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https://www.readbyqxmd.com/read/29098740/does-non-contact-low-frequency-ultrasound-nlfu-therapy-contribute-to-wound-healing-at-the-molecular-level
#1
Cornelia Wiegand, Kyle Bittenger, Robert D Galiano, Vickie R Driver, Gary W Gibbons
Non-contact low frequency ultrasound (NLFU) is used to treat various types of chronic wounds including venous, diabetic and pressure ulcers. The objective for this sub study of the IN BALANCE RCT VLU trial was to characterize and compare the NLFU treatment group and patients receiving standard of care (SOC) with respect to the effect of the assigned study treatment on content/quantity of inflammatory cytokines and fibrinogen as well as bacteria. Higher mean wound area reduction was observed in the NLFU treatment group (67...
November 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29077990/supervised-exercise-training-as-an-adjunct-therapy-for-venous-leg-ulcers-a-randomised-controlled-feasibility-trial
#2
M Klonizakis, G A Tew, A Gumber, H Crank, B King, G Middleton, J A Michaels
BACKGROUND: Almost 70% of all leg ulcers have a venous component. Venous leg ulcers (VLU's) are typically painful and heal slowly, resulting in an impaired quality of life (QoL), social isolation and reduced work productivity. Compression therapy offers high healing rates, however, improvements aren't usually sustained. Exercise is a low-cost, low-risk, and effective strategy for improving physical and mental health. However, little is currently known about the feasibility and efficacy of supervised exercise training used in combination with compression therapy in this patient group...
October 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29065449/chronic-venous-insufficiency-transforming-growth-factor-%C3%AE-isoforms-and-soluble-endoglin-concentration-in-different-states-of-wound-healing
#3
Daniela Ligi, Lidia Croce, Giovanni Mosti, Joseph D Raffetto, Ferdinando Mannello
Venous leg ulcer (VLU) is a huge healthcare problem with poorly understood pathophysiology. Transforming growth factor-β (TGF-β) and endoglin (Eng), are inflammatory and wound healing mediators. Eng, co-receptor for TGF-β type-II receptors, may be cleaved forming soluble Eng (sEng), antagonizing TGF-β signaling, a crucial process in vascular pathologies. We evaluated the accumulation in wound fluid (WF) of TGF-β isoforms and sEng in healing stages, showing the effects of sulodexide treatments, a glycosaminoglycan with clinical efficacy in VLU healing...
October 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29037356/three-dimensional-digital-imaging-is-as-accurate-and-reliable-to-measure-leg-ulcer-area-as-transparent-tracing-with-digital-planimetry
#4
Guillaume Chaby, Catherine Lok, Jean Philippe Thirion, Arnaud Lucien, Patricia Senet
OBJECTIVE: An accurate and reliable method for measuring venous leg ulcer (VLU) area is important in assessing treatment effects. The new three-dimensional (3D) LifeViz digital imaging system (QuantifiCare S.A., Valbonne, France) combines a compact, easy to use stereovision camera and image management software to provide 3D medical images. The aim of this prospective study was to investigate whether the 3D LifeViz digital imaging system could be considered a suitable alternative to manual transparent wound tracing for the measurement of VLU area and 4-week healing rates...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29037354/baseline-factors-affecting-closure-of-venous-leg-ulcers
#5
William A Marston, William J Ennis, John C Lantis, Robert S Kirsner, Robert D Galiano, Wolfgang Vanscheidt, Sabine A Eming, Marcin Malka, D Innes Cargill, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials. METHODS: Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs standard therapy with compression bandaging was evaluated in three phase 3 clinical trials of similar design. Two trials enrolled subjects with VLUs ranging from 2 cm(2) to 12 cm(2) in area with 12-week treatment periods; the third trial enrolled subjects with VLUs between >12 cm(2) and ≤36 cm(2) with a 16-week treatment period...
November 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29024419/a-multicentre-randomised-controlled-trial-evaluating-the-efficacy-of-dehydrated-human-amnion-chorion-membrane-epifix%C3%A2-allograft-for-the-treatment-of-venous-leg-ulcers
#6
Christian Bianchi, Shawn Cazzell, Dean Vayser, Alexander M Reyzelman, Hasan Dosluoglu, Gregory Tovmassian
A randomised, controlled, multicentre clinical trial was conducted to evaluate the efficacy of dehydrated human amnion/chorion membrane (EpiFix) allograft as an adjunct to multilayer compression therapy for the treatment of non-healing full-thickness venous leg ulcers. We randomly assigned 109 subjects to receive EpiFix and multilayer compression (n = 52) or dressings and multilayer compression therapy alone (n = 57). Patients were recruited from 15 centres around the USA and were followed up for 16 weeks...
