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Mast cell il33

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https://www.readbyqxmd.com/read/27372570/il-33-promotes-food-anaphylaxis-in-epicutaneously-sensitized-mice-by-targeting-mast-cells
#1
Claire Galand, Juan Manuel Leyva-Castillo, Juhan Yoon, Alex Han, Margaret S Lee, Andrew N J McKenzie, Michael Stassen, Michiko K Oyoshi, Fred D Finkelman, Raif S Geha
BACKGROUND: Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in patients with MC-dependent food anaphylaxis is unknown. OBJECTIVE: We sought to determine the role and mechanism of action of IL-33 in patients with food-induced anaphylaxis in a model of IgE-dependent food anaphylaxis elicited by oral challenge of epicutaneously sensitized mice...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27342734/early-activation-of-th2-th22-inflammatory-and-pruritogenic-pathways-in-acute-canine-atopic-dermatitis-skin-lesions
#2
Thierry Olivry, David Mayhew, Judy S Paps, Keith E Linder, Carlos Peredo, Deepak Rajpal, Hans Hofland, Javier Cote-Sierra
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR...
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/25313073/central-domain-of-il-33-is-cleaved-by-mast-cell-proteases-for-potent-activation-of-group-2-innate-lymphoid-cells
#3
Emma Lefrançais, Anais Duval, Emilie Mirey, Stéphane Roga, Eric Espinosa, Corinne Cayrol, Jean-Philippe Girard
Interleukin-33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 activates many immune cell types expressing the interleukin 1 receptor-like 1 (IL1RL1) receptor ST2, including group-2 innate lymphoid cells (ILC2s, natural helper cells, nuocytes), the major producers of IL-5 and IL-13 during type-2 innate immune responses and allergic airway inflammation. IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies...
October 28, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25234644/histologic-eosinophilic-gastritis-is-a-systemic-disorder-associated-with-blood-and-extragastric-eosinophilia-th2-immunity-and-a-unique-gastric-transcriptome
#4
Julie M Caldwell, Margaret H Collins, Emily M Stucke, Philip E Putnam, James P Franciosi, Jonathan P Kushner, J Pablo Abonia, Marc E Rothenberg
BACKGROUND: The definition of eosinophilic gastritis (EG) is currently limited to histologic EG based on the tissue eosinophil count. OBJECTIVE: We aimed to provide additional fundamental information about the molecular, histopathologic, and clinical characteristics of EG. METHODS: Genome-wide transcript profiles and histologic features of gastric biopsy specimens, as well as blood eosinophil counts, were analyzed in patients with EG and control subjects (n = 15 each)...
November 2014: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/22824976/involvement-of-pu-1-in-mast-cell-basophil-specific-function-of-the-human-il1rl1-st2-promoter
#5
Yosuke Baba, Keiko Maeda, Takuya Yashiro, Eisuke Inage, François Niyonsaba, Mutsuko Hara, Ryuyo Suzuki, Yoshikazu Ohtsuka, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Chiharu Nishiyama
BACKGROUND: The human IL1RL1/ST2 gene encodes IL33 receptor. Recently, IL33 has been recognized as a key molecule for the development of Th2 response. Although mast cells and basophils are major targets of IL33 and play important roles in IL33-mediated Th2-type immune responses, the expression mechanism of ST2 in mast cells and basophils is largely unknown. In the present study, we analyzed regulation mechanism of the human ST2 promoter in the human mast cell line LAD2 and basophilic cell line KU812...
September 2012: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/22460070/a-critical-role-of-il-33-in-experimental-allergic-rhinitis
#6
Yoko Haenuki, Kazufumi Matsushita, Shizue Futatsugi-Yumikura, Ken J Ishii, Tatsukata Kawagoe, Yoshimasa Imoto, Shigeharu Fujieda, Makoto Yasuda, Yasuo Hisa, Shizuo Akira, Kenji Nakanishi, Tomohiro Yoshimoto
BACKGROUND: We reported previously that serum levels of IL-33 are significantly increased in patients with allergic rhinitis (AR). However, very little is known about the role of IL-33 for the development of AR. OBJECTIVE: We thought to develop a novel murine model of ragweed pollen-specific AR and examined the pathologic role for ragweed-induced IL-33 in the development of AR manifestation using IL-33-deficient (il33(-/-)) mice. METHODS: Ragweed-immunized and ragweed-challenged mice were examined for early- and late-phase nasal responses...
July 2012: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/19995743/role-of-interleukin-33-in-human-immunopathology
#7
REVIEW
G E J Murphy, D Xu, F Y Liew, I B McInnes
Interleukin 33 (IL33) is a recently described member of the IL1 superfamily of cytokines. Originally defined on the basis of T-cell subset differentiation, IL33 is now recognised to mediate a wider role in regulating components of the innate immune response also, particularly via mast cell activation. In this paper the basic biology of IL33 is described together with that of its cognate receptor, ST2L, and the existing knowledge base for its potential role in mediating human pathology across a range of diseases is defined...
January 2010: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/19778913/the-il1-like-cytokine-il33-and-its-receptor-st2-are-abnormally-expressed-in-the-affected-skin-and-visceral-organs-of-patients-with-systemic-sclerosis
#8
Mirko Manetti, Lidia Ibba-Manneschi, Vasiliki Liakouli, Serena Guiducci, Anna Franca Milia, Gemma Benelli, Alessandra Marrelli, Maria Letizia Conforti, Eloisa Romano, Roberto Giacomelli, Marco Matucci-Cerinic, Paola Cipriani
BACKGROUND: Early endothelial cell (EC) activation/damage and profibrotic Th2-associated cytokines play a pivotal role in systemic sclerosis (SSc). Interleukin 33 (IL33) is a novel member of the IL1 family that promotes Th2 responses and inflammation through the ST2 receptor. IL33 is also a chromatin-associated transcriptional regulator in ECs. OBJECTIVE: To investigate the role of the IL33/ST2 axis in SSc. METHODS: Skin biopsies were obtained from 30 patients with SSc (15 early/15 late stage) and 10 healthy subjects...
March 2010: Annals of the Rheumatic Diseases
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