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Longterm Outcome

Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the absolute number of capillaries, observable in the first row, in 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy with the endothelin receptor antagonist bosentan (BOSE) and the synthetic analog of prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated with clinical outcomes. METHODS: Thirty patients with SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos) were recruited in the clinic...
October 1, 2016: Journal of Rheumatology
Kristine E Ensrud, Stephanie L Harrison, Jane A Cauley, Lisa Langsetmo, John T Schousboe, Deborah M Kado, Margaret L Gourlay, Jennifer G Lyons, Lisa Fredman, Nicolas Napoli, Carolyn J Crandall, Cora E Lewis, Eric S Orwoll, Marcia L Stefanick, Peggy M Cawthon
To determine the association of weight loss with risk of clinical fractures at the hip, spine and pelvis (central body fractures [CBF]) in older men with and without accounting for the competing risk of mortality, we used data from 4,523 men (mean age 77.5 years). Weight change between baseline and follow-up (mean 4.5 years between examinations) was categorized as moderate loss (loss ≥10%), mild loss (loss 5% to <10%), stable (<5% change) or gain (gain ≥5%). Participants were contacted every 4 months after the follow-up examination to ascertain vital status (deaths verified by death certificates) and ask about fractures (confirmed by radiographic reports)...
October 14, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Alexandros A Polymeris, Christopher Traenka, Lisa Hert, David J Seiffge, Nils Peters, Gian Marco De Marchis, Leo H Bonati, Philippe A Lyrer, Stefan T Engelter
BACKGROUND: Vitamin K antagonists (VKAs) and non-VKA oral anticoagulants (NOACs) are beneficial in patients with stroke and atrial fibrillation (AF). However, little is known about frequency and determinants of adherence to NOACs/VKAs in clinical practice. METHODS: This is a single-center explorative study from the Novel Oral Anticoagulants in Stroke Patients (NOACISP)-LONGTERM registry. We included consecutive AF-stroke patients treated with NOACs/VKAs and followed up for 3-24 months...
October 6, 2016: European Neurology
P Msellati, A Touré, M S Sow, K Cécé, B Taverne, A Desclaux, M Barry, J-F Etard, E Delaporte
Ebola virus disease (EVD) epidemic that spread in West Africa from the end of 2013 to early 2016 has reached more people than all past epidemics. Beyond care management of acute phase ill patients and measures for the control of the epidemic, the outcome of Ebola survivors became an important question as their number increased and raised new issues. A multidisciplinary prospective cohort of survivors in Guinea has been launched by IRD UMI 233 and Donka National Hospital, Conakry, Guinea, to assess the longterm clinical, psychological, sociological, immunological, and viral outcomes potentially related to EVD...
October 3, 2016: Bulletin de la Société de Pathologie Exotique
Liesjet Van Dokkum, Emmanuelle Le Bars, Denis Mottet, Alain Bonafe, Nicolas Menjot de Champfleur, Isabelle Laffont
OBJECTIVE: After stroke, the less affected upper-limb shows slight but substantial and longterm motor deficits [1]. Kinematically, this is reflected by an increased segmentation of movements. Here, we aim to define how these changes in behavior are accompanied by changes in brain activation. MATERIAL/PATIENTS AND METHODS: Twenty-one sub-acute post-stroke patients with a first-ever unilateral ischemic stroke of the middle cerebral artery participated in this study twice: within the first 6 weeks post-stroke and after 6 weeks of rehabilitation...
September 2016: Annals of Physical and Rehabilitation Medicine
Iswanto Sucandy, Susannah Cheek, Benjamin J Golas, Allan Tsung, David A Geller, James W Marsh
BACKGROUND: We aim to investigate long-term survival outcomes in patients undergoing radiofrequency ablation (RFA), based on our longitudinal 5 and 10 year follow-up data. METHODS: All patients who underwent RFA for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CLM) between 1999 and 2010. RESULTS: 320 patients were included with oncologic diagnoses of HCC in 122 (38.1%) and CLM in 198 (61.9%). The majority of patients had a single tumor ablation (71% RFA 1 lesion)...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Anita Mamtani, Monica Morrow
Breast-conserving therapy (BCT) and mastectomy result in equivalent longterm survival. Locoregional recurrence rates after BCT have decreased over time and are now similar to those after mastectomy. Contralateral breast cancer rates are declining as well owing to the widespread use of adjuvant systemic therapy. Despite these improved outcomes, increasing rates of bilateral mastectomy for unilateral cancer have been observed in the United States. Medical indications for mastectomy are well defined and present in a minority of patients, and women at increased risk for contralateral cancer are a small proportion of the breast cancer population...
