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Jeremy Lewis

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https://www.readbyqxmd.com/read/29336108/reversible-co2-addition-to-si-o-bond-and-synthesis-of-a-persistent-sio2-co2-cycloadduct-stabilized-by-a-lewis-donor-acceptor-ligand
#1
Tsuyoshi Kato, Ricardo Rodriguez, Isabel Alvarado-Beltran, Jérémy Saouli, Antoine Baceiredo, Nathalie Saffon-Merceron, Vicenç Branchadell
The donor-stabilized sila--lactone reacts with CO2 via a [2+2]-cycloaddition to form the spiro-cyclic silicon carbonate derivative. Of particular interest, this process is reversible at room temperature. Furthermore, the photolysis of resulting CO2 adduct affords the first persistent SiO2-CO2 mixed dimer (SiCO4), presenting a Si2O4-like structure, which is stabilized by a Lewis donor-acceptor type ligand. As predicted by theoretical calculations, in marked contrast to Si2O4, the mixed dimer SiCO4 is labile and readily releases CO2...
January 15, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29305377/are-corticosteroid-injections-more-beneficial-than-anaesthetic-injections-alone-in-the-management-of-rotator-cuff-related-shoulder-pain-a-systematic-review
#2
REVIEW
Tim Cook, Catherine Minns Lowe, Mark Maybury, Jeremy S Lewis
OBJECTIVE: To compare the effectiveness of corticosteroid injections to local anaesthetic injections in the management of rotator cuff-related shoulder pain (RCRSP). DESIGN: Systematic review with best evidence synthesis. DATA SOURCES: The Cochrane, PubMed, CINAHL Plus, PEDro and EMBASE electronic databases were searched (inception until 8 June 2017). Reference lists of included articles were also hand searched. ELIGIBILITY CRITERIA: Two reviewers independently evaluated eligibility...
January 5, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29297596/neuropathology-of-autonomic-dysfunction-in-synucleinopathies
#3
REVIEW
Elizabeth A Coon, Jeremy K Cutsforth-Gregory, Eduardo E Benarroch
The synucleinopathies-Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure-result from distinct patterns of abnormal α-synuclein aggregation throughout the nervous system. Autonomic dysfunction in these disorders results from variable involvement of the central and peripheral autonomic networks. The major pathologic hallmark of Parkinson's disease and dementia with Lewy bodies is Lewy bodies and Lewy neurites; of multiple system atrophy, oligodendroglial cytoplasmic inclusions; and of pure autonomic failure, peripheral neuronal cytoplasmic inclusions...
January 3, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29291281/benefits-and-threats-to-using-social-media-for-presenting-and-implementing-evidence
#4
Chad E Cook, Neil E O'Connell, Toby Hall, Steven Z George, Gwendolen Jull, Alexis A Wright, Enrique Lluch Girbés, Jeremy Lewis, Mark Hancock
As a potential high-yield tool for disseminating information that can reach many people, social media is transforming how clinicians, the public, and policy makers are educated and find new knowledge associated with research-related information. Social media is available to all who access the internet, reducing selected barriers to acquiring original source documents such as journal articles or books and potentially improving implementation-the process of formulating a conclusion and moving on that decision...
January 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29217293/an-evaluation-of-two-types-of-exercise-classes-containing-shoulder-exercises-or-a-combination-of-shoulder-and-thoracic-exercises-for-the-treatment-of-nonspecific-shoulder-pain-a-case-series
#5
Eva Barrett, Carmela Conroy, Marie Corcoran, Kieran O' Sullivan, Helen Purtill, Jeremy Lewis, Karen McCreesh
STUDY DESIGN: A case series was carried out. INTRODUCTION: There is a lack of evidence exploring the effectiveness of group exercise classes for people with nonspecific shoulder pain (NSSP). Also, there is a lack of research that measures potential reductions in thoracic kyphosis after exercise interventions in people with NSSP. PURPOSE OF THE STUDY: To observe changes in shoulder pain, disability, and thoracic kyphosis in 2 groups of people with NSSP, after 2 different types of group exercise classes...
