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Syringomyelia

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https://www.readbyqxmd.com/read/29784434/cell-therapy-with-autologous-mesenchymal-stromal-cells-in-post-traumatic-syringomyelia
#1
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Concepcion Aguayo, Cecilia Fernandez, Gregorio Rodriguez-Boto, Esperanza Marin, Noemi Tapiador, Marta Sevilla, Joaquin Carballido, David Vazquez, Damian Garcia-Olmo, Hector Guadalajara, Miguel Leon, Ignacio Valverde
BACKGROUND AIMS: Recently, clinical studies show that cell therapy with mesenchymal stromal cells (MSCs) improves the sequelae chronically established in paraplegic patients, being necessary to know which of them can obtain better benefit. METHODS: We present here a phase 2 clinical trial that includes six paraplegic patients with post-traumatic syringomyelia who received 300 million MSCs inside the syrinx and who were followed up for 6 months. Clinical scales, urodynamic, neurophysiological, magnetic resonance (MR) and studies of ano-rectal manometry were performed to assess possible improvements...
May 18, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29776403/rostral-cranial-fossa-as-a-site-for-cerebrospinal-fluid-drainage-volumetric-studies-in-dog-breeds-of-different-size-and-morphotype
#2
Wojciech Sokołowski, Norbert Czubaj, Michał Skibniewski, Karolina Barszcz, Marta Kupczyńska, Wojciech Kinda, Zdzisław Kiełbowicz
BACKGROUND: Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the cribriform plate located in the rostral cranial fossa (RCF) is a site of cerebrospinal fluid (CSF) drainage, the RCF has not been studied extensively. Literature reports indicate that a decreased caudal cranial fossa (CCF) volume in the course of the Chiari-like malformation may obstruct CSF circulation...
May 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29770929/two-cases-of-sarcoidosis-presenting-as-longitudinally-extensive-transverse-myelitis
#3
REVIEW
Amanda Mary Scott, Janeth Yinh, Timothy McAlindon, Robert Kalish
Neurosarcoidosis is uncommon with an incidence of approximately 5 to 15%. Central nervous system involvement can be divided into brain and spinal cord neurosarcoidosis. Spinal cord sarcoidosis is extremely rare, occurring in less than 1% of all sarcoidosis cases. Its manifestations may include cauda equina syndrome, radiculopathy, syringomyelia, cord atrophy, arachnoiditis, and myelopathy or transverse myelitis. We highlight two cases of spinal cord sarcoidosis, each presenting with longitudinally extensive transverse myelitis, that demonstrate the dilemmas that physicians face with regard to diagnosis and treatment...
May 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29766943/brain-stem-hemangioblastomas-the-seemingly-innocuous-lesion-in-a-perilous-location
#4
Jeena Joseph, Sanjay Behari, Shruti Gupta, Kamlesh Singh Bhaisora, Anish Gandhi, Arun Srivastava, Awadhesh K Jaiswal
Introduction: Hemangioblastomas [75% sporadic, 25% with Von Hippel Lindau (VHL) disease] are highly vascular, benign lesions. The surgical nuances, management, and complication avoidance in brain-stem hemangioblastomas (BHs) have been studied. Material and Methods: Over 18 years, 27(mean age: 29 years; range 15-60 years) consecutive cases of BH underwent microsurgical excision. All patients were assessed clinico-radiologically for neurological deficits and screened for VHL disease...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29748208/relationship-between-cough-associated-changes-in-csf-flow-and-disease-severity-in-chiari-i-malformation-an-exploratory-study-using-real-time-mri
#5
A F Bezuidenhout, D Khatami, C B Heilman, E M Kasper, S Patz, N Madan, Y Zhao, R A Bhadelia
BACKGROUND AND PURPOSE: Currently no quantitative objective test exists to determine disease severity in a patient with Chiari I malformation. Our aim was to correlate disease severity in symptomatic patients with Chiari I malformation with cough-associated changes in CSF flow as measured with real-time MR imaging. MATERIALS AND METHODS: Thirteen symptomatic patients with Chiari I malformation (tonsillar herniation of ≥5 mm) were prospectively studied. A real-time, flow-sensitized pencil-beam MR imaging scan was used to measure CSF stroke volume during rest and immediately following coughing and relaxation periods (total scan time, 90 seconds)...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29741445/cervical-spine-taper-ratios-normal-tolerance-limits
#6
Adrienne Thompson, Ryan Zea, Victor Haughton
Background Spinal canal tapering, which can be measured as taper ratios, affects cerebrospinal fluid flow dynamics. We calculated the tolerance interval for normal cervical spine taper ratios to facilitate the detection of abnormal taper ratios. Methods We collected a series of patients who had cervical spine magnetic resonance studies reported as normal. We measured anteroposterior diameters of the cervical spine and calculated C1-C4, C4-C7, and C1-C7 taper by standard methodology. We calculated the normal tolerance limits for taper ratios and compared results of this study with data in previous reports on taper ratios...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29734193/spontaneous-resolution-of-chiari-1-associated-syringomyelia-a-report-of-two-cases
#7
R Ramnarayan, C V Shankar Ganesh, Ramesh Kumar
BACKGROUND: Traditional teaching is that Chiari 1 malformations with syrinx should be operated as soon as possible. We present 2 cases of a radiologically proven Chiari 1 malformation with syrinx which were treated nonoperatively and improved radiologically. METHODS: Two children with an MRI-proven Chiari 1 malformations were followed up nonoperatively for 7 years (2010-2017). One was a boy aged 8 years and the other a girl aged 9 years at first presentation. Their parents were not interested in a surgical option and so it was decided to adopt a wait-and-watch policy...
