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https://www.readbyqxmd.com/read/29149796/effectiveness-of-treatment-in-wards-for-patients-with-dementia-and-issues-associated-with-this-treatment-a-prospective-analysis
#1
Shogo Taniguchi, Teruyuki Matsuoka, Takeshi Hikawa, Atsushi Machihara, Keisuke Shibata, Hideki Miki, Hiroshi Shimizu, Jin Narumoto
In order to optimize the treatment in wards for patients with dementia, we investigated predictors of the length of stay in the ward for patients with dementia. A prospective analysis of 72 patients with dementia was conducted in two wards for patients with dementia. Severity of dementia was assessed by the Clinical Dementia Rating, basic activities of daily living were evaluated using the Physical Self-Maintenance Scale, and severity of behavioral and psychological symptoms of dementia and caregiver distress were determined with the Nursing Home version of the Neuropsychiatric Inventory...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149795/development-of-a-psycho-educational-support-program-for-individuals-with-primary-progressive-aphasia-and-their-care-partners
#2
Darby J Morhardt, Mary C O'Hara, Kristine Zachrich, Christina Wieneke, Emily J Rogalski
Primary progressive aphasia is a language-based dementia that initially spares other cognitive domains; however, aphasia interferes with many life roles such as work and interpersonal relationships. Psycho-educational programs, such as support groups have been shown to be effective for persons with Alzheimer's dementia; however, little is known regarding their effectiveness for persons with primary progressive aphasia. This paper describes the development of a program that offers support, education and activities for persons with primary progressive aphasia and their care-partners and its feasibility...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149781/macrophages-from-behcet-s-disease-patients-express-decreased-level-of-aryl-hydrocarbon-receptor-ahr-mrna
#3
Mohammad Taghi Palizgir, Maryam Akhtari, Mahdi Mahmoudi, Shayan Mostafaei, Alireza Rezaeimanesh, Massoomeh Akhlaghi, Farhad Shahram
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients in comparison to healthy controls. Isolated monocytes from 10 healthy controls and 10 active BD patients were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for 7 days...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149778/the-changes-of-th17-treg-and-related-cytokines-il-17-il-23-il-10-and-tgf-%C3%AE-in-respiratory-syncytial-virus-bronchiolitis-rat-model
#4
Meng Gao, Liang-Xiao Liu, Fu-Ling Wu, Xuejing Zhang, Ying-Ying Li, Tao Shi, De-Zhi Li, Ting-Ting Han
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and hospitalization that lead to high morbidity and mortality among young infants. T helper 17 (Th17) cells and regulatory T cells (Tregs) play essential roles in the pathogenesis of autoimmune, cancer, and inflammatory diseases. However, whether changes in T-cell subsets are related to the systemic immune responses in RSV-caused bronchiolitis merit further investigation. Three-week-old Sprague Dawley (SD) rats were randomly divided into the normal control (NC) and RSV bronchiolitis (RSV-B) groups...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149772/natural-history-of-infantile-onset-spinal-muscular-atrophy
#5
Stephen J Kolb, Christopher S Coffey, Jon W Yankey, Kristin Krosschell, W David Arnold, Seward B Rutkove, Kathryn J Swoboda, Sandra P Reyna, Ai Sakonju, Basil T Darras, Richard Shell, Nancy Kuntz, Diana Castro, Julie Parsons, Anne M Connolly, Claudia A Chiriboga, Craig McDonald, W Bryan Burnette, Klaus Werner, Mathula Thangarajh, Perry B Shieh, Erika Finanger, Merit E Cudkowicz, Michelle M McGovern, D Elizabeth McNeil, Richard Finkel, Susan T Iannaccone, Edward Kaye, Allison Kingsley, Samantha R Renusch, Vicki L McGovern, Xueqian Wang, Phillip G Zaworski, Thomas W Prior, Arthur H M Burghes, Amy Bartlett, John T Kissel
OBJECTIVE: Infantile-onset spinal muscular atrophy (SMA) is the most common genetic cause of infant mortality, typically resulting in death prior to age 2. Clinical trials in this population require an understanding of disease progression and identification of meaningful biomarkers to hasten therapeutic development and predict outcomes. METHODS: A longitudinal, multi-center, prospective natural history study enrolled 26 SMA infants, and 27 control infants less than six months of age...