December 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29196240/the-pathophysiology-of-human-obstructive-cholestasis-is-mimicked-in-cholestatic-gold-syrian-hamsters
#6
Rowan F van Golen, Pim B Olthof, Lianne R de Haan, Robert-Jan Coelen, Alexandros Pechlivanis, Mark J de Keijzer, Ruud Weijer, Dirk R de Waart, André B P van Kuilenburg, Jeroen Roelofsen, Pim W Gilijamse, Martinus A Maas, Matthew R Lewis, Jeremy K Nicholson, Joanne Verheij, Michal Heger
Obstructive cholestasis causes liver injury via accumulation of toxic bile acids (BAs). Therapeutic options for cholestatic liver disease are limited, partially because the available murine disease models lack translational value. Profiling of time-related changes following bile duct ligation (BDL) in Gold Syrian hamsters revealed a biochemical response similar to cholestatic patients in terms of BA pool composition, alterations in hepatocyte BA transport and signaling, and suppression of BA production. Hamsters tolerated cholestasis well for up to 28days and progressed relatively slowly to fibrotic liver injury...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29190003/p16-immunohistochemistry-in-oropharyngeal-squamous-cell-carcinoma-using-the-e6h4-antibody-clone-a-technical-method-study-for-optimal-dilution
#7
James S Lewis, Jeremy Shelton, Krystle Lang Kuhs, Derek K Smith
Routine testing for p16 immunohistochemistry (with selective HPV-specific test use) has been recommended for clinical practice in oropharyngeal squamous cell carcinoma (OPSCC). Data suggests that the E6H4 clone performs best for this purpose, yet no studies have evaluated the optimal antibody concentration for OPSCC testing. We evaluated three concentrations (undiluted, 1:5, and 1:10) of the primary antibody solution for E6H4 using tissue microarrays from a cohort of 199 OPSCC patients with a > 70% staining cutoff for positivity...
November 30, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29189267/in-response
#8
Emily J MacKay, Michael D Stubna, Daniel N Holena, Patrick M Reilly, Mark J Seamon, Brian P Smith, Lewis J Kaplan, Jeremy W Cannon
No abstract text is available yet for this article.
November 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29183925/cohort-profile-the-truenth-global-registry-an-international-registry-to-monitor-and-improve-localised-prostate-cancer-health-outcomes
#9
Sue M Evans, Jeremy L Millar, Caroline M Moore, John D Lewis, Hartwig Huland, Fanny Sampurno, Sarah E Connor, Paul Villanti, Mark S Litwin
PURPOSE: Globally, prostate cancer treatment and outcomes for men vary according to where they live, their race and the care they receive. The TrueNTH Global Registry project was established as an international registry monitoring care provided to men with localised prostate cancer (CaP). PARTICIPANTS: Sites with existing CaP databases in Movember fundraising countries were invited to participate in the international registry. In total, 25 Local Data Centres (LDCs) representing 113 participating sites across 13 countries have nominated to contribute to the project...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29153987/development-and-characterization-of-a-human-and-mouse-intestinal-epithelial-cell-monolayer-platform
#10
Kenji Kozuka, Ying He, Samantha Koo-McCoy, Padmapriya Kumaraswamy, Baoming Nie, Karen Shaw, Priscilla Chan, Michael Leadbetter, Limin He, Jason G Lewis, Ziyang Zhong, Dominique Charmot, Marwan Balaa, Andrew J King, Jeremy S Caldwell, Matthew Siegel
We describe the development and characterization of a mouse and human epithelial cell monolayer platform of the small and large intestines, with a broad range of potential applications including the discovery and development of minimally systemic drug candidates. Culture conditions for each intestinal segment were optimized by correlating monolayer global gene expression with the corresponding tissue segment. The monolayers polarized, formed tight junctions, and contained a diversity of intestinal epithelial cell lineages...