May 7, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29732422/developments-in-the-treatment-of-chiari-type-1-malformations-over-the-past-decade
#8
Peter G Passias, Alexandra Pyne, Samantha R Horn, Gregory W Poorman, Muhammad B Janjua, Dennis Vasquez-Montes, Cole A Bortz, Frank A Segreto, Nicholas J Frangella, Matthew Y Siow, Akhila Sure, Peter L Zhou, John Y Moon, Bassel G Diebo, Shaleen N Vira
Background: Chiari malformations type 1 (CM-1), a developmental anomaly of the posterior fossa, usually presents in adolescence or early adulthood. There are few studies on the national incidence of CM-1, taking into account outcomes based on concurrent diagnoses. To quantify trends in treatment and associated diagnoses, as retrospective review of the Kid's Inpatient Database (KID) from 2003-2012 was conducted. Methods: Patients aged 0-20 with primary diagnosis of CM-1 in the KID database were identified...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29731280/-sandwich-deformity-in-klippel-feil-syndrome-a-full-spectrum-presentation-of-associated-craniovertebral-junction-abnormalities
#9
Yinglun Tian, Dongwei Fan, Nanfang Xu, Shenglin Wang
Klippel-Feil syndrome (KFS) is defined as congenital fusion of two or more cervical vertebrae resulting from a segmentation failure in the developing spine. According to Samartzis et al., the most commonly fused segments are found at C2/3 (74.1%) and C6/7 (70.4%). In patients with C2/3 fusion, especially when there is additional C1 occipitalization, several secondary anomalies including atlantoaxial dislocation (AAD), basilar invagination (BI), Chiari malformation, and syringomyelia can be identified. In this report, we present a case of a 12-year-old patient with C2/3 and occipitalization and a "Full-Spectrum" presentation of associated CVJ abnormalities including C0/1 fusion, AAD, BI, Chiari malformation, syringomyelia, myelopathy and cranial neuropathy received neurological decompression of the cervico-medullary junction by posterior reduction of the AAD and reconstruction of her CVJ using an unconventional hybrid construct due to a high-riding right vertebral artery in C2...
May 3, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29721352/dorsal-hemangioblastoma-manifesting-as-holocord-syringomyelia
#10
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind K Srivastava, Anita Jagetia, Atul Agrawal
Background: Intramedullary spinal hemangioblastomas are known to be accompanied by syringomyelia. Case Description: Here, we report a patient who presented with symptoms of a Chiari malformation but was found to have a D4 intramedullary hemangioblastoma with a holocord syrinx. Conclusions: Although rare, neurosurgeons should keep in mind the possibility of an intramedullary hemangioblastoma in patients presenting with symptoms of a Chiari malformation...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29704892/fluid-outflow-in-the-rat-spinal-cord-the-role-of-perivascular-and-paravascular-pathways
#11
Shinuo Liu, Magdalena A Lam, Alisha Sial, Sarah J Hemley, Lynne E Bilston, Marcus A Stoodley
BACKGROUND: Cerebrospinal fluid (CSF) is thought to flow into the brain via perivascular spaces around arteries, where it mixes with interstitial fluid. The precise details concerning fluid outflow remain controversial. Although fluid dynamics have been studied in the brain, little is known about spinal cord fluid inflow and outflow. Understanding the normal fluid physiology of the spinal cord may give insight into the pathogenesis of spinal cord oedema and CSF disorders such as syringomyelia...
April 29, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29701558/syringobulbia-in-pediatric-patients-with-chiari-malformation-type-i
#12
Arnold H Menezes, Jeremy D W Greenlee, Brian J Dlouhy
OBJECTIVE Syringobulbia (SB) is a rare entity, with few cases associated with Chiari malformation type I (CM-I) in the pediatric population. The authors reviewed all pediatric cases of CM-I-associated SB managed at their institution in order to better understand the presentation, treatment, and surgical outcomes of this condition. METHODS A prospectively maintained institutional database of craniovertebral junction abnormalities was analyzed to identify all cases of CM-I and SB from the MRI era (i.e., after 1984)...
