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https://www.readbyqxmd.com/read/27917896/astragaloside-iv-ameliorates-allergic-inflammation-by-inhibiting-key-initiating-factors-in-the-initial-stage-of-sensitization
#1
Kai-Fan Bao, Xi Yu, Xiao Wei, Li-Li Gui, Hai-Liang Liu, Xiao-Yu Wang, Yu Tao, Guo-Rong Jiang, Min Hong
To illuminate the anti-allergy mechanism of astragaloside IV (AS-IV), we assessed its effects in a murine model of allergic contact dermatitis (ACD). AS-IV administered in the sensitization phase, rather than in the elicitation phase, dramatically alleviated the symptoms of allergic inflammation. We hypothesized that AS-IV exerts its anti-allergy effects by regulating the production of key pro-allergic cytokines based on the fact that interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) levels increase significantly in the initial stage of the sensitization phase...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826297/lipopolysaccharide-attenuates-induction-of-proallergic-cytokines-thymic-stromal-lymphopoietin-and-interleukin-33-in-respiratory-epithelial-cells-stimulated-with-polyi-c-and-human-parechovirus
#2
Tsang-Hsiung Lin, Chih-Chi Cheng, Hsing-Hao Su, Nan-Chieh Huang, Jih-Jung Chen, Hong-Yo Kang, Tsung-Hsien Chang
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the hygiene hypothesis. Epithelial cells are the first line of response to microbial products in the environment and bridge the innate and adaptive immune systems; however, their role in the hygiene hypothesis is unknown. To demonstrate the hygiene hypothesis in airway epithelial cells, we examined the effect of lipopolysaccharide (LPS; toll-like receptor 4 ligand) on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27613653/novel-biologicals-for-the-treatment-of-allergic-diseases-and-asthma
#3
REVIEW
Hern-Tze Tina Tan, Kazunari Sugita, Cezmi A Akdis
PURPOSE OF REVIEW: The development of biological therapies has rapidly progressed during the last few years, and major advances were reported for the treatment of allergic diseases, such as atopic dermatitis, allergic rhinitis, urticaria, food allergy, and asthma. Here, we review biologicals targeting the type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, natural killer T cells, mast cells, basophils, and epithelial cells, such as IL-4, IL-5, IL-13, IL-31, tumor necrosis factor alpha (TNF-α), and thymic stromal lymphopoietin (TSLP)...
October 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27466848/the-role-of-innate-immunity-and-aeroallergens-in-chronic-rhinosinusitis
#4
Nyall R London, Anuj Tharakan, Murugappan Ramanathan
Allergy has been inferred to contribute to the pathophysiology of chronic rhinosinusitis (CRS) although this role is controversial and the mechanism is debated. Furthermore, the role of aeroallergens in CRS is poorly defined and has been postulated to contribute to CRS through direct penetration in the sinuses or downstream systemic consequences. Common aeroallergens implicated in chronic rhinosinusitis include air pollution/second hand smoke, dust mite and pollen [<citeref rid="ref1">1</citeref>,<citeref rid="ref2">2</citeref>,<citeref rid="ref3">3</citeref>]...
