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https://www.readbyqxmd.com/read/27933656/change-in-trabecular-bone-score-tbs-with-antiresorptive-therapy-does-not-predict-fracture-in-women-the-manitoba-bmd-cohort
#1
William D Leslie, Sumit R Majumdar, Uzanne N Morin, Didier Hans, Lisa M Lix
Bone mineral density (BMD) and trabecular bone score (TBS), along with additional clinical risk factors, can be used to identify individuals at high fracture risk. Whether change in TBS in untreated or treated women independently affects fracture risk is unclear. Using the Manitoba (Canada) DXA Registry containing all BMD results for the population we identified 9044 women age >40 years with two consecutive DXA scans and who were not receiving osteoporosis treatment at baseline (baseline mean age 62 ± 10 years)...
December 8, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27933422/dual-mobility-cups-in-revision-total-hip-arthroplasty
#2
Anthony Viste, Romain Desmarchelier, Michel-Henri Fessy
AIM: The purpose of our study was to evaluate the dislocation and aseptic loosening rates of a dual mobility construct in revision total hip arthroplasty (THA). METHODS: Three hundred thirty-four revision THAs performed between 2006 and 2011, using a dual mobility cup, were included in this retrospective study. The indications for revision were aseptic loosening (70%), infection (21%) and recurrent instability (9%). The minimum follow-up was five years (mean 7 ± 2 years, maximum 10 years)...
December 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27932436/multifactorial-pathological-hip-subluxation-in-neurofibromatosis-type-1-nf1-due-to-intra-articular-plexiform-neurofibroma-lumbar-radiculopathy-and-neurofibromatous-polyneuropathy
#3
Waqar Waheed, Diego F Diego F Lemos, Nelms Nathaniel Nelms, Rup Tandan
Neurofibromatosis type-1 (NF1) is a multisystem disorder with very rare descriptions of hip instability. We report a case of a 37-year-old man with known NF1 and childhood-onset of left foot drop, who developed persistent left hip pain following a minor trauma. Physical examination revealed left-sided mild foot drop, hip abductor weakness, bilateral sensory loss in feet and an antalgic gait. Work-up revealed anterolateral subluxation of the left femoral head along with left hip plexiform neurofibroma (PN), dysplastic and degenerative changes, neurofibromatous neuropathy and chronic left L5 radiculopathy...
December 8, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27932358/association-between-lower-limb-osteoarthritis-and-incidence-of-depressive-symptoms-data-from-the-osteoarthritis-initiative
#4
Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby O Smith, Marianna Noale, Cyrus Cooper, Stefania Maggi
BACKGROUND: osteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence. OBJECTIVE: to determine whether OA was associated with an increased odds of developing depressive symptoms. DESIGN: longitudinal cohort study (follow-up: 4.2 years). SETTING: data were gathered from the North American Osteoarthritis Initiative (OAI) dataset...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27931884/a-sense-of-security-spouses-experiences-of-participating-in-an-orthopaedic-case-management-intervention-the-sicam-trial
#5
Connie Bøttcher Cb Berthelsen, Jimmie Kristensson
The aim of the study was to explore and describe spouses' experiences of participating in a case management intervention during older patients' fast-track programme having total hip replacement as well as which intervention elements they found useful. Data were collected through qualitative interviews with 10 spouses from the intervention group of the SICAM-trial, directed by predetermined codes based on elements of the intervention. Data were analysed by both authors using directed content analysis. The results showed that the spouses were very pleased about being a part of the case management intervention...
June 23, 2016: International Journal of Orthopaedic and Trauma Nursing
https://www.readbyqxmd.com/read/27931702/peripheral-nerve-blocks-causing-increased-risk-for-fall-and-difficulty-in-ambulation-for-the-hip-and-knee-joint-replacement-patient
#6
Bonnie L Crumley Aybar, Michael J Gillespie, Sean F Gipson, Caitlin E Mullaney, Melissa Tommasino-Storz
A systematic review of the literature was completed by the Evidence-Based Practice Group for the Patient population, Intervention/Issue, Comparison Intervention, Outcomes, Timing (PICOT) question: "Does the use of a peripheral nerve block increase the risk for falls and difficulty ambulation in patients after lower extremity surgery through postoperative day 2?" A search of multiple databases using specified key terms resulted in 258 articles for total knee arthroplasty or total hip arthroplasty. These were reduced to 13 with exclusion criteria and became primary evidence...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27931698/the-effectiveness-of-nurse-led-preoperative-assessment-clinics-for-patients-receiving-elective-orthopaedic-surgery-a-systematic-review
#7
Chan Sau-Man Conny, Ip Wan-Yim
PURPOSE: Nurse-led preoperative assessment clinics (POAC) have been introduced in different specialty areas to assess and prepare patients preoperatively in order to avoid last-minute surgery cancellations. Not all patients are referred to POACs before surgery, and the benefits of nurse-led POACs are not well documented in Hong Kong. The purpose of this systemic review was to identify the best available research evidence to inform current clinical practice, guide health care decision making and promote better care...
