain body mass. Clinical approaches to these problems often involve hormone replacement therapy (HRT) and other modalities of therapeutic intervention...
October 14, 2016: Current Drug Metabolism
A Minami, H Matsushita, D Ieno, Y Matsuda, Y Horii, A Ishii, T Takahashi, H Kanazawa, A Wakatsuki, T Suzuki
OBJECTIVE: Royal jelly (RJ) from honeybees (Apis mellifera) has estrogenic activity. Estrogen deficiency after menopause leads to a high risk of memory impairment and depression as well as metabolic syndrome and osteoporosis. We here investigated the effect of RJ on memory impairment and depression-like behaviors in ovariectomized (OVX) rats. METHODS: OVX rats were administered with RJ for 82 days. Hippocampus-dependent spatial memory and depression-like behaviors were assessed by the Morris water maze test and the forced swimming test, respectively...
October 13, 2016: Climacteric: the Journal of the International Menopause Society
Savita Rani Singhal, Wansalan Kuru Shullai
OBJECTIVE: This study was planned to compare the effects of gabapentin and isoflavones in menopausal vasomotor symptoms. MATERIALS AND METHODS: This prospective comparative study was conducted on 100 patients with complaints of hot flashes, divided into two groups of 50 each. Group I received 900 mg of gabapentin and Group II received 60 mg of isoflavones daily for 3 months. The patients were interviewed to calculate hot flash, global and depression scores and were rescored after 2, 4, 8, and 12 weeks...
July 2016: Journal of Mid-life Health
Sarah Adams Schoenrock, Daniel Oreper, Nancy Young, Robin Betsch Ervin, Molly A Bogue, William Valdar, Lisa M Tarantino
Women are at an increased risk for developing affective disorders during times of hormonal flux, including menopause when the ovaries cease production of estrogen. However, while all women undergo menopause, not all develop an affective disorder. Increased vulnerability can result from genetic predisposition, environmental factors and gene by environment interactions. In order to investigate interactions between genetic background and estrogen depletion, we performed bilateral ovariectomy, a surgical procedure that results in estrogen depletion and is thought to model the post-menopausal state, in a genetically defined panel of 37 inbred mouse strains...
September 28, 2016: Physiology & Behavior
Tania A Perich, Gloria Roberts, Andrew Frankland, Carina Sinbandhit, Tanya Meade, Marie-Paul Austin, Philip B Mitchell
OBJECTIVE: Although there is clear evidence that reproductive cycle events are associated with mood episodes for women with bipolar disorder, few studies have examined for relationships between these and specific clinical characteristics of the disorder. This study aimed to explore the relationship between mood symptoms associated with reproductive cycle events and features of the disorder indicative of a more severe lifetime course. METHOD: Totally, 158 women of at least 18 years of age participated in the study...
September 28, 2016: Australian and New Zealand Journal of Psychiatry
Weam W Ibrahim, Marwa M Safar, Mahmoud M Khattab, Azza M Agha
The prevalence or recurrence of depression is seriously increased in women during the transition to and after menopause. The chronic hypo-estrogenic state of menopause may reduce the response to antidepressants; however the influence of estrogen therapy on their efficacy is still controversial. This study aimed at investigating the effects of combining escitalopram with 17β-estradiol on depression and cognitive impairment induced by ovariectomy, an experimental model of human menopause. Young adult female Wistar rats were subjected to either sham operation or ovariectomy...
September 26, 2016: Psychoneuroendocrinology
Hadine Joffe, Sybil L Crawford, Marlene P Freeman, David P White, Matt T Bianchi, Semmie Kim, Nicole Economou, Julie Camuso, Janet E Hall, Lee S Cohen
CONTEXT: Women are at increased risk for mood disturbance during the menopause transition. Hot flashes (HFs), sleep disruption, and fluctuating estradiol levels correlate with menopause-associated depression but co-occur, making cause and effect relationships difficult to disentangle. OBJECTIVE: Using a GnRH agonist (GnRHa) experimental model, we investigated whether depressive symptoms are associated with HFs and/or are explained by concomitant sleep fragmentation in the absence of estradiol fluctuation...
October 2016: Journal of Clinical Endocrinology and Metabolism
Flávia L Osório, Ana Carolina F Carvalho, Mariana F Donadon, André L Moreno, Omero Polli-Neto
AIM: To compare the prevalence of psychiatric disorders and early emotional traumas between women with chronic pelvic pain (CPP) and healthy women. METHODS: One hundred women in reproductive age, 50 of them had CPP (according to the criteria set by the International Association for Study of Pain), and 50 were considered healthy after the gynecological evaluation. The eligibility criteria were defined as follows: chronic or persistent pain perceived in the pelvis-related structures (digestive, urinary, genital, myofascial or neurological systems)...
September 22, 2016: World Journal of Psychiatry
Susan R Davis
No abstract text is available yet for this article.
September 27, 2016: Journal of Women's Health
Cynthia L Bethea, Arubala P Reddy, Fernanda Lima Christian
Serotonin plays a key role in mood or affect, and dysfunction of the serotonin system has been linked to depression in humans and animal models. Depression appears prior to or coincident with overt symptoms of Alzheimer's disease (AD) in about 50% of patients, and some experts consider it a risk factor for the development of AD. In addition, AD is more prevalent in women, who also show increased incidence of depression. Indeed, it has been proposed that mechanisms underlying depression overlap the mechanisms thought to hasten AD...