November 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29149770/a-multicenter-retrospective-medical-record-review-of-x-linked-myotubular-myopathy-the-recensus-study
#6
Alan H Beggs, Barry J Byrne, Sabine de Chastonay, Tmirah Haselkorn, Imelda Hughes, Emma S James, Nancy L Kuntz, Jennifer Simon, Lindsay C Swanson, Michele L Yang, Zi-Fan Yu, Sabrina W Yum, Suyash Prasad
INTRODUCTION: X-linked myotubular myopathy (XLMTM), characterized by severe hypotonia, weakness, respiratory distress, and early mortality, is rare and natural history studies are few. METHODS: RECENSUS is a multicenter chart review of male XLMTM patients characterizing disease burden and unmet medical needs. Data were collected between September 2014 and June 2016. RESULTS: Analysis included 112 patients at six clinical sites. Most recent patient age recorded was ≤18 months for 40 patients and >18 months for 72 patients...
November 17, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29149767/the-effects-of-sleep-on-the-neural-correlates-of-pattern-separation
#7
Christopher R Doxey, Cooper Hodges, Ty Bodily, Nathan M Muncy, C Brock Kirwan
Effective memory representations must be specific to prevent interference between episodes that may overlap in terms of place, time, or items present. Pattern separation, a computational process performed by the hippocampus, overcomes this interference by establishing non-overlapping memory representations. Although it is widely accepted that declarative memories are consolidated during sleep, the effects of sleep on pattern separation have yet to be elucidated. We used whole-brain, high-resolution functional neuroimaging to investigate the effects of sleep on a task that places high demands on pattern separation...
November 17, 2017: Hippocampus
https://www.readbyqxmd.com/read/29149765/sorption-desorption-of-antimony-species-onto-calcined-hydrotalcite-surface-structure-and-control-of-competitive-anions
#8
Leonel Vinicius Constantino, Juliana Nunes Quirino, Taufik Abrão, Paulo Sérgio Parreira, Alexandre Urbano, Maria Josefa Santos
Calcined hydrotalcite can be applied to remove anionic contaminants from aqueous systems such as antimony species due to its great anion exchange capacity and high surface area. Hence, this study evaluated antimonite and antimonate sorption-desorption processes onto calcined hydrotalcite in the presence of nitrate, sulfate and phosphate. Sorption and desorption experiments of antimonite and antimonate were carried out in batch equilibrium and the post-sorption solids were analyzed by X-ray fluorescence (EDXRF)...
November 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29149764/human-saliva-as-a-diagnostic-material
#9
REVIEW
Sylwia Chojnowska, Tomasz Baran, Iwona Wilińska, Paulina Sienicka, Iwona Cabaj-Wiater, Małgorzata Knaś
Today blood biochemical laboratory tests are essential elements to the diagnosis and monitoring of the treatment of diseases. However, many researchers have suggested saliva as an preferable diagnostic material. The collection of saliva is simple, painless, cheap and safe, both for patients and medical staff. An additional advantage of saliva is the fact that it may be retrieved several times a day, which makes repeat analysis much easier. Furthermore, saliva has very high durability. Although 94-99% of salivary content is water, saliva also contains numerous cellular elements and many organic and inorganic substances, including most biological markers present in the blood and urine that may be used in the early detection and monitoring of many dental and general diseases...
November 14, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29149760/patterns-of-relapse-in-poor-prognosis-germ-cell-tumours-in-the-getug-13-trial-implications-for-assessment-of-brain-metastases
#10
Y Loriot, L Pagliaro, A Fléchon, J Mardiak, L Geoffrois, P Kerbrat, C Chevreau, R Delva, F Rolland, C Theodore, G Roubaud, G Gravis, J C Eymard, J P Malhaire, C Linassier, M Habibian, A L Martin, F Journeau, M Reckova, C Logothetis, A Laplanche, G Le Teuff, S Culine, K Fizazi
BACKGROUND: The GETUG 13 phase III trial tested personalised chemotherapy based on tumour marker decline in patients with poor-prognosis germ-cell tumour (GCT) and demonstrated that a dose-dense regimen improves progression-free survival in patients with an unfavourable decline. We investigated the pattern of relapse for patients included in GETUG 13. METHODS: We conducted an analysis of relapse events in patients from GETUG 13. Baseline procedures before inclusion in the trial comprised a thoraco-abdomino-pelvic computed tomography scan and a magnetic resonance imaging of the brain...
