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Traumatic Brain Injuries

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https://www.readbyqxmd.com/read/29913244/during-development-ng2-glial-cells-of-the-spinal-cord-are-restricted-to-the-oligodendrocyte-lineage-but-generate-astrocytes-upon-acute-injury
#1
Wenhui Huang, Xianshu Bai, Laura Stopper, Bogdan Catalin, Luciana Politti Cartarozzi, Anja Scheller, Frank Kirchhoff
NG2 glia are self-renewal cells widely populating the entire central nervous system (CNS). The differentiation potential of NG2 glia in the brain has been systematically studied. However, the fate of NG2 glia in the spinal cord during development and after injury is still unclear. Here, we took advantage of faithful expression of Cre in NG2-CreERT2 knock-in mice to demonstrate that spinal NG2 glia remain committed to the oligodendrocyte (OL) lineage and generate OLs, but not astrocytes or neurons, during development...
June 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29913220/nootropic-nanocomplex-with-enhanced-blood-brain-barrier-permeability-for-treatment-of-traumatic-brain-injury-associated-neurodegeneration
#2
REVIEW
Jeongmin Park, Eunshil Choi, Seulgi Shin, Sungsu Lim, Dohee Kim, Suji Baek, Kang Pa Lee, Jae Jun Lee, Byeong Han Lee, Bokyung Kim, Keunsoo Jeong, Ja-Hyun Baik, Yun Kyung Kim, Sehoon Kim
Traumatic brain injury (TBI) is an intracranial injury which can induce immediate neuroinflammation and long-term neurological deficits. Methylene blue (MB) as a nootropic has a great potential to treat neurodegeneration after TBI because of its anti-inflmmatory and neuroprotective functions. However, its limited accumulation to the brain across the blood-brain barrier (BBB) remains a major hurdle to be overcome. In this paper, we present a polymer surfactant-encapsulated nanocomplex of MB as a delivery system with high BBB permeability for efficacious treatment of TBI-induced neurodegeneration...
June 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29913089/deficits-in-saccades-and-smooth-pursuit-eye-movements-in-adults-with-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#3
Revathy Mani, Lisa Asper, Sieu K Khuu
PURPOSE: To conduct a review of literature and quantify the effect that traumatic brain injury (TBI) has on oculomotor functions (OM). METHODS: A systematic review and meta-analysis was conducted from papers that objectively measured saccades and smooth-pursuit eye movements in mild and severe TBI. RESULTS: The overall impact of TBI on OM functions was moderate and significant with an effect size of 0.42 from 181 OM case-control comparisons...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29913083/risk-factors-for-recurrent-neurotrauma-a-population-based-study-in-southeastern-michigan
#4
R David Hayward, Mary M Fessler, Joseph Buck, Richard D Fessler
INTRODUCTION: Studies have shown an increased risk of traumatic brain injury (TBI) for individuals who suffer an initial TBI. The current study hypothesized that individuals with recurrent neurotrauma would originate from populations considered 'vulnerable', i.e. low income and/or with psychiatric comorbidities. METHODS: Data from the Michigan State Inpatient Database from 2006 to 2014 for the Detroit metropolitan area enlisted a study population of 50 744 patients with neurotrauma...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29913077/higher-exosomal-tau-amyloid-beta-42-and-il-10-are-associated-with-mild-tbis-and-chronic-symptoms-in-military-personnel
#5
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29912463/the-veterans-health-administration-s-traumatic-brain-injury-screen-and-evaluation-service-delivery-insights
#6
D Helen Moore, Gail Powell-Cope, Heather G Belanger
Background: In recognition of the incidence of traumatic brain injuries (TBIs) in the Iraq and Afghanistan conflicts, the Department of Veterans Affairs (VA) has, since 2007, examined returning U.S. service members for symptoms of TBI, a pre-condition for VA treatment of TBI. This study characterizes "Traumatic Brain Injury screen" service delivery, according to the barrier and facilitator viewpoints of those experiencing the delivery. Methods: The purposeful sample comprised both Veteran patient and VA staff participants in the TBI screen program (n = 64), including patients (n = 14), health care providers (n = 38), and key informants (n = 12)...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29912436/acquired-stuttering-in-veterans-of-the-wars-in-iraq-and-afghanistan-the-role-of-traumatic-brain-injury-post-traumatic-stress-disorder-and-medications
#7
Rocío S Norman, Carlos A Jaramillo, Blessen C Eapen, Megan E Amuan, Mary Jo Pugh
