keyword
MENU ▼
Read by QxMD icon Read
search

obesity AND diabetes

keyword
https://www.readbyqxmd.com/read/28654184/recycling-of-glucagon-receptor-to-plasma-membrane-increases-in-adipocytes-of-obese-rats-by-soy-protein-implications-for-glucagon-resistance
#1
Laura A Velázquez-Villegas, Claudia Tovar-Palacio, Berenice Palacios-González, Nimbe Torres, Armando R Tovar, Andrea Díaz-Villaseñor
SCOPE: Hyperglucagonemia contributes to hyperglycemia in type 2 diabetes (T2D). Previously, we have found that soy protein normalized fasting hyperglucagonemia in obese Zucker (fa/fa) rats, sensitizing the HSL-lipolytic signaling pathway in white adipose tissue (WAT), however the mechanism remains unknown. METHODS AND RESULTS: Zucker (fa/fa) rats were fed casein or soy protein diet in combination with soybean or coconut oil. Glucagon receptor (GR) was increased at the plasma membrane of adipocytes of rats fed soy protein compared to those fed casein, without changes in total GR abundance...
June 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28653652/obesity-and-age-related-alterations-in-fat-cd36-translocation-and-lipin-1-subcellular-localization-in-skeletal-muscle-of-the-zucker-rats
#2
Snjezana Romic, Katarina Krskova, Rafal Olszanecki, Lucia Balazova, Viktoria Lory, Goran Koricanac, Miroslava Slamkova, Stefan Zorad
Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor κB (NF-κB) p65 protein content in quadriceps muscle of young and old obese Zucker fa/fa rats and their lean controls were analyzed by immunoblot to define obesity- and aging-related alterations in FA uptake, their subsequent metabolic fate and potential to activate pro-inflammatory signaling...
June 27, 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28653181/laparoscopic-sleeve-gastrectomy-for-the-management-of-type-1-diabetes-mellitus
#3
Salman Al Sabah, Eliana Al Haddad, Talal H Muzaffar, Ahmad Almulla
BACKGROUND: The prevalence of obesity is on a continuous rise worldwide, with major studies clearly correlating obesity with the development of chronic metabolic disorders including type 2 diabetes. Bariatric surgery has proven to be beneficial in the management of this condition; however, a limited number of studies exist on its effect on type 1 diabetes. OBJECTIVE: The objective of this study is to evaluate the outcome of laparoscopic sleeve gastrectomy for the management of patients with type 1 diabetes (DM1)...
June 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28653126/impact-of-metabolic-hormones-secreted-in-human-breast-milk-on-nutritional-programming-in-childhood-obesity
#4
REVIEW
Pilar Amellali Badillo-Suárez, Maricela Rodríguez-Cruz, Xóchitl Nieves-Morales
Obesity is the most common metabolic disease whose prevalence is increasing worldwide. This condition is considered a serious public health problem due to associated comorbidities such as diabetes mellitus and hypertension. Perinatal morbidity related to obesity does not end with birth; this continues affecting the mother/infant binomial and could negatively impact on metabolism during early infant nutrition. Nutrition in early stages of growth may be essential in the development of obesity in adulthood, supporting the concept of "nutritional programming"...
