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https://www.readbyqxmd.com/read/28232510/regulation-of-na-channel-inactivation-by-the-diii-and-div-voltage-sensing-domains
#1
Eric J Hsu, Wandi Zhu, Angela R Schubert, Taylor Voelker, Zoltan Varga, Jonathan R Silva
Functional eukaryotic voltage-gated Na(+) (NaV) channels comprise four domains (DI-DIV), each containing six membrane-spanning segments (S1-S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1-S4), which together form a voltage-sensing domain (VSD). A critical NaV channel gating process, inactivation, has previously been linked to activation of the VSDs in DIII and DIV. Here, we probe this interaction by using voltage-clamp fluorometry to observe VSD kinetics in the presence of mutations at locations that have been shown to impair NaV channel inactivation...
February 23, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28231853/reconstruction-of-the-pulmonary-posterior-wall-using-in-situ-autologous-tissue-for-the-treatment-of-pulmonary-atresia-with-ventricular-septal-defect
#2
Chengming Fan, Yifeng Yang, Lian Xiong, Ni Yin, Qin Wu, Mi Tang, Jinfu Yang
BACKGROUND: To evaluate the early and mid-term results of pulmonary trunk reconstruction using a technique in which autogenous tissue is preserved in situ in pulmonary atresia patients with a ventricular septal defect (PA-VSD). METHODS: The pulmonary artery was reconstructed using autogenous tissue that had been preserved in situ and a bovine jugular venous patch in 24 patients who were diagnosed with PA-VSD (the observation group). The traditional operation using a bovine jugular venous conduit was performed in 40 other cases of PA-VSD (the control group)...
February 23, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28227375/motion-invariant-contrast-enhancement-of-optical-imaging-data-in-the-gradient-domain
#3
Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Daniel J Strauss, Alejandro Romero-Santiago, Jacek Szczygielski, Karsten Schwerdtfeger, Philipp Flotho, Lars Haab
Functional optical imaging (OI) of intrinsic signals (like blood oxygenation coupled reflection changes) and of extrinsic properties of voltage sensitive probes (like voltage-sensitive dyes (VSD)) forms a group of neuroimaging techniques that possess up to date highest temporal and spatial resolution on a meso-to macroscopic scale. An inherent problem of OI is a very low signal to noise ratio (SNR), which restricts the recordings to be completely motionless and requires detailed knowledge of the properties of the different noise sources...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227367/statistical-identification-of-stimulus-activated-network-nodes-in-multi-neuron-voltage-sensitive-dye-optical-recordings
#4
Elham Fathiazar, Jorn Anemuller, Jutta Kretzberg, Elham Fathiazar, Jorn Anemuller, Jutta Kretzberg, Elham Fathiazar, Jutta Kretzberg, Jorn Anemuller
Voltage-Sensitive Dye (VSD) imaging is an optical imaging method that allows measuring the graded voltage changes of multiple neurons simultaneously. In neuroscience, this method is used to reveal networks of neurons involved in certain tasks. However, the recorded relative dye fluorescence changes are usually low and signals are superimposed by noise and artifacts. Therefore, establishing a reliable method to identify which cells are activated by specific stimulus conditions is the first step to identify functional networks...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225378/traumatic-ventricular-septal-defect-in-a-1-year-old-boy-after-accidental-chest-compression-by-an-adult
#5
Huang-Wei Wu, Jen-Hung Chien, Ken-Pen Weng, Chu-Chuan Lin, Bo-Hau Chen, Shih-Ming Huang, Yu-Chi Hung
We report a 1-year-old boy with a delayed diagnosis of traumatic ventricular septal defect (VSD) related to chest compression. His cardiac function was stable after adequate medical treatment. Spontaneous closure of traumatic VSD occurred to this patient at the age of 4 years. This is a rare case of traumatic VSD associated with accidental chest compression, which is similar to rupture of the ventricular septum after blunt chest trauma. It should be kept in mind that traumatic VSD and concomitant thoracic injuries can develop during chest compression...
