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https://www.readbyqxmd.com/read/29768333/association-between-vegf-genetic-variants-and-diabetic-foot-ulcer-in-chinese-han-population-a-case-control-study
#1
Xiaolei Li, Yonghua Lu, Peng Wei
The aim of this study was to investigate the association of vascular endothelial growth factor (VEGF) gene polymorphisms with diabetic foot ulcer (DFU) susceptibility in a Chinese Han population.Around 88 type 2 diabetes mellitus (T2DM) patients without DFU and 97 T2DM patients with DFU were enrolled in this study. A total of 103 age and gender matched healthy individuals were recruited as healthy control. VEGF gene polymorphisms rs699947 and rs13207351 were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29746429/dual-frequency-ultrasound-as-a-new-treatment-modality-for-refractory-rosacea-a-retrospective-study
#2
Jun Yeong Park, Min Kyun Ahn, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim
BACKGROUND: Dual-frequency ultrasound (DFU) has emerged as a new treatment modality for improving inflammatory skin disorders. Although there have been few pilot studies, there are a limited number of studies that investigated efficacy of DFU on refractory rosacea. OBJECTIVE: This study investigated the effect of DFU on patients with refractory rosacea. MATERIALS AND METHODS: The authors retrospectively analyzed medical records of 42 patients with refractory rosacea (erythematotelangiectatic rosacea [ETR], n = 26; papulopustular rosacea [PPR], n = 14, mixed, n = 2)...
May 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29738301/ultrasound-assisted-debridement-of-neuroischaemic-diabetic-foot-ulcers-clinical-and-microbiological-effects-a-case-series
#3
José Luis Lázaro-Martínez, Francisco Javier Álvaro-Afonso, Yolanda García-Álvarez, Raúl Juan Molines-Barroso, Esther García-Morales, David Sevillano-Fernández
OBJECTIVE: To evaluate the clinical and microbiological effects of sequential wound debridement in a case series of neuroischaemic diabetic foot ulcers (DFUs) using an ultrasound-assisted wound debridement (UAW) device. METHOD: A prospective, single-centre study, involving a case series of 24 neuroischaemic DFUs, was conducted to evaluate sequential wound debridement with UAW during a six-week treatment period. Soft tissue punch biopsies were taken every second week of treatment, both before and after wound debridement sessions...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29738299/perception-of-diabetic-foot-ulcers-among-general-practitioners-in-four-european-countries-knowledge-skills-and-urgency
#4
José Luis Garcia-Klepzig, Juan Pedro Sánchez-Ríos, Chris Manu, Raju Ahluwalia, Claas Lüdemann, Marco Meloni, Elisabetta Lacopi, Víctor Rodriguez-Saenz De Buruaga, Benjamin Bouillet, Julien Vouillarmet, Jose Luis Lazaro Martinez, Kristien Van Acker
OBJECTIVE: Diabetic foot ulcers (DFU) have the potential to deteriorate rapidly, in the absence of prompt assessment and treatment. The aim of this study was to analyse the awareness and perception of DFU among general practitioners (GPs) from four European countries, and to find possible differences between these countries in terms of management. METHOD: A two-part, quantitative, online questionnaire was distributed to GPs across four countries in Europe-the UK, France, Germany and Spain...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29738294/clinical-application-of-a-3d-printed-scaffold-in-chronic-wound-treatment-a-case-series
#5
Haining Sun, Huayao Lv, Fanghui Qiu, Duolun Sun, Yue Gao, Ning Chen, YongKe Zheng, Kunxue Deng, Yaya Yang, Haitao Zhang, Tao Xu, Dongni Ren
OBJECTIVE: This case series evaluates the safety and effectiveness of 3D-printed scaffold in chronic wounds. The scaffold is a composite of natural and synthetic materials, and can be prepared in the form of powder or membrane. METHOD: We recruited patients with pressure ulcera (PU) and/or a diabetic foot ulcers (DFU). We used two methods: 3D-printed scaffolds alone, or 3D-printing powder mixed with platelet-rich fibrinogen (PRF). Clinicians and patients were asked to rate the scaffold's ease of application and comfort during use...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29736169/incidence-and-risk-factors-of-diabetic-foot-ulcer-a-population-based-diabetic-foot-cohort-adfc-study-two-year-follow-up-study
#6
Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Saeed Hesam
Aim/Introduction: This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU). Materials and Methods: In this prospective cohort study in a university hospital, all the participants were examined and followed up for new DFU as final outcome for two years. To analyze the data, the variables were first evaluated with a univariate analysis. Then variables with P value < 0.2 were tested with a multivariate analysis, using backward-elimination multiple logistic regression...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29718812/safety-and-efficacy-of-an-autologous-blood-clot-product-in-the-management-of-texas-1a-or-2a-neuropathic-diabetic-foot-ulcers-a-prospective-multicenter-open-label-pilot-study
#7
Robert J Snyder, Maria A Kasper, Keyur Patel, Marissa J Carter, Igal Kushnir, Alon Kushnir, Thomas E Serena
OBJECTIVE: This pilot study evaluates safety in terms of the occurrence of adverse events (AEs) as well as the efficacy in terms of complete wound healing rates of a blood clot product when applied to chronic neuropathic diabetic foot ulcers (DFUs). MATERIALS AND METHODS: Participants were chosen from patients with DFUs visiting the wound care clinic. Up to 10 mL of blood drawn from each participant was injected into the product's clotting tray. Within 12 minutes, the blood clot product was formed, applied to the single DFU of each participant, and covered with primary and secondary dressings...
