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Tslp il33

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https://www.readbyqxmd.com/read/27826297/lipopolysaccharide-attenuates-induction-of-proallergic-cytokines-thymic-stromal-lymphopoietin-and-interleukin-33-in-respiratory-epithelial-cells-stimulated-with-polyi-c-and-human-parechovirus
#1
Tsang-Hsiung Lin, Chih-Chi Cheng, Hsing-Hao Su, Nan-Chieh Huang, Jih-Jung Chen, Hong-Yo Kang, Tsung-Hsien Chang
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the hygiene hypothesis. Epithelial cells are the first line of response to microbial products in the environment and bridge the innate and adaptive immune systems; however, their role in the hygiene hypothesis is unknown. To demonstrate the hygiene hypothesis in airway epithelial cells, we examined the effect of lipopolysaccharide (LPS; toll-like receptor 4 ligand) on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27058054/asthma-susceptibility-variants-are-more-strongly-associated-with-clinically-similar-subgroups
#2
Emilie Lavoie-Charland, Jean-Christophe Bérubé, Louis-Philippe Boulet, Yohan Bossé
OBJECTIVE: Genome-wide association studies (GWAS) identified single nucleotide polymorphisms (SNPs) reproducibly associated with asthma. This study evaluated whether GWAS-nominated SNPs are more strongly associated with asthma patients sharing the same clinical characteristics in order to refine the role of recently identified genes. METHODS: Analyses were performed in unrelated French Canadian subjects (566 cases and 416 controls) with data collected on lung function, blood cell counts, atopy, disease history and medication...
November 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/26321245/the-pathogenesis-of-chronic-eosinophilic-esophagitis-in-sharpin-deficient-mice
#3
Syu-Jhe Chien, Kathleen A Silva, Victoria E Kennedy, Harm HogenEsch, John P Sundberg
Increased numbers of eosinophils in the esophagus are common in several esophageal and systemic diseases, and a prominent feature of eosinophilic esophagitis. Mouse models can provide insight into the mechanisms of eosinophil infiltration and their pathogenic role. SHARPIN-deficient cpdm mice develop a chronic proliferative dermatitis and an esophagitis characterized by epithelial hyperplasia and the accumulation of eosinophils in the serosa, submucosa, lamina propria and epithelium of the esophagus. We conducted a detailed investigation of the pathogenesis of the esophagitis by light microscopy, immunohistochemistry, and gene expression as the mice aged from 4 to 10 weeks...
December 2015: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/26287664/correlation-of-tslp-il-33-and-cd4%C3%A2-%C3%A2-cd25%C3%A2-%C3%A2-foxp3%C3%A2-%C3%A2-t-regulatory-treg-in-pediatric-asthma
#4
Anil Chauhan, Meenu Singh, Amit Agarwal, Nandini Paul
OBJECTIVE: Newly discovered cytokines TSLP and IL33 are being studied as important indicators of Th2 inflammation and their effect on Treg cells is likely to modulate immune response. We attempted to study TSLP and IL-33 and then correlated with Tregs in order to find possible biomarker in these patients. METHODS: Sixty-five children (37 with asthma only and 28 with asthma and rhinitis) aged 6.4 ± 3.2 years (patient group) and 15 healthy children aged 8.0 ± 2...
2015: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/26119467/eqtl-of-bronchial-epithelial-cells-and-bronchial-alveolar-lavage-deciphers-gwas-identified-asthma-genes
#5
X Li, A T Hastie, G A Hawkins, W C Moore, E J Ampleford, J Milosevic, H Li, W W Busse, S C Erzurum, N Kaminski, S E Wenzel, D A Meyers, E R Bleecker
BACKGROUND: Genome-wide association studies (GWASs) have identified various genes associated with asthma, yet, causal genes or single nucleotide polymorphisms (SNPs) remain elusive. We sought to dissect functional genes/SNPs for asthma by combining expression quantitative trait loci (eQTLs) and GWASs. METHODS: Cis-eQTL analyses of 34 asthma genes were performed in cells from human bronchial epithelial biopsy (BEC, n = 107) and from bronchial alveolar lavage (BAL, n = 94)...
October 2015: Allergy
https://www.readbyqxmd.com/read/26048654/triclosan-induces-thymic-stromal-lymphopoietin-in-skin-promoting-th2-allergic-responses
#6
Nikki B Marshall, Ewa Lukomska, Carrie M Long, Michael L Kashon, Douglas D Sharpnack, Ajay P Nayak, Katie L Anderson, B Jean Meade, Stacey E Anderson
Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses...
