Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Leena Alhusari, Mahmoud Abdallah, Kemnasom Nwanwene, Mina Shenouda
Immune-related adverse events (IrAEs) involving the bladder are seldom reported and tend to be overlooked by oncologists. Cystitis caused by immune checkpoint inhibitors (ICIs) is rarely reported, with only four documented instances in the literature, of which just one case is attributed to pembrolizumab. We present a rare occurrence of pembrolizumab-induced hemorrhagic cystitis in a 71-year-old male with stage II-b lung adenocarcinoma with an chronic indwelling Foley catheter. He presented with persistent hematuria despite the completion of a course of antibiotics for a urinary infection; a cystoscopic examination was also normal...
March 2024: Curēus
#2
JOURNAL ARTICLE
Allegra L Fierro, Carolyn Foley, Tomer Lagziel, John C Lantis
Autologous blood-derived therapies have emerged as a unique and promising treatment option for chronic wounds. From whole blood clots to spun-down clot constituents, these therapies are highly versatile and tend to have a lower cost profile, allow for point-of-service preparation, and inherently carry minimal to no risk of rejection or allergic reaction when compared to many alternative cellular and matrix-like products. Subsequently, a diversity of processing systems, devices, and kits have surfaced on the market for preparing autologous blood-derived products (ABDPs) and many have demonstrated preclinical and clinical efficacy in facilitating chronic wound healing...
March 29, 2024: Surgical Technology International
#3
Clayton R Welsh, Cassidy M Foley Davelaar
Pediatric avulsion fractures most commonly occur at sites of secondary ossification and are often associated with chronic stress from repetitive movements. Because of a variety of risk factors, youth athletes place higher stress on ossification centers, and their activities may predispose them to injury. This case report describes a 12-year-old female softball player who presented with pain at the distal acromion, worsened by her overhead throwing motion. Further questioning revealed improper throwing mechanics placing extenuated stress on the shoulder...
February 2024: Curēus
#4
JOURNAL ARTICLE
Kamyar Zahedi, Sharon Barone, Marybeth Brooks, Tracy Murray Stewart, Jackson R Foley, Ashley Nwafor, Robert A Casero, Manoocher Soleimani
Cisplatin, a chemotherapeutic agent, can cause nephrotoxic and ototoxic injuries. Using a mouse model of repeated low dose cisplatin (RLDC), we compared the kidneys of cisplatin- and vehicle-treated mice on days 3 (early injury phase) and 35 (late injury/recovery phase) after the final treatment. RNA-seq analyses revealed increases in the expression of markers of kidney injury (e.g., lipocalin 2 and kidney injury molecule 1) and fibrosis (e.g., collagen 1, fibronectin, and vimentin 1) in RLDC mice. In addition, we observed increased expression of polyamine catabolic enzymes (spermidine/spermine N1 -acetyltransferase, Sat1 , and spermine oxidase, Smox ) and decreased expression of ornithine decarboxylase ( Odc1 ), a rate-limiting enzyme in polyamine synthesis in mice subjected to RLDC...
March 13, 2024: Biomedicines
#5
REVIEW
Kate E Foley, Donna M Wilcock
Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular origins. With the advancement of imaging and pathological studies, we now understand that VCID is often comorbid with Alzheimer disease. While researchers in the Alzheimer disease field have been working for years to establish and test blood-based biomarkers for Alzheimer disease diagnosis, prognosis, clinical therapy discovery, and early detection, blood-based biomarkers for VCID are in their infancy and also face challenges...
April 2024: Stroke; a Journal of Cerebral Circulation
#6
JOURNAL ARTICLE
Olivera Antic, Yevgeniya E Koshman, Brandan M Bird, Geena Jasiek, Amanda S Wilsey, Scott W Mittelstadt, C Michael Foley
The strategic and targeted use of an anesthetized canine cardiovascular model early in drug discovery enables a comprehensive cardiovascular and electrophysiological assessment of potential safety liabilities and guides compound selection prior to initiation of chronic toxicological studies. An ideal model would enable exposure-response relationships to guide safety margin calculations, have a low threshold to initiate, and have quick delivery of decision quality data. We have aimed to profile compounds with diverse mechanism of actions (MoAs) of "non-QT" cardiovascular drug effects and evaluate the ability of nonclinical in vivo cardiovascular models to detect clinically reported effects...