June 27, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28652832/cognitive-behavioral-therapy-to-aid-weight-loss-in-obese-patients-current-perspectives
#5
REVIEW
Gianluca Castelnuovo, Giada Pietrabissa, Gian Mauro Manzoni, Roberto Cattivelli, Alessandro Rossi, Margherita Novelli, Giorgia Varallo, Enrico Molinari
Obesity is a chronic condition associated with risk factors for many medical complications and comorbidities such as cardiovascular diseases, some types of cancer, osteoarthritis, hypertension, dyslipidemia, hypercholesterolemia, type-2 diabetes, obstructive sleep apnea syndrome, and different psychosocial issues and psychopathological disorders. Obesity is a highly complex, multifactorial disease: genetic, biological, psychological, behavioral, familial, social, cultural, and environmental factors can influence in different ways...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28652673/cardiovascular-risk-factors-in-middle-eastern-patients-undergoing-percutaneous-coronary-intervention-results-from-the-first-jordanian-percutaneous-coronary-intervention-study
#6
Ayman J Hammoudeh, Imad A Alhaddad, Yousef Khader, Ramzi Tabbalat, Eyas Al-Mousa, Akram Saleh, Mohamad Jarrah, Assem Nammas, Mahmoud Izraiq
Background and aims: Cardiovascular disease (CVD) is the leading cause of death in the Middle East. We sought to study the prevalence and coexistence of 6 cardiovascular risk factors (RFs) among patients who underwent percutaneous coronary intervention (PCI), and to evaluate the impact of age and gender on the presence of multiple RFs. METHODS AND RESULTS: In this prospective, multicenter study, 2426 consecutive patients were enrolled. Mean age was 59.0 ± 10.1 years and 500 (20.6%) were women...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28652538/the-role-of-acylated-ghrelin-in-the-regulation-of-sucrose-intake
#7
Tetsuya Kouno, Nobuteru Akiyama, Takahito Ito, Kumiko Fujieda, Isamu Nanchi, Tomohiko Okuda, Mitsuru Notoya, Takanori Iwasaki, Hideo Yukioka
The octanoyl modification of ghrelin by ghrelin O-acyltransferase (GOAT) is essential for exerting its physiologic actions. Since exogenous acylated-ghrelin has shown to stimulate food intake in humans and rodents, GOAT has been regarded as a promising target for modulating appetite, thereby treating obesity and diabetes. However, GOAT-knockout (KO) mice have been reported to show no meaningful body weight reduction, when fed a high-fat diet. In this study, we sought to determine whether GOAT has a role in the regulation of body weight and food intake when fed a dietary sucrose...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28651852/differences-in-repolarization-heterogeneity-among-heart-failure-with-preserved-ejection-fraction-phenotypic-subgroups
#8
Suzanne K Oskouie, Stuart B Prenner, Sanjiv J Shah, Andrew J Sauer
Heart failure with preserved ejection fraction (HFpEF) is a highly heterogeneous syndrome associated with multiple medical comorbidities and pathophysiologic pathways or phenotypes. We recently developed a phenomapping method combining deep phenotyping with machine learning analysis to classify HFpEF patients into 3 clinically distinct phenotypic subgroups (phenogroups) with different clinical outcomes. Phenogroup #1 was younger with lower B-type natriuretic peptide levels, phenogroup #2 had the highest prevalence of obesity and diabetes mellitus, and phenogroup #3 was the oldest with the most factors for chronic kidney disease, the most dysfunctional myocardial mechanics, and the highest adverse outcomes...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28651739/no-correlation-between-body-mass-index-and-30-day-prognostic-outcome-in-asians-with-acute-st-elevation-myocardial-infarction-undergoing-primary-coronary-intervention
#9
Po-Jui Wu, Hui-Ting Wang, Pei-Hsun Sung, Meng-Shen Tong, Cheng-Hsu Yang, Chien-Jen Chen, Cheng-Jei Lin, Shu-Kai Hsueh, Sheng-Ying Chung, Wen-Jung Chung, Chi-Ling Hang, Chiung-Jen Wu, Hon-Kan Yip
BACKGROUND: This study investigated whether body mass index (BMI) was a risk factor predictive of 30-day prognostic outcome in Asians with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). MATERIAL AND METHODS: Data regarding the impact of BMI on the prognostic outcome in Asian populations after acute STEMI is scarce. A number of 925 STEMI patients were divided into three groups according to the BMI: normal weight (<25 kg/m(2)), overweight (≥25...
June 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28651658/the-impact-of-diet-based-glycaemic-response-and-glucose-regulation-on-cognition-evidence-across-the-lifespan
#10
Sandra I Sünram-Lea, Lauren Owen
The brain has a high metabolic rate and its metabolism is almost entirely restricted to oxidative utilisation of glucose. These factors emphasise the extreme dependence of neural tissue on a stable and adequate supply of glucose. Whereas initially it was thought that only glucose deprivation (i.e. under hypoglycaemic conditions) can affect brain function, it has become apparent that low-level fluctuations in central availability can affect neural and consequently, cognitive performance. In the present paper the impact of diet-based glycaemic response and glucose regulation on cognitive processes across the lifespan will be reviewed...
