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https://www.readbyqxmd.com/read/28240004/gut-microbiota-and-pancreatic-diseases
#1
Marianna Signoretti, Roberta Roggiolani, Caterina Stornello, Gianfranco Delle Fave, Gabriele Capurso
Changes in diet, lifestyle and exposition to environmental risk factors account for the increased incidence of pancreatic disorders, including acute and chronic pancreatitis, and pancreatic cancer. The role of the microbiome in the development of pancreatic disorders is increasingly recognized. The translocation of gut bacteria and endotoxins following gut barrier failure is a key event contributing to the severity of acute pancreatitis, while small intestine bacterial overgrowth is common in patients with chronic pancreatitis and further worsens their symptoms and malnutrition...
February 24, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28239982/phytochemicals-in-quinoa-and-amaranth-grains-and-their-antioxidant-anti-inflammatory-and-potential-health-beneficial-effects-a-review
#2
Yao Tang, Rong Tsao
Quinoa (Chenopodium quinoa Willd.) and amaranth (Amaranthus cruentus L.) are pseudocereal grains rich in both macronutrients and micronutrients including vitamins and minerals. The proteins are particularly of high nutritional quality due to the outstanding balance of essential amino acids. However, recent research strongly suggests that the essential nutrients such as phytochemicals of quinoa and amaranth may also with potential health beneficial effects. This review focuses on the phytochemical composition of quinoa and amaranth seeds, the antioxidant and anti-inflammatory activities of hydrophilic (e...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28239907/effects-of-oral-%C3%AE-lipoic-acid-administration-on-body-weight-in-overweight-or-obese-subjects-a-crossover-randomized-double-blind-placebo-controlled-trial
#3
Nong Li, Weili Yan, Xiaojuan Hu, Yongdi Huang, Fugang Wang, Weiguo Zhang, Qian Wang, Xiaoling Wang, Kehong Sun
OBJECTIVE: Alpha-lipoic acid (ALA) has shown beneficial properties on diabetes and obesity. The aim of this study was to examine the effects of oral ALA on body weight in subjects with overweight or obese. DESIGN: Single-centre, randomized, double-blind, crossover controlled study. PARTICIPANTS: A total of 166 subjects of Chinese Han ethnicity with a BMI ≥25 kg/m(2) were screened and 103 subjects fulfilled the study requirements, in terms of informed consent and participation to the study...
January 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28239653/the-human-brain-produces-fructose-from-glucose
#4
Janice J Hwang, Lihong Jiang, Muhammad Hamza, Feng Dai, Renata Belfort-DeAguiar, Gary Cline, Douglas L Rothman, Graeme Mason, Robert S Sherwin
Fructose has been implicated in the pathogenesis of obesity and type 2 diabetes. In contrast to glucose, CNS delivery of fructose in rodents promotes feeding behavior. However, because circulating plasma fructose levels are exceedingly low, it remains unclear to what extent fructose crosses the blood-brain barrier to exert CNS effects. To determine whether fructose can be endogenously generated from glucose via the polyol pathway (glucose → sorbitol → fructose) in human brain, 8 healthy subjects (4 women/4 men; age, 28...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239649/switching-harmful-visceral-fat-to-beneficial-energy-combustion-improves-metabolic-dysfunctions
#5
Xiaoyan Yang, Wenhai Sui, Meng Zhang, Mei Dong, Sharon Lim, Takahiro Seki, Ziheng Guo, Carina Fischer, Huixia Lu, Cheng Zhang, Jianmin Yang, Meng Zhang, Yangang Wang, Caixia Cao, Yanyan Gao, Xingguo Zhao, Meili Sun, Yuping Sun, Rujie Zhuang, Nilesh J Samani, Yun Zhang, Yihai Cao
Visceral fat is considered the genuine and harmful white adipose tissue (WAT) that is associated to development of metabolic disorders, cardiovascular disease, and cancer. Here, we present a new concept to turn the harmful visceral fat into a beneficial energy consumption depot, which is beneficial for improvement of metabolic dysfunctions in obese mice. We show that low temperature-dependent browning of visceral fat caused decreased adipose weight, total body weight, and body mass index, despite increased food intake...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239070/lipid-lowering-therapy-to-modify-plaque-microstructures
#6
Yu Kataoka, Jordan Andrews, Rishi Puri, Peter Psaltis, Stephen J Nicholls
Due to the pandemics of obesity and diabetes mellitus, especially in the Western countries, atherosclerotic cardiovascular disease (ASCVD) has become a major health burden and is expected to increase in the future. Modifying lipid targets, especially low-density lipoprotein cholesterol (LDL-C) level, has become the first-line therapy for primary and secondary prevention of ASCVD. Intravascular imaging modalities have contributed to elucidating clinical efficacy of lipid lowering therapy on atherosclerotic plaques...