March 11, 2024: Journal of Pharmacological and Toxicological Methods
#7
JOURNAL ARTICLE
Patrick D Mahar, Susan J Robertson, David Orchard, Christopher Baker, Peter Foley
As with adults, paediatric patients may benefit from a number of advanced targeted therapies for inflammatory skin disease. This brief report aims to be an accessible reference tool with respect to regulatory approval and reimbursement of these treatments within Australia.
March 6, 2024: Australasian Journal of Dermatology
#8
JOURNAL ARTICLE
Mohammad Iqbal H Bhuiyan, Khadija Habib, Md Tipu Sultan, Fenghua Chen, Israt Jahan, Zhongfang Weng, Md Shamim Rahman, Rabia Islam, Lesley M Foley, T Kevin Hitchens, Xianming Deng, Scott W Canna, Dandan Sun, Guodong Cao
BACKGROUND: Astrogliosis and white matter lesions (WML) are key characteristics of vascular contributions to cognitive impairment and dementia (VCID). However, the molecular mechanisms underlying VCID remain poorly understood. Stimulation of Na-K-Cl cotransport 1 (NKCC1) and its upstream kinases WNK (with no lysine) and SPAK (the STE20/SPS1-related proline/alanine-rich kinase) play a role in astrocytic intracellular Na+ overload, hypertrophy, and swelling. Therefore, in this study, we assessed the effect of SPAK inhibitor ZT-1a on pathogenesis and cognitive function in a mouse model of VCID induced by bilateral carotid artery stenosis (BCAS)...
March 2024: CNS Neuroscience & Therapeutics
#9
JOURNAL ARTICLE
Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
February 27, 2024: Epilepsia
#10
JOURNAL ARTICLE
Gurkan Uncu, Isil Kasapoglu, Kiper Aslan
OBJECTIVE: To demonstrate the surgical approach for Müllerian agenesis with bilateral uterine remnants containing functional endometrium. DESIGN: Stepwise demonstration of the technique with narrated video footage. SETTING: Reproductive surgery unit of a tertiary university hospital. PATIENT: An 18-year-old adolescent was admitted to a tertiary university hospital with complaints of primary amenorrhea and cyclic pelvic pain...
February 23, 2024: Fertility and Sterility
#11
JOURNAL ARTICLE
Maoling Luo, Si Li, Wenying Luo
BACKGROUND: Pseudomonas aeruginosa (PA) is a prevalent opportunistic pathogen that has close associations with both acute and chronic infections. However, there exists an insufficiency of accurate and comprehensive data pertaining to the antimicrobial susceptibility patterns and clinical characteristics of both mucoid and non-mucoid strains of PA (mPA and non-mPA, respectively). METHODS: From January 1, 2021 to December 31, 2022, a thorough retrospective study was carried out to examine and compare the antibiotic susceptibility test outcomes and clinical characteristics of hospitalized patients with mPA and non-mPA infections...
2024: Frontiers in Public Health
#12
JOURNAL ARTICLE
J Mbarga, C Favre, C Ribeiro, C Pichonnaz, C Ancey, R-A Foley, B Leger, F Luthi
CONTEXT: Individuals must change the way they perform activities in response to chronic pain. In the literature, three activity patterns are commonly described: avoidance, pacing, and persistence. Many studies have explored these activity patterns. However, little research has delved into the factors that lead people to adopt a particular activity behaviour. This study aimed to explore the relationship that people with chronic musculoskeletal pain have with activity and highlight the factors underlying their practices...
January 31, 2024: European Journal of Pain: EJP
#13
JOURNAL ARTICLE
Katelyn M Foley, Kevin F Kennedy, Fabio V Lima, Eric A Secemsky, Subhash Banerjee, Philip P Goodney, Mehdi H Shishehbor, Peter A Soukas, Omar N Hyder, J Dawn Abbott, Herbert D Aronow
BACKGROUND: Little is known about treatment variability across US hospitals for patients with chronic limb-threatening ischemia (CLTI). METHODS AND RESULTS: Data were collected from the 2016 to 2018 National Inpatient Sample. All patients aged ≥18 years, admitted to nonfederal US hospitals with a primary diagnosis of CLTI, were identified. Patients were classified according to their clinical presentation (rest pain, skin ulceration, or gangrene) and were further characterized according to the treatment strategy used...