Introduction: Determine the association between acquired stuttering (AS), traumatic brain injury (TBI), and post-traumatic stress disorder (PTSD) in a cohort of 309,675 U.S. Iraq and Afghanistan veterans. The secondary aim was to determine the association between AS and medication patterns for veterans in the sample. Materials and Methods: Retrospective study using data from the Veterans Health Administration National Repository for veterans deployed in support of combat operations in Iraq and Afghanistan and who received Veterans Health Administration care in 2010 and 2011...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29912146/effective-treatment-of-traumatic-brain-injury-in-rowett-nude-rats-with-stromal-vascular-fraction-transplantation
#8
Sean Berman, Toni L Uhlendorf, Mark Berman, Elliot B Lander
Traumatic brain injury (TBI) affects 1.9 million Americans, including blast TBI that is the signature injury of the Iraq and Afghanistan wars. Our project investigated whether stromal vascular fraction (SVF) can assist in post-TBI recovery. We utilized strong acoustic waves (5.0 bar) to induce TBI in the cortex of adult Rowett Nude (RNU) rats. One hour post-TBI, harvested human SVF (500,000 cells suspended in 0.5 mL lactated Ringers) was incubated with Q-Tracker cell label and administered into tail veins of RNU rats...
June 18, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29912113/optimization-of-care-for-adults-with-moderate-traumatic-brain-injury-a-place-for-transcranial-doppler
#9
Pierre Esnault, Cédric Nguyen, Ambroise Montcriol, Bertrand Prunet, Eric Meaudre
No abstract text is available yet for this article.
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29911915/targeting-glucose-dependent-insulinotropic-polypeptide-receptor-for-neurodegenerative-disorders
#10
Mahip K Verma, Rajan Goel, Nandakumar Krishnadas, Kumar V S Nemmani
Incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide (GLP-1) exert pleiotropic effects on the endocrine pancreas and nervous system. Expression of GIP and GIP receptor (GIPR) in neurons, their roles in neurogenesis, synaptic plasticity, neurotransmission and neuromodulation, uniquely positions GIPR for therapeutic applications in neurodegenerative disorders. GIP analogues acting as GIPR agonists attenuate neurobehavioral and neuropathological sequelae of neurodegenerative disorders in preclinical models, e...
June 18, 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29911576/symptoms-disabilities-and-life-satisfaction-five-years-after-whiplash-injuries
#11
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911289/homing-and-tracking-of-iron-oxide-labelled-mesenchymal-stem-cells-after-infusion-in-traumatic-brain-injury-mice-a-longitudinal-in-vivo-mri-study
#12
Sushanta Kumar Mishra, Subash Khushu, Ajay K Singh, Gurudutta Gangenahalli
Stem cells transplantation has emerged as a promising alternative therapeutic due to its potency at injury site. The need to monitor and non-invasively track the infused stem cells is a significant challenge in the development of regenerative medicine. Thus, in vivo tracking to monitor infused stem cells is especially vital. In this manuscript, we have described an effective in vitro labelling method of MSCs, a serial in vivo tracking of implanted stem cells at traumatic brain injury (TBI) site through 7 T magnetic resonance imaging (MRI)...
June 17, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29910733/preclinical-models-of-traumatic-brain-injury-emerging-role-of-glutamate-in-the-pathophysiology-of-depression
#13
REVIEW
Darik A O'Neil, Melissa A Nicholas, Naima Lajud, Anthony E Kline, Corina O Bondi
More than 10 million people worldwide incur a traumatic brain injury (TBI) each year, with two million cases occurring in the United States. TBI survivors exhibit long-lasting cognitive and affective sequelae that are associated with reduced quality of life and work productivity, as well as mental and emotional disturbances. While TBI-related disabilities often manifest physically and conspicuously, TBI has been linked with a "silent epidemic" of psychological disorders, including major depressive disorder (MDD)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29909586/fractal-dimension-brain-morphometry-a-novel-approach-to-quantify-white-matter-in-traumatic-brain-injury
#14
Venkateswaran Rajagopalan, Abhijit Das, Luduan Zhang, Frank Hillary, Glenn R Wylie, Guang H Yue
Traumatic brain injury (TBI) is the main cause of disability in people younger than 35 in the United States. The mechanisms of TBI are complex resulting in both focal and diffuse brain damage. Fractal dimension (FD) is a measure that can characterize morphometric complexity and variability of brain structure especially white matter (WM) structure and may provide novel insights into the injuries evident following TBI. FD-based brain morphometry may provide information on WM structural changes after TBI that is more sensitive to subtle structural changes post injury compared to conventional MRI measurements...