August 26, 2016: Annual Review of Medicine
Michał Karczewski, Sebastian Woźniak, Radomir Skowronek, Marian Burysz, Marcin Fischer, Lech Anisimowicz, Marcin Demkow, Marek Konka, Wojciech Ogorzeja
AIM: To present the results of treatment and evaluate 6 months of follow-up in a group of patients with non-valvular atrial fibrillation, who underwent the procedure of percutaneous left atrial appendage occlusion (PLAAO). MATERIAL AND METHODS: Percutaneous left atrial appendage occlusion was performed in 34 patients with non-valvular atrial fibrillation and contraindications for oral anticoagulation therapy. The risk of thromboembolic and bleeding complications was determined based on the CHA2DS2VASc and HAS-BLED scales...
June 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
Michael R Charlton
Longterm outcomes in liver transplant recipients has undergone a dramatic transition, driven by three factors: i. efficacy of immunosuppression, ii. declining impact of viral hepatitis with surge in obesity and alcohol -related liver diseases, and iii. shortage of donor organs with subsequent recipient frailty at the time of transplantation. Graft function in general and rejection specifically are uncommon determinants of longterm outcomes. The most common causes of mortality in liver transplant recipients are cardiovascular disease, renal failure and malignancies, all of which are contributed to by immunosuppression and the metabolic syndrome...
August 12, 2016: Liver Transplantation
T Otaševič, P Vališ, M Rouchal, J Novák, M Repko, A Šprláková, M Krbec
UNLABELLED: PUPOSE OF THE STUDY The treatment of osteochondral lesions of weight-bearing joints remains a serious therapeutic challenge, largely due to the minimal ability of articular hyaline cartilage to regenerate. The authors present the long-term clinical and MRI results of treating deep chondral and osteochondral defects of the ankle joint by the method of implantation of autologous chondrocytes in the form of a solid chondrograft. MATERIAL AND METHODS The method of solid chondrograft implantation in the ankle joint was used in our Department from the year 2003...
2016: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Nasir T Wabe, Michael J Sorich, Mihir D Wechalekar, Leslie G Cleland, Leah McWilliams, Anita T Y Lee, Llewellyn D Spargo, Robert G Metcalf, Cindy Hall, Susanna M Proudman, Michael D Wiese
OBJECTIVE: To investigate the association between adherence to treat-to-target (T2T) protocol and disease activity, functional outcomes, and radiographic outcomes in early rheumatoid arthritis (RA). METHODS: Data from a longitudinal cohort of patients with early RA were used. Adherence was determined at each followup visit over 3 years according to predefined criteria. The primary endpoint was remission according to Disease Activity Score in 28 joints (DAS28) and Simplified Disease Activity Index (SDAI) criteria...
September 2016: Journal of Rheumatology
Maciej Wiatr, Renata Gawlik, Aleksandra Boroń, Agnieszka Wiatr, Jacek Składzień
BACKGROUND: Otosclerosis is the most common cause of condactive hearing loss between 15 and 50 years old. The most common symptoms are hearinglosss and tinnitus. Surgery is currently the preferred treatment method. AIM: The aim of our study was to analyze the outcomes of patients treated surgically due to otosclerosis in terms of the observed changes in pure tone audiometry and speech audiometry Material and methods: We observated 300 patients operated on middle ear for the fist time in the Department of Otolarygology at the Jagiellonian University of Cracow from 2010 to 2011...
June 30, 2016: Otolaryngologia Polska. the Polish Otolaryngology
J Zimmer, C Tomuschat, P Puri
INTRODUCTION: Several operative techniques have been developed for the treatment of Hirschsprung's disease (HD) in the past decades. Since one-stage transanal pull-through (TAPT) was first performed in 1998, multiple studies have shown favourable short-and midterm results compared to other techniques with shorter operation length, shorter hospital stay and lower complication rates. The aim of this meta-analysis was to determine the longterm results following TAPT for HD. METHODS: A systematic literature search for relevant articles was performed in four databases using the following terms "Hirschsprung/Hirschsprung's disease", "aganglionosis", "transanal", "pullthrough/pull-through", "longterm/long-term" "results", "follow-up" and "outcome"...