October 11, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28976834/managing-real-world-venous-leg-ulcers-with-fetal-bovine-acellular-dermal-matrix-a-single-centre-retrospective-study
#7
J A Paredes, S Bhagwandin, Polanco T, J C Lantis
OBJECTIVE: As compression treatment offers moderate improvement, especially to recurrent venous leg ulcers (VLUs), several alternative therapies using cellular based and/or tissue-derived products (CTPs) have emerged from bovine, porcine, and equine sources. Our aim was to look at the effect of a CTP in 'real-life' VLUs. METHODS: This study looked at complex patients with chronic, large wounds in a single-centre retrospective review. All patients were treated with fetal bovine acellular dermal matrix (FBADM) for VLUs at our outpatient urban wound care programme...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28943804/treatment-in-the-home-setting-with-intermittent-pneumatic-compression-for-a-woman-with-chronic-leg-ulcers-a-case-report
#8
Katrina Young, Harrison Ng Chok, Lesley Wilkes
BACKGROUND: Intermittent Pneumatic Compression (IPC) is shown to improve the healing rate of Venous Leg Ulcers (VLU) in the hospital setting. The current Australian "Gold Standard" treatment according to the Australian and New Zealand Wound Management Associations' (AWMA) Prevention & Management of Venous Leg Ulcer guidelines is compression, generally in the form of bandaging then progressing to hosiery once wounds are healed to prevent recurrence. This is recommended in conjunction with other standards of wound management including; nutrition, exercise, client education and addressing underlying pathophysiology and psychosocial factors...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28798504/molecular-aspects-of-wound-healing-and-the-rise-of-venous-leg-ulceration-omics-approaches-to-enhance-knowledge-and-aid-diagnostic-discovery
#9
REVIEW
Daniel A Broszczak, Elizabeth R Sydes, Daniel Wallace, Tony J Parker
Chronic wounds, in particular venous leg ulcers (VLU), represent a substantial burden for economies, healthcare systems and societies worldwide. This burden is exacerbated by the recalcitrant nature of these wounds, despite best practice, evidence-based care, which substantially reduces the quality of life of patients. Furthermore, co-morbidities such as diabetes and cardiovascular disease within ageing populations further contribute to the increasing prevalence in developed countries. This review provides an overview of the literature concerning the cellular and molecular mechanisms of wound healing and aspects where this process fails, resulting in a chronic wound...
February 2017: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/28777054/an-investigation-of-skin-perfusion-in-venous-leg-ulcer-after-exercise
#10
Omar Mutlak, Mohammed Aslam, Nigel J Standfield
INTRODUCTION: A venous leg ulcer (VLU) has a major impact on the quality of life and functional ability of individuals, but no single treatment is yet effective. This study investigates the changes induced by dorsiflexion exercise on skin perfusion in VLU patients to achieve a better understanding of venous ulcer pathophysiology. METHODS: Seventy-eight venous leg ulcer patients were randomised into four groups. The non-exercise groups included a control group (n = 18) and a compression therapy group (n = 20) and the exercise groups included an exercise-only group (n = 20) and a compression and exercise group (n = 20)...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28750144/therapy-of-ulcus-cruris-of-venous-and-mixed-venous-arterial-origin-with-autologous-adult-native-progenitor-cells-from-subcutaneous-adipose-tissue-a-prospective-clinical-pilot-study
#11
A Konstantinow, A Arnold, K Djabali, W Kempf, J Gutermuth, T Fischer, T Biedermann
BACKGROUND: The stromal vascular fraction (SVF) of adipose tissue consists of cellular subpopulations with distinct regenerative potential. OBJECTIVE: To investigate the regenerative capacities of autologous SVF cells in the treatment of chronic leg ulcers of venous (VLU) and arterial-venous (AVLU) origin. METHODS: Multimorbid ulcer patients received a singular topical treatment with 9-15x10(6) SVF cells, separated from abdominal lipoaspirates by digestion with collagenase and neutral protease and applied immediately after isolation...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28727481/leucocyte-and-platelet-rich-fibrin-l-prf-as-a-regenerative-medicine-strategy-for-the-treatment-of-refractory-leg-ulcers-a-prospective-cohort-study
#12
Nelson R Pinto, Matias Ubilla, Yelka Zamora, Verónica Del Rio, David M Dohan Ehrenfest, Marc Quirynen
Chronic wounds (VLU: venous leg ulcer, DFU: diabetic foot ulcer, PU: pressure ulcer, or complex wounds) affect a significant proportion of the population. Despite appropriate standard wound care, such ulcers unfortunately may remain open for months or even years. The use of leukocyte- and platelet-rich fibrin (L-PRF) to cure skin ulcers is a simple and inexpensive method, widely used in some countries but unknown or neglected in most others. This auto-controlled prospective cohort study explored and quantified accurately for the first time the adjunctive benefits of topical applications of L-PRF in the management of such refractory ulcers in a diverse group of patients...