April 20, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29707757/transcutaneous-oxygen-pressure-as-a-predictor-for-short-term-survival-in-patients-with-type-2-diabetes-and-foot-ulcers-a-comparison-with-ankle-brachial-index-and-toe-blood-pressure
#8
K Fagher, P Katzman, M Löndahl
AIMS: Ankle-brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO2 ), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO2 could be a marker for mortality in the high-risk population of DFU patients has not been evaluated before. The aim of this study was to evaluate the predictive value of TcPO2 in comparison with ABI and toe blood pressure (TBP) on 1-year mortality in type 2 diabetes patients with DFU...
April 30, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29688043/the-clinical-value-of-diffusion-weighted-magnetic-resonance-imaging-in-diabetic-foot-infection
#9
Mehmet Ali Eren, Ekrem Karakaş, Ayşe Nur Torun, Tevfik Sabuncu
BACKGROUND: Osteomyelitis is a common complication in the diabetic foot which can be concluded with amputation. The purpose of this study was to evaluate the role of diffusion-weighted MRI (DWI) in the diagnosis of osteomyelitis in the diabetic foot ulcer (DFU). METHODS: Thirty patients with type 2 diabetes mellitus having DFU were enrolled. DWI and conventional MRI were obtained. Apparent Diffusion Coefficient (ADC) measurements were made by transferring the images to the workstation...
April 24, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29683538/effectiveness-of-viable-cryopreserved-placental-membranes-for-management-of-diabetic-foot-ulcers-in-a-real-world-setting
#10
Katherine M Raspovic, Dane K Wukich, Daniel Q Naiman, Lawrence A Lavery, Robert S Kirsner, Paul J Kim, John S Steinberg, Christopher E Attinger, Alla Danilkovitch
In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% vs. 21% (p < 0.01). However, patients in RCTs are not representative of daily physician practice. Healthcare databases serve as a valuable tool to evaluate therapy effectiveness and to supplement evidence from RCTs. The objective of this study was to evaluate the effectiveness of vCPM for DFU management using Net Health's WoundExpert® electronic health records (EHR)...
April 23, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29675434/the-role-of-serum-procalcitonin-interleukin-6-and-fibrinogen-levels-in-differential-diagnosis-of-diabetic-foot-ulcer-infection
#11
Pınar Korkmaz, Havva Koçak, Kevser Onbaşı, Polat Biçici, Ahmet Özmen, Cemile Uyar, Duru Mıstanoğlu Özatağ
Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR). Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29651391/the-wound-healing-effects-of-herbal-cream-containing-oliveria-decumbens-and-pelargonium-graveolens-essential-oils-in-diabetic-foot-ulcer-model
#12
Mohaddese Mahboubi, Mohsen Taghizadeh, Tahereh Khamechian, Omid Reza Tamtaji, Rasoul Mokhtari, Sayyed Alireza Talaei
BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS: The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651102/exosomes-from-adipose-derived-stem-cells-overexpressing-nrf2-accelerate-cutaneous-wound-healing-by-promoting-vascularization-in-a-diabetic-foot-ulcer-rat-model
#13
Xue Li, Xiaoyun Xie, Weishuai Lian, Rongfeng Shi, Shilong Han, Haijun Zhang, Ligong Lu, Maoquan Li
Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. We also evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells (ADSCs) on stress-mediated senescence of EPCs induced by high glucose. Additionally, the effects of exosomes and Nrf2 overexpression in ADSCs were investigated in vitro and in vivo in a diabetic rat model...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29644145/publicly-reported-wound-healing-rates-the-fantasy-and-the-reality
#14
REVIEW
Caroline E Fife, Kristen A Eckert, Marissa J Carter
Significance: We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Recent Advances: Because no method has existed by which wounds could be stratified according to their likelihood of healing among real-world patients, practitioners have reported fantastically high healing rates. The USWR has developed several risk-stratified wound healing quality measures for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) as part of its Qualified Clinical Data Registry (QCDR)...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29622357/the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-independently-predicts-wound-healing-in-diabetic-foot-ulcers
#15
Caitlin W Hicks, Joseph K Canner, Nestoras Mathioudakis, Ronald Sherman, Mahmoud B Malas, James H Black, Christopher J Abularrage
OBJECTIVE: Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. METHODS: All patients presenting to our multidisciplinary DFU clinic from June 2012 to July 2017 were enrolled in a prospective database...