September 2015: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/25866971/airway-epithelial-spdef-integrates-goblet-cell-differentiation-and-pulmonary-th2-inflammation
#7
Priya Rajavelu, Gang Chen, Yan Xu, Joseph A Kitzmiller, Thomas R Korfhagen, Jeffrey A Whitsett
Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens that are inhaled throughout life. The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells lining the conducting airways, where they regulate goblet cell differentiation and mucus production. Moreover, these transcription factors are upregulated in chronic lung disorders, including asthma. Here, we show that expression of SPDEF or FOXA3 in airway epithelial cells in neonatal mice caused goblet cell differentiation, spontaneous eosinophilic inflammation, and airway hyperresponsiveness to methacholine...
May 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/25813919/coexpression-of-type-2-immune-targets-in-sputum-derived-epithelial-and-dendritic-cells-from-asthmatic-subjects
#8
Bertram Bleck, Angeliki Kazeros, Keren Bakal, Lymaris Garcia-Medina, Alexandra Adams, Mengling Liu, Richard A Lee, Doris B Tse, Amanda Chiu, Gabriele Grunig, John P Egan, Joan Reibman
BACKGROUND: Noninvasive sputum sampling has enabled the identification of biomarkers in asthmatic patients. Studies of discrete cell populations in sputum can enhance measurements compared with whole sputum in which changes in rare cells and cell-cell interactions can be masked. OBJECTIVE: We sought to enrich for sputum-derived human bronchial epithelial cells (sHBECs) and sputum-derived myeloid type 1 dendritic cells (sDCs) to describe transcriptional coexpression of targets associated with a type 2 immune response...
September 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25399934/the-role-of-gr-1-cells-and-tumour-necrosis-factor-%C3%AE-signalling-during-clostridium-difficile-colitis-in-mice
#9
Andrew J McDermott, Kathryn E Higdon, Ryan Muraglia, John R Erb-Downward, Nicole R Falkowski, Roderick A McDonald, Vincent B Young, Gary B Huffnagle
The host response to Clostridium difficile infection in antibiotic-treated mice is characterized by robust recruitment of Gr-1(+) cells, increased expression of inflammatory cytokines including tumour necrosis factor-α (TNF-α), and the development of severe epithelial damage. To investigate the role of Gr-1(+) cells and TNF-α during C. difficile colitis, we treated infected mice with monoclonal antibodies against Gr-1 or TNF-α. Mice were challenged with vegetative cells of C. difficile strain VPI 10463 following treatment with the third-generation cephalosporin ceftriaxone...
April 2015: Immunology
https://www.readbyqxmd.com/read/24465642/chronic-proliferative-dermatitis-in-sharpin-null-mice-development-of-an-autoinflammatory-disease-in-the-absence-of-b-and-t-lymphocytes-and-il4-il13-signaling
#10
Christopher S Potter, Zhe Wang, Kathleen A Silva, Victoria E Kennedy, Timothy M Stearns, Lisa Burzenski, Leonard D Shultz, Harm Hogenesch, John P Sundberg
SHARPIN is a key regulator of NFKB and integrin signaling. Mice lacking Sharpin develop a phenotype known as chronic proliferative dermatitis (CPDM), typified by progressive epidermal hyperplasia, apoptosis of keratinocytes, cutaneous and systemic eosinophilic inflammation, and hypoplasia of secondary lymphoid organs. Rag1(-/-) mice, which lack mature B and T cells, were crossed with Sharpin(-/-) mice to examine the role of lymphocytes in CDPM. Although inflammation in the lungs, liver, and joints was reduced in these double mutant mice, dermatitis was not reduced in the absence of functional lymphocytes, suggesting that lymphocytes are not primary drivers of the inflammation in the skin...
2014: PloS One
https://www.readbyqxmd.com/read/24372091/analysis-of-the-mucosal-immune-responses-induced-by-single-and-trickle-infections-with-the-bovine-abomasal-nematode-ostertagia-ostertagi
#11
B Mihi, F van Meulder, S Vancoppernolle, M Rinaldi, K Chiers, W van den Broeck, B M Goddeeris, J Vercruysse, E Claerebout, P Geldhof
The purpose of this study was to provide more information on the kinetics of the immunological changes occurring in the abomasal mucosa after single and trickle infections with the bovine parasite Ostertagia ostertagi. The time course analysis of gene expression revealed that the major changes coincided with the emergence of adult worms from the gastric glands. These changes consisted of a simultaneous upregulation of Th1- and Th2-type cytokines. In addition, a single O. ostertagi infection elicited an upregulation of the epithelial-derived cytokine IL33, while TSLP expression levels were not impacted...
