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Chronic foley

Aaron M Foley, David G Hewitt, Charles A DeYoung, Randy W DeYoung, Matthew J Schnupp
White-tailed deer are a culturally and economically important game species in North America, especially in South Texas. The recent discovery of chronic wasting disease (CWD) in captive deer facilities in Texas has increased concern about the potential emergence of CWD in free-ranging deer. The concern is exacerbated because much of the South Texas region is a semi-arid environment with variable rainfall, where precipitation is strongly correlated with fawn recruitment. Further, the marginally productive rangelands, in combination with erratic fawn recruitment, results in populations that are frequently density-independent, and thus sensitive to additive mortality...
2016: PloS One
Michael P Leovic, Hailey N Robbins, Michael R Foley, Roman Starikov
Management of the critically-ill pregnant patient presents a clinical dilemma in which there is sparse objective data to determine the optimal setting for provision of high-quality care to these patients. This clinical scenario will continue to present a challenge for providers as the chronic illness and comorbid conditions continue to become more commonly encountered in the obstetric population. Various care models exist across a broad spectrum of facilities that are characterized by differing levels of resources; however, no studies have identified which model provides the highest level of care and patient safety while maintaining a reasonable degree of cost-effectiveness...
August 20, 2016: American Journal of Obstetrics and Gynecology
Alison M Vargovich, Daniel W McNeil, Kimberly P Foley, Jeannie Sperry
BACKGROUND AND OBJECTIVES: The misuse and abuse of opioids has increased across the United States in recent years, associated with a rise in opioid-related overdose deaths. Physicians report having difficulty discerning substance abuse or drug diversion, which can lead to over- or under-prescribing of opioids and poor pain management. Additionally, research suggests that patient characteristics (eg, sex, ethnicity/race, age) may unduly influence the pain management decisions of health care providers...
July 2016: Family Medicine
Anna Shmagel, Erin Krebs, Kristine Ensrud, Robert Foley
STUDY DESIGN: A population-based cross-sectional survey. OBJECTIVE: The aim of this study was to compare the prevalence of illicit drug use among US adults with and without chronic low back pain (cLBP). SUMMARY OF BACKGROUND DATA: Although addictive medications, such as opioids and benzodiazepines, are frequently prescribed to patients with cLBP, little is known about illicit drug use among Americans with cLBP. METHODS: We used data from the back pain survey, administered to a representative sample of US adults aged 20 to 69 years (N = 5103) during the 2009 to 2010 cycle of the National Health and Nutrition Examination Survey (NHANES)...
September 2016: Spine
Rachel D Moloney, Jahangir Sajjad, Tara Foley, Valeria D Felice, Timothy G Dinan, John F Cryan, Siobhain M O'Mahony
BACKGROUND: Early-life stress (ELS) is a recognized risk factor for chronic pain disorders, and females appear to be more sensitive to the negative effects of stress. Moreover, estrous cycle-related fluctuations in estrogen levels have been linked with alternating pain sensitivity. Aberrant central circuitry involving both the anterior cingulate cortex (ACC) and the lumbosacral spinal cord has also been implicated in the modulation of visceral pain in clinical and preclinical studies...
2016: Biology of Sex Differences
N M W J de Bruin, A van Loevezijn, K M Wicke, M de Haan, J Venhorst, J H M Lange, L de Groote, M A W van der Neut, J Prickaerts, E Andriambeloson, A G Foley, M van Drimmelen, M van der Wetering, C G Kruse
In the present study, our aim was to investigate whether the novel highly selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist SLV can ameliorate impairments in cognition and social interaction with potential relevance for both schizophrenia and Alzheimer's disease (AD). SLV sub-chronically - treated Wistar rats reared in isolation showed significantly enhanced prepulse inhibition (PPI) and object recognition performance when compared to vehicle - treated rats. In the isolated rats, also a significant reduction in expression of hippocampal neural cell adhesion molecule polysialylation (NCAM-PSA) was found which was ameliorated following treatment with SLV (30mg/kg)...
September 2016: Neurobiology of Learning and Memory
Alan R Parrish
The incidence of chronic kidney disease (CKD) is increasing, with an estimated prevalence of 12% in the United States (Synder et al., 2009). While CKD may progress to end-stage renal disease (ESRD), which necessitates renal replacement therapy, i.e. dialysis or transplantation, most CKD patients never reach ESRD due to the increased risk of death from cardiovascular disease. It is well-established that regardless of the initiating insult - most often diabetes or hypertension - fibrosis is the common pathogenic pathway that leads to progressive injury and organ dysfunction (Eddy, 2014; Duffield, 2014)...
