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Chronic urinary obstruction

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https://www.readbyqxmd.com/read/28075040/n-acetyl-seryl-aspartyl-lysyl-proline-mediates-the-anti-fibrotic-properties-of-captopril-in-unilateral-ureteric-obstructed-balb-c-mice
#1
Gary Cw Chan, Hao Jia Wu, Kam Wa Chan, Stella Yiu, Ailis Zou, Xiao Ru Huang, Hui Yao Lan, Kar Neng Lai, Sydney Cw Tang
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEi) are widely employed to deter the progression of chronic kidney disease (CKD). Besides controlling hypertension and reduction of intra-glomerular pressure, ACEi appear to have anti-fibrotic effects in the renal cortex. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), an endogenous tetrapeptide that is degraded by ACE, has also been shown to ameliorate the pro-fibrotic phenotype displayed in CKD in our recent study. Whether the anti-fibrotic properties of ACEi are mediated by Ac-SDKP has not been fully investigated...
January 11, 2017: Nephrology
https://www.readbyqxmd.com/read/28005240/complicated-pregnancies-in-inherited-distal-renal-tubular-acidosis-importance-of-acid-base-balance
#2
Harald Seeger, Peter Salfeld, Rüdiger Eisel, Carsten A Wagner, Nilufar Mohebbi
Inherited distal renal tubular acidosis (dRTA) is caused by impaired urinary acid excretion resulting in hyperchloremic metabolic acidosis. Although the glomerular filtration rate (GFR) is usually preserved, and hypertension and overt proteinuria are absent, it has to be considered that patients with dRTA also suffer from chronic kidney disease (CKD) with an increased risk for adverse pregnancy-related outcomes. Typical complications of dRTA include severe hypokalemia leading to cardiac arrhythmias and paralysis, nephrolithiasis and nephrocalcinosis...
December 22, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/28001292/predictors-for-unplanned-hospitalization-of-new-home-care-clients
#3
Jukka K Rönneikkö, Matti Mäkelä, Esa R Jämsen, Heini Huhtala, Harriet Finne-Soveri, Anja Noro, Jaakko N Valvanne
OBJECTIVES: To identify factors predicting unplanned hospitalization of new home care clients using the Resident Assessment Instrument for Home Care (RAI-HC). DESIGN: A register-based study based on RAI-HC assessments and nationwide hospital discharge records. SETTING: Municipal home care services in Finland. PARTICIPANTS: New Finnish home care clients aged 63 and older (N = 15,700). MEASUREMENTS: Information from home care clients' first RAI-HC assessment was connected to information regarding their first hospitalization over 1 year of follow-up...
December 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27999595/seborrheic-keratoses-as-the-first-sign-of-bladder-carcinoma-case-report-of-leser-tr%C3%A3-lat-sign-in-a-rare-association-with-urinary-tract-cancer
#4
Aline Stollmeier, Bernardo Augusto Rosario, Bruna Loise Mayer, Gibran Avelino Frandoloso, Francisco Luiz Gomide Mafra Magalhães, Gustavo Lenci Marques
Introduction. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Although rarely observed, the sudden appearance and/or rapid increase in number and size of seborrheic keratoses can be associated with malignant neoplasms, known as the sign of Leser-Trélat. The aim of this report is to unveil a case of a patient whose recently erupted seborrheic keratoses led to investigation and consequent diagnosis of bladder cancer...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27993290/increased-levels-of-prostaglandin-e-major-urinary-metabolite-pge-mum-in-chronic-fibrosing-interstitial-pneumonia
#5
Tsugumi Horikiri, Hiromichi Hara, Nayuta Saito, Jun Araya, Naoki Takasaka, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Kenichiro Shimizu, Takanori Numata, Seiji Arihiro, Yumi Kaneko, Katsutoshi Nakayama, Tomokazu Matsuura, Masaaki Matsuura, Mutsunori Fujiwara, Isao Okayasu, Satoru Ito, Kazuyoshi Kuwano
BACKGROUND: Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF), as PGE-MUM is reflective of systemic PGE2 production...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27965420/microalbuminuria-in-subjects-with-copd-relationship-to-the-new-version-of-global-initiative-for-chronic-obstructive-lung-disease-staging
#6
Fulsen Bozkus, Nursel Dikmen, Anil Samur
BACKGROUND: Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality for any reason and of cardiovascular events. Recent research on the management of COPD has focused more on comorbidities, including cardiovascular events. The objective of this study was to investigate the incidence of microalbuminuria and whether it is associated with physiological and clinical features in a subject group that was classified in line with the new version of the Global Initiative for Chronic Obstructive Lung Disease stages...
December 13, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27929243/epididymitis-an-overview
#7
John R McConaghy, Bethany Panchal
Inflammation of the epididymis, or epididymitis, is commonly seen in the outpatient setting. Etiology and treatment are based on patient age and the likely causative organisms. Epididymitis presents as the gradual onset of posterior scrotal pain that may be accompanied by urinary symptoms such as dysuria and urinary frequency. Physical findings include a swollen and tender epididymis with the testis in an anatomically normal position. Although the etiology is largely unknown, reflux of urine into the ejaculatory ducts is considered the most common cause of epididymitis in children younger than 14 years...
