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Jeremy Lewis

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https://www.readbyqxmd.com/read/28641737/exploring-experiences-barriers-and-enablers-to-home-and-class-based-exercise-in-rotator-cuff-tendinopathy-a-qualitative-study
#1
Fiona M Sandford, Thomas A B Sanders, Jeremy S Lewis
STUDY DESIGN: Qualitative study. INTRODUCTION: Adherence is paramount to the successful outcome of exercise-based treatment. PURPOSE OF STUDY: The barriers and enablers to adherence to a home- and class-based exercise program were explored in this qualitative study. METHODS: Semi-structured interviews were carried out to establish common themes relating to the participants' experiences during a year-long randomized controlled trial...
April 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28621317/p16-immunohistochemistry-in-oropharyngeal-squamous-cell-carcinoma-a-comparison-of-antibody-clones-using-patient-outcomes-and-high-risk-human-papillomavirus-rna-status
#2
Jeremy Shelton, Bibianna M Purgina, Nicole A Cipriani, William D Dupont, Dale Plummer, James S Lewis
High-risk human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas have a more favorable prognosis than HPV-negative ones. p16 immunohistochemistry has been recommended as a prognostic test in clinical practice. Several p16 antibodies are available, and their performance has not been directly compared. We evaluated three commercially available p16 antibody clones (E6H4, JC8 and G175-405) utilizing 199 cases of oropharyngeal squamous cell carcinoma from a tissue microarray, read by three pathologists with three different cutoffs for positivity: any staining, >50% and >75%...
June 16, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28547805/quality-and-impact-of-eviq-cancer-treatments-online-www-eviq-org-au-the-medical-oncologist-s-perspective
#3
Lydia P Y Loke, Tina Y T Chen, Craig R Lewis, Robyn L Ward, Shelley A Rushton, Jeremy D Shapiro
INTRODUCTION: eviQ Cancer Treatments Online is a free, web-based resource providing access to over 600 evidence-based treatment protocols in medical oncology, radiation oncology, hematology and cancer genetics. With over 60 000 registrants from 148 countries, eviQ is widely used by cancer clinicians globally. The aim of this study was to examine the perceived quality of eviQ by Australian medical oncologists, the impact it had on their knowledge and practice, and the effect it had on their patients...
May 25, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28422371/effects-of-m1-and-m4-activation-on-excitatory-synaptic-transmission-in-ca1
#4
Catherine A Thorn, Michael Popiolek, Eda Stark, Jeremy R Edgerton
Hippocampal networks are particularly susceptible to dysfunction in many neurodegenerative diseases and neuropsychiatric disorders including Alzheimer's disease, Lewy body dementia, and schizophrenia. CA1, a major output region of the hippocampus, receives glutamatergic input from both hippocampal CA3 and entorhinal cortex, via the Schaffer collateral (SC) and temporoammonic (TA) pathways, respectively. SC and TA inputs to CA1 are thought to be differentially involved in the retrieval of previously stored memories versus the encoding of novel information, and switching between these two crucial hippocampal functions is thought to critically depend on acetylcholine (ACh) acting at muscarinic receptors...
July 2017: Hippocampus
https://www.readbyqxmd.com/read/28299879/how-accurate-are-medical-oncologists-impressions-of-management-of-metastatic-colorectal-cancer-in-australia
#5
Lewis Au, Natalie Turner, Hui-Li Wong, Kathryn Field, Belinda Lee, David Boadle, Prasad Cooray, Deme Karikios, Suzanne Kosmider, Lara Lipton, Louise Nott, Phillip Parente, Jeanne Tie, Ben Tran, Rachel Wong, Desmond Yip, Jeremy Shapiro, Peter Gibbs
AIM: Current efforts to understand patient management in clinical practice are largely based on clinician surveys with uncertain reliability. The TRACC (Treatment of Recurrent and Advanced Colorectal Cancer) database is a multisite registry collecting comprehensive treatment and outcome data on consecutive metastatic colorectal cancer (mCRC) patients at multiple sites across Australia. This study aims to determine the accuracy of oncologists' impressions of real-word practice by comparing clinicians' estimates to data captured by TRACC...
