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D-amino acid oxidase

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https://www.readbyqxmd.com/read/29335871/validation-of-tautomeric-and-protomeric-binding-modes-by-free-energy-calculations-a-case-study-for-the-structure-based-optimization-of-d-amino-acid-oxidase-inhibitors
#1
Zoltán Orgován, György G Ferenczy, Thomas Steinbrecher, Bence Szilágyi, Dávid Bajusz, György M Keserű
Optimization of fragment size D-amino acid oxidase (DAAO) inhibitors was investigated using a combination of computational and experimental methods. Retrospective free energy perturbation (FEP) calculations were performed for benzo[d]isoxazole derivatives, a series of known inhibitors with two potential binding modes derived from X-ray structures of other DAAO inhibitors. The good agreement between experimental and computed binding free energies in only one of the hypothesized binding modes strongly support this bioactive conformation...
January 15, 2018: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29274788/human-d-amino-acid-oxidase-the-inactive-g183r-variant
#2
Giulia Murtas, Laura Caldinelli, Pamela Cappelletti, Silvia Sacchi, Loredano Pollegioni
In the brain, the enzyme d-amino acid oxidase (DAAO) catalyzes the oxidative deamination of d-serine, a main positive modulator of the N-methyl-d-aspartate subtype of glutamate receptors (NMDAR). Dysregulation in d-serine signaling is implicated in the NMDAR dysfunctions observed in various brain diseases, such as amyotrophic lateral sclerosis, Alzheimer's disease, schizophrenia. A strain of ddY mice lacking DAAO activity due to the G181R substitution (DAAOG181R mice) and exhibiting increased d-serine concentration as compared to wild-type mice shows altered pain response, improved adaptative learning and cognitive functions, and larger hippocampal long-term potentiation...
December 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29274353/oxidative-stress-in-the-amygdala-contributes-to-neuropathic-pain
#3
B Sagalajev, H Wei, Z Chen, I Albayrak, A Koivisto, A Pertovaara
Earlier studies indicate that the central nucleus of the amygdala (CeA) contributes to neuropathic pain. Here we studied whether amygdaloid administration of antioxidants or antagonists of TRPA1 that is among ion channels activated by oxidative stress attenuates nociceptive or affective pain in experimental neuropathy, and whether this effect involves amygdaloid astrocytes or descending serotonergic pathways acting on the spinal 5-HT1A receptor. The experiments were performed in rats with spared nerve injury (SNI)...
December 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/29273565/identification-of-d-amino-acid-oxidase-and-propiverine-interaction-partners-and-their-potential-role-in-the-propiverine-mediated-nephropathy
#4
Marcia Y Maier, Lisanne Luks, Oliver Baudendistel, Valentin Wittmann, Daniel R Dietrich
Propiverine, a frequently-prescribed pharmaceutical for the treatment of symptoms associated with overactive bladder syndrome, provoked massive intranuclear and cytosolic protein inclusions in rat proximal tubule epithelium, primarily consisting of the peroxisomal targeting signal 1 (PTS1) containing protein d-amino acid oxidase (DAAO). As this type of nephropathy was also observed for other drugs, the aim was to determine whether propiverine interferes with trafficking and/or import of peroxisomal proteins...
December 19, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29250527/competitive-inhibitors-unveil-structure-function-relationships-in-human-d-amino-acid-oxidase
#5
REVIEW
Gianluca Molla
D-amino acid oxidase (DAAO) catalyzes the oxidative deamination of several neutral D-amino acids and is the enzyme mainly responsible (together with serine racemase) for degrading D-serine (D-Ser) in the central nervous system of mammals. This D-amino acid, which binds the coagonist site of the N-methyl-D-aspartate receptor, is thus a key neuromodulator of glutamatergic neurotransmission. Altered D-Ser metabolism results in several pathological conditions (e.g., amylotrophic lateral sclerosis or schizophrenia, SZ) for which effective "broad spectrum" pharmaceutical drugs are not yet available...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29235217/heterologous-protein-expression-in-pichia-pastoris-latest-research-progress-and-applications
#6
REVIEW
Veeresh Juturu, Jin Chuan Wu
Pichia pastoris is a well-known platform strain for heterologous protein expression. Over the past five years, different strategies to improve the efficiency of recombinant protein expression by this yeast strain have been developed; these include a patent-free protein expression kit, construction of the P. pastoris CBS7435Ku70 platform strain with its high efficiency in site-specific recombination of plasmid DNA into the genomic DNA, the design of synthetic promoters and their variants by combining different core promoters with multiple putative transcription factors, the generation of mutant GAP promoter variants with various promoter strengths, codon optimization, engineering the α-factor signal sequence by replacing the native glutamic acid at the Kex2 cleavage site with the other 19 natural amino acids and the addition of mammalian signal sequence to the yeast signal sequence, and the co-expression of single chaperones, multiple chaperones or helper proteins that aid in recombinant protein folding...
