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https://www.readbyqxmd.com/read/28328967/phenotypic-and-molecular-characterization-of-antimicrobial-resistance-in-enterobacter-spp-isolates-from-companion-animals-in-japan
#1
Kazuki Harada, Takae Shimizu, Yujiro Mukai, Ken Kuwajima, Tomomi Sato, Akari Kajino, Masaru Usui, Yutaka Tamura, Yui Kimura, Tadashi Miyamoto, Yuzo Tsuyuki, Asami Ohki, Yasushi Kataoka
The emergence of antimicrobial resistance among Enterobacter spp., including resistance to extended-spectrum cephalosporins (ESC), is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance among 60 isolates of Enterobacter spp., including E. cloacae (n = 44), E. aerogenes (n = 10), and E. asburiae (n = 6), from clinical specimens of dogs and cats from 15 prefectures in Japan. Furthermore, we characterized the resistance mechanisms harbored by these isolates, including extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR); and assessed the genetic relatedness of ESC-resistant Enterobacter spp...
2017: PloS One
https://www.readbyqxmd.com/read/28325626/group-b-streptococcal-necrotizing-pneumonia-in-a-diabetic-adult-patient
#2
Andrea Pacha, Ramiro Luna Cian, Laura Bonofiglio, Melisa Solari, Virginia Strada, Mariana Suárez, Laura Vigliarolo, Carina Tersigni, Marta Mollerach, Horacio Lopardo
The aim of this report is to describe a rare case of necrotizing pneumonia due to group B Streptococcus serotype III in a relatively young male adult (48 years old) suffering from diabetes. The organism was isolated from his pleural fluid and was only resistant to tetracycline. The patient first received ceftazidime (2g/8h i.v.)+clindamycin (300mg/8h) for 18 days and then he was discharged home and orally treated with amoxicillin clavulanic acid (1g/12h) for 23 days with an uneventful evolution. As in the cases of invasive infection by Streptococcus pyogenes, clindamycin could prevent streptococcal toxic shock syndrome...
March 18, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28303125/antibiotic-and-desiccation-resistance-of-cronobacter-sakazakii-and-c-malonaticus-isolates-from-powdered-infant-formula-and-processing-environments
#3
Peng Fei, Yujun Jiang, Jing Feng, Stephen J Forsythe, Ran Li, Yanhong Zhou, Chaoxin Man
This study evaluated the antimicrobial and desiccation resistance of Cronobacter sakazakii and Cronobacter malonaticus isolates from powdered infant formula and processing environments. The antimicrobial susceptibility tests showed that the 70 Cronobacter strains, representing 19 sequence types, were susceptible to the most of the antibiotics except for amoxicillin-clavulanate, ampicillin, and cefazolin. Furthermore, the growth of six C. sakazakii and two C. malonaticus strains from different sequence types (STs) in hyperosmotic media was measured...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28284685/identifying-priorities-to-improve-paediatric-in-hospital-antimicrobial-use-by-cross-sectional-evaluation-of-prevalence-and-appropriateness-of-prescription
#4
Walter Alfredo Goycochea-Valdivia, Francisco Moreno-Ramos, José Ramón Paño-Pardo, Francisco Javier Aracil-Santos, Fernando Baquero-Artigao, Teresa Del Rosal-Rabes, María José Mellado-Peña, Luis Escosa-García
INTRODUCTION: Information about paediatric in-hospital antimicrobial usage and prescribing patterns to guide improvement strategies is scant. We aim to use an evaluation of the prevalence and appropriateness of antimicrobial prescription to identify antimicrobial stewardship priorities in children. METHODS: A cross-sectional point study was performed on hospitalised paediatric patients in a Spanish tertiary hospital, assessing the prevalence of antimicrobial prescription (PAP) and appropriateness of antimicrobial prescription (AAP)...
March 8, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28276834/drug-induced-liver-injury-due-to-antibiotics
#5
Einar S Björnsson
Drug-induced liver injury (DILI) is an important differential diagnosis in patients with abnormal liver tests and normal hepatobiliary imaging. Of all known liver diseases, the diagnosis of DILI is probably one of the most difficult one to be established. In all major studies on DILI, antibiotics are the most common type of drugs that have been reported. The clinical phenotype of different types of antibiotics associated with liver injury is highly variable. Some widely used antibiotics such as amoxicillin-clavulanate have been shown to have a delayed onset on liver injury and recently cefazolin has been found to lead to liver injury 1-3 weeks after exposure of a single infusion...
February 20, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28272016/cactus-spine-wounds-a-case-report-and-short-review-of-the-literature
#6
Raymond A Dieter, Lisa R Whitehouse, Rebecca Gulliver
INTRODUCTION: Cactus plants are commonly seen in arid southwestern regions of the United States. Due to their ready availability, they have become a popular houseplant. The spines or glochidia can easily puncture the skin with only minor pressure (ie, bumping or touching the cactus). Removal of the offending spine is difficult, even with tweezers. CASE: An 18-year-old woman initially self-removed the spines, and marked discomfort and intense erythematous reaction developed within 8 to 10 hours...