February 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28220881/use-of-selective-serotonin-reuptake-inhibitors-in-the-first-trimester-and-risk-of-cardiovascular-related-malformations-a-meta-analysis-of-cohort-studies
#6
Tie-Ning Zhang, Shan-Yan Gao, Zi-Qi Shen, Da Li, Cai-Xia Liu, Hai-Chen Lv, Yuan Zhang, Ting-Ting Gong, Xin Xu, Chao Ji, Qi-Jun Wu
The relationship between selective serotonin-reuptake inhibitors (SSRIs) use during first trimester and cardiovascular-related malformations of infants is still uncertain. Therefore, we conducted this systematic review and meta-analysis to assess the aforementioned association. A systematic literature review identified studies for cohort studies about SSRIs use and cardiovascular-related malformations in PubMed and Web of Science. We summarized relative risk (RRs) and 95% confidence intervals (CIs) of cardiovascular-related malformations using random-effects model, and heterogeneity and publication-bias analyses were conducted...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218213/surgical-treatment-of-double-outlet-right-ventricle-complicated-by-pulmonary-hypertension
#7
Qing-Yu Wu, Dong-Hai Li, Hong-Yin Li, Ming-Kui Zhang, Zhong-Hua Xu, Hui Xue
BACKGROUND: Double outlet right ventricle (DORV) is a group of complex congenital heart abnormalities. Preoperative pulmonary hypertension (PH) is considered an important risk factor for early death during the surgical treatment of DORV. The aim of this study was to report our experience on surgical treatment of DORV complicated by PH. METHODS: From June 2004 to November 2016, 61 patients (36 males and 25 females) aged 2 weeks to 26 years (median: 0.67 years and interquartile range: 0...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28207550/retrospective-analysis-of-vocal-cord-to-suprasternal-notch-distance-implications-for-preventing-endotracheal-tube-cuff-induced-vocal-cord-injury
#8
Hyerim Kim, Jee-Eun Chang, Jung-Hee Ryu, Haesun Jung, Seong-Won Min, Jung-Man Lee, Jin-Young Hwang
Endotracheal tube (ETT) positioning using the cuff ballottement test, which confirms that the inflated cuff is positioned at the suprasternal notch with squeezing or inflating a pilot balloon, has been reported to be a simple and reliable method of preventing endobronchial intubation. However, in patients with a short vocal cord-to-suprasternal notch, ETT placement using the cuff ballottement test can cause vocal cord injury. In the present study, we assessed the distance from a point 15 mm below the vocal cord to the suprasternal notch (VSD-15), the safe position for ETT cuff placement above the suprasternal notch, and investigated variables for predicting VSD-15...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28185740/vaccine-adverse-events-in-a-safety-net-healthcare-system-and-a-managed-care-organization
#9
Komal J Narwaney, Kristin Breslin, Colleen A Ross, Jo Ann Shoup, Kris F Wain, Eric S Weintraub, Michael M McNeil, Simon J Hambidge
BACKGROUND: The Institute of Medicine, in a 2013 report, recommended that the Vaccine Safety Datalink (VSD) expand collaborations to include more diversity in the study population. Kaiser Permanente Colorado (KPCO), an established VSD site, partnered with Denver Health (DH), an integrated safety net healthcare system, to demonstrate the feasibility of integrating DH data within the VSD. Prior to incorporating the data, we examined the identification of specific vaccine associated adverse events (VAEs) in these two distinct healthcare systems...