December 13, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29222016/the-toxin-bjussulaao-ii-induces-oxidative-stress-and-dna-damage-upregulates-the-inflammatory-cytokine-genes-tnf-and-il6-and-downregulates-the-apoptotic-related-genes-bax-bcl2-and-rela-in-human-caco-2-cells
#7
A R T Machado, A F Aissa, D L Ribeiro, L C Hernandes, C S Machado, M L P Bianchi, S V Sampaio, L M G Antunes
Colorectal carcinoma is one of the most common cancers in adults. As chemotherapy, the first-choice treatment for colorectal carcinoma, is often infeasible due to acquired tumor resistance and several adverse effects. It is important to discover and explore new molecules with better therapeutic action. Snake venom toxins have shown promising results with high cytotoxicity against tumor cells, but their mechanisms of action remain unclear. Here we examined how BjussuLAAO-II, an L-amino acid oxidase isolated from Bothrops jararacussu snake venom, exerts cytotoxicity towards colorectal adenocarcinoma human cells (Caco-2) and in human umbilical vein endothelial cell line (HUVEC)...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29215951/regulation-of-aqueous-humor-dynamics-by-hydrogen-sulfide-potential-role-in-glaucoma-pharmacotherapy
#8
Sunny E Ohia, Jenaye Robinson, Leah Mitchell, Kalu K Ngele, Segewkal Heruye, Catherine A Opere, Ya Fatou Njie-Mbye
Hydrogen sulfide (H2S) is a gaseous transmitter with well-known biological actions in a wide variety of tissues and organs. The potential involvement of this gas in physiological and pathological processes in the eye has led to several in vitro, ex vivo, and in vivo studies to understand its pharmacological role in some mammalian species. Evidence from literature demonstrates that 4 enzymes responsible for the biosynthesis of this gas (cystathionine β-synthase, CBS; cystathionine γ-lyase, CSE; 3-mercaptopyruvate sulfurtransferase, 3MST; and d-amino acid oxidase) are present in the cornea, iris, ciliary body, lens, and retina...
December 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29209893/immobilization-of-enzymes-using-a-multifunctional-fusion-polypeptide
#9
Dan Liu, Kun Du, Wei Feng
OBJECTIVE: To design a fusion polypeptide combining functions of self-assembly and purification for immobilizing enzymes. RESULTS: A collagen-like polypeptide (CLP) was fused to an elastin-like polypeptide (ELP) through genetic engineering. CLP-ELP was separately fused to superoxide dismutase (SOD) and D-amino acid oxidase (DAAO). The recombinant enzymes were purified with using reversible phase transition. The interfering effect of H2O2 on the secondary structures of the recombinant enzymes was significantly reduced...
December 5, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29197158/design-synthesis-and-molecular-docking-studies-of-n-9-10-anthraquinone-2-carbonyl-amino-acid-derivatives-as-xanthine-oxidase-inhibitors
#10
Ting-Jian Zhang, Song-Ye Li, Wei-Yan Yuan, Yi Zhang, Fan-Hao Meng
A series of N-(9,10-anthraquinone-2-carbonyl)amino acid derivatives (1a-j) was designed and synthesized as novel XO inhibitors. Among them, the L/D-phenylalanine derivatives (1d and 1i) and the L/D-tryptophan derivatives (1e and 1j) were effective with micromolar level potency. In particular, the L-phenylalanine derivative 1d (IC50 = 3.0 μM) and the D-phenylalanine derivative 1i (IC50 = 2.9 μM) presented the highest potency, and were both more potent than the positive control allopurinol (IC50 = 8.1 μM)...