February 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28270546/variability-in-antibiotic-prescribing-for-community-acquired-pneumonia
#7
Lori K Handy, Matthew Bryan, Jeffrey S Gerber, Theoklis Zaoutis, Kristen A Feemster
BACKGROUND AND OBJECTIVES: Published guidelines recommend amoxicillin for most children with community-acquired pneumonia (CAP), yet macrolides and broad-spectrum antibiotics are more commonly prescribed. We aimed to determine the patient and clinician characteristics associated with the prescription of amoxicillin versus macrolide or broad-spectrum antibiotics for CAP. METHODS: Retrospective cohort study in an outpatient pediatric primary care network from July 1, 2009 to June 30, 2013...
March 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28265870/correlation-between-antibiotic-consumption-and-resistance-of-bloodstream-bacteria-in-a-university-hospital-in-north-eastern-italy-2008-2014
#8
Marta Mascarello, Omar Simonetti, Anna Knezevich, Ludovica Ilaria Carniel, Jacopo Monticelli, Marina Busetti, Paolo Schincariol, Lucio Torelli, Roberto Luzzati
PURPOSE: The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS: Antibiotic consumption (Defined Daily Dose-DDD-per 100 patient/days) and antibiotic resistance (percentage of antibiotic intermediate o resistant isolates) were analyzed independently with linear correlation by year...
March 6, 2017: Infection
https://www.readbyqxmd.com/read/28260538/intervention-to-reduce-broad-spectrum-antibiotics-and-treatment-durations-prescribed-at-the-time-of-hospital-discharge-a-novel-stewardship-approach
#9
Norihiro Yogo, Katherine Shihadeh, Heather Young, Susan L Calcaterra, Bryan C Knepper, William J Burman, Philip S Mehler, Timothy C Jenkins
OBJECTIVE For most common infections requiring hospitalization, antibiotic treatment is completed after hospital discharge. Postdischarge therapy is often unnecessarily broad spectrum and prolonged. We developed an intervention to improve antibiotic selection and shorten treatment durations. DESIGN Single center, quasi-experimental retrospective cohort study METHODS Patients prescribed oral antibiotics at hospital discharge before (July 2012-June 2013) and after (October 2014-February 2015) an intervention consisting of (1) institutional guidance for oral step-down antibiotic selection and duration of therapy and (2) pharmacy audit of discharge prescriptions with real-time prescribing recommendations to providers...
March 6, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28253087/genome-wide-association-studies-for-idiosyncratic-drug-induced-hepatotoxicity-looking-back-looking-forward-to-next-generation-innovation
#10
Zelalem Petros, Eyasu Makonnen, Eleni Aklillu
Idiosyncratic drug-induced hepatotoxicity is a formidable challenge for rational drug discovery and development, as well as the science of personalized medicine. There is evidence that hereditary factors, in part, contribute to drug toxicity. This expert analysis and review offer the insights gained, and the challenges ahead, for genome-wide association studies (GWASs) of idiosyncratic drug-induced hepatotoxicity. Published articles on genome-wide and subsequent replication studies were systematically searched in the PubMed electronic database...
March 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28248674/prevalence-serotype-distribution-and-antimicrobial-resistance-of-salmonella-isolated-from-food-products-in-morocco
#11
Nadia Amajoud, Brahim Bouchrif, Mohammed El Maadoudi, Nadia Skalli Senhaji, Bouchra Karraouan, Abdeltif El Harsal, Jamal El Abrini
INTRODUCTION: Salmonellosis is one of the most common foodborne diseases worldwide. The irrational use of antibiotics in medicine and in animal feed has greatly promoted the emergence and spread of resistant strains of non-typhoidal Salmonella. METHODOLOGY: A total of 464 food products were collected in Tetouan from January 2010 to December 2012. The isolation and identification of Salmonella were performed according to Moroccan standard 08.0.116. All isolates were serotyped and were then tested for antibiotic resistance using the disk diffusion method...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28247727/-changes-in-the-structure-of-pathogens-of-calculous-pyelonephritis-complicated-with-diabetes-mellitus-type-ii-in-the-hospital-urology-of-the-city-of-volgograd
#12
V I Petrov, A Z Vinarov, M A Vekilyan, N G Kulchenko
Among the diseases complicating the course of calculous pyelonephritis, are among the leaders of diabetes mellitus, which is associated with reduced immune response, deterioration of renal hemodynamics, the reduced sensitivity to antibacterial drugs. The purpose of the study is to improve the results of treatment of patients with calculous pyelonephritis and diabetes mellitus type 2. The materials and methods of research. We studied 179 people. This was a retrospective pharmaco-epidemiological analysis of medical records of patients who were treated in 2009 and 2013, in hospital of Volgograd...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28231527/rapid-discrimination-and-determination-of-antibiotics-drugs-in-plastic-syringes-using-near-infrared-spectroscopy-with-chemometric-analysis-application-to-amoxicillin-and-penicillin
#13
Laetitia Minh Mai Lê, Luc Eveleigh, Ikram Hasnaoui, Patrice Prognon, Arlette Baillet-Guffroy, Eric Caudron
The aim of this study was to investigate near infrared spectroscopy (NIRS) combined to chemometric analysis to discriminate and quantify three antibiotics by direct measurement in plastic syringes.Solutions of benzylpenicillin (PENI), amoxicillin (AMOX) and amoxicillin/clavulanic acid (AMOX/CLAV) were analyzed at therapeutic concentrations in glass vials and plastic syringes with NIR spectrometer by direct measurement. Chemometric analysis using partial least squares regression and discriminative analysis was conducted to develop qualitative and quantitative calibration models...