February 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28164029/trends-in-pediatric-echocardiography-and-the-yield-for-congenital-heart-disease-in-a-major-cardiac-referral-hospital-in-cameroon
#10
Clovis Nkoke, Eric Balti, Alain Menanga, Anastase Dzudie, Alain Lekoubou, Samuel Kingue, Andre Pascal Kengne
BACKGROUND: Congenital heart disease (CHD) is a common condition in children in Sub-Saharan Africa (SSA), where it is associated with poor outcomes. Diagnosis of CHD in SSA depends essentially on echocardiography, which is available only in few urban referral centers. Our aim was to assess time changes in the pattern of referral for pediatric echocardiography and the subsequent diagnosis of structural CHD in a major SSA city. METHODS: All pediatric echocardiography performed between 2004 and 2013 at the echocardiography laboratory of the Yaounde General Hospital were reviewed...
January 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28164015/post-traumatic-ventricular-septal-defect-a-rare-indication-for-extracorporeal-membrane-oxygenation-as-a-bridge-to-transplant
#11
María Alejandra Restrepo-Córdoba, Francisco José Hernández-Pérez, Manuel Francisco Gómez-Bueno, Juan Manuel Escudier-Villa, Evaristo Castedo, Javier Segovia, Luis Antonio Alonso-Pulpón
A ventricular septal defect (VSD) is a rare complication of blunt chest trauma. This report presents the case of a 44-year-old man who developed a VSD as a result of high-energy closed chest trauma. We describe the initial surgical and medical management of the cardiac rupture. After failed repair surgery, extracorporeal membrane oxygenation (ECMO) was used as a bridge to heart transplantation. We discuss the successful use of ECMO to improve the prognosis results in this rare and complex entity.
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28162173/-clinical-effect-of-double-layer-vacuum-sealing-drainage-in-the-treatment-of-delayed-severe-infection-after-calcaneal-fracture-operation
#12
H D Ma, J Bai, X J Du, H D Liu, Y Gao, J J Li, W D Liang, L H Cao, J F Qu
Objective: To observe the clinical effect of vacuum sealing drainage (VSD) technique and simple dressing change in the treatment of delayed severe infection after calcaneal fracture surgery. Methods: From August 2008 to July 2015 , 73 patients with delayed severe infection were treated after calcaneal fractures 3 months in Department of Foot and Ankle, the Second Hospital of Tangshan City, according to the treatment methods are divided into vacuum sealing drainage group of 38 cases, 35 cases of simple dressing group...
January 17, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28161424/integration-of-data-from-a-safety-net-health-care-system-into-the-vaccine-safety-datalink
#13
Simon J Hambidge, Colleen Ross, Jo Ann Shoup, Kris Wain, Komal Narwaney, Kristin Breslin, Eric S Weintraub, Michael M McNeil
BACKGROUND: In 2013 the Institute of Medicine suggested that the Vaccine Safety DataLink (VSD) should broaden its population by including data of more patients from low income and racially and ethnically diverse backgrounds. In response, Kaiser Permanente Colorado (KPCO) partnered with Denver Health (DH), an integrated safety net health care system, to explore the integration of DH data. METHODS: We compared three different methods (reference date of September 1, 2013): "Empanelment" (any patient who has had a primary care visit in the past 18months), "Proxy-enrollment" (two health care visits in 3years separated by 90days), and "Enrollment" in a managed care plan...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28154913/right-ventricle-to-pulmonary-artery-shunt-in-pulmonary-atresia-with-a-ventricular-septal-defect-a-word-of-caution
#14
Kwang Ho Choi, Si Chan Sung, Hyungtae Kim, Hyoung Doo Lee, Gil Ho Ban, Geena Kim, Hoon Ko
The management of pulmonary atresia with a ventricular septal defect (PA/VSD) depends on the anatomy of the pulmonary artery or on the surgical strategy used at individual institutions. In our institution, we adopted a right ventricle-to-pulmonary artery (RV-PA) shunt in 2011 as a palliative procedure for PA/VSD to overcome the disadvantages of a Blalock-Taussig shunt. We evaluated the results of the RV-PA shunt as initial palliative surgery for PA/VSD. Thirteen patients with ductus-dependent PA/VSD from August 2011 to August 2015 were enrolled...