November 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27924790/can-the-lower-urinary-tract-storage-symptoms-be-completely-resolved-after-plasmakinetic-enucleation-of-the-prostate
#8
Bing-Kun Li, Bin-Shen Chen, Yu-Hong Xin, Chun-Xiao Liu, Shao-Bo Zheng, Ya-Wen Xu, Hu-Lin Li, Yong Zou, Li-Ping Li
The aim of this study was to determine whether the lower urinary tract storage symptoms of benign prostatic obstruction (BPO) could be completely resolved after plasmakinetic enucleation of the prostate (PKEP) and the possible predictors of persistent symptoms. Two hundred and sixty-seven cases of BPO performed PKEP from July 2008 to June 2009 were retrospectively analyzed. Five-year postoperative data were collected and compared with the preoperative data. According to the urodynamic results, the patients were divided into involuntary detrusor contraction (IDC) group (n = 95) and no IDC group (n = 172) preoperatively; the patients with IDC were divided into IDC-persistent group (n = 33) and IDC-resolved group (n = 62) after PKEP...
December 2, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27920972/potentially-preventable-hospitalizations-for-acute-and-chronic-conditions-in-alaska-2010-2012
#9
Prabhu P Gounder, Sara M Seeman, Robert C Holman, Alice Rarig, Mary K McEwen, Claudia A Steiner, Michael L Bartholomew, Thomas W Hennessy
OBJECTIVE: The U.S. Agency for Healthcare Research and Quality's Prevention Quality Indicators comprise acute and chronic conditions for which hospitalization can be potentially prevented by high-quality ambulatory care. The Healthy Alaska 2020 initiative (HA2020) targeted reducing potentially preventable hospitalizations (PPH) for acute and chronic conditions among its health indicators. We estimated the PPH rate for adults aged ≥ 18 years in Alaska during 2010-2012. METHODS: We conducted a cross-sectional analysis of state-wide hospital discharge data obtained from the Healthcare Cost and Utilization Project and the Indian Health Service...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27915241/xanthogranulomatous-pyelonephritis-presenting-as-proteus-preperitoneal-abscess
#10
Yuyi Yeow, Yew-Lam Chong
Xanthogranulomatous pyelonephritis (XGPN) is a rare form of chronic pyelonephritis with progressive loss of renal function. Commonly, obstructing urinary calculi are seen. It is difficult to differentiate between XGPN and malignancy in many cases, and the diagnosis is usually only confirmed post-operatively upon histopathological examination of the specimen. Surgical treatment is often the main treatment modality due to suspicion for malignancy. Here, we present a case of XGPN that presented with abdominal distension, which was eventually discovered to be due to a preperitoneal abscess...
December 2, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27876076/bladder-outlet-obstruction-a-rare-complication-of-the-neglected-schistosome-schistosoma-haematobium-two-case-reports-and-public-health-challenges
#11
Valirie Ndip Agbor, Tsi Njim, Franklin Ngu Mbolingong
BACKGROUND: Schistosomiasis is a severe parasitic infestation with debilitating complications and is the third most devastating tropical disease in the world. It is one of the neglected tropical diseases (NTDs) with a high disease-burden. We present two rare cases of bladder outlet obstruction: one which led to a chronic kidney disease and ultimately death and a second which recovered after treatment with praziquantel. CASE PRESENTATIONS: A 72 year old male presented with lower urinary tract symptoms which culminated in an episode of acute urinary retention...
November 22, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27854510/variation-in-post-sepsis-readmission-patterns-a-cohort-study-of-veterans-affairs-beneficiaries
#12
Hallie C Prescott
RATIONALE: Re-hospitalization is common after sepsis, but little is known about the variation in readmission patterns across patient groups and care locations. OBJECTIVES: To examine the variation in post-sepsis readmission rates and diagnoses by patient age, nursing facility use, admission year, and hospital among U.S. Veterans Affairs (VA) beneficiaries. METHODS: Observational cohort study of VA beneficiaries who survived a sepsis hospitalization (2009-2011) at 114 VA hospitals, stratified by age (<65 versus ≥ 65 years), nursing home usage (none, chronic, or acute), year of admission (2009, 2010, 2011), and hospital...
November 17, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27842627/polyarteritis-nodosa-presenting-as-a-bladder-outlet-obstruction
#13
M Borkum, H Y Abdelrahman, R Roberts, A A Kalla, I G Okpechi
Polyarteritis nodosa (PAN) of the urinary tract is rare. An unusual case of systemic PAN involving the bladder neck is described. A 27-year-old man, with known diastolic hypertension diagnosed 2 years earlier, was admitted with chronic urinary obstruction complicated by hydronephrosis. He had symptoms of myalgia and weight loss, was afebrile but had an elevated erythrocyte sedimentation rate and acute-on-chronic renal impairment. All virological and serological tests including hepatitis B and anti-neutrophil cytoplasmic antibody were negative...