March 16, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28280627/minimally-invasive-ivor-lewis-esophagectomy-for-esophageal-cancer-with-right-aortic-arch
#6
Jeremy Linson, Michael Latzko, Bestoun Ahmed, Ziad Awad
Right aortic arch (RAA) is a rare congenital vascular abnormality in which the aorta descends in the right thorax and encircles the esophagus. Historically, esophagectomy for patients for RAA is done through a left thoracotomy as exposure and mobilization of the esophagus is difficult through a right thoracotomy. A 73-year-old male was found to have an esophageal adenocarcinoma. Endoscopic ultrasound showed a T3N0 lesion in the lower third of the esophagus. PET CT demonstrated a circumferential lesion without evidence of distant disease or involved lymph nodes and a RAA which was not associated with congenital heart disease or symptoms...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28267733/us-immigration-order-strikes-against-biotech
#7
Jeremy M Levin, Steven H Holtzman, John Maraganore, Paul J Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall, James E Audia, Martin Babler, Peter Barrett, Zoe Barry, Nessan Bermingham, Stephen Bloch, Robert I Blum, Paul B Bolno, Michael W Bonney, Bruce Booth, Daniel M Bradbury, Steven K Brauer, Brook Byers, Pablo J Cagnoni, Brian M Cali, Isaac Ciechanover, Chip Clark, Michael D Clayman, Jeff L Cleland, Paula Cobb, Ron Cooper, Mark G Currie, John Diekman, Eric L Dobmeier, Doug Doerfler, Elizabeth Lr Donley, Deborah Dunsire, Matthew During, Jens W Eckstein, Eric Elenko, Neil A Exter, Jonathan J Fleming, Gregory J Flesher, Jean-Francois Formela, Robert Forrester, Cedric Francois, Heather Franklin, Mason W Freeman, Howard Furst, Leonard Patrick Gage, Nicholas Galakatos, Brian M Gallagher, James A Geraghty, Simba Gill, David V Goeddel, Mark A Goldsmith, Maxine Gowen, Vikas Goyal, Tom Graney, David Grayzel, Barry Greene, Paul Grint, J C Gutierrez-Ramos, Bill Haney, Tuan Ha-Ngoc, Tim Harris, Faheem Hasnain, Yujiro Steve Hata, Peter Hecht, Leslie Henshaw, Rich Heyman, Herve Hoppenot, H Robert Horvitz, Thomas E Hughes, Wende S Hutton, Stephen T Isaacs, Annalisa Jenkins, Jeff Jonker, Jeff Kaplan, Perry Karsen, Jeb Keiper, Jean Kim, Jeff Kindler, Rachel King, Vanessa King, Nina Kjellson, Scott Koenig, Gerhard Koenig, Peter Kolchinsky, Paul Laikind, Robert Bob Langer, John J Lee, Jonathan S Leff, Bruce A Leicher, Nick Leschly, Andrew Levin, Mark Levin, Arnold J Levine, Alan Levy, David R Liu, Harvey F Lodish, Uri Lopatin, Ted W Love, Guy Macdonald, Gail J Maderis, Ankit Mahadevia, Nagesh K Mahanthappa, Joel F Martin, Alex Martin, W Eddie Martucci, James G McArthur, Corey M McCann, Sean A McCarthy, C Geoffrey McDonough, John Mendlein, Larry Miller, Diego Miralles, Kenneth I Moch, Bob More, Andrew G Myers, Michael A Narachi, Amir Nashat, Wendy Nelson, William J Newell, Bernat Olle, John E Osborn, Julia C Owens, Atul Pande, Stelios Papadopoulos, H Stewart Parker, Kush M Parmar, Matthew R Patterson, Steve M Paul, Rob Perez, Matthew Perry, Cary G Pfeffer, Mike Powell, Mark Pruzanski, Dennis J Purcell, Amit Rakhit, Kartik Ramamoorthi, William Rastetter, Adrian Ad Rawcliffe, Laurence E Reid, Ron C Renaud, Jason P Rhodes, William J Rieflin, Chad Robins, Scott M Rocklage, Michael Rosenblatt, Jonathan G Rosin, William J Rutter, Saurabh Saha, Camille Samuels, Vicki L Sato, George Scangos, John A Scarlett, David Schenkein, Stuart L Schreiber, Andrew Schwab, Paul Sekhri, Rajeev Shah, Thomas Shenk, Clay B Siegall, Nick J Simon, Nancy Simonian, Jeff Stein, Michael Su, Mary T Szela, Marco Taglietti, Nina Tandon, Henri Termeer, Nancy A Thornberry, Martin Tolar, Richard Ulevitch, Akshay K Vaishnaw, Anne VanLent, Martin Varsavsky, George P Vlasuk, Michel Vounatsos, Samuel G Waksal, Neil Warma, Ryan J Watts, Yaron Werber, Christoph Westphal, Wendell Wierenga, Doug E Williams, Lewis Rusty Williams, Kleanthis G Xanthopoulos, Daphne Zohar, Sandford Sandy Zweifach
No abstract text is available yet for this article.