June 16, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29909182/diffuse-axonal-injury-dai-in-moderate-to-severe-head-injured-patients-pure-dai-vs-non-pure-dai
#15
Moinay Kim, Jae Sung Ahn, Wonhyoung Park, Suk Kyung Hong, Sang Ryong Jeon, Sung Woo Roh, Seungjoo Lee
OBJECTIVE: Diffuse axonal injury (DAI) is known to be associated with poor outcome. DAI often associates with other intracranial injuries but their distinct features have not been established. In this retrospective cohort study, we compared clinical outcomes between pure and non-pure DAI patients. PATIENTS AND METHODS: Total of 1047 traumatic brain injury (TBI) patients visited our institute between 2011 and 2017. Age ranged between 15-85 years old and Glasgow coma scale (GCS) score less than 13 were included...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29908489/work-related-fatal-injuries-in-brescia-county-northern-italy-1982-to-2015-a-forensic-analysis
#16
REVIEW
Silvia Perotti, Maria Cristina Russo
Work-related deaths represent an important social problem. We report all the occupational fatal injuries recorded by the Brescia Institute of Forensic Medicine from 1982 to 2015. A total of 426 post-mortem examinations due to accidental work injuries were retrospectively analysed according to temporal distribution (year, month and day of the workplace accident); workers' characteristics (sex, age, nationality); type of occupation; cause of death; anatomical region of fatal injuries and timing of death. The accidental occupational events occurred with a mean of 12...
June 6, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29908224/implication-of-surgical-procedure-in-the-induction-of-headache-and-generalized-painful-sensation-in-a-fluid-percussion-injury-model-in-rats
#17
Fernando da SilvaFiorin, Caroline Cunha do Espírito Santo, Adair Roberto Soares Santos, Michele Rechia Fighera, Luiz Fernando Freire Royes
BACKGROUND: This study demonstrated the effects of traumatic brain injury (TBI) and each step of the surgical procedure for a fluid percussion injury (FPI) model on periorbital allodynia. NEW METHOD: Adult male Wistar rats were divided in naive, incision, scraping, sham-TBI and TBI groups. Periorbital allodynia was evaluated using von Frey filaments, and heat hyperalgesia of the hindpaws was evaluated by a Plantar Test Apparatus. RESULTS: The statistical analyses revealed that the surgical procedure decreased von Frey filaments thresholds twenty-four hours after the surgery in all groups when compared to the naive group (p < 0...
June 13, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29907235/rapid-valproic-acid-induced-modulation-of-the-traumatic-proteome-in-a-porcine-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#18
Michael Weykamp, Vahagn C Nikolian, Isabel S Dennahy, Gerald A Higgins, Patrick E Georgoff, Henriette Remmer, Mohamed H Ghandour, Hasan B Alam
BACKGROUND: Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma. Although VPA is known to modulate transcription, its ability to reduce mortality within minutes of administration suggests involvement of a rapid, posttranslational mechanism. We hypothesized that VPA treatment would cause proteomic changes within minutes of treatment including quantitative and/or posttranslational differences in structural and/or effector proteins...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907217/hydrogen-rich-water-attenuates-oxidative-stress-in-rats-with-traumatic-brain-injury-via-nrf2-pathway
#19
Jia Yuan, Difen Wang, Ying Liu, Xianjun Chen, Hailing Zhang, Feng Shen, Xu Liu, Jiangquan Fu
BACKGROUND: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906420/invited-commentary-on-the-report-to-congress-on-the-management-of-traumatic-brain-injury-in-children
#20
Stacy J Suskauer, Amy J Houtrow
The Centers for Disease Control and Prevention published the "Report to Congress on the Management of Traumatic Brain Injury in Children" in the spring of 2018. The report is a call to action for professionals providing care for children with traumatic brain injury in the health, social and educational sectors and for researchers, administrators and agencies to develop strategies to improve outcomes. For pediatric rehabilitation providers there are clear opportunities to improve service delivery for individual patients and for the population of children after traumatic brain injury more generally...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
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