December 1, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29194436/characterisation-of-the-pathogenic-effects-of-the-in-vivo-expression-of-an-als-linked-mutation-in-d-amino-acid-oxidase-phenotype-and-loss-of-spinal-cord-motor-neurons
#11
Nazanin Rahmani Kondori, Praveen Paul, Jacqueline P Robbins, Ke Liu, John C W Hildyard, Dominic J Wells, Jacqueline S de Belleroche
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances in understanding ALS disease mechanisms has come from the identification of pathogenic mutations in dominantly inherited familial ALS (FALS). We previously reported a coding mutation in D-amino acid oxidase (DAOR199W) associated with FALS. DAO metabolises D-serine, an essential co-agonist at the N-Methyl-D-aspartic acid glutamate receptor subtype (NMDAR)...
2017: PloS One
https://www.readbyqxmd.com/read/29180043/isolation-and-pharmacological-characterization-of-a-new-cytotoxic-l-amino-acid-oxidase-from-bungarus-multicinctus-snake-venom
#12
Wuguang Lu, Lingling Hu, Jie Yang, Xiaoyan Sun, Huaijiang Yan, Jinman Liu, Jiao Chen, Xiaolan Cheng, Qian Zhou, Ye Yu, Ji-Fu Wei, Peng Cao
ETHNOPHARMACOLOGICAL RELEVANCE: Bungarus multicinctus snake belongs to Elapidae family and is widely distributed in southern China. It is widely used in traditional Chinese medicine with the effect of dispelling wind and removing obstruction in the meridians. Moreover, it is also as a chief ingredient of many polyherbal formulations for the treatment of cancer. AIM OF THE STUDY: To evaluate the antitumor activity of Bungarus multicinctus snake venom components and isolate, characterize the most effective anti-tumor component of Bungarus multicinctus snake venom...
November 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29154867/monoamine-oxidases-inhibitors-from-colvillea-racemosa-isolation-biological-evaluation-and-computational-study
#13
Enas I Mohamed, Mohamed A Zaki, Narayan D Chaurasiya, Asmaa I Owis, Sameh AbouZid, Yan-Hong Wang, Bharathi Avula, Ahmed A Seida, Babu L Tekwani, Samir A Ross
Bioassay-guided fractionation and chemical investigation of Colvillea racemosa stems led to identification of two new α, β-dihydroxydihydrochalcones, colveol A (1) and colveol B (2) along with fifteen known compounds. The structures were elucidated via interpretation of spectroscopic data. The absolute configurations of the dihydrochalcones 1 and 2 were assigned by a combination of chemical modification and electronic circular dichroism data. The isolated compounds were evaluated for their inhibition activity toward recombinant human monoamine oxidases (rhMAO-A and -B)...
November 14, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29146915/transcriptional-profiling-provides-new-insights-into-the-role-of-nitric-oxide-in-enhancing-ganoderma-oregonense-resistance-to-heat-stress
#14
Cheng Chen, Qiang Li, Qiangfeng Wang, Daihua Lu, Hong Zhang, Jian Wang, Rongtao Fu
Ganoderma is well known for its use in traditional Chinese medicine and is widely cultivated in China, Korea, and Japan. Increased temperatures associated with global warming are negatively influencing the growth and development of Ganoderma. Nitric oxide is reported to play an important role in alleviating fungal heat stress (HS). However, the transcriptional profiling of Ganoderma oregonense in response to HS, as well as the transcriptional response regulated by NO to cope with HS has not been reported. We used RNA-Seq technology to generate large-scale transcriptome data from G...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114206/controversial-effects-of-d-amino-acid-oxidase-activator-daoa-g72-on-d-amino-acid-oxidase-dao-activity-in-human-neuronal-astrocyte-and-kidney-cell-lines-the-n-methyl-d-aspartate-nmda-receptor-hypofunction-point-of-view
#15
Vinita Jagannath, Zacharias Faidon Brotzakis, Michele Parrinello, Susanne Walitza, Edna Grünblatt
Dysfunction of D-amino acid oxidase (DAO) and DAO activator (DAOA)/G72 genes have been linked to neuropsychiatric disorders. The glutamate hypothesis of schizophrenia has proposed that increased DAO activity leads to decreased D-serine, which subsequently may lead to N-methyl-D-aspartate (NMDA) receptor hypofunction. It has been shown that DAOA binds to DAO and increases its activity. However, there are also studies showing DAOA decreases DAO activity. Thus, the effect of DAOA on DAO is controversial. We aimed to understand the effect of DAOA on DAO activity in neuron-like (SH-SY5Y), astrocyte-like (1321N1) and kidney-like (HEK293) human cell lines...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29111971/rheinheimera-salexigens-sp-nov-isolated-from-a-fishing-hook-and-emended-description-of-the-genus-rheinheimera
#16
Kazukuni Hayashi, Hans-Jürgen Busse, Jan Golke, James Anderson, Xuehua Wan, Shaobin Hou, Patrick S G Chain, Rebecca D Prescott, Stuart P Donachie
A Gram-negative, rod-shaped bacterium, designated KH87(T), was isolated from a fishing hook that had been baited and suspended in seawater off O'ahu, Hawai'i. Based on a comparison of 1524 nt of the 16S rRNA gene sequence of strain KH87(T), its nearest neighbours were the GammaproteobacteriaRheinheimera nanhaiensis E407-8(T) (96.2 % identity), Rheinheimera chironomi K19414(T) (96.0 %), Rheinheimera pacifica KMM 1406(T) (95.8 %), Rheinheimera muenzenbergensis E49(T) (95.7 %), Alishewanella solinquinati KMK6(T) (94...