October 2016: Pharmacology & Therapeutics
Brooke E Starkoff, Elizabeth K Lenz, Lauren Lieberman, John Foley
BACKGROUND: Specific sedentary behaviors (SB) are associated with risk factors for preventable chronic health conditions in adults, yet time participating in SB has increased over the years. OBJECTIVE: To explore the SB habits of individuals with visual impairments (VI) and the relationship with self-reported visual acuity (VA). METHODS: Individuals participated in this cross-sectional study by completing the Patient-centered Assessment & Counseling for Exercise (PACE+) Sedentary Behavior Questionnaire (SBQ) for adults to assess estimated time spent in nine SB...
October 2016: Disability and Health Journal
Urszula Kowalik, Mark K Plante
Urinary retention is an important and potentially avoidable postoperative complication. Identifying risk factors for retention is important given expedient bladder decompression is important for long-term outcomes. Age, benign prostatic hyperplasia, and lower urinary tract symptoms are patient factors that predispose to retention. Surgery-related factors include operative time, intravenous fluid administration, type of anesthesia, and procedure type. The mainstay for treatment in the acute setting is Foley catheter placement...
June 2016: Surgical Clinics of North America
Debapriya Datta, Raymond Foley, Rong Wu, James Grady, Paul Scalise
OBJECTIVE: Malnutrition is common in chronic critically ill patients on prolonged mechanical ventilation (PMV) and may affect weaning. The creatinine height index (CHI), which reflects lean muscle mass, is regarded as the most accurate indicator of malnutrition. The objective of this study was to determine the impact of CHI in comparison with other traditional nutritional indices on successful weaning and survival in patients on PMV after critical illness. METHODS: Records of 167 patients on PMV following critical illness, admitted for weaning, were reviewed...
May 13, 2016: Journal of Intensive Care Medicine
Stephen Couban, Mahmoud Aljurf, Sylvie Lachance, Irwin Walker, Cynthia Toze, Morel Rubinger, Jeffrey H Lipton, Stephanie J Lee, Richard Szer, R Doocey, Ian D Lewis, Lothar Huebsch, Kang Howson-Jan, Michel Lalancette, Fahad Almohareb, Nadeem Chaudhri, Sabine Ivison, Raewyn Broady, Megan Levings, Diane Fairclough, Gerald Devins, David Szwajcer, Ronan Foley, Clayton Smith, Tony Panzarella, Holly Kerr, Amina Kariminia, Kirk R Schultz
In adult hematopoietic cell transplantation (HCT), filgrastim-mobilized peripheral blood (G-PB) has largely replaced unstimulated marrow for allografting. Although the use of G-PB results in faster hematopoietic recovery, it is also associated with more chronic graft-versus-host disease (cGVHD). A potential alternative allograft is filgrastim-stimulated marrow (G-BM), which we hypothesized may be associated with prompt hematopoietic recovery but with less cGVHD. We conducted a phase 3, open-label, multicenter randomized trial of 230 adults with hematologic malignancies receiving allografts from siblings after myeloablative conditioning to compare G-PB with G-BM...
August 2016: Biology of Blood and Marrow Transplantation
Shingo Ashida, Ichiro Yamasaki, Kenji Tamura, Tsutomu Shimamoto, Keiji Inoue, Shinji Kariya, Kana Kobayashi, Takuji Yamagami, Taro Shuin
The aim of the present study was to evaluate the feasibility and preliminary outcomes of high-dose-rate (HDR)-brachytherapy as a monotherapy in two fractions within 1 day for localized prostate cancer, including high-/very high-risk cases. Among the 68 patients treated with HDR monotherapy between July 2011 and December 2014, 65 had a minimal follow-up of 12 months without adjuvant androgen deprivation therapy and were enrolled in the present study [42/65 (64.6%) exhibited high-/very high-risk diseases]. HDR monotherapy was performed in two fractions with a minimal interval of 6 h and the prescribed dose was 13...
May 2016: Molecular and Clinical Oncology
T Raymond Foley, R Kevin Rogers
Chronic mesenteric ischemia (CMI) most commonly occurs as a consequence of multivessel atherosclerotic disease of the mesenteric vasculature. Risk factors include smoking, hypertension, dyslipidemia, and advanced age, and women are more commonly affected than men. The clinical presentation of CMI is characterized by postprandial abdominal pain and weight loss. Left untreated, patients often develop severe malnutrition. Current consensus guidelines recommend secondary prevention medications such as statins and aspirin for all patients with known atherosclerosis to reduce the risk of stroke and MI, but data specific to medical therapy in CMI are lacking...