February 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28230273/comparison-of-pathogen-eradication-rate-and-safety-of-anti-bacterial-agents-for-bronchitis-a-network-meta-analysis
#14
Jinghua Wang, Haiyang Xu, Dunwei Wang, Mingxian Li
OBJECTIVE: A large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. Although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. We are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28225904/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#15
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28225898/invasive-haemophilus-influenzae-disease-in-the-vaccine-era-in-rio-de-janeiro-brazil
#16
Mari Tuyama, Jessica Corrêa-Antônio, Jessica Schlackman, Jane W Marsh, Maria C Rebelo, Elaine O Cerqueira, Márcio Nehab, Fabíola Kegele, Getúlio F Carmo, Dominique Ca Thielmann, Paulo F Barroso, Lee H Harrison, David E Barroso
BACKGROUND: Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES: The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS: Surveillance data from 1986 to 2014 were analysed...
February 16, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28215892/feeding-of-waste-milk-to-holstein-calves-affects-antimicrobial-resistance-of-escherichia-coli-and-pasteurella-multocida-isolated-from-fecal-and-nasal-swabs
#17
G Maynou, A Bach, M Terré
The use of milk containing antimicrobial residues in calf feeding programs has been shown to select for resistant fecal Escherichia coli in dairy calves. However, information is scarce about the effects of feeding calves waste milk (WM) on the prevalence of multidrug-resistant bacteria. The objective of this study was to determine the antimicrobial resistance patterns of fecal E. coli and nasal Pasteurella multocida isolates from calves fed either milk replacer (MR) or WM in 8 commercial dairy farms (4 farms per feeding program)...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28209132/urinary-tract-infection-among-fistula-patients-admitted-at-hamlin-fistula-hospital-addis-ababa-ethiopia
#18
Matifan Dereje, Yimtubezinesh Woldeamanuel, Daneil Asrat, Fekade Ayenachew
BACKGROUND: Urinary Tract Infection (UTI) causes a serious health problem and affects millions of people worldwide. Patients with obstetric fistula usually suffer from incontinence of urine and stool, which can predispose them to frequent infections of the urinary tract. Therefore the aim of this study was to determine the etiologic agents, drug resistance pattern of the isolates and associated risk factor for urinary tract infection among fistula patients in Addis Ababa fistula hospital, Ethiopia...
February 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28207509/relationship-between-drug-resistance-and-the-clustered-regularly-interspaced-short-palindromic-repeat-associated-protein-genes-cas1-and-cas2-in-shigella-from-giant-panda-dung
#19
Lu Ren, Lin-Hua Deng, Ri-Peng Zhang, Cheng-Dong Wang, De-Sheng Li, Li-Xin Xi, Zhen-Rong Chen, Rui Yang, Jie Huang, Yang-Ru Zeng, Hong-Lin Wu, San-Jie Cao, Rui Wu, Yong Huang, Qi-Gui Yan
BACKGROUND: To detect drug resistance in Shigella obtained from the dung of the giant panda, explore the factors leading to drug resistance in Shigella, understand the characteristics of clustered, regularly interspaced, short, palindromic repeats (CRISPR), and assess the relationship between CRISPR and drug resistance. METHODS: We collected fresh feces from 27 healthy giant pandas in the Giant Panda Conservation base (Wolong, China). We identified the strains of Shigella in the samples by using nucleotide sequence analysis...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28199151/antimicrobial-resistance-percentages-of-salmonella-and-shigella-in-seafood-imported-to-jordan-higher-percentages-and-more-diverse-profiles-in-shigella
#20
Mohammad M Obaidat, Alaa E Bani Salman
This study determined the prevalence and antimicrobial resistance of human-specific ( Shigella spp.) and zoonotic ( Salmonella enterica ) foodborne pathogens in internationally traded seafood. Sixty-four Salmonella and 61 Shigella isolates were obtained from 330 imported fresh fish samples from Egypt, Yemen, and India. The pathogens were isolated on selective media, confirmed by PCR, and tested for antimicrobial resistance. Approximately 79 and 98% of the Salmonella and Shigella isolates, respectively, exhibited resistance to at least one antimicrobial, and 8 and 49% exhibited multidrug resistance (resistance to three or more antimicrobial classes)...
February 15, 2017: Journal of Food Protection
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