November 2, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27832323/deep-pelvic-endometriosis-a-radiologist-s-guide-to-key-imaging-features-with-clinical-and-histopathologic-review
#14
REVIEW
Ayeh Darvishzadeh, Wendaline McEachern, Thomas K Lee, Priya Bhosale, Ali Shirkhoda, Christine Menias, Chandana Lall
While endometriosis typically affects the ovaries, deep infiltrating endometriosis can affect the gastrointestinal tract, urinary tract, and deep pelvis, awareness of which is important for radiologists. Symptoms are nonspecific and can range from chronic abdominal and deep pelvic pain to nausea, vomiting, diarrhea, constipation, hematuria, and rectal bleeding. Ultrasound and computed tomography may show nonspecific soft-tissue density masses causing bowel obstruction and hydronephrosis. This constellation of presenting symptoms and imaging evidence is easily mistaken for other pathologies including infectious gastroenteritis, diverticulitis, appendicitis, and malignancy, which may lead to unnecessary surgery or mismanagement...
December 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27798778/hospitalizations-for-chronic-conditions-among-indigenous-australians-after-medication-copayment-reductions-the-closing-the-gap-copayment-incentive
#15
Amal N Trivedi, Ross Bailie, Jodie Bailie, Alex Brown, Margaret Kelaher
BACKGROUND: To close health disparities between Indigenous and non-Indigenous Australians, the Australian government in 2010 reduced medication copayments for Indigenous Australians living with, or at risk of, a chronic disease. Patients were registered for this incentive by their general practitioner. OBJECTIVE: To assess rates of hospitalizations for chronic conditions among Indigenous Australians before and after copayment reductions. DESIGN: Observational time-trend study of hospitalizations for chronic conditions sensitive to medication adherence...
October 31, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27756993/urinary-balantidiasis-a-rare-incidental-finding-in-a-patient-with-chronic-obstructive-pulmonary-disease
#16
Sukhpreet Kaur, Avinash Gupta
Balantidiasis is a rare zoonotic disease in humans. Balantidium coli is the causative ciliated protozoan. We present a case of urinary balantidiasis in a patient having chronic obstructive pulmonary disease (COPD) who was on steroids for a long time. He has no symptoms of bowel or urinary involvement. We are reporting this case because of its rarity in human urine and also for future references.
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27746247/cowper-s-syringocele-a-rare-differential-diagnosis-of-infravesical-obstruction-in-boys-and-young-adults
#17
Felix Blasl, Wolfgang H Rösch, Mark Koen, Mircia-Aurel Ardelean, Anne-Karoline Ebert
OBJECTIVE AND INTRODUCTION: Cowper's syringocele is a cystic dilation of the bulbourethral gland duct, initially defined by Maizels et al. in 1983. Although obstructive and non-obstructive types of this rare anomaly are described, clinical symptoms are highly unspecific. Therefore, we report 12 cases of children and young adults diagnosed with Cowper's syringocele to further clarify clinical course, comorbidity and treatment strategies. STUDY DESIGN: We retrospectively collected clinical data of 12 children and young adults from birth to 18...
October 8, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27732117/inhaled-long-acting-anticholinergics-and-urinary-tract-infection-in-individuals-with-copd
#18
Andrea S Gershon, Alice M Newman, Hadas D Fischer, Peter C Austin, Nick Daneman, Chaim M Bell, Anne L Stephenson, Sudeep S Gill, Nicholas T Vozoris, Paula A Rochon
Inhaled, long-acting anticholinergic medication (LAA), commonly used for moderate-to-severe chronic obstructive pulmonary disease (COPD), has been shown to decrease COPD hospitalizations, emergency department visits, and acute exacerbations but has also been associated with urinary tract infection (UTI) in a prior meta-analysis. The objective of this study was to verify if there was an association between LAA and UTI in older individuals with COPD. A population-based, real-world cohort study using health administrative data from Ontario, Canada was conducted...
October 12, 2016: COPD
https://www.readbyqxmd.com/read/27709382/effect-of-doxazosin-on-autonomic-nervous-control-and-urodynamics-of-rat-urinary-bladder-during-modeled-infravesical-obstruction
#19
V I Kirpatovskii, I S Mudraya, S V Revenko, A Yu Bablumyan, N K Adamyan, V P Ivanov
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pmax, and increased amplitude of spontaneous oscillations of intravesical pressure ΔPdet in filled bladder...
September 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27704056/endoureteral-management-of-renal-graft-ureteral-stenosis-by-the-use-of-long-term-metal-stent-an-appealing-treatment-option
#20
Patrick-Julien Treacy, Art R Rastinehad, Laetitia Imbert de la Phalecque, Laetitia Albano, Matthieu Durand
Background: Ureteral stenosis is part of the common complications of renal graft reported in 3% to 7% of cases. Multiple treatments have been introduced regarding length and position of the stenosis. Metal stents for urologic purpose were created in 1998. Double percutaneous antegrade and transurethral retrograde access to a ureteral stenosis to a long-term metal stent procedure has been rarely described. Case Presentation: Here, we present a case of a ureteral stricture in a double ipsilateral kidney graft with a common ureter...
2016: Journal of Endourology Case Reports
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