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https://www.readbyqxmd.com/read/29770201/recent-advances-in-managing-septal-defects-ventricular-septal-defects-and-atrioventricular-septal-defects
#1
REVIEW
P Syamasundar Rao, Andrea D Harris
This review discusses the management of ventricular septal defects (VSDs) and atrioventricular septal defects (AVSDs). There are several types of VSDs: perimembranous, supracristal, atrioventricular septal, and muscular. The indications for closure are moderate to large VSDs with enlarged left atrium and left ventricle or elevated pulmonary artery pressure (or both) and a pulmonary-to-systemic flow ratio greater than 2:1. Surgical closure is recommended for large perimembranous VSDs, supracristal VSDs, and VSDs with aortic valve prolapse...
2018: F1000Research
https://www.readbyqxmd.com/read/29764557/-development-and-application-of-disposable-constant-volume-and-negative-pressure-drainage-device
#2
Dongzhi Liu
The common negative pressure drainage bottle used in the vacuum sealing drainage (VSD) cannot quantitative and automatically cut off. Excessive drainage damages the negative pressure source, causes drainage interruption, so once drainage was continuously performed, medical staff need to closely observe drainage bottle calibration. It was also important to known whether there was a large amount of fresh blood sucked out during continuous drainage because it could lose too much blood. To solve these two problems, we designed a kind of negative pressure drainage device, which volume was constant, with the function of automatic cutting off continuous drainage...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29762087/genomics-and-epigenomics-of-congenital-heart-defects-expert-review-and-lessons-learned-in-africa
#3
Nicholas Ekow Thomford, Kevin Dzobo, Nana Akyaa Yao, Emile Chimusa, Jonathan Evans, Emmanuel Okai, Paul Kruszka, Maximilian Muenke, Gordon Awandare, Ambroise Wonkam, Collet Dandara
Congenital heart defects (CHD) are structural malformations found at birth with a prevalence of 1%. The clinical trajectory of CHD is highly variable and thus in need of robust diagnostics and therapeutics. Major surgical interventions are often required for most CHDs. In Africa, despite advances in life sciences infrastructure and improving education of medical scholars, the limited clinical data suggest that CHD detection and correction are still not at par with the rest of the world. But the toll and genetics of CHDs in Africa has seldom been systematically investigated...
May 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29753092/sex-differences-for-major-congenital-heart-defects-in-down-syndrome-a-population-based-study
#4
Michele Santoro, Alessio Coi, Isabella Spadoni, Fabrizio Bianchi, Anna Pierini
BACKGROUND: Down syndrome (DS) is the most common autosomal chromosomal anomaly in liveborn infants. About 40% of infants with DS have a major congenital heart defect (CHD). Among them, atrioventricular septal defects (AVSD), atrial septal defects (ASD), ventricular septal defect (VSD) and Tetralogy of Fallot (ToF) are the most common. The aim of this study was to estimate the sex difference in the occurrence of CHD in infants with DS comparing it with non-DS infants. METHOD: Live birth cases of DS diagnosed by the first year of life were extracted from the Registry of Congenital Anomalies of Tuscany (2003-2015 period)...
May 9, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29744658/catheter-mri-and-ct-imaging-in-newborns-with-pulmonary-atresia-with-ventricular-septal-defect-and-aortopulmonary-collaterals-quantifying-the-risks-of-radiation-dose-and-anaesthetic-time
#5
David F A Lloyd, Sebastian Goreczny, Conal Austin, Tarique Hussain, Shakeel A Qureshi, Eric Rosenthal, Thomas Krasemann
A comprehensive understanding of the native pulmonary blood supply is crucial in newborns with pulmonary atresia with ventricular septal defect and aortopulmonary collaterals (PA/VSD/MAPCA). We sought to describe the accuracy in terms of identifying native pulmonary arteries, radiation dose and anaesthetic time associated with multi-modality imaging in these patients, prior to their first therapeutic intervention. Furthermore, we wanted to evaluate the cumulative radiations dose and anaesthetic time over the study period...
May 9, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29744095/postinfarction-ventricular-septal-defect-on-catheterization-table-challenging-and-unique-occurrence-at-a-community-based-hospital
#6
Ahsan Wahab, Hafiz Khan, Mahin Khan, Hameem Changezi, Susan Smith
Ventricular septal defect (VSD), one of the major mechanical complications of myocardial infarction, portends a severe threat to life and hence demands a high degree of suspicion, appropriate investigations, and emergent repair, particularly in cases of cardiogenic shock. Although the development of VSD in extensive or anterior infarction is not unexpected, its occurrence during cardiac catheterization frames a unique, challenging experience and creates a learning opportunity. We present a patient who developed postinfarction VSD during cardiac catheterization...