2016: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27453775/atopic-dermatitis-prevention-in-children-following-maternal-probiotic-supplementation-does-not-appear-to-be-mediated-by-breast-milk-tslp-or-tgf-%C3%AE
#5
Melanie Rae Simpson, Anne Dorthea Bjerkenes Rø, Øystein Grimstad, Roar Johnsen, Ola Storrø, Torbjørn Øien
BACKGROUND: The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence of atopic dermatitis (AD) in infancy. The mechanisms behind this effect are incompletely understood and breast milk cytokines have been postulated as possible mediating factors. In this study we aimed to assess whether breast milk TLSP and TGF-β are affected by a maternal probiotic supplementation regime, and their contribution to the preventive effect of this regime on AD in the offspring...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27304220/tslp-regulates-eosinophil-migration-via-phosphorylation-of-l-plastin-in-atopic-dermatitis
#6
Ji Yeon Noh, Jung U Shin, Chang Ook Park, Nara Lee, Shan Jin, Seo Hyung Kim, Ji Hye Kim, Arim Min, Myeong Heon Shin, Kwang Hoon Lee
Infiltration of eosinophils in atopic dermatitis (AD), which contains inflammatory molecules and cytokines, recruits more inflammatory cells and causes further skin damage. Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine that induces the proinflammatory Th2 immune response and plays an important role in allergic disease. In this study, we aimed to identify a novel protein that regulates TSLP in eosinophils to further understand the role of eosinophils in atopic dermatitis. Using a proteomics approach, we identified the TSLP-inducible protein L-plastin and confirmed upregulation of L-plastin and p-L-plastin in TSLP-treated human eosinophilic leukemic (EoL-1) cells and in eosinophils from AD patients...
June 15, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27152943/tslp-il-31-il-33-and-sst2-are-new-biomarkers-in-endophenotypic-profiling-of-adult-and-childhood-atopic-dermatitis
#7
U Nygaard, M Hvid, C Johansen, M Buchner, R Fölster-Holst, M Deleuran, C Vestergaard
BACKGROUND: Recent years have seen growing interest in identifying new biomarkers in atopic dermatitis (AD) that could serve as indicators of disease severity and predictors of treatment response. OBJECTIVES: We compared serum levels of thymic stromal lymphopoietin (TSLP), interleukin(IL)-31, IL-33 and soluble(s)ST2 in AD patients and healthy controls, investigated the possible correlation with disease severity, investigated if other atopic comorbidities could play a role, and assessed their potential as biomarkers in AD...
May 6, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27096066/lung-derived-innate-cytokines-new-epigenetic-targets-of-allergen-specific-sublingual-immunotherapy
#8
Abbas Pishdadian, Abdolreza Varasteh, Mehran Gholamin, Leila Roozbeh Nasiraie, Mitra Hosseinpour, Malihe Moghadam, Mojtaba Sankian
OBJECTIVES: Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. MATERIALS AND METHODS: BALB/c mice were sensitized intraperitoneally and challenged intranasally. Then, they received sublingual treatment with recombinant Che a 2 (rChe a 2), a major allergen of Chenopodium album...
January 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27050744/specific-induction-of-tslp-by-the-viral-rna-analogue-poly-i-c-in-primary-epithelial-cells-derived-from-nasal-polyps
#9
Korneliusz Golebski, Joost van Tongeren, Danielle van Egmond, Esther J de Groot, Wytske J Fokkens, Cornelis M van Drunen
INTRODUCTION: Chronic rhinosinusitis with nasal polyposis is an inflammatory disease that, although not directly linked to allergy, often displays a Th2-skewed inflammation characterized by elevated local IgE and IL-5 levels. The nasal cavity is constantly exposed to bacteria and viruses that may trigger epithelial inflammatory responses. To gain more insight into mechanisms by which such a biased inflammation might arise, we have investigated the epithelial expression of the Th2 skewing mediators (TSLP, IL-25, and IL-33) in relationship to disease and microbial triggers...
2016: PloS One
https://www.readbyqxmd.com/read/26999524/upregulated-thymic-stromal-lymphopoietin-receptor-expression-in-children-with-asthma
#10
Sheng-Chieh Lin, Jian-Jhang Huang, Jiu-Yao Wang, Hsiao-Chi Chuang, Bor-Luen Chiang, Yi-Ling Ye
BACKGROUND: Thymic stromal lymphopoietin (TSLP) plays an important role in pathogenesis in patients with asthma. However, the role of thymic stromal lymphopoietin receptor (TSLPR) and correlation with IL-7Rα and clinical severity in asthmatic or nonasthmatic children remain unclear. We investigated TSLPR and IL-7Rα mRΝΑ levels in asthma and nonasthma and assessed TSLPR expression in children who were sensitive to mites. MATERIALS AND METHODS: We enrolled asthmatic and nonasthmatic children...
