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Jeremy Lewis

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https://www.readbyqxmd.com/read/29716652/%C3%AE-synuclein-fibril-induced-paradoxical-structural-and-functional-defects-in-hippocampal-neurons
#1
Jessica M Froula, Benjamin W Henderson, Jose Carlos Gonzalez, Jada H Vaden, John W Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H Herskowitz, Laura A Volpicelli-Daley
Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson's Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the hippocampus, yet functional consequences are unclear. To determine if pathologic α-syn causes neuronal defects, we induced endogenous α-syn to form inclusions resembling those found in diseased brains by treating hippocampal neurons with α-syn fibrils. At seven days after adding fibrils, α-syn inclusions are abundant in axons, but there is no cell death at this time point, allowing us to assess for potential alterations in neuronal function that are not caused by neuron death...
May 1, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29715290/exome-array-analysis-of-adverse-reactions-to-fluoropyrimidine-based-therapy-for-gastrointestinal-cancer
#2
Matthew Traylor, Jemma L Walker, Adele A Corrigan, Monica A Hernandez, Stephen J Newhouse, Amos A Folarin, Hamel Patel, Paul J Ross, Jeremy D Sanderson, James Spicer, Natalie J Prescott, Christopher G Mathew, Anthony M Marinaki, Cathryn M Lewis
Fluoropyrimidines, including 5-fluororacil (5FU) and its pro-drug Capecitabine, are the common treatment for colorectal, breast, neck and head cancers-either as monotherapy or in combination therapy. Adverse reactions (ADRs) to the treatment are common and often result in treatment discontinuation or dose reduction. Factors contributing to ADRs, including genetic variation, are poorly characterized. We performed exome array analysis to identify genetic variants that contribute to adverse reactions. Our final dataset consisted of 504 European ancestry individuals undergoing fluoropyrimidine-based therapy for gastrointestinal cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29668958/long-term-empirical-and-observational-evidence-of-practical-helicoverpa-zea-resistance-to-cotton-with-pyramided-bt-toxins
#3
Dominic D Reisig, Anders S Huseth, Jack S Bacheler, Mohammad-Amir Aghaee, Lewis Braswell, Hannah J Burrack, Kathy Flanders, Jeremy K Greene, D Ames Herbert, Alana Jacobson, Silvana V Paula-Moraes, Phillip Roberts, Sally V Taylor
Evidence of practical resistance of Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) to Bt cotton in the United States is debatable, supported with occasional reports of boll damage in the field. Our objective was to provide both empirical and long-term observational evidence of practical resistance by linking both in-season and end-of-season measurements of H. zea damage to pyramided Bt cotton bolls and to provide Cry1Ac diet-based bioassay data in support of these damage estimates. In-season boll damage from H...
April 16, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29660004/renal-transplant-outcomes-and-de-novo-donor-specific-anti-human-leukocyte-antigen-antibodies-a-systematic-review
#4
Ankit Sharma, Joshua R Lewis, Wai H Lim, Suetonia Palmer, Giovanni Strippoli, Jeremy R Chapman, Stephen I Alexander, Jonathan C Craig, Germaine Wong
Background: Pre-transplant donor-specific anti-human leukocyte antigen antibodies (DSAs) are known risk factors for acute rejection and reduced graft survival after kidney transplantation. DSAs may also develop de novo DSAs (dnDSAs) after transplantation but the clinical implications of these antibodies remain uncertain. Methods: We undertook a systematic review of observational studies that examined the association between dnDSAs and graft and patient outcomes (through August 2017) with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system of reporting used to assess the quality of evidence available...
April 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29629771/evidence-for-redox-mechanisms-in-organometallic-chemisorption-and-reactivity-on-sulfated-metal-oxides
#5
Rachel C Klet, David M Kaphan, Cong Liu, Ce Yang, A Jeremy Kropf, Frédéric A Perras, Marek Pruski, Adam S Hock, Massimiliano Delferro
The chemical and electronic interactions of organometallic species with metal oxide support materials are of fundamental importance for the development of new classes of catalytic materials. Chemisorption of Cp*(PMe3 )IrMe2 on sulfated alumina (SA) and sulfated zirconia (SZ) led to an unexpected redox mechanism for deuteration of the ancillary Cp* ligand. Evidence for this oxidative mechanism was provided by studying the analogous homogeneous reactivity of the organometallic precursors toward trityl cation ([Ph3 C]+ ), a Lewis acid known to effect formal hydride abstraction by one-electron oxidation followed by hydrogen abstraction...