February 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28238694/interaction-of-physical-activity-and-body-mass-index-on-mortality-in-coronary-heart-disease-data-from-the-nord-tr%C3%A3-ndelag-health-study
#7
Trine Moholdt, Carl J Lavie, Javaid Nauman
AIMS: The role of physical activity in the BMI-survival relationship in coronary heart disease is unclear. Our aim was to examine isolated and combined associations between BMI and physical activity, and mortality in subjects with coronary heart disease.. METHODS AND RESULTS: 6 493 participants (34.4% women) with coronary heart disease from the Nord-Trøndelag Health Study, with examinations in 1986, 1996, and 2007, were followed until the end of 2014. We calculated hazard ratios (HR) for all-cause and cardiovascular disease mortality, estimated using Cox proportionate hazard regression adjusted for age, smoking, diabetes, hypertension, self-reported health status, and alcohol...
February 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28238670/association-of-pregnancy-with-stone-formation-among-us-women-a-national-health-and-nutrition-examination-survey-analysis-2007-2012
#8
Lael Reinstatler, Sari Khaleel, Vernon M Pais
PURPOSE: Lithogenic urinary changes occur during pregnancy. Such changes may increase stone proclivity in working and child rearing aged women thereafter. However, such an association has not been previously identified. MATERIALS AND METHODS: We analyzed nationally representative data from 2007-2012 National Health and Nutrition Examination Survey to assess the association between pregnancy and nephrolithiasis. RESULTS: The weighted national prevalence of nephrolithiasis among women ≤50 was 6...
February 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28238100/self-reported-sleep-duration-and-daytime-napping-are-associated-with-renal-hyperfiltration-in-general-population
#9
Miao Lin, Qing Su, Junping Wen, Shichao Wei, Jin Yao, Huibin Huang, Jixing Liang, Liantao Li, Wei Lin, Lixiang Lin, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Gang Chen
STUDY OBJECTIVES: Renal hyperfiltration (RHF) has emerged as a novel marker of early renal damage in various conditions such as diabetes and metabolic syndrome. Aberrant sleep duration and excessive daytime napping may affect the development of chronic kidney disease (CKD). In this study, the association between sleep duration, daytime napping, and renal hyperfiltration was assessed. SETTING: This study was conducted in three communities in China. PARTICIPANTS: A total of 16,119 community volunteers (5735 males and 10,384 females) aged 40-65 years without CKD were included for the study...
February 26, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28237857/genetic-association-analysis-of-polymorphisms-in-psd3-gene-with-obesity-type-2-diabetes-and-hdl-cholesterol
#10
Shaoqing Gong, Chun Xu, Liang Wang, Ying Liu, Daniel Owusu, Beth A Bailey, Yujing Li, Kesheng Wang
BACKGROUND: The pleckstrin and Sec7 domain-containing 3 (PSD3) gene has been linked to immune diseases. We examined whether the genetic variants within the PSD3 gene are associated with obesity, type 2 diabetes (T2D), and high-density lipoprotein (HDL) cholesterol level. METHODS: Multiple logistic regression model and linear regression model were used to examine the associations of 259 single nucleotide polymorphisms (SNPs) within the PSD3 gene with obesity and T2D as binary traits, and HDL level as a continuous trait using the Marshfield data, respectively...