July 20, 2017: Platelets
https://www.readbyqxmd.com/read/28704156/quality-of-life-in-patients-with-leg-ulcers-results-from-challenge-a-double-blind-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
S Meaume, A Dompmartin, C Lok, I Lazareth, M Sigal, F Truchetet, A Sauvadet, S Bohbot
OBJECTIVE: We recently showed the superiority of a matrix metalloproteinase (MMP) modulating dressing (foam impregnated with NOSF, nano-oligosaccharide factor) compared with a lipidocolloid matrix (TLC) control dressing in median wound area reduction (WAR). Here we report the results from the same study assessing the performance and safety of TLC-NOSF in the local management of venous leg ulcers (VLUs) or mixed leg ulcers and determining its impact on the patient's health-related quality of life (HRQoL)...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28682676/a-double-blind-placebo-controlled-randomized-evaluation-of-the-effect-of-low-level-laser-therapy-on-venous-leg-ulcers
#14
Julian Vitse, Farid Bekara, Stephanie Byun, Christian Herlin, Luc Teot
This study aimed to determine the effect of low-level laser therapy (LLLT) on chronic venous leg ulcers (VLUs). A double-blinded prospective randomized controlled trial was conducted to compare incidence of complete wound closure, ulcer size and pain reduction in patients randomized to 24 treatments of placebo or LLLT (635 nm) over 12 weeks. Patients presented with a 6-week history of VLUs ranging in size from 5 to 20 cm(2). Venous origin was confirmed by Doppler ultrasound and an ankle brachial index of 0...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28619238/mesenchymal-stem-cell-in-venous-leg-ulcer-an-intoxicating-therapy
#15
REVIEW
Anjali Athanerey, Pradeep Kumar Patra, Awanish Kumar
Venous leg ulcers (VLU) are a prevalent and reoccurring type of complicated wound, turning as a considerable public healthcare issue, with critical social and economic concern. There are both medical and surgical therapies to treat venous leg ulcers; however, a cure does not yet exist. Mesenchymal stem cells (MSC) are capable and proved of accelerating wound healing in vivo and their study with human chronic wounds is currently awaited. MSCs are a promising source of adult progenitor cells for cellular therapy and have been demonstrated to differentiate into various mesenchymal cell lineages...
June 7, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28598757/exudates-absorption-and-proteases-trapping-in-venous-leg-ulcers
#16
P Humbert, C Courderot-Masuyer, S Robin, D Oster, R Pegahi
OBJECTIVE: In venous leg ulcer (VLU), the impaired healing has been shown to be associated with excessive levels of protease activities such as matrix metalloproteinases (MMPs) and elastases found in exudates. The present study focused on exudates absorption and proteases trapping capacity of a new generation of polyacrylate superabsorbent, Tegaderm superabsorber (TS), compared with a traditional dressing such as Zetuvit. METHOD: We studied the proteases implicated in VLU (MMP-1, MMP-2, MMP-9 and PMN elastase)...
June 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28342202/treatment-of-chronic-venous-ulcers-experience-in-six-patients-treated-with-terminal-interruption-of-the-reflux-source-tirs-tirs-effective-option-for-the-treatment-of-venous-ulcers
#17
LETTER
M Mendieta-Eckert, J L Azpiazu-Macho, R Lambea-Crespo
No abstract text is available yet for this article.
October 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28277996/venous-leg-ulcer-healing-with-electric-stimulation-therapy-a-pilot-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
C Miller, W McGuiness, S Wilson, K Cooper, T Swanson, D Rooney, N Piller, M Woodward
OBJECTIVE: Compression therapy is a gold standard treatment to promote venous leg ulcer (VLU) healing. Concordance with compression therapy is, however, often sub-optimal. The aim of this study was to evaluate the effectiveness of electric stimulation therapy (EST) to facilitate healing of VLUs among people who do not use moderate-to-high levels of compression (>25 mmHg). METHOD: A pilot multicentre, single-blinded randomised controlled trial was conducted. Participants were randomised (2:1) to the intervention group or a control group where EST or a sham device was used 4 times daily for 20 minutes per session...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28102916/internet-based-learning-programme-to-increase-nurses-knowledge-level-about-venous-leg-ulcer-care-in-home-health-care
#19
Minna Ylönen, Jaakko Viljamaa, Hannu Isoaho, Kristiina Junttila, Helena Leino-Kilpi, Riitta Suhonen
AIMS AND OBJECTIVES: To test the effectiveness of an Internet-based education programme about venous leg ulcer nursing care on perceived and theoretical knowledge levels and attitudes among nurses working in home health care. BACKGROUND: Nurses have been shown to have knowledge gaps in venous leg ulcer nursing care. Internet-based learning could offer a means for flexible continuing education for home healthcare environment. DESIGN: Quasi-experimental study with pre- and postmeasurements and nonequivalent intervention and comparison groups...
November 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28060003/clinical-characteristics-of-mixed-arteriovenous-leg-ulcers-a-descriptive-study
#20
Joseph A Marin, Kevin Y Woo
PURPOSE: The purpose of this study was to identify the clinical characteristics of mixed arteriovenous leg ulcers (MLU) that differentiated them from venous leg ulcers (VLU). DESIGN: Secondary analysis of data from larger electronic database. SUBJECTS AND SETTING: The sample comprised 1007 persons with lower extremity ulcers. Two hundred sixty three individuals with MLU were compared to 744 individuals with VLU; their ankle brachial indices were 0...
January 2017: Journal of Wound, Ostomy, and Continence Nursing
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