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29709363/staged-ventricular-recruitment-in-patients-with-borderline-ventricles-and-large-ventricular-septal-defects
#7
Olubunmi O Oladunjoye, Breanna Piekarski, Puja Banka, Gerald Marx, Roger E Breitbart, Pedro J Del Nido, Sitaram M Emani
OBJECTIVES: Patients with borderline ventricles and ventricular septal defects (VSDs) who have previously undergone single ventricle palliation might be candidates for staged ventricular recruitment with the ultimate goal of biventricular conversion. This study aimed to determine the effect of atrial septal defect (ASD) restriction without VSD closure on ventricular growth in patients with borderline right or left ventricles and VSDs. METHODS: Patients with borderline ventricles and VSD who underwent a staged ventricular recruitment procedure with strategies to increase blood flow through hypoplastic ventricle via ASD restriction without VSD closure after single ventricle palliation were retrospectively reviewed...
April 4, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29707567/hotair-is-a-potential-novel-biomarker-in-patients-with-congenital-heart-diseases
#8
Yu Jiang, Hongdan Mo, Jing Luo, Suhong Zhao, Shuang Liang, Maomao Zhang, Jie Yuan
Objective: To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods: qRT-PCR was used to detect the expression of HOTAIR in right atrial appendage tissues of 16 patients with CHDs and 14 patients with rheumatic valvular heart diseases (RVHDs), as well as in plasma of 36 normal people and 90 patients with CHDs including 36 cases of ASD, 23 cases of VSD, and 31 cases of PDA...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29695412/dimerization-of-the-voltage-sensing-phosphatase-controls-its-voltage-sensing-and-catalytic-activity
#9
Vamseedhar Rayaprolu, Perrine Royal, Karen Stengel, Guillaume Sandoz, Susy C Kohout
Multimerization is a key characteristic of most voltage-sensing proteins. The main exception was thought to be the Ciona intestinalis voltage-sensing phosphatase (Ci-VSP). In this study, we show that multimerization is also critical for Ci-VSP function. Using coimmunoprecipitation and single-molecule pull-down, we find that Ci-VSP stoichiometry is flexible. It exists as both monomers and dimers, with dimers favored at higher concentrations. We show strong dimerization via the voltage-sensing domain (VSD) and weak dimerization via the phosphatase domain...
April 25, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29684532/a-complicated-complex-ion-channels-voltage-sensing-cell-membranes-and-peptide-inhibitors
#10
REVIEW
Alan H Zhang, Gagan Sharma, Eivind A B Undheim, Xinying Jia, Mehdi Mobli
Voltage-gated ion channels (VGICs) are specialised ion channels that have a voltage dependent mode of action, where ion conduction, or gating, is controlled by a voltage-sensing mechanism. VGICs are critical for electrical signalling and are therefore important pharmacological targets. Among these, voltage-gated sodium channels (NaV s) have attracted particular attention as potential analgesic targets. NaV s, however, comprise several structurally similar subtypes with unique localisations and distinct functions, ranging from amplification of action potentials in nociception (e...
April 21, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29683008/first-trimester-combined-screening-biochemistry-in-detection-of-congenital-heart-defects
#11
Julia Alanen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Leskinen, Mika Gissler, Markku Ryynanen, Jaana Nevalainen
OBJECTIVE: To evaluate the performance of first trimester biochemical markers, pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (fβ-hCG), and nuchal translucency (NT) in detection of severe congenital heart defects (CHDs). METHODS: During the study period from 1 January 2008 to 31 December 2011, biochemical markers and NT were measured in 31,144 women as part of voluntary first trimester screening program for Down's syndrome in Northern Finland...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29667735/beyond-voltage-gated-ion-channels-voltage-operated-membrane-proteins-and-cellular-processes
#12
REVIEW
Jianping Zhang, Xingjuan Chen, Yucong Xue, Nikita Gamper, Xuan Zhang
Voltage-gated ion channels were believed to be the only voltage-sensitive proteins in excitable (and some non-excitable) cells for a long time. Emerging evidence indicates that the voltage-operated model is shared by some other transmembrane proteins expressed in both excitable and non-excitable cells. In this review, we summarize current knowledge about voltage-operated proteins, which are not classic voltage-gated ion channels as well as the voltage-dependent processes in cells for which single voltage-sensitive proteins have yet to be identified...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29664500/nutritional-recovery-after-cardiac-surgery-in-children-with-congenital-heart-disease
#13
I Oyarzún, C Claveria, G Larios, C Le Roy
INTRODUCTION: Malnutrition is common in children with congenital heart disease (CHD). Medical treatment and surgical interventions contribute improving the nutritional status of these children. OBJECTIVE: To describe nutritional recovery in children with CHD and associated factors after surgery. PATIENTS AND METHOD: Longitudinal study. 46 Children under 18 years old admitted for CHD surgery between April 2015 and April 2016 were recruited...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664428/-case-report-and-the-surgical-treatment-of-two-cases-with-pulmonary-atresia-in-which-pulmonary-arteries-is-circulated-by-coronary-arteries
#14
Kahraman Yakut, Kürşad Tokel, Birgül Varan, İlkay Erdoğan, Murat Özkan
Pulmonary atresia (PA) and ventricular septal defect (VSD) can occur in a variety of ways, from simple valve atresia to a condition in which circulation to the pulmonary bed occurs through collateral arteries separated from the aorta and there are no real pulmonary arteries, or they are present but hypoplastic. The size of the pulmonary arteries and concomitant complex cardiac lesions are important in making decisions about treatment and correctional alternatives. While complete correction surgeries in the style of a correction of tetralogy of Fallot are performed in simpler cases, many very invasive procedures are also performed and the resulting quality of life is very variable...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29651448/high-performance-inexpensive-setup-for-simultaneous-multisite-recording-of-electrophysiological-signals-and-mesoscale-voltage-imaging-in-the-mouse-cortex
#15
Edgar Bermudez-Contreras, Sergey Chekhov, Jianjun Sun, Jennifer Tarnowsky, Bruce L McNaughton, Majid H Mohajerani
Simultaneous recording of optical and electrophysiological signals from multiple cortical areas may provide crucial information to expand our understanding of cortical function. However, the insertion of multiple electrodes into the brain may compromise optical imaging by both restricting the field of view and interfering with the approaches used to stabilize the specimen. Existing methods that combine electrophysiological recording and optical imaging in vivo implement either multiple surface electrodes, silicon probes, or a single electrode for deeper recordings...