February 10, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28237841/relationship-between-serum-anti-heat-shock-protein-27-antibody-levels-and-obesity
#11
Mehrdad Kargari, Samira Tavassoli, Amir Avan, Mahmoud Ebrahimi, Mahmoud Reza Azarpazhooh, Rasool Asoodeh, Mohsen Nematy, Seyed Mahdi Hassanian, Farzad Rahmani, Elham Mohammadzade, Habibollah Esmaeili, Mohsen Moohebati, Gordon A Ferns, Majid Ghayour-Mobarhan, Seyed Mohammad Reza Parizadeh
BACKGROUND: Heat shock protein 27 (HSP27) is an intracellular molecular chaperone that is expressed at high levels following the exposure of cells to environmental stressors such as heat, toxins, and free radicals. High levels of HSP antigens and antibody titers have been reported in several conditions including cardiovascular disease and cancers. We measured serum anti-HSP27 antibody levels in 993 subjects and assessed the associations between serum anti-HSP27 antibody levels and demographic characteristics including coronary risk factors...
February 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28237819/the-complex-roles-of-mechanistic-target-of-rapamycin-in-adipocytes-and-beyond
#12
REVIEW
Peter L Lee, Su Myung Jung, David A Guertin
Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity epidemic, which is unveiling a myriad of comorbidities associated with excess adipose tissue including type 2 diabetes, cardiovascular disease, and cancer. Lipodystrophy also causes insulin resistance, emphasizing the importance of having a balanced amount of fat. In cells, the mechanistic target of rapamycin (mTOR) complexes 1 and 2 (mTORC1 and mTORC2, respectively) link nutrient and hormonal signaling with metabolism, and recent studies are shedding new light on their in vivo roles in adipocytes...
February 22, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28237791/long-term-incidence-of-microvascular-disease-after-bariatric-surgery-or-usual-care-in-patients-with-obesity-stratified-by-baseline-glycaemic-status-a-post-hoc-analysis-of-participants-from-the-swedish-obese-subjects-study
#13
Lena M S Carlsson, Kajsa Sjöholm, Cecilia Karlsson, Peter Jacobson, Johanna C Andersson-Assarsson, Per-Arne Svensson, Ingrid Larsson, Stephan Hjorth, Martin Neovius, Magdalena Taube, Björn Carlsson, Markku Peltonen
BACKGROUND: Bariatric surgery is associated with remission of diabetes and prevention of diabetic complications in patients with obesity and type 2 diabetes. Long-term effects of bariatric surgery on microvascular complications in patients with prediabetes are unknown. The aim of this study was to examine the effects of bariatric surgery on incidence of microvascular complications in patients with obesity stratified by baseline glycaemic status. METHODS: Patients were recruited to the Swedish Obese Subjects (SOS) study between Sept 1, 1987, and Jan 31, 2001...
February 22, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28237721/cytoprotective-effect-of-kaempferol-against-palmitic-acid-induced-pancreatic-%C3%AE-cell-death-through-modulation-of-autophagy-via-ampk-mtor-signaling-pathway
#14
Ritu Varshney, Sumeet Gupta, Partha Roy
Lipotoxicity of pancreatic β-cells is the pathological manifestation of obesity-linked type II diabetes. We intended to determine the cytoprotective effect of kaempferol on pancreatic β-cells undergoing apoptosis in palmitic acid (PA)-stressed condition. The data showed that kaempferol treatment increased cell viability and anti-apoptotic activity in PA-stressed RIN-5F cells and murine pancreatic islets. Furthermore, kaempferol's ability to instigate autophagy was illustrated by MDC-LysoTracker red staining and TEM analysis which corroborated well with the observed increase in LC3 puncta and LC3-II protein expressions along with the concomitant decline in p62 expression...
