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Tslp allergy

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https://www.readbyqxmd.com/read/29704811/involvement-of-ion-channels-in-allergy
#1
REVIEW
Lucette Pelletier, Magali Savignac
Allergic asthma is a complex disease, often characterized by an inappropriate Th2 response to normally harmless allergens. Epithelial cells damaged or activated by the allergen produce IL-33, TSLP and IL-25, activating ILC2 and dendritic cells. The latter migrate into lymph nodes where they induce Th2-cell commitment. Th2 and other type 2 innate inflammatory cells trigger inflammation and airway hyper-reactivity. The toolbox consisting of the ion channels varies from one cellular type to another and depends on its activation state, offering the possibility to design novel drugs in the field of allergy...
April 25, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29670037/expression-and-regulation-of-thymic-stromal-lymphopoietin-and-thymic-stromal-lymphopoietin-receptor-heterocomplex-in-the-innate-adaptive-immunity-of-pediatric-asthma
#2
REVIEW
Sheng-Chieh Lin, Fang-Yi Cheng, Jun-Jen Liu, Yi-Ling Ye
Asthma is a chronic inflammatory disease affecting the airway, and it is characterized by a wheezing breathing sound, variable airflow obstruction and the presence of inflammatory cells in the submucosa of the bronchi. Viral infection, pollutants and sensitivity to aeroallergens damage the epithelium from childhood, which causes asthma. The pathogenesis of asthma includes pathways of innate stimulation by environmental microbes and irritant pathogens. Damaged epithelial cells produce thymic stromal lymphopoietin (TSLP) and stimulate myeloid dendritic cell maturation through the thymic stromal lymphopoietin receptor (TSLPR) heterocomplex...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29511165/food-allergen-triggers-are-increased-in-children-with-the-tslp-risk-allele-and-eosinophilic-esophagitis
#3
Lisa M Fahey, Prasanna M Chandramouleeswaran, Shaobo Guan, Alain J Benitez, Glenn T Furuta, Seema S Aceves, Mei-Lun Wang, Chris A Liacouras, Amanda B Muir, Patrick Ma Sleiman, Hakon Hakonarson, Jonathan M Spergel, Antonella Cianferoni
OBJECTIVES: TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide polymorphism position RS3806932. Presently, the phenotypic characteristics in EoE children with the TSLP EoE risk allele are unknown. METHODS: A retrospective analysis was performed of all children with EoE who had TSLP genotyping at The Children's Hospital of Philadelphia from 2008-2014...
March 6, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29439856/the-optimal-age-for-epicutaneous-sensitization-following-tape-stripping-in-balb-c-mice
#4
Masato Tamari, Keisuke Orimo, Kenichiro Motomura, Ken Arae, Akio Matsuda, Susumu Nakae, Hirohisa Saito, Hideaki Morita, Kenji Matsumoto
BACKGROUND: Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sensitization is needed. However, a fundamental problem in that regard is that the optimal age for epicutaneous sensitization of mice is unknown. In this study, we attempted to elucidate that optimal age. METHODS: Dorsal skin of wild-type BALB/c female mice (1, 3, 8 and 24 weeks old) was shaved, depilated and tape-stripped...
February 10, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29399438/type-2-cytokine-responses-regulating-immunity-to-helminth-parasites-and-allergic-inflammation
#5
Everett K Henry, Juan M Inclan-Rico, Mark C Siracusa
Purpose of Review: It is well established that T helper type 2 (TH 2) immune responses are necessary to provide protection against helminth parasites but also to promote the detrimental inflammation associated with allergies and asthma. Given the importance of type 2 immunity and inflammation, many studies have focused on better understanding the factors that regulate TH 2 cell development and activation. As a result, significant progress has been made in understanding the signaling pathways and molecular events necessary to promote TH 2 cell polarization...
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29339496/thymic-stromal-lymphopoietin-drives-the-development-of-il-13-th2-cells
#6
Sotaro Ochiai, Ferdinand Jagot, Ryan L Kyle, Evelyn Hyde, Ruby F White, Melanie Prout, Alfonso J Schmidt, Hidehiro Yamane, Olivier Lamiable, Graham Le Gros, Franca Ronchese
T helper 2 (Th2) cells are pivotal in the development of allergy. Allergen exposure primes IL-4+ Th2 cells in lymph node, but production of effector cytokines including IL-5 and IL-13 is thought to require additional signals from antigen and the environment. Here we report that a substantial proportion of naive CD4+ T cells in spleen and lymph node express receptors for the epithelium-derived inflammatory cytokine thymic stromal lymphopoietin (TSLP). Culture of naive CD4+ T cells in anti-(a)CD3, aCD28, and TSLP-supplemented Th2 conditions enabled the development of a unique population of IL-13-single positive (IL-13-SP) CD4+ T cells; TSLP and Th2 conditions were both required for their development...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29273672/cd1a-presentation-of-endogenous-antigens-by-group-2-innate-lymphoid-cells
#7
Clare S Hardman, Yi-Ling Chen, Maryam Salimi, Rachael Jarrett, David Johnson, Valtteri J Järvinen, Raymond J Owens, Emmanouela Repapi, David J Cousins, Jillian L Barlow, Andrew N J McKenzie, Graham Ogg
Group 2 innate lymphoid cells (ILC2) are effectors of barrier immunity, with roles in infection, wound healing, and allergy. A proportion of ILC2 express MHCII (major histocompatibility complex II) and are capable of presenting peptide antigens to T cells and amplifying the subsequent adaptive immune response. Recent studies have highlighted the importance of CD1a-reactive T cells in allergy and infection, activated by the presentation of endogenous neolipid antigens and bacterial components. Using a human skin challenge model, we unexpectedly show that human skin-derived ILC2 can express CD1a and are capable of presenting endogenous antigens to T cells...