June 27, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28650899/evaluation-of-a-digital-behavioral-counseling-program-for-reducing-risk-factors-for-chronic-disease-in-a-workforce
#11
Mark G Wilson, Cynthia M Castro Sweet, Michael D Edge, Erica N Madero, Megan McGuire, Megan Pilsmaker, Dan Carpenter, Scott Kirschner
OBJECTIVE: To evaluate a digitally delivered, intensive behavioral counseling program for a workforce at risk for obesity-related chronic disease. METHODS: Employees were offered a digital health program modeled after the diabetes prevention program (DPP). Annual workforce health assessments were used to examine changes in chronic disease risk factors between participants (n = 634) relative to a matched comparison group (n = 1268). RESULTS: Overall, employees were gaining an average of 3...
June 23, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28650578/intake-of-energy-and-protein-is-associated-with-overweight-risk-at-age-5-5-years-results-from-the-prospective-teddy-study
#12
Andreas Beyerlein, Ulla M Uusitalo, Suvi M Virtanen, Kendra Vehik, Jimin Yang, Christiane Winkler, Mathilde Kersting, Sibylle Koletzko, Desmond Schatz, Carin Andrén Aronsson, Helena Elding Larsson, Jeffrey P Krischer, Anette-G Ziegler, Jill M Norris, Sandra Hummel
OBJECTIVE: The associations of energy, protein, carbohydrate, and fat intake with weight status up to the age of 5.5 years were prospectively assessed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. METHODS: Food record data (over 3 days) and BMI measurements between 0.25 and 5.5 years were available from 5,563 children with an increased genetic risk for type 1 diabetes followed from shortly after birth. Odds ratios (ORs) were calculated for overweight and obesity by previous intake of energy, protein, carbohydrate, and fat with adjustment for potential confounders...
June 26, 2017: Obesity
https://www.readbyqxmd.com/read/28650389/prevalence-of-pancreatic-cystic-lesions-is-associated-with-diabetes-mellitus-and-obesity-an-analysis-of-5296-individuals-who-underwent-a-preventive-medical-examination
#13
Suguru Mizuno, Hiroyuki Isayama, Yousuke Nakai, Takeharu Yoshikawa, Kazunaga Ishigaki, Saburo Matsubara, Natsuyo Yamamoto, Hideaki Ijichi, Keisuke Tateishi, Minoru Tada, Naoto Hayashi, Kazuhiko Koike
OBJECTIVES: Pancreatic cystic lesions (PCLs) are considered precursors of pancreatic cancer. Diabetes mellitus (DM) and obesity are known as risk factors for pancreatic cancer. We investigated the prevalence of PCLs in the general population and the relationship between PCLs and DM/obesity. METHODS: This cross-sectional analysis included 5296 individuals who underwent a preventive medical examination between October 2006 and June 2013 at our institution. Magnetic resonance imaging, including magnetic resonance cholangiopancreatography, was performed using a 3...
June 22, 2017: Pancreas
https://www.readbyqxmd.com/read/28649714/exercise-during-short-term-exposure-to-hypoxia-or-hyperoxia-novel-treatment-strategies-for-type-2-diabetic-patients
#14
REVIEW
C Brinkmann, W Bloch, K Brixius
Both hypoxia (decreased oxygen availability) and hyperoxia (increased oxygen availability) have been shown to alter exercise adaptations in healthy subjects. This review aims to clarify the possible benefits of exercise during short-term exposure to hypoxia or hyperoxia for patients with type 2 diabetes mellitus (T2DM). There is evidence that exercise during short-term exposure to hypoxia can acutely increase skeletal muscle glucose uptake more than exercise in normoxia, and that post-exercise insulin sensitivity in T2DM patients is more increased when exercise is performed under hypoxic conditions...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28649577/in%C3%A2-vivo-murine-matured-human-cd3-cells-as-a-preclinical-model-for-t-cell-based-immunotherapies
#15
Kevin G Haworth, Christina Ironside, Zachary K Norgaard, Willimark M Obenza, Jennifer E Adair, Hans-Peter Kiem
Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successful clinical application until recent years. Despite significant progress in creating engineered receptors against both malignant and viral epitopes, no efficient preclinical animal models exist for rapidly testing and directly comparing these engineered receptors...