April 2018: Neurophotonics
https://www.readbyqxmd.com/read/29626455/septal-leaflet-versus-chordal-detachment-in-closure-of-hard-to-expose-ventricular-septal-defects
#16
Kamal K Pourmoghadam, Agnieszka Boron, Mark Ruzmetov, Sukumar Suguna Narasimhulu, Alicia Kube, Michael C O'Brien, William M DeCampli
BACKGROUND: Different techniques have been used for exposure of ventricular septal defect (VSD) margins when there is crowding of the VSD anatomy by tricuspid valve (TV) subvalvar apparatus. The aim of this study was to compare surgical outcomes, for the two techniques of TV leaflet detachment and the rarely described TV chordal detachment for hard-to-expose VSDs. METHODS: Patients undergoing transatrial VSD repair were identified from our institutional database...
April 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29625102/tricuspid-valve-detachment-in-ventricular-septal-defect-closure-does-not-impact-valve-function
#17
Charles D Fraser, Xun Zhou, Sandeep Palepu, Cecillia Lui, Alejandro Suarez-Pierre, Todd C Crawford, J Trent Magruder, Marshall L Jacobs, Duke E Cameron, Naru Hibino, Luca A Vricella
BACKGROUND: Although tricuspid valve detachment (TVD) facilitates improved exposure during trans-atrial ventricular septal defect (VSD) closure, few have analyzed the impact of TVD on long-term valve durability. METHODS: Pediatric patients undergoing VSD closure at our institution from 1997 to 2013 were identified, and charts were retrospectively reviewed. Patients were separated into groups based on utilization of TVD. Propensity score matching was then performed using a non-parsimonious logistic regression model involving 7 variables...
April 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29615572/the-role-of-hedgehog-signalling-in-the-formation-of-the-ventricular-septum
#18
REVIEW
Antonia Wiegering, Ulrich Rüther, Christoph Gerhardt
An incomplete septation of the ventricles in the vertebrate heart that disturbes the strict separation between the contents of the two ventricles is termed a ventricular septal defect (VSD). Together with bicuspid aortic valves, it is the most frequent congenital heart disease in humans. Until now, life-threatening VSDs are usually treated surgically. To avoid surgery and to develop an alternative therapy (e.g., a small molecule therapy), it is necessary to understand the molecular mechanisms underlying ventricular septum (VS) development...
December 12, 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/29607145/anatomic-and-surgical-factors-affecting-the-switch-from-minimally-invasive-transthoracic-occlusion-to-open-surgery-during-ventricular-septal-defect-repair
#19
Jian Fang, Shaobo Xie, Lunchao Ma, Chao Yang
Background: This study aimed to investigate the specific causes for switching patients from minimally invasive transthoracic occlusion to surgical repair under cardiopulmonary bypass (CPB). By retrospectively analyzing 340 cases, we sought to provide the clinical reference for improving the success rate of minimally invasive transthoracic device closure of ventricular septal defect (VSD). Methods: Among the 340 patients who underwent transthoracic closure of VSDs in the past 3 years at our hospital, 26 patients needed to be switched to surgical repair under CPB due to failure of transthoracic closure...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29600109/two-cases-of-stone-heart-with-fatal-outcome
#20
Mathias Hald, Jesper Hønge, Rolf Porskjær Dall, Signe Holm Larsen
The "stone heart" syndrome is a rare but often fatal complication of cardiac surgery associated with hypertrophy of the myocardium. The mechanisms behind the syndrome are not fully understood. In this case report, we describe two cases of stone heart in newborn girls. Both girls were born with congenital heart abnormalities including ventricular septum defects (VSD), hypertrophy of the myocardium and patent arterial duct (PDA), which was prenatally diagnosed. In each of the two cases, the stone heart became evident immediately after initiating cardiopulmonary bypass, and ended fatally...
January 2018: Journal of Thoracic Disease
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