December 22, 2017: Science Immunology
https://www.readbyqxmd.com/read/29222519/virtual-screening-for-inhibitors-of-the-human-tslp-tslpr-interaction
#8
Dries Van Rompaey, Kenneth Verstraete, Frank Peelman, Savvas N Savvides, Koen Augustyns, Pieter Van Der Veken, Hans De Winter
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis. TSLP forms a ternary complex with the TSLP receptor (TSLPR) and the interleukin-7-receptor subunit alpha (IL-7Rα), thereby activating a signaling cascade that culminates in the release of pro-inflammatory mediators. In this study, we conducted an in silico characterization of the TSLP:TSLPR complex to investigate the drugability of this complex...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29179209/calycosin-suppresses-epithelial-derived-initiative-key-factors-and-maintains-epithelial-barrier-in-allergic-inflammation-via-tlr4-mediated-nf-%C3%AE%C2%BAb-pathway
#9
Yu Tao, Yan Wang, Xiaoyu Wang, Can Wang, Kaifang Bao, Lv Ji, Guorong Jiang, Min Hong
BACKGROUND/AIMS: Calycosin is a bioactive component of Astragali Radix, a Chinese herb for treating allergy. We have previously demonstrated that calycosin effectively inhibited allergic inflammation efficiently. The aim of this study was to explore the mechanism of calycosin on epithelial cells in allergic inflammation. METHODS: An initial stage of atopic dermatitis (AD) model in which mice were just sensitized with FITC, was established in vivo and immortalized human keratinocytes (HaCaT cells) were utilized in vitro...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29067997/il-33-promotes-gastrointestinal-allergy-in-a-tslp-independent-manner
#10
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
No abstract text is available yet for this article.
October 25, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28953906/analysis-of-chromatin-accessibility-in-human-epidermis-identifies-putative-barrier-dysfunction-sensing-enhancers
#11
Julie M Lander, Dorothy M Supp, Hua He, Lisa J Martin, Xiaoting Chen, Matthew T Weirauch, Steven T Boyce, Raphael Kopan
To identify putative gene regulatory regions that respond to epidermal injury, we mapped chromatin dynamics in a stratified human epidermis during barrier maturation and disruption. Engineered skin substitutes (ESS) cultured at the air-liquid interface were used as a model of developing human epidermis with incomplete barrier formation. The epidermal barrier stabilized following engraftment onto immunocompromised mice, and was compromised again upon injury. Modified formaldehyde-assisted isolation of regulatory elements (FAIRE) was used to identify accessible genomic regions characteristic of monolayer keratinocytes, ESS in vitro, grafted ESS, and tape-stripped ESS graft...
2017: PloS One
https://www.readbyqxmd.com/read/28917991/enhanced-expression-of-pd-l1-and-ifn-%C3%AE-on-dendritic-cells-is-associated-with-bcg-induced-th2-inhibition
#12
A C C Gouveia, F G Braga, M Mota, F M C Silva, A S S Brugiolo, E E Oliveira, M C Ayupe, H C Teixeira, A P Ferreira
Accumulating evidence indicates that the exposure to Mycobacterium bovis bacillus Calmette-Guérin (BCG) prevents the development of allergy and the airway dendritic cells (DCs) may be involved in this protective effect. However, studies to better characterize the specific interactions between BCG and DCs and their role in this mycobacteria-mediated Th2 cell suppression are still ongoing. This study aimed to evaluate the effect of the neonatal BCG vaccination in the innate immune response in a mouse model of ovalbumin (OVA)-induced airway inflammation...
November 2017: Cytokine
https://www.readbyqxmd.com/read/28861617/novel-therapeutic-approaches-to-atopic-dermatitis
#13
REVIEW
Katarzyna Osinka, Karolina Dumycz, Bartłomiej Kwiek, Wojciech Feleszko
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. The number of people affected by AD is relatively high and seems to be rising. Although mild and moderate forms of the disease can be well controlled by the use of emollients, topical corticosteroids, and topical calcineurin inhibitors, treatment of severe is still a huge challenge. The new hope is biologic drugs, magic bullets in allergy, targeted at different points of the complex pathomechanism of inflammation in AD. In this review, novel biologic therapies are discussed, including recombinant monoclonal antibodies directed against various interleukin pathways (such as IL-4, IL-13, TSLP, IL-31, and IL-12/23), on immunoglobulin E, molecules acting as T cells, B cells, etc...