June 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26786889/inhibitory-effects-of-nicotine-derived-from-cigarette-smoke-on-thymic-stromal-lymphopoietin-production-in-epidermal-keratinocytes
#11
Jiangxu Dong, Ryosuke Segawa, Natsumi Mizuno, Masahiro Hiratsuka, Noriyasu Hirasawa
Thymic stromal lymphopoietin (TSLP) is regarded as the main factor responsible for the pathogenesis of atopic dermatitis (AD). Cigarette smoke is an aggravating factor for allergies, but has been reported to decrease the risk of AD. In the present study, we evaluated the role of nicotine, the main constituent in cigarette smoke extract, and its underlying mechanism of action in the regulation of TSLP expression. We found that nicotine significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced TSLP expression in BALB/c mice and the mouse keratinocyte cell line PAM212...
April 2016: Cellular Immunology
https://www.readbyqxmd.com/read/26566180/inflammation-controls-sensitivity-of-human-and-mouse-intestinal-epithelial-cells-to-galectin-1
#12
Cecilia I Muglia, Rodrigo Papa Gobbi, Paola Smaldini, María Lucía Orsini Delgado, Martín Candia, Carolina Zanuzzi, Alicia Sambuelli, Andrés Rocca, Marta A Toscano, Gabriel A Rabinovich, Guillermo H Docena
Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze the effect of galectin-1 (Gal-1) in the function of intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs isolated from mice or patients with inflammatory bowel diseases (IBD) were incubated with different pro-inflammatory cytokines, and Gal-1 binding, secretion of homeostatic factors and viability were assessed. Experimental models of food allergy and colitis were used to evaluate the in vivo influence of inflammation on Gal-1 binding and modulation of IECs...
July 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/26552776/an-allergist-s-perspective-to-the-evaluation-of-eosinophilic-esophagitis
#13
REVIEW
Jonathan M Spergel
Eosinophilic Esophagitis (EoE) is a classic atopic disease as it shares features with other atopic disease on all levels including pathogenesis, genetics, epidemiology, and treatment options. EoE has elements of Th2 pathogenesis with increase levels of Th2 cytokines (IL4, 5, and 13). In addition, it shares atopic genetic risk factors including thymic stromal lymphopoietin (TSLP) loci as a risk factor in genome wide association studies. EoE patients have a higher rate of other atopic disease (asthma, allergic rhinitis and food allergy) compared to the general population indicating their atopic phenotype...
October 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26552770/allergic-mechanisms-of-eosinophilic-oesophagitis
#14
REVIEW
John Leung, Koen Robert Beukema, Alice Hangzhou Shen
Eosinophilic oesophagitis (EoE) is characterized by oesophageal dysfunction and oesophageal eosinophilia refractory to proton-pump-inhibitor treatment. EoE is a food allergy, as elimination of food trigger(s) abrogates the disease, while trigger reintroduction causes recurrence. The allergic mechanism of EoE involves both IgE and non-IgE processes. There is a break in oral tolerance, the immune mechanism allowing enteric exposure to food and micro-organisms without causing deleterious immune responses. Changes in life-style, alterations in gut flora and use of antibiotics may be increasing disease prevalence...
October 2015: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/26390218/klk5-inactivation-reverses-cutaneous-hallmarks-of-netherton-syndrome
#15
Laetitia Furio, Georgios Pampalakis, Iacovos P Michael, Andras Nagy, Georgia Sotiropoulou, Alain Hovnanian
Netherton Syndrome (NS) is a rare and severe autosomal recessive skin disease which can be life-threatening in infants. The disease is characterized by extensive skin desquamation, inflammation, allergic manifestations and hair shaft defects. NS is caused by loss-of-function mutations in SPINK5 encoding the LEKTI serine protease inhibitor. LEKTI deficiency results in unopposed activities of kallikrein-related peptidases (KLKs) and aberrantly increased proteolysis in the epidermis. Spink5⁻/⁻ mice recapitulate the NS phenotype, display enhanced epidermal Klk5 and Klk7 protease activities and die within a few hours after birth because of a severe skin barrier defect...