August 2016: Pediatric Surgery International
Maciej Wiatr, Renata Gawlik, Aleksandra Boroń, Agnieszka Wiatr, Jacek Składzień
BACKGROUND: Otosclerosis is the most common cause of condactive hearing loss between 15 and 50 years old. The most common symptoms are hearinglosss and tinnitus. Surgery is currently the preferred treatment method. AIM: The aim of our study was to analyze the outcomes of patients treated surgically due to otosclerosis in terms of the observed changes in pure tone audiometry and speech audiometryMaterial and methods:We observated 300 patients operated on middle ear for the fist time in the Department of Otolarygology at the Jagiellonian University of Cracow from 2010 to 2011...
2016: Otolaryngologia Polska. the Polish Otolaryngology
Alexis Ghanem, Sandeep Pasumarthy, Vinisha Ranna, Sergio Varela Kellesarian, Tariq Abduljabbar, Fahim Vohra, Hans Malmstrom
BACKGROUND: The aim of the present study was to review the pertinent literature on the effects of mechanical curettage (MC) with and without adjunct photodynamic therapy (PDT) for the management of peri-implantitis. METHODS: The addressed focused question was "Is PDT effective in the treatment of peri-implantitis?" A search without language or time restrictions up to March 2016 was conducted using various key words. The exclusion criteria included; review papers, in vitro Studies, case reports, commentaries, interviews, and letters to the editors...
September 2016: Photodiagnosis and Photodynamic Therapy
Hao Wang, Zhitao Gu, Jianyong Ding, Lijie Tan, Jianhua Fu, Yi Shen, Yucheng Wei, Peng Zhang, Yongtao Han, Chun Chen, Renquan Zhang, Yin Li, Ke-Neng Chen, Hezhong Chen, Yongyu Liu, Youbing Cui, Yun Wang, Liewen Pang, Zhentao Yu, Xinming Zhou, Yangchun Liu, Yuan Liu, Wentao Fang
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) theoretically offers advantages over open thymectomy for clinically early-stage (Masaoka-Koga stage I and II) thymic malignancies. However, longterm outcomes have not been well studied. We compared the postoperative outcomes and survival from a cohort study based on the database of the Chinese Alliance for Research in Thymomas (ChART). METHODS: Between 1994 and 2012, data of 1,117 patients having surgery for clinically early-stage (Masaoka-Koga stage I and II) tumors were enrolled for the study...
July 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Ewout S Veltman, Jelle J Halma, Arthur de Gast
INTRODUCTION: The objective of the present study was to review the current data on the long-term outcomes of posterior malleolar fractures, with special emphasis on the role of the type of treatment, surgical approach, and reduction and internal fixation. METHODS: The search was limited to skeletally mature patients. Major databases were searched from 1978 to 2014 to identify studies relating to functional outcome, subjective outcome, and radiographic evaluation at least 2 years after either surgical or conservative treatment of posterior malleolar fractures...
June 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
K Lenz, R Buder, G Lohr, P Piringer, M Voglmayr
Renal failure is a serious complication in patients with advanced cirrhosis. It occurs in about 20 % of patients hospitalized with cirrhosis. In about 70 % it is caused by prerenal failure, and in 30 % it is due to intrarenal causes. In about 70 % of patients with rperenal failure, renal function can be restored with fluid replacement, but the remaining 30 % are unresponsive to volume expansion. Minor increase in serum creatinine have been shown to be clinically relevant and can adversely affect survival...
June 2016: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Chanchal Kumar, Inusha Panigrahi, Abhishek Somasekhara Aradhya, Babu Lal Meena, Niranjan Khandelwal
BACKGROUND: The advent of bisphosphonates (BPs) has revolutionised the outcome of Osteogenesis imperfecta (OI) in the last few years. There has always been a safety concern regarding zoledronate's use due to a paucity of studies. The current study is a retrospective evaluation of children with OI on the short- and long-term side effects of zoledronate and the frequency of fractures per year after the drug was introduced. METHODS: A total of 26 children diagnosed with OI, with a median age of 84 (45-121) months were enrolled in the study...
August 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Florian Seemüller, Michael Obermeier, Rebecca Schennach, Michael Bauer, Mazda Adli, Peter Brieger, Gerd Laux, Michael Riedel, Peter Falkai, Hans-Jürgen Möller
BACKGROUND: Remission is a common outcome of short-term trials and the main goal of acute and longterm treatment. The longitudinal stability of remission has rarely been investigated under naturalistic treatment conditions. METHODS: Naturalistic multisite follow-up study. Three-year symptomatic long-term outcome of initially hospitalized tertiary care patients (N = 784) with major depressive episodes. Remission rates as well as the switch rates between remission and non-remission were reported...
2016: BMC Psychiatry
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