August 31, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28819104/der-f-31-a-novel-allergen-from-dermatophagoides-farinae-activates-epithelial-cells-and-enhances-lung-resident-group-2-innate-lymphoid-cells
#14
Hui Wang, Jianli Lin, Lu Zeng, Chunyan Ouyang, Pixin Ran, Pingchang Yang, Zhigang Liu
Airway epithelial cell-derived thymic stromal lymphopoietin (TSLP) and IL-33 can enhance lung-resident group 2 innate lymphoid cells (ILC2s), and they play an important role in the development of allergic diseases. This study tests the hypothesis that Der f 31 (Dermatophagoides farinae-31), an allergen, modulates airway epithelial cell functions and increases the frequency of lung ILC2s. Our previous research identified cofilin (Der f 31) as a novel allergen. In this study, we found that recombinant Der f 31 (r-Der f 31) upregulated the expression of co-stimulatory molecules in DCs and promoted Th2-skewed polarization...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689020/ferulic-acid-supresses-th2-immune-response-and-prevents-remodeling-in-ovalbumin-induced-pulmonary-allergy-associated-with-inhibition-of-epithelial-derived-cytokines
#15
Alessa Sin Singer Brugiolo, Ana Cláudia Carvalho Gouveia, Caio César de Souza Alves, Flávia Márcia de Castro E Silva, Érick Esteves de Oliveira, Ana Paula Ferreira
Asthma is characterized by intermittent airway obstruction and chronic inflammation, orchestrated primarily by Th2 cytokines. There is a strong rationale for developing new asthma therapies, since current treatment protocols present side effects and may not be effective in cases of difficult-to-control asthma. The purpose of this study was to evaluate the effect of ferulic acid, a phenolic acid commonly present in plants, in the ovalbumin-induced pulmonary allergy murine model. METHODS: BALB/c mice were sensitized and challenged with ovalbumin, and treatments were provided by gavage...
August 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28658558/the-atopic-march-current-insights-into-skin-barrier-dysfunction-and-epithelial-cell-derived-cytokines
#16
REVIEW
Hongwei Han, Florence Roan, Steven F Ziegler
Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28656964/il-33-promotes-gastrointestianl-allergy-in-a-tslp-independent-manner
#17
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal (GI) allergy...
June 28, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28629743/association-study-of-childhood-food-allergy-with-genome-wide-association-studies-discovered-loci-of-atopic-dermatitis-and-eosinophilic-esophagitis
#18
Tomomitsu Hirota, Tsuguhisa Nakayama, Sakura Sato, Noriyuki Yanagida, Teruaki Matsui, Shiro Sugiura, Yuri Takaoka, Nobuyuki Hizawa, Shigeharu Fujieda, Akihiko Miyatake, Takashi Sasaki, Masayuki Amagai, Satoru Doi, Komei Ito, Motohiro Ebisawa, Mayumi Tamari
No abstract text is available yet for this article.
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28597545/cimifugin-suppresses-allergic-inflammation-by-reducing-epithelial-derived-initiative-key-factors-via-regulating-tight-junctions
#19
Xiaoyu Wang, Xiaoyan Jiang, Xi Yu, Hailiang Liu, Yu Tao, Guorong Jiang, Min Hong
Cimifugin is a bioactive component of Saposhnikovia divaricata, a Chinese herb for treating allergy. Our previous studies demonstrated that cimifugin inhibited allergic inflammation efficiently. This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation. Mice were sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. The initial stage of AD model, in which mice were just sensitized with FITC, was established in vivo and immortalized human epidermal (HaCaT) cells were utilized in vitro...
November 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28552763/prevention-of-food-allergy-development-and-suppression-of-established-food-allergy-by-neutralization-of-thymic-stromal-lymphopoietin-il-25-and-il-33
#20
Marat V Khodoun, Sunil Tomar, Joel E Tocker, Yui Hsi Wang, Fred D Finkelman
BACKGROUND: Food allergy (FA) is an increasing problem that has no approved treatment. The pro-TH 2 cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are associated with FA, and mAbs to these cytokines are reported to suppress murine FA development. OBJECTIVE: We sought to determine whether anti-pro-TH 2 cytokine mAbs can block both FA maintenance and induction. METHODS: IgE-mediated FA was induced in BALB/c mice by oral gavage with medium-chain triglycerides (MCTs) plus egg white (EW) and was characterized by increased numbers of lamina propria TH 2 cells, mast cells, and eosinophils, shock (hypothermia), mast cell degranulation (increased serum mouse mast cell protease 1), increased serum IgG1 anti-EW and IgE levels, and increased IL-4 and IL-13 secretion after MCT/EW challenge...
January 2018: Journal of Allergy and Clinical Immunology
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