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28649427/global-rise-of-potential-health-hazards-caused-by-blue-light-induced-circadian-disruption-in-modern-aging-societies
#16
REVIEW
Megumi Hatori, Claude Gronfier, Russell N Van Gelder, Paul S Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28649104/-aging-and-homeostasis-development-of-novel-adipor-targeted-drugs-with-exercise-mimicking-and-anti-aging-properties
#17
Miki Okada-Iwabu, Toshimasa Yamauchi, Masato Iwabu, Takashi Kadowaki
We have so far clarified that adiponectin, an adipocyte-secreted physiologically active substance, is decreased with the onset of obesity and that lifestyle-related diseases are primarily accounted for by the systemically decreased action of adiponectin/adiponectin receptors(AdipoRs). The activation of adiponectin/AdipoR has caloric restrictive and exercise-mimicking effects thus prolonging lifespan. We were the first in the world to succeed in identifying small-molecule compounds that serve as seed compounds for candidate AdipoR-activating drugs...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28649086/early-life-risk-factors-for-incident-atrial-fibrillation-in-the-helsinki-birth-cohort-study
#18
Linda S B Johnson, Minna Salonen, Eero Kajantie, David Conen, Jeff S Healey, Clive Osmond, Johan G Eriksson
BACKGROUND: Early life risk factors are associated with cardiometabolic disease, but have not been fully studied in atrial fibrillation (AF). There are discordant results from existing studies of birth weight and AF, and the impact of maternal body size, gestational age, placental size, and birth length is unknown. METHODS AND RESULTS: The Helsinki Birth Cohort Study includes 13 345 people born as singletons in Helsinki in the years 1934-1944. Follow-up was through national registries, and ended on December 31, 2013, with 907 incident cases...
June 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28648584/control-of-lipid-droplet-fusion-and-growth-by-cide-family-proteins
#19
REVIEW
Guangang Gao, Feng-Jung Chen, Linkang Zhou, Lu Su, Dijin Xu, Li Xu, Peng Li
Cell death-inducing DFF45-like effector (CIDE) family proteins including Cidea, Cideb and Cidec/Fsp27 are expressed in many different tissues and are known as lipid droplet (LD)-and ER-associated proteins. Systematic analyses using genetically modified animal models have demonstrated that CIDE proteins play important roles in regulating various aspects of lipid homeostasis, including lipid storage, lipolysis and lipid secretion. Recent research in ours and other laboratories has revealed that CIDE proteins are crucial regulators of LD fusion and growth in the adipose tissue, liver, skin and mammary glands...
June 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28648393/etiologies-trends-and-predictors-of-30-day-readmissions-in-patients-with-diastolic-heart-failure
#20
Shilpkumar Arora, Sopan Lahewala, Hafeez Ul Hassan Virk, Saman Setareh-Shenas, Prashant Patel, Varun Kumar, Byomesh Tripathi, Harshil Shah, Viralkumar Patel, Umesh Gidwani, Abhishek Deshmukh, Apurva Badheka, Radha Gopalan
An estimated half of all heart failure (HF) populations has been categorized to have diastolic HF (DHF), but sparse data are available describing etiologies and predictors of 30-day readmission in DHF population. The study cohort was derived from the National Readmission Database 2013 to 2014, a subset of the Healthcare Cost and Utilization Project sponsored by the Agency for Healthcare Research and Quality. DHF was identified using International Classification of Diseases, 9th Revision code 428.3x in primary diagnosis field...
June 1, 2017: American Journal of Cardiology
keyword
keyword
25086
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"