February 3, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28151885/single-cortex-is-better-than-double-cortex-in-fibula-grafts-for-large-tibia-bone-defect-in-a-2-year-old-child-a-case-report-of-a-successful-surgery-and-discussion-of-bone-graft-choices
#15
Jianbin Li, Zhijun Pan, Shigui Yan, Xiang Zhao
BACKGROUND: Large bone defect in infant or small patients has been little reported and the management of such a patient is difficult. Considering the little knowledge of this area, we present this special case of a successful single-cortex fibula graft for the treatment of a large tibia bone defect in a 2-year-old patient to share our experience. CASE SUMMARY: A 2-year-old male patient presented to our hospital with history of leg pain for 4 months. According to his medical records, he was involved in a traffic accident and diagnosed with open tibia fracture...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28124786/first-report-of-transcatheter-closure-of-a-ruptured-sinus-of-valsalva-aneurysm-using-the-nit-occlud-le-vsd-occluder
#16
Robert Sabiniewicz, Lidia Woźniak, Piotr Potaż, Maksymilian Mielczarek, Dariusz Ciećwierz
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28119477/comparison-of-a-5-mm-and-10-mm-vessel-sealing-device-in-an-open-ovariectomy-model-in-dogs
#17
N Devriendt, B Van Goethem, L Van Brantegem, M De Ridder, A Kitshoff, M Or, H de Rooster
The objectives of this study were to compare (1) the extent of thermal damage and (2) the time between the 5-mm LigaSure V (LS5) and 10-mm LigaSure Atlas (LS10) vessel sealing devices (VSD) when performing open ovariectomy in dogs. A prospective, randomised, clinical trial was performed in 40 client-owned sexually entire female dogs. In each dog, one ovary was randomly assigned to be surgically removed using LS5 and the contralateral using LS10. The depth of thermal spread, measured on histopathological preparations, was significantly larger for LS10 (LS10 1...
January 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28111108/effect-of-incomplete-closure-of-a-gerbode-defect-with-the-nit-occlud-l%C3%A3%C2%AA-vsd-coil-severe-hemolysis-requiring-a-second-procedure
#18
Armando Pérez de Prado, José Luis Zunzunegui Martínez, Raúl Carbonell de Blas, Miguel Ángel Rodríguez García, Tomás Benito González, Felipe Fernández Vázquez
No abstract text is available yet for this article.
January 19, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28108755/measurement-of-aortic-valve-coaptation-and-effective-height-using-echocardiography-in-patients-with-ventricular-septal-defects-and-aortic-valve-prolapse
#19
Satoru Iwashima, Hiroki Uchiyama, Takamichi Ishikawa, Kiyohiro Takigiku, Ken Takahashi, Manatomo Toyono, Nao Inoue, Masaki Nii
Decreased coaptation height in adults has been identified as a marker of early valve failure. We evaluated aortic valve coaptation and effective height in healthy children and in children with a ventricular septal defect (VSD) with aortic cusp prolapse (ACP), using echocardiography. We included 45 subjects with VSD with ACP, 27 did not develop aortic regurgitation (AR) by ACP and 18 developed AR by ACP, and 83 healthy children as controls. Aortic root anatomy was estimated using the parasternal long-axis view...
January 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28102704/thimerosal-exposure-and-disturbance-of-emotions-specific-to-childhood-and-adolescence-a-case-control-study-in-the-vaccine-safety-datalink-vsd-database
#20
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
BACKGROUND: This study evaluated Thimerosal-containing childhood vaccines and the risk of a diagnosis called disturbance of emotions specific to childhood and adolescence (ED). Thimerosal is an organic-mercury (Hg)-containing compound used in some vaccines. METHODS: A hypothesis-testing prospective, longitudinal case-control study evaluated Hg exposure from Thimerosal in hepatitis B vaccines administered at specific times within the first 6 months of life and its association with medically diagnosed ED (313...
2017: Brain Injury: [BI]
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