April 2014: Parasite Immunology
https://www.readbyqxmd.com/read/24261947/transport-of-pru-p-3-across-gastrointestinal-epithelium-an-essential-step-towards-the-induction-of-food-allergy
#12
L Tordesillas, C Gómez-Casado, M Garrido-Arandia, A Murua-García, A Palacín, J Varela, P Konieczna, J Cuesta-Herranz, C A Akdis, L O'Mahony, A Díaz-Perales
BACKGROUND: Since intestinal absorption of food protein can trigger an allergic reaction, the effect of plant food allergen on intestinal epithelial cell permeability and its ability to cross the epithelial monolayer was evaluated. OBJECTIVE: To study the interaction of Pru p 3 with intestinal epithelium, its natural entrance, analyzing transport kinetics and cellular responses that trigger. METHODS: This was achieved using Pru p 3, the peach LTP, as a model...
December 2013: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/23541324/genome-wide-association-study-identifies-th1-pathway-genes-associated-with-lung-function-in-asthmatic-patients
#13
Xingnan Li, Gregory A Hawkins, Elizabeth J Ampleford, Wendy C Moore, Huashi Li, Annette T Hastie, Timothy D Howard, Homer A Boushey, William W Busse, William J Calhoun, Mario Castro, Serpil C Erzurum, Elliot Israel, Robert F Lemanske, Stanley J Szefler, Stephen I Wasserman, Sally E Wenzel, Stephen P Peters, Deborah A Meyers, Eugene R Bleecker
BACKGROUND: Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function. OBJECTIVE: We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations. METHODS: Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses...
August 2013: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/22694930/genome-wide-association-studies-of-asthma-indicate-opposite-immunopathogenesis-direction-from-autoimmune-diseases
#14
Xingnan Li, Elizabeth J Ampleford, Timothy D Howard, Wendy C Moore, Dara G Torgerson, Huashi Li, William W Busse, Mario Castro, Serpil C Erzurum, Elliot Israel, Dan L Nicolae, Carole Ober, Sally E Wenzel, Gregory A Hawkins, Eugene R Bleecker, Deborah A Meyers
BACKGROUND: Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and WD repeat domain 36 region (TSLP-WDR36), and HLA-DR/DQ regions. OBJECTIVE: A GWAS of asthma was performed in a non-Hispanic white population. METHODS: A GWAS was performed in 813 Severe Asthma Research Program/Collaborative Studies on the Genetics of Asthma/Chicago Asthma Genetics Study cases and 1564 control subjects...
October 2012: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/21804549/meta-analysis-of-genome-wide-association-studies-of-asthma-in-ethnically-diverse-north-american-populations
#15
Dara G Torgerson, Elizabeth J Ampleford, Grace Y Chiu, W James Gauderman, Christopher R Gignoux, Penelope E Graves, Blanca E Himes, Albert M Levin, Rasika A Mathias, Dana B Hancock, James W Baurley, Celeste Eng, Debra A Stern, Juan C Celedón, Nicholas Rafaels, Daniel Capurso, David V Conti, Lindsey A Roth, Manuel Soto-Quiros, Alkis Togias, Xingnan Li, Rachel A Myers, Isabelle Romieu, David J Van Den Berg, Donglei Hu, Nadia N Hansel, Ryan D Hernandez, Elliott Israel, Muhammad T Salam, Joshua Galanter, Pedro C Avila, Lydiana Avila, Jose R Rodriquez-Santana, Rocio Chapela, William Rodriguez-Cintron, Gregory B Diette, N Franklin Adkinson, Rebekah A Abel, Kevin D Ross, Min Shi, Mezbah U Faruque, Georgia M Dunston, Harold R Watson, Vito J Mantese, Serpil C Ezurum, Liming Liang, Ingo Ruczinski, Jean G Ford, Scott Huntsman, Kian Fan Chung, Hita Vora, Xia Li, William J Calhoun, Mario Castro, Juan J Sienra-Monge, Blanca del Rio-Navarro, Klaus A Deichmann, Andrea Heinzmann, Sally E Wenzel, William W Busse, James E Gern, Robert F Lemanske, Terri H Beaty, Eugene R Bleecker, Benjamin A Raby, Deborah A Meyers, Stephanie J London, Frank D Gilliland, Esteban G Burchard, Fernando D Martinez, Scott T Weiss, L Keoki Williams, Kathleen C Barnes, Carole Ober, Dan L Nicolae
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups...
July 31, 2011: Nature Genetics
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