April 27, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29698796/long-term-outcomes-of-a-new-minimally-invasive-approach-in-chiari-type-1-and-1-5-malformations-technical-note-and-preliminary-results
#13
Kadir Kotil, Selcuk Ozdogan, Selim Kayaci, Hanife Gulden Duzkalir
PURPOSE: The treatment options for patients with Chiari malformation type-1(CM1) and Chiari malformation type-1.5(CM1.5) have not yet been standardized. In these malformations, the main factors include obstruction at the level of the foramen magnum, dural and ligamentous thickening. Here we have presented our outcomes of surgery and decompression using minimal invasive surgery(MIS) technique. MATERIALS AND METHODS: Sixty-one patients admitted to our clinics between 2009 and 2016 due to CM1 or CM1...
April 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29688076/case-report-development-of-syringomyelia-after-anatomically-successful-craniovertebral-decompression-for-chiari-i-malformation-without-syrinx
#14
Joshua Pepper, Graham Flint
An 18 year old female with headaches and radiologically confirmed Chiari I malformation, without syringomyelia, underwent an anatomically and clinically successful craniovertebral decompression. Five years later she returned with extensive syringomyelia. This was treated successfully by division of an arachnoid web at the foramen of Magendie.
April 24, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682854/association-of-syringomyelia-with-lower-urinary-tract-dysfunction-in-anterior-sacral-meningocele-with-a-tethered-spinal-cord-a-case-report-and-literature-summary
#15
Taiki Kato, Yoshinobu Moritoki, Kentaro Mizuno, Motoo Nakagawa, Goro Kondo, Takahiro Yasui
No abstract text is available yet for this article.
April 22, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29675087/chari-1-malformation-with-scoliosis-and-holocord-syringomyelia-a-rare-association
#16
Raja K Kutty, B S SunilKumar, Anilkumar Peethambaran
Syringomyelia and scoliosis are not uncommon phenomena in the spectrum of Chiari malformations. However, the presence of holocord syrinx in association with Chiari 1 malformation is quite rare.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29662730/myelopathy-improvement-following-removal-of-cervical-sublaminar-wiring
#17
Hurtis J Tullos, Robert G Briggs, Andrew K Conner, Allison E Williams, John B Maxwell, Michael D Martin
Posterior cervical wiring has been used by spine surgeons in fixation procedures for patients with spinal instability. It is historically considered an effective method of treating cervical instability with a low risk of complications leading to neurological deterioration. We experienced a case of delayed neurological decline associated with myelopathy, lower extremity spasticity, and associated syringomyelia secondary to instrumentation failure and resultant sublaminar wire protrusion into the cervical spinal cord...
February 14, 2018: Curēus
https://www.readbyqxmd.com/read/29621191/syringomyelia-in-an-adult-american-paint-horse
#18
Jacqueline P Kurz, Kate E Schoenhals, Gordon A Hullinger, Arnaud J Van Wettere
Syringomyelia is a form of myelodysplasia defined by the formation of one or more fluid-filled cavities within the spinal cord that do not communicate with the central canal. The defect may be congenital or acquired. Clinical signs correlate to the segment of spinal cord affected and include pain, paresis, proprioceptive deficits, alterations in sensation, scoliosis, and autonomic dysfunction. This report describes the clinical and pathologic changes in a case of acquired syringomyelia in a 10-year-old American Paint Horse mare...
April 5, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29618081/origin-of-syrinx-fluid-in-syringomyelia-a-physiological-study
#19
John D Heiss, Katie Jarvis, René K Smith, Eric Eskioglu, Mortimer Gierthmuehlen, Nicholas J Patronas, John A Butman, Davis P Argersinger, Russell R Lonser, Edward H Oldfield
BACKGROUND: The origin of syrinx fluid is controversial. OBJECTIVE: To elucidate the mechanisms of syringomyelia associated with cerebrospinal fluid pathway obstruction and with intramedullary tumors, contrast transport from the spinal subarachnoid space (SAS) to syrinx was evaluated in syringomyelia patients. METHODS: We prospectively studied patients with syringomyelia: 22 with Chiari I malformation and 16 with SAS obstruction-related syringomyelia before and 1 wk after surgery, and 9 with tumor-related syringomyelia before surgery only...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29610967/early-analysis-of-operative-management-of-chiari-i-malformation-in-pediatric-cystic-fibrosis-patients
#20
Derek C Samples, Dewey J Thoms, Izabela Tarasiewicz
INTRODUCTION: Chiari I malformation, defined as herniation of the cerebellar tonsils at least 5 mm below the foramen magnum, can result from congenital or acquired pathology. While the mechanism is not well understood, an association between Chiari I and cystic fibrosis has been described in the literature. The lifelong respiratory status management necessitated by cystic fibrosis creates a greater risk of Chiari symptomatology as well as post-operative CSF-related complications in the setting of duraplasty secondary to recurrent transient increases in intracranial pressure...
April 2, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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