November 7, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29111847/validation-of-the-manual-inclinometer-and-flexicurve-for-the-measurement-of-thoracic-kyphosis
#11
Eva Barrett, Brian Lenehan, Kieran O'sullivan, Jeremy Lewis, Karen McCreesh
INTRODUCTION: Physiotherapists commonly use the manual inclinometer and Flexicurve for the clinical measurement of thoracic spinal posture. The aim of this study is to examine the concurrent validity of the Flexicurve and manual inclinometer in relation to the radiographic Cobb angle for the measurement of thoracic kyphosis. METHODS: Eleven subjects (seven males, four females) underwent a sagittal plane spinal radiograph. Immediately following the radiograph, a physiotherapist measured thoracic kyphosis using the Flexicurve and manual inclinometer before the subjects moved from position...
November 7, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29105928/lego-bricks-and-the-octet-rule-molecular-models-for-biochemical-pathways-with-plastic-interlocking-toy-bricks
#12
Henry J Lin, Jennifer Lehoang, Isabel Kwan, Anita Baghaee, Priya Prasad, Stephanie J Ha-Chen, Tanesha Moss, Jeremy D Woods
The 8 studs on a 2 × 4 Lego brick conveniently represent the outer shell of electrons for carbon, nitrogen, and oxygen atoms. We used Lego bricks to model these atoms, which are then joined together to form molecules by following the Lewis octet rule. A variety of small biological molecules can be modeled in this way, such as most amino acids, fatty acids, glucose, and various intermediate metabolites. Model building with these familiar toys can be a helpful, hands-on exercise for learning-or re-learning-biochemical pathways...
November 6, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29092942/pdx-mi-minimal-information-for-patient-derived-tumor-xenograft-models
#13
Terrence F Meehan, Nathalie Conte, Theodore Goldstein, Giorgio Inghirami, Mark A Murakami, Sebastian Brabetz, Zhiping Gu, Jeffrey A Wiser, Patrick Dunn, Dale A Begley, Debra M Krupke, Andrea Bertotti, Alejandra Bruna, Matthew H Brush, Annette T Byrne, Carlos Caldas, Amanda L Christie, Dominic A Clark, Heidi Dowst, Jonathan R Dry, James H Doroshow, Olivier Duchamp, Yvonne A Evrard, Stephane Ferretti, Kristopher K Frese, Neal C Goodwin, Danielle Greenawalt, Melissa A Haendel, Els Hermans, Peter J Houghton, Jos Jonkers, Kristel Kemper, Tin O Khor, Michael T Lewis, K C Kent Lloyd, Jeremy Mason, Enzo Medico, Steven B Neuhauser, James M Olson, Daniel S Peeper, Oscar M Rueda, Je Kyung Seong, Livio Trusolino, Emilie Vinolo, Robert J Wechsler-Reya, David M Weinstock, Alana Welm, S John Weroha, Frédéric Amant, Stefan M Pfister, Marcel Kool, Helen Parkinson, Atul J Butte, Carol J Bult
Patient-derived tumor xenograft (PDX) mouse models have emerged as an important oncology research platform to study tumor evolution, mechanisms of drug response and resistance, and tailoring chemotherapeutic approaches for individual patients. The lack of robust standards for reporting on PDX models has hampered the ability of researchers to find relevant PDX models and associated data. Here we present the PDX models minimal information standard (PDX-MI) for reporting on the generation, quality assurance, and use of PDX models...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29080011/oil-spill-response-capabilities-and-technologies-for-ice-covered-arctic-marine-waters-a-review-of-recent-developments-and-established-practices
#14
Jeremy Wilkinson, C J Beegle-Krause, Karl-Ulrich Evers, Nick Hughes, Alun Lewis, Mark Reed, Peter Wadhams
Renewed political and commercial interest in the resources of the Arctic, the reduction in the extent and thickness of sea ice, and the recent failings that led to the Deepwater Horizon oil spill, have prompted industry and its regulatory agencies, governments, local communities and NGOs to look at all aspects of Arctic oil spill countermeasures with fresh eyes. This paper provides an overview of present oil spill response capabilities and technologies for ice-covered waters, as well as under potential future conditions driven by a changing climate...