September 20, 2016: Journal of Alzheimer's Disease: JAD
Hye Won Lee, Jiae Choi, YoungJoo Lee, Ki-Jung Kil, Myeong Soo Lee
BACKGROUND: The aim of this systematic review was to update, complete, and critically evaluate the evidence from placebo-controlled randomized clinical trials (RCTs) of ginseng for managing menopausal women's health. METHODS: We searched the literature using 13 databases (MEDLINE, AMED, EMBASE, the Cochrane Library, 6 Korean Medical, and 3 Chinese Databases) from their inception to July 2016 and included all double-blind RCTs that compared any type of ginseng with a placebo control in postmenopausal women...
September 2016: Medicine (Baltimore)
Angelo Cagnacci, Federica Palma, Maria Maddalena Carbone, Giovanni Grandi, Anjeza Xholli
OBJECTIVE: The aim of the study was to evaluate whether climacteric symptoms are related to urinary incontinence (UI) in postmenopausal women. METHODS: A cross-sectional investigation was performed on 1,502 postmenopausal women attending the outpatient service for menopause at a University Hospital. Data regarding climacteric symptoms, evaluated by the Greene Climacteric Scale, objective pelvic floor defects, and UI of any type, were retrieved from an electronic database...
September 19, 2016: Menopause: the Journal of the North American Menopause Society
Thania Galvan, Julia Camuso, Kathryn Sullivan, Semmie Kim, David White, Susan Redline, Hadine Joffe
OBJECTIVE: Women's risk of obstructive sleep apnea (OSA) increases substantially during and after the menopausal transition, when depression risk is also elevated, raising the possibility that estrogen withdrawal contributes to OSA vulnerability, in turn contributing to mood disturbance. We examined the association between estradiol levels and OSA in depressed peri- and postmenopausal women. METHODS: Thirty depressed peri-/postmenopausal women (mean body mass index [BMI] 30...
September 19, 2016: Menopause: the Journal of the North American Menopause Society
Cristina Lemini, María Estela Avila, Martha Medina, Carlos Sánchez, Alejandra Figueroa, Juana García-Mondragón, Arsenio Vargas-Vázquez, Alejandro Jiménez-Orozco
The 17β-aminoestrogens (AEs) prolame, butolame and pentolame are weakly oestrogenic in rodents and display anticoagulant properties in contrast to oestradiol (E2 ) which presents procoagulant effects, potentially thrombogenic. They possess anti-anxiety and anti-depressive properties, being good candidates for menopausal hormone therapy. Their capability to induce proliferation of MCF-7 human breast cancer cells, which proliferative rate depends on oestrogens, has not been explored; thus, the aim of this work was to characterize it...
September 16, 2016: Basic & Clinical Pharmacology & Toxicology
Alexandre González-Rodríguez, Rosa Catalán, Rafael Penadés, Victoria Ruiz Cortés, Mercè Torra, Mary V Seeman, Miquel Bernardo
BACKGROUND: The loss of estrogens in the menopause may lead to increased vulnerability for psychotic relapse, poor clinical outcome, and a need for increased antipsychotic dose. However, confounders such as cumulative estrogen exposure and time since menopause have been inadequately studied. Our aim was to investigate potential variables capable of influencing antipsychotic response in a sample of postmenopausal women with schizophrenia. METHODS: Sixty-four postmenopausal schizophrenic women were followed in a 12-week prospective treatment-by-clinical requirement study...
September 13, 2016: Journal of Clinical Psychopharmacology
Alison Berent-Spillson, Courtney Marsh, Carol Persad, John Randolph, Jon-Kar Zubieta, Yolanda Smith
Disturbances of emotion regulation and depressive symptoms are common during the menopause transition. Reproductive hormone levels are not directly correlated with depressive symptoms, and other factors may influence mood symptoms during menopause. In this study, we sought to determine the role of metabolic function in mood symptoms during menopause, hypothesizing an association with menopause status and long-term glucose load. We studied 54 women across three menopause transition stages (15 premenopause, 11 perimenopause, and 28 postmenopause), examining effects of age, hormones, and metabolism on mood and neural activation during emotional discrimination...
September 5, 2016: Psychoneuroendocrinology
Osvaldo P Almeida, Kylie Marsh, Karen Murray, Martha Hickey, Moira Sim, Andrew Ford, Leon Flicker
OBJECTIVE: To determine if health coaching (HC) decreases the incidence of depression, reduces the severity of symptoms, and increases quality of life during the menopausal transition (MT). RESEARCH DESIGN AND METHODS: Parallel, single-blinded, randomised controlled trial of 6 sessions of phone-delivered HC compared with usual care. Participants were 351 community-dwelling women free of major depression going through the MT, of whom 180 were assigned the intervention and 171 usual care...
October 2016: Maturitas
Jeong In Choi, Kyung-do Han, Sa Jin Kim, Min Jeong Kim, Jae Eun Shin, Hae Nam Lee
OBJECTIVES: The study investigated the association between childbirth history and health-related quality of life (QOL) in menopausal South Korean women. STUDY DESIGN: Cross-sectional analysis of data from the 2010-2012 Korean National Health and Nutrition Examination Surveys (KNHANES) for 4277 menopausal women aged over 50. We used the EuroQol index to measure health-related QOL. MAIN OUTCOME MEASURES: The relationship between delivery history and health-related QOL in menopausal South Korean women was analyzed...
October 2016: Maturitas
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