June 2016: Current Treatment Options in Cardiovascular Medicine
Perry Foley, Dori Steinberg, Erica Levine, Sandy Askew, Bryan C Batch, Elaine M Puleo, Laura P Svetkey, Hayden B Bosworth, Abigail DeVries, Heather Miranda, Gary G Bennett
INTRODUCTION: Obesity continues to disproportionately affect medically vulnerable populations. Digital health interventions may be effective for delivering obesity treatment in low-resource primary care settings. METHODS: Track is a 12-month randomized controlled trial of a digital health weight loss intervention in a community health center system. Participants are 351 obese men and women aged 21 to 65years with an obesity-related comorbidity. Track participants are randomized to usual primary care or to a 12-month intervention consisting of algorithm-generated tailored behavior change goals, self-monitoring via mobile technologies, daily self-weighing using a network-connected scale, skills training materials, 18 counseling phone calls with a Track coach, and primary care provider counseling...
May 2016: Contemporary Clinical Trials
Anna Shmagel, Robert Foley, Hassan Ibrahim
OBJECTIVE: To describe epidemiologic characteristics and associations with increased healthcare utilization in US adults with chronic low back pain (cLBP). METHODS: NHANES back pain survey 2009-2010, administered to adults aged 20-69 (N = 5103). cLBP was defined as pain in the area between the lower posterior margin of the ribcage and the horizontal gluteal fold, with a history of pain lasting almost every day for at least 3 months. Demographic and behavioral characteristics were compared between those with cLBP and without...
March 18, 2016: Arthritis Care & Research
Elizabeth Halcomb, Moira Stephens, Julianne Bryce, Elizabeth Foley, Christine Ashley
AIMS AND OBJECTIVES: This paper reports an integrative review of the literature on nursing competency standards for nurses working in primary health care and, in particular, general practice. BACKGROUND: Internationally, there is growing emphasis on building a strong primary health care nursing workforce to meet the challenges of rising chronic and complex disease. However, there has been limited emphasis on examining the nursing workforce in this setting. DESIGN: Integrative review...
May 2016: Journal of Clinical Nursing
Thomas Müller, Paul Foley
Several compounds developed the treatment of Alzheimer's disease and Parkinson's disease have been clinically unsuccessful. Suggested reasons for these failures have included heterogeneous symptom expression, inappropriate assessment of effects, safety and tolerability hurdles, short duration of disease-modifying trials, recruiting pressure on study centers, administrative and bureaucratic overload, and pooling results from trial centers in different health care systems with differing quality and therapeutic concepts...
May 2016: Expert Review of Neurotherapeutics
Jeffrey M Sobell, Peter Foley, Darryl Toth, Ulrich Mrowietz, Giampiero Girolomoni, Joana Goncalves, Robert M Day, Rongdean Chen, Gil Yosipovitch
Pruritus and skin discomfort/pain negatively impact health-related quality of life (HRQoL). The effects of apremilast, an oral phosphodiesterase inhibitor, on pruritus, skin discomfort/pain, and patient global assessment of psoriasis disease activity (PgAPDA) were assessed in moderate/severe chronic plaque psoriasis patients in the phase 3 ESTEEM trials. Significant improvements in pruritus and skin discomfort/pain observed at Week 2 with apremilast versus placebo (both studies, p < 0.0001) were sustained through Week 32...
May 2016: Acta Dermato-venereologica
Anthony Galenza, Jaclyn Hutchinson, Shelagh D Campbell, Bart Hazes, Edan Foley
The acquisition of nutrients is essential for maintenance of metabolic processes in all organisms. Nutritional imbalance contributes to myriad metabolic disorders that include malnutrition, diabetes and even cancer. Recently, the importance of macronutrient ratio of food has emerged as a critical factor to determine health outcomes. Here we show that individual modifications to a completely defined diet markedly impact multiple aspects of organism wellbeing in Drosophila melanogaster. Through a longitudinal survey of several diets we demonstrate that increased levels of dietary glucose significantly improve longevity and immunity in adult Drosophila...
2016: Biology Open
Anne M Murray, Elizabeth J Bell, David E Tupper, Cynthia S Davey, Sarah L Pederson, Elizabeth M Amiot, Kathleen M Miley, Lauren McPherson, Brooke M Heubner, David T Gilbertson, Robert N Foley, Paul E Drawz, Yelena Slinin, Rebecca C Rossom, Kamakshi Lakshminarayan, Prashanthi Vemuri, Clifford R Jack, David S Knopman
BACKGROUND: The Brain in Kidney Disease (BRINK) Study aims to identify mechanisms that contribute to increased risk for cognitive impairment in patients with chronic kidney disease (CKD). We describe the rationale, design, and methods of the study and report baseline recruitment and cognitive function results. STUDY DESIGN: Longitudinal observational cohort study of the epidemiology of cognitive impairment in CKD. The primary aim is to characterize the association between (1) baseline and incident stroke, white matter disease, estimated glomerular filtration rate (eGFR), inflammation, microalbuminuria, and dialysis initiation and (2) cognitive decline over 3 years in a CKD cohort with a mean eGFR<45 mL/min/1...
April 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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