December 2017: Ambio
https://www.readbyqxmd.com/read/29074231/the-engage-study-integrating-neuroimaging-virtual-reality-and-smartphone-sensing-to-understand-self-regulation-for-managing-depression-and-obesity-in-a-precision-medicine-model
#15
Leanne M Williams, Adam Pines, Andrea N Goldstein-Piekarski, Lisa G Rosas, Monica Kullar, Matthew D Sacchet, Olivier Gevaert, Jeremy Bailenson, Philip W Lavori, Paul Dagum, Brian Wandell, Carlos Correa, Walter Greenleaf, Trisha Suppes, L Michael Perry, Joshua M Smyth, Megan A Lewis, Elizabeth M Venditti, Mark Snowden, Janine M Simmons, Jun Ma
Precision medicine models for personalizing achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behaviors is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and obesity - two top contributors to the global burden of disease and disability. To optimize treatments and address these burdens, behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings...
October 7, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28971642/increased-cd11b-cells-and-interleukin-1-il-1-alpha-levels-during-cardiomyopathy-induced-by-chronic-adrenergic-activation
#16
Jeremy Ben-Shoshan, Ayman Jubran, Ran Levy, Gad Keren, Michal Entin-Meer
BACKGROUND: Systemic CD11b+ cells have been associated with several cardiac diseases, such as chronic heart failure. OBJECTIVES: To assess the levels of circulating CD11b+ cells and pro-inflammatory cytokines in cardiomyopathy induced by chronic adrenergic stimulation. METHODS: Male Lewis rats were injected with low doses of isoproterenol (isoprel) for 3 months. Cardiac parameters were tested by echocardiography. The percentage of CD11b+ cells was tested by flow cytometry...
September 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28958785/cognitive-impairment-mediates-workplace-impairment-in-persons-with-type-2-diabetes-mellitus-results-from-the-motivaction-study
#17
Yena Lee, Allan Smofsky, Priscilla Nykoliation, Stephen Allain, Linda Lewis-Daly, Jeremy Schwartz, Joshua Hart Pollack, Jean-Eric Tarride, Roger S McIntyre
OBJECTIVES: Type 2 diabetes mellitus (DM) is associated with substantial impairments in workplace function; however, the mediators of workplace performance in DM are not well characterized. Herein, we investigate depressive symptomatology and cognitive dysfunction as mediators of workplace productivity and hypothesize that workplace impairment is mediated principally by cognitive dysfunction in DM. METHODS: The Motivaction study screened individuals employed across Canada for diabetes...
September 25, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28950735/systematic-review-of-examination-techniques-for-the-central-slip-of-the-digital-extensor-tendon-mechanism
#18
Lewis Dingle, Michael Field, Jeremy N Rodrigues
No abstract text is available yet for this article.
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28874329/outcome-after-turndown-for-elective-abdominal-aortic-aneurysm-surgery
#19
Joshua D Whittaker, Lewis Meecham, Virginia Summerour, Sheirin Khalil, Georgia Layton, Marianne Yousif, Adrian Jennings, Micheal Wall, Jeremy Newman
OBJECTIVES: The aim was to assess the survival of patients who had been turned down for repair of an abdominal aortic aneurysm (AAA) and to examine the factors influencing this. METHODS: This was a retrospective observational study of a prospectively maintained database of all patients turned down for AAA intervention by the Black Country Vascular Network multidisciplinary team (MDT) from January 2013 to December 2015. Data on AAA size, cardiopulmonary exercise testing (CPET) and cause of death were recorded...
November 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28853740/erratum-structural-and-conformational-determinants-of-macrocycle-cell-permeability
#20
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
No abstract text is available yet for this article.
July 18, 2017: Nature Chemical Biology
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