April 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29610659/survival-is-influenced-by-approaches-to-local-treatment-of-ewing-sarcoma-within-an-international-randomised-controlled-trial-analysis-of-eicess-92
#6
Jeremy Whelan, Allan Hackshaw, Anne McTiernan, Robert Grimer, David Spooner, Jessica Bate, Andreas Ranft, Michael Paulussen, Herbert Juergens, Alan Craft, Ian Lewis
Background: Two national clinical trial groups, United Kingdom Children's Cancer and Leukaemia Group (CCLG) and the German Paediatric Oncology and Haematology Group (GPOH) together undertook a randomised trial, EICESS-92, which addressed chemotherapy options for Ewing's sarcoma. We sought the causes of unexpected survival differences between the study groups. Methods: 647 patients were randomised. Cox regression analyses were used to compare event-free survival (EFS) and overall survival (OS) between the two study groups...
2018: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29555342/effectiveness-of-a-type-2-diabetes-screening-intervention-in-the-canadian-workplace
#7
Jean-Eric Tarride, Allan Smofsky, Priscilla Nykoliation, Stephen Allain, Linda Lewis-Daly, David Satok, Jeremy Schwartz, Joshua Hart Pollack, Jason Robert Guertin, Roger S McIntyre
OBJECTIVES: There is a lack of Canadian data concerning the effectiveness of diabetes interventions in the workplace. The objective of this study was to evaluate the effectiveness of Motivaction, a diabetes screening and education pilot program, in the workplace. METHODS: The Motivaction program involves a voluntary web-based diabetes health-risk assessment, the Canadian Diabetes Risk Questionnaire (CANRISK), combined with an opportunity for those eligible (i.e...
December 18, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29522906/daily-therapy-with-a-slow-releasing-h-2-s-donor-gyy4137-enables-early-functional-recovery-and-ameliorates-renal-injury-associated-with-urinary-obstruction
#8
Shouzhe Lin, Dameng Lian, Weihua Liu, Aaron Haig, Ian Lobb, Ahmed Hijazi, Hassan Razvi, Jeremy Burton, Matthew Whiteman, Alp Sener
OBJECTIVES: To assess the effects of slow-releasing H2 S donor GYY4137 on post-obstructive renal function and injury following unilateral ureteral obstruction (UUO) by using the UUO and reimplantation (UUO-R) model in rats and to elucidate potential mechanisms by using an in vitro model of epithelial-mesenchymal transition (EMT). METHODS: Male Lewis rats underwent UUO at the left ureterovesical junction. From post-operative day (POD) 1-13, rats received daily intraperitoneal (IP) injection of phosphate buffered saline (PBS, 1 mL) or GYY4137 (200 μmol/kg/day in 1 mL PBS, IP)...
June 1, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29490599/the-end-of-an-era
#9
Jeremy Lewis
In 1972, American orthopaedic surgeon Charles Neer published his seminal paper, "Anterior Acromioplasty for the Chronic Impingement Syndrome in the Shoulder: A Preliminary Report." It wasn't a robust scientific paper; however, it changed the direction of orthopaedic practice for the next half century. Neer argued that a primary cause of shoulder pain was attrition of the supraspinatus tendon and related structures from the overlying acromion, especially when the arm was elevated. Neer recommended surgical removal to stop the impingement, and over the last half century, it could be argued that millions of people around the globe would have undergone acromioplasty surgery to stop this portion of the bone impinging onto the soft tissues located in the subacromial space...