December 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/27931556/non-physician-health-workers-for-improving-adherence-to-medications-and-healthy-lifestyle-following-acute-coronary-syndrome-24-month-follow-up-study
#8
Krishna Kumar Sharma, Rajeev Gupta, Mukul Mathur, Vishnu Natani, Sailesh Lodha, Sanjeeb Roy, Denis Xavier
OBJECTIVE: To evaluate usefulness of non-physician health workers (NPHW) to improve adherence to medications and lifestyles following acute coronary syndrome (ACS). METHODS: We randomized 100 patients at hospital discharge following ACS to NPHW intervention (n=50) or standard care (n=50) in an open label study. NPHW was trained for interventions to improve adherence to medicines - antiplatelets, β-blockers, renin-angiotensin system (RAS) blockers and statins and healthy lifestyles...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27930536/the-effect-of-sequential-therapy-for-postmenopausal-women-with-osteoporosis-a-prisma-compliant-meta-analysis-of-randomized-controlled-trials
#9
Shenghan Lou, Houchen Lv, Guoqi Wang, Zhirui Li, Ming Li, Licheng Zhang, Peifu Tang
BACKGROUND: Osteoporosis, more likely to occur in postmenopausal women, is a chronic condition that usually requires a long-term treatment strategy, but the use of either antiresorptive or anabolic drugs should be limited to 18 to 24 months. Discontinuing antiosteoporosis drugs may result in rapidly declining bone mineral density (BMD). Therefore, many patients are treated with the sequential use of 2 or more drugs. However, whether switching treatment from anabolic to antiresorptive drugs or the reverse could maintain or further increase BMD; and whether the sequential therapy could outperform the monotherapy under the same treatment duration still remains unclear...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27928825/patient-involvement-in-own-rehabilitation-after-early-discharge
#10
Britta Hørdam, Merete Watt Boolsen
BACKGROUND: A European Union Commission report in 2015 concluded that the concept of patient involvement refers specially to the right of patients to have a central position in the healthcare process (EU Commission 2012, http://ec.europa.eu/public_opinion/archives/quali/ql_5937_patient_en.pdf). Recent research suggests that patient involvement after hip replacement is a very effective strategy in older adults with regard to improving walking ability and reducing pain and thereby lessening loss of physical, mental and social aspects of the quality of life...
December 8, 2016: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/27928599/understanding-wear-in-dual-mobility-total-hip-replacement-first-generation-explant-wear-patterns
#11
Bertrand Boyer, Thomas Neri, Jean Geringer, Alexandre Di Iorio, Remi Philippot, Frederic Farizon
PURPOSE: Dual mobility was introduced by Pr. G. Bousquet to improve the dislocation risk of total hip arthroplasty (THR). The wear mechanisms of this implant remain to be understood. Could enhanced explant wear analysis explain liner wear behaviour? METHODS: Sixty-six explanted liners were selected. Non-destructive 3D scanning and heat colour treatment allowed reporting wear patterns on both convex and concave sides of the liners. RESULTS: For many liners, liner convexity wear was found to be homogeneous, and linked to a longer implantation time...
December 7, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27927541/is-there-a-gender-specific-full-body-sagittal-profile-for-different-spinopelvic-relationships-a-study-on-propensity-matched-cohorts
#12
Shaleen Vira, Bassel G Diebo, Matthew Adam Spiegel, Barthelemy Liabaud, Jensen K Henry, Jonathan H Oren, Renaud Lafage, Elizabeth M Tanzi, Themistocles S Protopsaltis, Thomas J Errico, Frank J Schwab, Virginie Lafage
DESIGN: Retrospective review. OBJECTIVE: To evaluate gender-related differences in compensatory recruitment to progressive sagittal malalignment. SUMMARY OF BACKGROUND DATA: Recent research has elucidated compensatory mechanisms recruited in response to sagittal malalignment, but gender-specific differences in compensatory recruitment patterns is unknown. METHODS: Single-center study of patients with full body x-rays...
March 2016: Spine Deformity
https://www.readbyqxmd.com/read/27926588/incidence-trends-and-clinical-pathological-characteristics-of-invasive-cutaneous-melanoma-from-1980-to-2010-in-the-canton-of-zurich-switzerland
#13
Remo Minini, Sabine Rohrmann, Ralph Braun, Dimitri Korol, Silvia Dehler
The aims of this paper are to describe the incidence trends of invasive cutaneous melanoma in the Canton of Zurich and to evaluate clinical and pathological factors such as cancer subtype, localization, age and Breslow thickness. A retrospective analysis was carried out with data from the population-based Cancer Registry of Zurich and Zug located in Zurich. A total of 8469 cases in 8034 different patients of invasive cutaneous melanoma were registered for the period 1980-2010 in the Canton of Zurich. Incidence trends were age standardized to the European standard population...
December 6, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27925642/high-complication-rate-in-young-patients-with-high-energy-intertrochanteric-femoral-fractures
#14
Michael H Amini, John J Feldman, John C Weinlein
Although intertrochanteric femoral fractures in elderly patients are common injuries that have been studied extensively, little has been reported about high-energy intertrochanteric fractures in younger patients. This study examined the injury characteristics and outcomes of high-energy intertrochanteric fractures in patients younger than 65 years treated with either sliding hip screws (SHSs) or cephalomedullary nails (CMNs). A total of 37 patients younger than 65 years (mean age, 45 years) with high-energy intertrochanteric fractures and mean follow-up of 34 weeks were identified; 21 patients were treated with SHSs, and 16 patients were treated with CMNs...