April 2, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29614308/relationship-between-plasma-angiogenic-growth-factors-and-diabetic-foot-ulcers
#16
Zongcun Chen, Shasha Fu, Zurong Wu, Jinyi Chen, Yalian Huang, Yi Wang, Maoxiong Fu
BACKGROUND: Angiogenic growth factors play an important role in wound healing. However, their associations with diabetic foot ulcers (DFUs) in humans have rarely been investigated. We examined the relationships between circulating concentrations of vascular endothelial growth factor (VEGF)-A and placenta growth factor (PlGF), and DFU risk. METHODS: We recruited 447 participants, including169 DFU patients, 182 diabetes patients without DFUs, and 96 diabetes-free individuals...
March 31, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29611155/managing-the-diabetic-foot-ulcer-how-best-practices-fit-the-real-2018-united-states
#17
Nicole Ilonzo, Munir Patel, John C Lantis
Diabetes Mellitus is a serious systemic illness that has an epidemic-like increasing prevalence in the United States, as well as the rest of the world. With the increasing number of people with diabetes comes the higher incidence of diabetes-related complications. One of these known complications, diabetic foot ulcers (DFU), has an estimated lifetime incidence of 15% in diabetics. Having a DFU increases the risk of infection, amputation, and even death, which is why prompt treatment and surveillance of such ulcers is imperative...
March 29, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29602761/prevalence-and-related-risk-factors-of-diabetic-foot-ulcer-in-ahvaz-south-west-of-iran
#18
Leila Yazdanpanah, Hajieh Shahbazian, Iraj Nazari, Hamid Reza Arti, Fatemeh Ahmadi, Seyed Ehsan Mohammadianinejad, Bahman Cheraghian, Seyed Mahmoud Latifi
AIMS: The aim of this study was to evaluate the prevalence of diabetic foot ulcer and its related risk factors. MATERIALS AND METHODS: In this descriptive cross-sectional study, 605 patients with diabetes were evaluated in July 2014. A checklist was used to obtain demographic data, diabetes related data, past medical history, and physical examination data. RESULTS: The prevalence of diabetic foot ulcer was 6.4% (95% CI: 4.64-8.73). Seventeen cases of them were female (4...
March 22, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29566422/clinical-prospective-study-on-the-use-of-subcutaneous-carboxytherapy-in-the-treatment-of-diabetic-foot-ulcer
#19
Lynda Khiat, Gustavo H Leibaschoff
Diabetic footfoot ulcer (DFU) is a serious complication of diabetes mellitus, and possibly the major morbidity of the diabetic foot. It is the most common foot injury in diabetic patients and can lead to lower-extremity amputation. Management of DFU requires a systematic knowledge of the major risk factors for amputation, frequent routine evaluation, scrupulous preventive maintenance, and correction of peripheral arterial insufficiency. Carboxytherapy refers to the subcutaneous injection of CO2 to improve the microcirculation and promote wound-healing by stimulating the microcirculation...
March 22, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29563821/decreased-health-related-quality-of-life-in-patients-with-diabetic-foot-problems
#20
Jin Sothornwit, Gulapar Srisawasdi, Atchara Suwannakin, Apiradee Sriwijitkamol
Purpose: The aim of this study was to investigate health-related quality of life (HRQoL) in patients with diabetic foot problems and compare the HRQoL between diabetic patients with: 1) diabetic foot problems (DF), including diabetic foot ulcer (DFU) or amputation (AMPU); 2) other diabetic complications (COM), such as diabetic retinopathy (DR), end-stage renal disease (ESRD), or coronary artery disease (CAD); and 3) no diabetic complication (CON). Patients and methods: A total of 254 diabetic patients were studied in a cross-sectional setting...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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