March 7, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28267381/dynamics-of-5-carboxylcytosine-during-hepatic-differentiation-potential-general-role-for-active-demethylation-by-dna-repair-in-lineage-specification
#8
Lara C Lewis, Peggy Cho Kiu Lo, Jeremy M Foster, Nan Dai, Ivan R Corrêa, Paulina M Durczak, Gary Duncan, Ashley Ramsawhook, Guruprasad Padur Aithal, Chris Denning, Nicholas R F Hannan, Alexey Ruzov
Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression. TET proteins oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Both 5fC and 5caC can be recognized and excised from DNA by thymine-DNA glycosylase (TDG) followed by the subsequent incorporation of unmodified cytosine into the abasic site via the base excision repair (BER) pathway. We previously demonstrated that 5caC accumulates during lineage specification of neural stem cells (NSCs) suggesting that such active demethylation pathway is operational in this system; however, it is still unknown if TDG/BER-dependent demethylation is used during other types of cellular differentiation...
April 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28241237/association-of-testosterone-levels-with-anemia-in-older-men-a-controlled-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
Cindy N Roy, Peter J Snyder, Alisa J Stephens-Shields, Andrew S Artz, Shalender Bhasin, Harvey J Cohen, John T Farrar, Thomas M Gill, Bret Zeldow, David Cella, Elizabeth Barrett-Connor, Jane A Cauley, Jill P Crandall, Glenn R Cunningham, Kristine E Ensrud, Cora E Lewis, Alvin M Matsumoto, Mark E Molitch, Marco Pahor, Ronald S Swerdloff, Denise Cifelli, Xiaoling Hou, Susan M Resnick, Jeremy D Walston, Stephen Anton, Shehzad Basaria, Susan J Diem, Christina Wang, Stanley L Schrier, Susan S Ellenberg
Importance: In one-third of older men with anemia, no recognized cause can be found. Objective: To determine if testosterone treatment of men 65 years or older with unequivocally low testosterone levels and unexplained anemia would increase their hemoglobin concentration. Design, Setting, and Participants: A double-blinded, placebo-controlled trial with treatment allocation by minimization using 788 men 65 years or older who have average testosterone levels of less than 275 ng/dL...
April 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28240543/integrated-analytical-and-statistical-two-dimensional-spectroscopy-strategy-for-metabolite-identification-application-to-dietary-biomarkers
#10
Joram M Posma, Isabel Garcia-Perez, James C Heaton, Paula Burdisso, John C Mathers, John Draper, Matt Lewis, John C Lindon, Gary Frost, Elaine Holmes, Jeremy K Nicholson
A major purpose of exploratory metabolic profiling is for the identification of molecular species that are statistically associated with specific biological or medical outcomes; unfortunately, the structure elucidation process of unknowns is often a major bottleneck in this process. We present here new holistic strategies that combine different statistical spectroscopic and analytical techniques to improve and simplify the process of metabolite identification. We exemplify these strategies using study data collected as part of a dietary intervention to improve health and which elicits a relatively subtle suite of changes from complex molecular profiles...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/27911006/lrrk2-levels-and-phosphorylation-in-parkinson-s-disease-brain-and-cases-with-restricted-lewy-bodies
#11
Nicolas Dzamko, Amanda M Gysbers, Rina Bandopadhyay, Marc F Bolliger, Akiko Uchino, Ye Zhao, Masaki Takao, Sandrine Wauters, Wilma D J van de Berg, Junko Takahashi-Fujigasaki, R Jeremy Nichols, Janice L Holton, Shigeo Murayama, Glenda M Halliday
BACKGROUND: Leucine rich repeat kinase 2 (LRRK2) is a promising target for the treatment of Parkinson's disease; however, little is known about the expression of LRRK2 in human brain and if/how LRRK2 protein levels are altered in Parkinson's disease. OBJECTIVES: We measured the protein levels of LRRK2 as well as its phosphorylation on serines 910, 935, and 973 in the postmortem brain tissue of Parkinson's disease patients and aged controls with and without Lewy bodies...