February 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28237564/cost-utility-analysis-for-bariatric-surgery-compared-with-usual-care-for-the-treatment-of-obesity-in-australia
#15
Robbie James, Ryan Ishmael Salton, Joshua Michael Byrnes, Paul Anthony Scuffham
BACKGROUND: The uptake of bariatric surgery in Australia has been hampered by the lack of funding and lack of evidence on relative value for money. OBJECTIVES: To determine the cost-effectiveness of adjustable gastric banding (AGB), Roux-En-Y gastric bypass (RYGB), and sleeve gastrectomy (SG) versus usual care (UC). SETTING: Perspective of the Australian public healthcare system. METHODS: A Markov model was constructed to simulate the costs and outcomes for 4 approaches to managing obesity...
December 26, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28237513/unraveling-the-role-of-er-stress-inhibitors-in-the-context-of-metabolic-diseases
#16
REVIEW
Chodisetty Sarvani, Dornadula Sireesh, Kunka Mohanram Ramkumar
ER stress is provoked by the accumulation of unfolded and misfolded proteins in the ER lumen leading to perturbations in ER homeostasis. ER stress activates a signaling cascade called the Unfolded Protein Response (UPR) which triggers a set of transcriptional and translational events that restore ER homeostasis, promoting cell survival and adaptation. If this adaptive response fails, a terminal UPR program commits such cells to apoptosis. Existing preclinical and clinical evidence testify that prolonged ER stress escalates the risk of several metabolic disorders including diabetes, obesity and dyslipidemia...
February 22, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28237320/a-perspective-on-metabolic-surgery-from-a-gastroenterologist
#17
REVIEW
Yu-Fong Syu, Akio Inui, Chih-Yen Chen
Type 2 diabetes (T2D) and obesity are important public health problems. The global prevalence of diabetes mellitus is 8.8%. Interventional diabetology and obesitology have been recently advocated as treatment options for T2D and obesity. The roles of metabolic surgery such as Roux-en-Y gastric bypass, sleeve gastrectomy, gastric banding, and biliopancreatic diversion are focused. Different types of metabolic surgeries have different glucose-lowering and weight loss effects. Endoscopic treatments include the intra-gastric balloon (to restrict the gastric volume) and duodenal-jejunal bypass liner (DJBL, as a malabsorptive procedure)...
January 19, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28237263/3-years-of-liraglutide-versus-placebo-for-type-2-diabetes-risk-reduction-and-weight-management-in-individuals-with-prediabetes-a-randomised-double-blind-trial
#18
Carel W le Roux, Arne Astrup, Ken Fujioka, Frank Greenway, David C W Lau, Luc Van Gaal, Rafael Violante Ortiz, John P H Wilding, Trine V Skjøth, Linda Shapiro Manning, Xavier Pi-Sunyer
BACKGROUND: Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes. METHODS: In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m(2), or at least 27 kg/m(2) with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-calorie diet and increased physical activity...
February 22, 2017: Lancet
https://www.readbyqxmd.com/read/28236446/effects-of-roux-en-y-gastric-bypass-on-insulin-secretion-and-sensitivity-glucose-homeostasis-and-diabetic-control-a-prospective-cohort-study-in-chinese-patients
#19
Mohsen Mazidi, Hong-Kai Gao, Liang Li, Han Hui, Zhang Ye
BACKGROUND: To report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients. METHODS: This was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation. RESULTS: Mean body mass index was decreased by 18.1% from 30.31 ± 5.38 kg/m(2) at baseline to 24...
February 21, 2017: Surgery
https://www.readbyqxmd.com/read/28236374/adaptive-outcomes-of-microvascular-networks-to-obesity-and-type-2-diabetes-mellitus-insulin-resistance
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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