November 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29149758/oligotrophy-as-a-major-driver-of-mercury-bioaccumulation-in-medium-to-high-trophic-level-consumers-a-marine-ecosystem-comparative-study
#11
Tiphaine Chouvelon, Pierre Cresson, Marc Bouchoucha, Christophe Brach-Papa, Paco Bustamante, Sylvette Crochet, Françoise Marco-Miralles, Bastien Thomas, Joël Knoery
Mercury (Hg) is a global contaminant of environmental concern. Numerous factors influencing its bioaccumulation in marine organisms have already been described at both individual and species levels (e.g., size or age, habitat, trophic level). However, few studies have compared the trophic characteristics of ecosystems to explain underlying mechanisms of differences in Hg bioaccumulation and biomagnification among food webs and systems. The present study aimed at investigating the potential primary role of the trophic status of systems on Hg bioaccumulation and biomagnification in temperate marine food webs, as shown by their medium-to high-trophic level consumers...
November 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29149753/identifying-relapse-prevention-elements-during-psychological-treatment-of-depression-development-of-an-observer-based-rating-instrument
#12
Katja Machmutow, Martin Grosse Holtforth, Tobias Krieger, Birgit Watzke
BACKGROUND: Although observer-rated instruments assessing therapist's adherence to relapse-preventive treatments are available, they do not adequately cover specific relapse-preventive elements that focus on implementation of strategies after terminating treatment. This study describes the development of the KERI-D (Kodierbogen zur Erfassung Rückfallprophylaktischer Interventionen bei Depression/Coding System to Assess Interventions of Relapse Prevention in Depression). The KERI-D is a new observer-based rating tool for acute or continuation/maintenance-phase sessions and assesses relapse-prevention elements including implementation into patient's daily routines...
November 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149750/friends-or-foes-monetized-life-cycle-assessment-and-cost-benefit-analysis-of-the-site-remediation-of-a-former-gas-plant
#13
Lies Huysegoms, Sandra Rousseau, Valérie Cappuyns
Site contamination is a global concern because of the potential risks for human health and ecosystem quality. Every contaminated site has its own specific characteristics and the increased availability and efficiency of remediation techniques makes the choice of remediation alternative increasingly complicated. In this paper an attributional Life Cycle Assessment (LCA) of the secondary environmental impacts of a site remediation is performed and its results are monetized using two different monetization techniques, namely Stepwise 2006 and Ecovalue 08...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149747/analysis-of-effect-of-particles-on-cake-layer-compressibility-during-ultrafiltration-of-upflow-biological-activated-carbon-effluent
#14
Lu Ao, Wenjun Liu, Minglu Zhang, Xiaomao Wang
Three different hollow-fibre ultrafiltration (UF) membranes were applied to treat upflow biological activated carbon (UBAC) effluent to determine the characteristics of membrane biofouling by microorganisms and particles. At the beginning of filtration, the cake layer formed on the membrane was loose and highly compressible, and the trans-membrane pressure (TMP) rapidly increased. When compressed to a certain extent, cake layer with low compressibility was formed by the accumulated particles and resulted in slower TMP increment...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149746/habitat-mosaics-and-path-analysis-can-improve-biological-conservation-of-aquatic-biodiversity-in-ecosystems-with-low-head-dams
#15
Sean M Hitchman, Martha E Mather, Joseph M Smith, Jane S Fencl
Conserving native biodiversity depends on restoring functional habitats in the face of human-induced disturbances. Low-head dams are a ubiquitous human impact that degrades aquatic ecosystems worldwide. To improve our understanding of how low-head dams impact habitat and associated biodiversity, our research examined complex interactions among three spheres of the total environment. i.e., how low-head dams (anthroposphere) affect aquatic habitat (hydrosphere), and native biodiversity (biosphere) in streams and rivers...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149730/divergence-of-insulin-superfamily-ligands-receptors-and-igf-binding-proteins-in-marine-versus-freshwater-stickleback-evidence-of-selection-in-known-and-novel-genes
#16
Tim Pellissier, Hend Al Nafea, Sara V Good
Three-spine stickleback (Gasterosteus aculeatus) is a teleost model for understanding genetic, physiological and morphological changes accompanying freshwater (FW) adaptation. There is growing evidence that the insulin superfamily plays important roles in traits involved in marine and FW adaptation. We performed a candidate gene analysis to look for evidence of selection on 33 insulin superfamily ligand-receptor genes and insulin-like growth factor binding proteins (Igfbp's) in stickleback. Using genotype data from 11 marine and 10 FW populations, we calculated the number of SNPs per site in regulatory and intronic regions, the number of synonymous and nonsynonymous mutations in coding regions, Wright's fixation index (Fst), and performed t-tests to identify SNPs with divergent genotype frequencies between marine/FW versus Atlantic/Pacific populations...