September 2015: PLoS Genetics
https://www.readbyqxmd.com/read/26258919/from-genetics-to-treatment-of-eosinophilic-esophagitis
#16
Antonella Cianferoni, Jonathan M Spergel
PURPOSE OF REVIEW: Eosinophilic Esophagitis (EoE) is an emerging chronic atopic disease. Recent advances in understanding its genetic and molecular biology pathogenesis may lead to a better management of the disease RECENT FINDINGS: EoE is an atopic disease. Most of the patients affected by EoE have other atopic diseases such as allergic rhinitis, asthma, IgE-mediated food allergies and/or atopic dermatitis. The local inflammation is a T helper type 2 (Th2) flogosis, which most likely is driven by a mixed IgE and n-IgE-mediated reaction to food and/or environmental allergens...
October 2015: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26194940/eosinophilic-esophagitis-a-comprehensive-review
#17
REVIEW
Antonella Cianferoni, Jonathan Spergel
Eosinophilic esophagitis (EoE) is an emerging chronic atopic clinical-pathologic disease with an estimated prevalence of 1/1000 similar to the one of Crohn's diseases. Usually, EoE is firstly suspected due to symptoms that are caused by esophageal dysfunction and/or fibrosis. EoE diagnosis is confirmed if the esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf) as a peak value in one or more of at least four specimens obtained randomly from the esophagus. Most of the patients affected by EoE have other atopic diseases such as allergic rhinitis, asthma, IgE-mediated food allergies, and/or atopic dermatitis...
April 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26117252/ilc2s-and-fungal-allergy
#18
REVIEW
Hirohito Kita
Innate lymphoid cells (ILCs) have emerged recently as an important component of the immune system and the cell type that regulates mucosal immune responses and tissue homeostasis. Group 2 ILCs (ILC2s), a subset of ILCs, reside in various tissues and are characterized by their capacity to produce type 2 cytokines and tissue growth factors. These ILC2s play an important role in allergic immune responses by linking signals in the atmospheric environment to the immune system. Fungi are one of the major allergens associated with human asthma, and animal and in vitro models using the fungal allergens have provided significant information toward our understanding of the mechanisms of allergic disease...
July 2015: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/26084354/maternal-exposure-to-metals-and-persistent-pollutants-and-cord-blood-immune-system-biomarkers
#19
Jillian Ashley-Martin, Adrian R Levy, Tye E Arbuckle, Robert W Platt, Jean S Marshall, Linda Dodds
BACKGROUND: The fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental exposures. Epidemiologists and toxicologists have hypothesized that persistent organic pollutants, pesticides and metals have immunotoxic properties. Immunotoxic effects may manifest as an altered immune system profile at birth. Immunoglobulin E, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) may be implicated in the etiology of childhood allergy and are detectable at birth...
2015: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/25913155/prenatal-exposure-to-phthalates-bisphenol-a-and-perfluoroalkyl-substances-and-cord-blood-levels-of-ige-tslp-and-il-33
#20
Jillian Ashley-Martin, Linda Dodds, Adrian R Levy, Robert W Platt, Jean S Marshall, Tye E Arbuckle
The fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental exposures. Epidemiologists and toxicologists have hypothesized that phthalates, bisphenol A (BPA) and perfluoroalkyl substance have immunotoxic properties. Immunotoxic effects of chemicals may manifest in an altered immune system profile at birth. Immunoglobulin E, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) are integral in the etiology of childhood allergy and detectable at birth...
July 2015: Environmental Research
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