December 7, 2016: Orthopedics
https://www.readbyqxmd.com/read/27925376/animated-activity-questionnaire-aaq-a-new-method-of-self-reporting-activity-limitations-in-patients-with-hip-and-knee-osteoarthritis-comparisons-with-observation-by-spouses-for-construct-validity
#15
W F Peter, H S Dagfinrud, N Østerås, C B Terwee
OBJECTIVE: The aim of the present study was to evaluate the construct validity of the Animated Activity Questionnaire (AAQ) for measuring activity limitations of patients with hip and knee osteoarthritis (HKOA). DESIGN: In a psychometric design, data from HKOA patients and their spouses in Norway and the Netherlands were collected independently of each other, using the AAQ, the Function of Daily Living (FDL) subscale from the Hip disability or Knee injury Osteoarthritis Outcome Scale (H/KOOS) and the Numerical Rating Scale for pain (NRS-pain)...
December 7, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27925188/a-human-3d-in-vitro-model-to-assess-the-relationship-between-osteoporosis-and-dissemination-to-bone-of-breast-cancer-tumour-cells
#16
F Salamanna, V Borsari, S Brogini, P Torricelli, S Cepollaro, M Cadossi, M Fini
Despite consistent improvements in diagnostic and therapeutic strategies for breast cancer, up to 40% of patients will develop bone metastases. To reduce the morbidity and complications related with bone metastases, it is imperative to reduce their etiological factors. Osteoporosis, being characterized by a sudden estrogen deficiency, may provide a favorable condition for bone metastasis. This work, using a humanized 3D in vitro model, aims at evaluating the relationship between osteoporosis and breast cancer-derived bone metastases...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27924959/effects-of-ramadan-fasting-on-body-composition-and-arterial-stiffness
#17
Yusuf Sezen, Ibrahim Halil Altiparmak, Muslihittin Emre Erkus, Aydemir Kocarslan, Zekeriya Kaya, Ozgur Gunebakmaz, Recep Demirbag
OBJECTIVE: To examine the effects of Ramadan fasting on body composition, arterial stiffness and resting heart rate. METHODS: This prospective study was conducted at the Department of Cardiology, Harran University, Sanliurfa, Turkey, during Ramadan 2015, and comprised overweight and obese males. Body composition, arterial stiffness and echocardiography were assessed before and after Ramadan. Body composition was assessed by bioelectrical impedance analysis using segmental body composition analyser...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27924742/dual-mobility-total-hip-replacement-in-a-high-risk-population
#18
Jatinder Singh Luthra, Amur Al Riyami, Mohamad Kasim Allami
OBJECTIVE: The purpose of the study was to evaluate results of dual mobility total replacement in a high risk population who take hip into hyperflexed position while sitting and praying on the floor. METHOD: The study included 65 (35 primary total replacement and 30 complex total hip replacement) cases of total hip replacement using avantage privilege dual mobility cup system from biomet. A cemented acetabular component and on femoral side a bimetric stem, either cemented or uncemented used depending on the canal type...
2016: SICOT-J
https://www.readbyqxmd.com/read/27924492/progression-of-gait-ataxia-in-patients-with-degenerative-cerebellar-disorders-a-4-year-follow-up-study
#19
Mariano Serrao, Giorgia Chini, Carlo Casali, Carmela Conte, Martina Rinaldi, Alberto Ranavolo, Christian Marcotulli, Luca Leonardi, Gaia Fragiotta, Fabiano Bini, Gianluca Coppola, Francesco Pierelli
In the present study, the progression of gait impairment in a group of patients with primary degenerative cerebellar ataxias was observed over a period of 4 years. A total of 30 patients underwent an initial gait analysis study, and thereafter only 12 were evaluated because they completed the 2- and 4-year follow-up evaluations. Time-distance parameters, trunk and joint range of motion (RoM), and variability parameters (e.g., coefficients of variation) were measured at the baseline and at each follow-up evaluation...
December 6, 2016: Cerebellum
https://www.readbyqxmd.com/read/27924447/associations-between-polymorphisms-in-the-nicd-domain-of-bovine-notch1-gene-and-growth-traits-in-chinese-qinchuan-cattle
#20
Mei Liu, Chenge Zhang, Xinsheng Lai, Jing Xue, Xianyong Lan, Chuzhao Lei, Yutang Jia, Hong Chen
NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles. However, similar research on the bovine NOTCH1 gene is lacking. In this study, we detected the polymorphisms of the bovine NOTCH1 gene in a total of 448 individuals from Chinese Qinchuan cattle with DNA pooling, forced PCR-RFLP, and DNA sequencing methods. Five novel SNPs were identified within the NICD domain, and eight haplotypes comprising combinations of these five SNPs were studied as well...
December 6, 2016: Journal of Applied Genetics
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