January 19, 2024: Journal of the American Heart Association
#14
Boris Kangabam, Amitkumar Khwairakpam, Yengkhom Daniel Singh, Babina Sorokhaibam
A fibroepithelial polyp (FEP) of the penis is a rare benign swelling and often under-recognised lesion that has the potential to become malignant in some cases. The pathogenesis is still unclear, but it is hypothesised to be due to chronic irritation most often associated with condom catheter use or phimosis. We describe a case of an FEP measuring 10 cm in largest diameter developing from the ventral prepuce with a longstanding post-radiation penoscrotal oedema. A 62-year-old male with a history of bladder cancer presented to the emergency department with abdominal distention, vomiting, and obstipation for three days to the emergency department...
December 2023: Curēus
#15
Youssef Youssef, Michael F Neblett, Adela G Cope, Tatnai L Burnett, Wendaline M VanBuren, Katherine T Andersen, Zaraq Khan
BACKGROUND: Endometriosis is a chronic, debilitating condition affecting up to 10% of reproductive-age women. Urinary tract endometriosis is found in 1-6% of women diagnosed with pelvic endometriosis, with the most common sites being the bladder (70-85%), ureter (9-23%), and kidney (4%). Patients typically present with symptoms such as lower abdominal pain, dysuria, and urgency. Unfortunately, urinary tract endometriosis is often asymptomatic, potentially leading to silent obstructive uropathy and kidney failure...
December 8, 2023: Urology
#16
S Pestelacci, N Hofer-Inteeworn, M Dennler, T Glaus
Choanal atresia is a rare congenital anomaly in humans and animals, characterized by the absence of communication of one or both nasal cavities with the nasopharynx. The severity of clinical signs depends on the presence of unilateral versus bilateral stenosis as well as comorbidities. With bilateral atresia, respiration may be severely compromised particularly during sleep, as airflow can only occur when breathing through the open mouth. Various therapeutic modalities have been described in people and adopted for animals...
December 2023: Schweizer Archiv Für Tierheilkunde
#17
JOURNAL ARTICLE
Maria Pierce, Louise Foley, Bridget Kiely, Aisling Croke, James Larkin, Susan M Smith, Barbara Clyne, Edel Murphy
BACKGROUND: Incorporating Public and Patient Involvement (PPI) into doctoral research is valued by PhD funders and scholars. Providing early career researchers with appropriate training to develop skills to conduct meaningful PPI involvement is important. The Health Research Board (HRB) Collaborative Doctoral Award in MultiMorbidity programme (CDA-MM) embedded formal PPI training in its structured education. The four participating PhD scholars established a PPI panel comprising people living with two or more chronic conditions, presenting an opportunity for experiential PPI training...
November 24, 2023: Research Involvement and Engagement
#18
JOURNAL ARTICLE
Ayisha Lightbourne, Sarah Foley, Maria Dempsey, Mary Cronin
Endometriosis is an incurable chronic condition associated with debilitating pain and subfertility, affecting 1 in 10 women. The current study aims to explore the perceptions and experiences of women with endometriosis regarding the diagnosis, support and treatment options available in Ireland. It will further determine whether additional supports or improvements are needed to care well and effectively for women with this disease in the Irish healthcare system. A qualitative study design was deemed most suitable...
November 21, 2023: Qualitative Health Research
#19
Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current cortico-centric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural MRI in 1,602 adults with epilepsy and 1,022 healthy controls across twenty-two sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
October 23, 2023: bioRxiv
#20
JOURNAL ARTICLE
Abigail W Batchelder, Moonseong Heo, Jacklyn D Foley, Matthew C Sullivan, Paula Lum, Irene Pericot Valverde, Lynn E Taylor, Shruti H Mehta, Arthur Y Kim, Brianna Norton, Judith I Tsui, Judith Feinberg, Kim Page, Alain H Litwin
BACKGROUND: Psycho-social experiences including shame and experienced and internalized stigma have been associated with substance use, HCV infection, and reluctance to disclose HCV status and pursue treatment. These psycho-social barriers have been examined independently for many chronic diseases, including HCV, but to our knowledge have not been quantitatively explored in a large multi-site US-based sample of people who inject drugs (PWID) in HCV treatment. METHODS: We examine baseline relationships with HCV-stigma and engagement across the HCV treatment cascade as well as baseline and longitudinal relationships between shame and engagement across the HCV treatment cascade including treatment initiation, adherence, completion, and sustained virologic response (SVR) among a multi-site sample of PWID with HCV, where N=755 were randomized to the pragmatic trial comparing HCV treatment outcomes in modified directly observed treatment (mDOT) or patient navigation, and N=623 initiated treatment...
October 31, 2023: Drug and Alcohol Dependence
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