November 7, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29100974/the-interaction-of-nos1ap-disc1-daoa-and-gsk3b-confers-susceptibility-of-early-onset-schizophrenia-in-chinese-han-population
#17
Guoqin Hu, Chengqing Yang, Lei Zhao, Yong Fan, Qinyu Lv, Jing Zhao, Minghuan Zhu, Xiangqing Guo, Chenxi Bao, Ahong Xu, Yong Jie, Yaqing Jiang, Chen Zhang, Shunying Yu, Zuowei Wang, Zezhi Li, Zhenghui Yi
Although many major breakthrough had identificated potential susceptibility genes for schizophrenia, the aetiology of schizophrenia is still unknown. In the present study, we focused on the N-methyl-Daspartate receptors related genes nitric oxide synthase 1 adaptor gene (NOS1AP), disrupted in schizophrenia 1 gene (DISC1), d-amino acid oxidase activator gene (DAOA), and glycogen synthase kinase 3-beta gene (GSK3B). A family-based genetic association study (459 Han Chinese subjects in 153 nuclear families) using 3 single nucleotide polymorphisms in NOS1AP, 2 in DISC1, 1 in DAOA and 1 in GSK3B was conducted...
October 31, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29093468/blood-levels-of-d-amino-acid-oxidase-vs-d-amino-acids-in-reflecting-cognitive-aging
#18
Chieh-Hsin Lin, Hui-Ting Yang, Chih-Chiang Chiu, Hsien-Yuan Lane
Feasible peripheral biomarker for Alzheimer's disease (AD) is lacking. Dysregulation of N-methyl-D-aspartate (NMDA) receptor is implicated in the pathogenesis of AD. D-amino acid oxidase (DAO) and amino acids can regulate the NMDA receptor function. This study aimed to examine whether peripheral DAO and amino acids levels are characteristic of age-related cognitive decline. We enrolled 397 individuals (including amnestic mild cognitive impairment (MCI), mild AD, moderate to severe AD, and healthy elderly). DAO levels in the serum were measured using ELISA...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067380/d-serine-enzymatic-metabolism-induced-formation-of-a-powder-remoldable-paam-cs-hydrogel
#19
Shuang Zhang, Qingcong Wei, Yinghui Shang, Qi Zhang, Qigang Wang
The metabolism of d-serine by d-amino acid oxidase was developed to induce radical polymerization and formation of a powder-remoldable PAAM-CS hydrogel.
October 25, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28989979/haplotype-based-association-analysis-of-general-cognitive-ability-in-generation-scotland-the-english-longitudinal-study-of-ageing-and-uk-biobank
#20
David M Howard, Mark J Adams, Toni-Kim Clarke, Eleanor M Wigmore, Yanni Zeng, Saskia P Hagenaars, Donald M Lyall, Pippa A Thomson, Kathryn L Evans, David J Porteous, Reka Nagy, Caroline Hayward, Chris S Haley, Blair H Smith, Alison D Murray, G David Batty, Ian J Deary, Andrew M McIntosh
BACKGROUND: Cognitive ability is a heritable trait with a polygenic architecture, for which several associated variants have been identified using genotype-based and candidate gene approaches. Haplotype-based analyses are a complementary technique that take phased genotype data into account, and potentially provide greater statistical power to detect lower frequency variants. METHODS: In the present analysis, three cohort studies (n total = 48,002) were utilised: Generation Scotland: Scottish Family Health Study (GS:SFHS), the English Longitudinal Study of Ageing (ELSA), and the UK Biobank...
2017: Wellcome Open Research
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