November 10, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29149719/tissue-specific-bioaccumulation-of-long-chain-perfluorinated-carboxylic-acids-and-halogenated-methylbipyrroles-in-dall-s-porpoises-phocoenoides-dalli-and-harbor-porpoises-phocoena-phocoena-stranded-in-northern-japan
#17
Yukiko Fujii, Yoshihisa Kato, Kentarou Sakamoto, Takashi Matsuishi, Harada H Kouji, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi
This study investigated accumulation of perfluoroalkyl substances (PFASs), persistent organochlorines (OCs), and naturally produced halogenated compounds (NHCs), including brominated methylbipyrroles and methoxylated bromodiphenyl ethers, in liver, blood, and blubber from Dall's porpoises (Phocoenoides dalli) and harbor porpoises (Phocoena phocoena) stranded in Hokkaido, northern Japan. Profiles of the PFASs were dominated by perfluoroundecanoic acid and perfluorotridecanoic acid, both of which accounted for 70% of the total measured PFAS concentrations in both porpoise species...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29149716/longitudinal-associations-between-resilience-and-quality-of-life-in-eating-disorders
#18
Esther Calvete, Carlota Las Hayas, Andrés Gómez Del Barrio
OBJECTIVE: This study examined the longitudinal reciprocal associations between resilience factors, quality of life (QoL) domains, and symptoms of eating disorders (EDs). Hypotheses included predictive paths from resilience factors of "acceptance of self and life" and "personal competence" to increased QoL and predictive paths from previous levels of QoL to resilience. METHOD: A total of 184 patients with EDs (mean age = 29.55, SD = 9.17, 94.8% women) completed measures of resilience, QoL, and EDs symptoms over three waves spaced six month apart...
November 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29149712/detection-of-perfluoroalkyl-acids-and-sulphonates-in-italian-eel-samples-by-hplc-hrms-orbitrap
#19
Luca Maria Chiesa, Maria Nobile, Elisa Pasquale, Claudia Balzaretti, Petra Cagnardi, Doriana Tedesco, Sara Panseri, Francesco Arioli
Perfluoroalkyl substances (PFASs) contain one or more carbon-bound hydrogens substituted by fluorine. Since the 1950s, these compounds have been used to manufacture fat- and water-resistant fabrics, paper and food containers, and to produce photographic films, firefighting foams, detergents and insecticides. The widespread use and global distribution of PFASs, have led to their accumulation in the environment. Food, particularly fish and other seafood, is considered the main route of human exposure to PFASs...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29149710/prevalence-and-sources-of-polychlorinated-biphenyls-in-the-atmospheric-environment-of-lake-victoria-east-africa
#20
Kenneth Arinaitwe, Derek C G Muir, Bernard T Kiremire, Phil Fellin, Henrik Li, Camilla Teixeira, Drake N Mubiru
The large surface area of Lake Victoria (about 68,800 km(2)) makes it vulnerable to high atmospheric deposition of chemical pollutants. We present measurements of polychlorinated biphenyls (PCBs) from the lake's atmospheric environment. High volume air (24 h) samples were collected within the northern Lake Victoria watershed in Uganda over two periods; 1999-2004 [at Kakira (KAK) and Entebbe (EBB)] and 2008-2010 (at EBB only). Precipitation samples were also collected monthly during the 2008-2010 period at EBB...
November 10, 2017: Chemosphere
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