Hsueh-Fu Wu, Kenyi Saito-Diaz, Chia-Wei Huang, Jessica L McAlpine, Dong Eun Seo, D Sumner Magruder, Mohamed Ishan, Harrison C Bergeron, William H Delaney, Fabio R Santori, Smita Krishnaswamy, Gerald W Hart, Ya-Wen Chen, Robert J Hogan, Hong-Xiang Liu, Natalia B Ivanova, Nadja Zeltner
Autonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and dysfunction in humans are vastly understudied due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void as a versatile platform. Here, we developed a differentiation paradigm detailing the derivation of functional human parasymNs from Schwann cell progenitors...
April 4, 2024: Cell Stem Cell