F R Cassee, C Y de Burbure, B Rambali, W Vleeming, A van de Kuil, H van Steeg, P H B Fokkens, J G C van Amsterdam, J A M A Dormans, A Opperhuizen
We investigated whether inhaling peak concentrations of aldehydes several times daily is more damaging than semi-continuously inhaling low-dose aldehydes. We exposed Xpa-/-p53+/- knock-out mice either intermittently or semi-continuously to mixed acetaldehyde, formaldehyde, and acrolein. The intermittent regimen entailed exposure to the aldehydes 7 min every 45 min, 12 times/day, 5 days/week, corresponding to concentrations inhaled by smokers. Semi-continuously exposed animals received half the dose of aldehydes in 8h/day, 5 days/week...
February 2008: Food and Chemical Toxicology