March 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29466839/memory-complaints-dementia-and-neuropathology-in-older-blacks-and-whites
#10
Zoe Arvanitakis, Sue E Leurgans, Debra A Fleischman, Julie A Schneider, Kumar B Rajan, Jeremy J Pruzin, Raj C Shah, Denis A Evans, Lisa L Barnes, David A Bennett
OBJECTIVE: To determine relationships of memory complaints to cognitive function and decline, incident dementia, and neurodegenerative and other neuropathologies, as well as the population-attributable risk for dementia in older black and white persons. METHODS: A total of 4,015 community-based persons (28% black; 74% women; mean baseline age = 78 years) were enrolled in 1 of 4 longitudinal cohort studies, and another 2,937 in a population-based cohort. Memory scores, assessed using 2 questions (5-point Likert scales) were categorized as complaints present or absent...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29429127/tissue-and-strain-specific-effects-of-a-genotoxic-carcinogen-1-3-butadiene-on-chromatin-and-transcription
#11
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29411672/management-of-fracture-dislocations-of-the-little-finger-carpometacarpal-joint-a-systematic-review
#12
Will A Cobb, Lewis Dingle, Raina Zarb Adami, Jeremy Rodrigues
Fracture-dislocations of the carpometacarpal joint (CMCJ) of the little ray involve dorsal subluxation of the metacarpal base and they may be associated with injury of neighbouring CMCJs. Different treatment options are described, with no clear consensus on their management. This study presents a systematic review of comparative studies describing the management of these injuries. A bespoke search strategy was applied across multiple databases. Results were screened against specified stepwise inclusion criteria and data were extracted independently by two authors with discrepancy resolution by a third...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29387444/comparison-of-standing-postural-control-and-gait-parameters-in-people-with-and-without-chronic-low-back-pain-a-cross-sectional-case-control-study
#13
Catharine Siân MacRae, Duncan Critchley, Jeremy S Lewis, Adam Shortland
Objective: Differences in postural control and gait have been identified between people with and without chronic low back pain (CLBP); however, many previous studies present data from small samples, or have used methodologies with questionable reliability. This study, employing robust methodology, hypothesised that there would be a difference in postural control, and spatiotemporal parameters of gait in people with CLBP compared with asymptomatic individuals. Methods: This cross-sectional case-control study age-matched and gender-matched 16 CLBP and 16 asymptomatic participants...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29367039/immunohistochemistry-testing-for-mismatch-repair-deficiency-in-stage-2-colon-cancer-a-cohort-study-of-two-cancer-centres
#14
Matthew Grant, Andrew Haydon, Lewis Au, Simon Wilkins, Karen Oliva, Eva Segelov, Yoland Antill, Peter Carne, Pravin Ranchod, Adrian Polglase, Chip Farmer, Martin Chin, Roger Wale, Paul Simpson, Stephen Bell, Stewart Skinner, Paul McMurrick, Jeremy Shapiro
BACKGROUND/OBJECTIVES: Adjuvant chemotherapy for Stage II colon cancer offers a small (2-3%) overall survival benefit and is not universally recommended. Mismatch repair deficiency (dMMR) confers an improved prognosis identifying patients unlikely to benefit from adjuvant chemotherapy. The aim of this study was to investigate the use of dMMR immunohistochemistry in two major cancer treatment centres. METHODS: Prospective data were collected on all patients with resected Stage II colon cancer between 2010 and 2015 across two large Australian hospitals...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29336108/reversible-co-2-addition-to-a-si-o-bond-and-synthesis-of-a-persistent-sio-2-co-2-cycloadduct-stabilized-by-a-lewis-donor-acceptor-ligand
#15
Ricardo Rodriguez, Isabel Alvarado-Beltran, Jérémy Saouli, Nathalie Saffon-Merceron, Antoine Baceiredo, Vicenç Branchadell, Tsuyoshi Kato
The donor-stabilized sila-β-lactone 1 reacts with CO2 via a remarkable reversible [2+2]-cycloaddition reaction to form the spiro-cyclic silicon carbonate derivative 2. Furthermore, photolysis of 2 under pressure of CO2 affords the first persistent SiO2 -CO2 cycloadduct 3, presenting a Si2 O4 -like structure, which is stabilized by a Lewis donor-acceptor type ligand. As predicted by theoretical calculations, in marked contrast to the thermodynamically stable SiO2 dimer, the SiO2 -CO2 mixed cycloadduct 3 is labile and readily releases CO2 ...