March 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27900200/inter-rater-reliability-of-the-shoulder-symptom-modification-procedure-in-people-with-shoulder-pain
#12
Jeremy S Lewis, Karen McCreesh, Eva Barratt, Eric J Hegedus, Julius Sim
BACKGROUND: Musculoskeletal conditions involving the shoulder are common and, because of the importance of the upper limb and hand in daily function, symptoms in this region are commonly associated with functional impairment in athletic and non-athletic populations. Deriving a definitive diagnosis as to the cause of shoulder symptoms is fraught with difficulty. Limitations have been recognised for imaging and for orthopaedic special tests. 1 solution is to partially base management on the response to tests aimed at reducing the severity of the patient's perception of symptoms...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900198/do-rocker-sole-shoes-influence-postural-stability-in-chronic-low-back-pain-a-randomised-trial
#13
C Sian MacRae, Duncan Critchley, Matthew Morrissey, Adam Shortland, Jeremy S Lewis
BACKGROUND: People with chronic low back pain (CLBP) demonstrate greater postural instability compared with asymptomatic individuals. Rocker-sole shoes are inherently unstable and may serve as an effective balance training device. This study hypothesised that wearing rocker-sole shoes would result in long-term improvement in barefoot postural stability in people with CLBP. METHODS: 20 participants with CLBP were randomised to wear rocker-sole or flat-sole shoes for a minimum of 2 hours each day...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899636/the-monarch-initiative-an-integrative-data-and-analytic-platform-connecting-phenotypes-to-genotypes-across-species
#14
Christopher J Mungall, Julie A McMurry, Sebastian Köhler, James P Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, J P Gourdine, Julius O B Jacobsen, Dan Keith, Bryan Laraway, Suzanna E Lewis, Jeremy NguyenXuan, Kent Shefchek, Nicole Vasilevsky, Zhou Yuan, Nicole Washington, Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N Robinson, Melissa A Haendel
The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype-phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27880749/early-diagnosis-of-hiv-infection-in-infants-one-caribbean-and-six-sub-saharan-african-countries-2011-2015
#15
Karidia Diallo, Andrea A Kim, Shirley Lecher, Dennis Ellenberger, R Suzanne Beard, Helen Dale, Mackenzie Hurlston, Molly Rivadeneira, Peter N Fonjungo, Laura N Broyles, Guoqing Zhang, Katrina Sleeman, Shon Nguyen, Steve Jadczak, Nadine Abiola, Raimi Ewetola, Jérémie Muwonga, Franck Fwamba, Christina Mwangi, Mary Naluguza, Charles Kiyaga, Isaac Ssewanyana, Deyde Varough, Domercant Wysler, David Lowrance, Frantz Jean Louis, Olbeg Desinor, Josiane Buteau, Francois Kesner, Vanessa Rouzier, Nat Segaren, Tessa Lewis, Abdoulaye Sarr, Geoffrey Chipungu, Sundeep Gupta, Daniel Singer, Reuben Mwenda, Hilary Kapoteza, Zawadi Chipeta, Nancy Knight, Sergio Carmona, William MacLeod, Gayle Sherman, Yogan Pillay, Clement B Ndongmo, Bridget Mugisa, Annie Mwila, James McAuley, Peter J Chipimo, Wezi Kaonga, Dailess Nsofwa, Davy Nsama, Fales Zulu Mwamba, Crispin Moyo, Clement Phiri, Marie-Yolande Borget, Leonard Ya-Kouadio, Abo Kouame, Christiane A Adje-Toure, John Nkengasong
Pediatric human immunodeficiency virus (HIV) infection remains an important public health issue in resource-limited settings. In 2015, 1.4 million children aged <15 years were estimated to be living with HIV (including 170,000 infants born in 2015), with the vast majority living in sub-Saharan Africa (1). In 2014, 150,000 children died from HIV-related causes worldwide (2). Access to timely HIV diagnosis and treatment for HIV-infected infants reduces HIV-associated mortality, which is approximately 50% by age 2 years without treatment (3)...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27875104/ct-guided-native-medical-renal-biopsy-cortical-tangential-versus-non-tangential-approaches-a-comparison-of-efficacy-and-safety
#16
COMPARATIVE STUDY
Bo Liu, Matthew O'Dell, Miguel Flores, Joseph Limback, Melissa Kendall, Julie Pepe, Jeremy R Burt, Francisco Contreras, Andrew R Lewis, Thomas J Ward
Purpose To review a single-center experience with the cortical tangential approach during computed tomography (CT)-guided native medical renal biopsy and to evaluate its efficacy and safety compared with those of a non-cortical tangential approach. Materials and Methods This retrospective study received institutional review board approval, with a waiver of the HIPAA requirement for informed consent. The number of cores, glomeruli, and complications were reviewed in 431 CT-guided medical renal biopsies performed between July 2007 and September 2015...