March 1, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29305377/are-corticosteroid-injections-more-beneficial-than-anaesthetic-injections-alone-in-the-management-of-rotator-cuff-related-shoulder-pain-a-systematic-review
#16
REVIEW
Tim Cook, Catherine Minns Lowe, Mark Maybury, Jeremy S Lewis
OBJECTIVE: To compare the effectiveness of corticosteroid injections to local anaesthetic injections in the management of rotator cuff-related shoulder pain (RCRSP). DESIGN: Systematic review with best evidence synthesis. DATA SOURCES: The Cochrane, PubMed, CINAHL Plus, PEDro and EMBASE electronic databases were searched (inception until 8 June 2017). Reference lists of included articles were also hand searched. ELIGIBILITY CRITERIA: Two reviewers independently evaluated eligibility...
April 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29297596/neuropathology-of-autonomic-dysfunction-in-synucleinopathies
#17
REVIEW
Elizabeth A Coon, Jeremy K Cutsforth-Gregory, Eduardo E Benarroch
The synucleinopathies-Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure-result from distinct patterns of abnormal α-synuclein aggregation throughout the nervous system. Autonomic dysfunction in these disorders results from variable involvement of the central and peripheral autonomic networks. The major pathologic hallmark of Parkinson's disease and dementia with Lewy bodies is Lewy bodies and Lewy neurites; of multiple system atrophy, oligodendroglial cytoplasmic inclusions; and of pure autonomic failure, peripheral neuronal cytoplasmic inclusions...
March 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29291281/benefits-and-threats-to-using-social-media-for-presenting-and-implementing-evidence
#18
Chad E Cook, Neil E O'Connell, Toby Hall, Steven Z George, Gwendolen Jull, Alexis A Wright, Enrique Lluch Girbés, Jeremy Lewis, Mark Hancock
As a potential high-yield tool for disseminating information that can reach many people, social media is transforming how clinicians, the public, and policy makers are educated and find new knowledge associated with research-related information. Social media is available to all who access the internet, reducing selected barriers to acquiring original source documents such as journal articles or books and potentially improving implementation-the process of formulating a conclusion and moving on that decision...
January 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29217293/an-evaluation-of-two-types-of-exercise-classes-containing-shoulder-exercises-or-a-combination-of-shoulder-and-thoracic-exercises-for-the-treatment-of-nonspecific-shoulder-pain-a-case-series
#19
Eva Barrett, Carmela Conroy, Marie Corcoran, Kieran O' Sullivan, Helen Purtill, Jeremy Lewis, Karen McCreesh
STUDY DESIGN: A case series was carried out. INTRODUCTION: There is a lack of evidence exploring the effectiveness of group exercise classes for people with nonspecific shoulder pain (NSSP). Also, there is a lack of research that measures potential reductions in thoracic kyphosis after exercise interventions in people with NSSP. PURPOSE OF THE STUDY: To observe changes in shoulder pain, disability, and thoracic kyphosis in 2 groups of people with NSSP, after 2 different types of group exercise classes...
December 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29196240/the-pathophysiology-of-human-obstructive-cholestasis-is-mimicked-in-cholestatic-gold-syrian-hamsters
#20
Rowan F van Golen, Pim B Olthof, Lianne R de Haan, Robert J Coelen, Alexandros Pechlivanis, Mark J de Keijzer, Ruud Weijer, Dirk R de Waart, André B P van Kuilenburg, Jeroen Roelofsen, Pim W Gilijamse, Martinus A Maas, Matthew R Lewis, Jeremy K Nicholson, Joanne Verheij, Michal Heger
Obstructive cholestasis causes liver injury via accumulation of toxic bile acids (BAs). Therapeutic options for cholestatic liver disease are limited, partially because the available murine disease models lack translational value. Profiling of time-related changes following bile duct ligation (BDL) in Gold Syrian hamsters revealed a biochemical response similar to cholestatic patients in terms of BA pool composition, alterations in hepatocyte BA transport and signaling, suppression of BA production, and adapted BA metabolism...
March 2018: Biochimica et Biophysica Acta
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