April 2017: Radiology
https://www.readbyqxmd.com/read/27802837/comparison-of-carnivore-omnivore-and-herbivore-mammalian-genomes-with-a-new-leopard-assembly
#17
Soonok Kim, Yun Sung Cho, Hak-Min Kim, Oksung Chung, Hyunho Kim, Sungwoong Jho, Hong Seomun, Jeongho Kim, Woo Young Bang, Changmu Kim, Junghwa An, Chang Hwan Bae, Youngjune Bhak, Sungwon Jeon, Hyejun Yoon, Yumi Kim, JeHoon Jun, HyeJin Lee, Suan Cho, Olga Uphyrkina, Aleksey Kostyria, John Goodrich, Dale Miquelle, Melody Roelke, John Lewis, Andrey Yurchenko, Anton Bankevich, Juok Cho, Semin Lee, Jeremy S Edwards, Jessica A Weber, Jo Cook, Sangsoo Kim, Hang Lee, Andrea Manica, Ilbeum Lee, Stephen J O'Brien, Jong Bhak, Joo-Hong Yeo
BACKGROUND: There are three main dietary groups in mammals: carnivores, omnivores, and herbivores. Currently, there is limited comparative genomics insight into the evolution of dietary specializations in mammals. Due to recent advances in sequencing technologies, we were able to perform in-depth whole genome analyses of representatives of these three dietary groups. RESULTS: We investigated the evolution of carnivory by comparing 18 representative genomes from across Mammalia with carnivorous, omnivorous, and herbivorous dietary specializations, focusing on Felidae (domestic cat, tiger, lion, cheetah, and leopard), Hominidae, and Bovidae genomes...
October 11, 2016: Genome Biology
https://www.readbyqxmd.com/read/27779598/clinical-significance-of-computed-tomography-contrast-extravasation-in-blunt-trauma-patients-with-a-pelvic-fracture
#18
Jeremy S Juern, David Milia, Panna Codner, Marshall Beckman, Lewis Somberg, Travis Webb, John A Weigelt
INTRODUCTION: Blunt pelvic fractures can be associated with major pelvic bleeding. The significance of contrast extravasation (CE) on computed tomography (CT) is debated. We sought to update our experience with CE on CT scan for the years 2009-2014 to determine the accuracy of CE in predicting the need for angioembolization. METHODS: This is a retrospective review of the trauma registry and our electronic medical record from a Level I trauma center. Patients seen from July 1, 2009, to September 7, 2014, with blunt pelvic fractures and contrast-enhanced CT were included...
January 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27748751/structural-and-conformational-determinants-of-macrocycle-cell-permeability
#19
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
Macrocycles are of increasing interest as chemical probes and drugs for intractable targets like protein-protein interactions, but the determinants of their cell permeability and oral absorption are poorly understood. To enable rational design of cell-permeable macrocycles, we generated an extensive data set under consistent experimental conditions for more than 200 non-peptidic, de novo-designed macrocycles from the Broad Institute's diversity-oriented screening collection. This revealed how specific functional groups, substituents and molecular properties impact cell permeability...
December 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27742439/spatial-variation-in-the-accumulation-of-pops-and-mercury-in-bottlenose-dolphins-of-the-lower-florida-keys-and-the-coastal-everglades-south-florida
#20
France Damseaux, Jeremy J Kiszka, Michael R Heithaus, George Scholl, Gauthier Eppe, Jean-Pierre Thomé, Jennifer Lewis, Wensi Hao, Michaël C Fontaine, Krishna Das
The bottlenose dolphin (Tursiops truncatus) is an upper trophic level predator and the most common cetacean species found in nearshore waters of southern Florida, including the Lower Florida Keys (LFK) and the Florida Coastal Everglades (FCE). The objective of this study was to assess contamination levels of total mercury (T-Hg) in skin and persistent organic pollutants (PCBs, PBDEs, DDXs, HCHs, HCB, Σ PCDD/Fs and Σ DL-PCBs) in blubber samples of bottlenose dolphins from LFK (n = 27) and FCE (n = 24)...
January 2017: Environmental Pollution
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