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https://www.readbyqxmd.com/read/29704926/language-as-an-application-of-mindfulness
#1
EDITORIAL
Sheryl Zimmerman, Paul R Katz, Philip D Sloane, Malaz Boustani, Mallory Brown, Matteo Cesari, Gustavo Duque, Kathryn Hyer, Francesco Landi, David Nace, Barbara Resnick, Martin Smalbrugge, David A Smith, Karl E Steinberg, Ladislav Volicer, Gregg Warshaw, Heidi K White
No abstract text is available yet for this article.
May 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29697550/use-of-infliximab-biosimilar-versus-originator-in-a-paediatric-united-kingdom-inflammatory-bowel-disease-induction-cohort
#2
Neil Chanchlani, Kajal Mortier, Linda J Williams, Rafeeq Muhammed, Marcus K H Auth, Mike Cosgrove, Andrew Fagbemi, John Fell, Sonny Chong, Veena Zamvar, Warren Hyer, W Michael Bisset, Mary-Anne Morris, Astor Rodrigues, Sally G Mitton, Su Bunn, R Mark Beattie, Anne Willmott, David C Wilson, Richard K Russell
OBJECTIVES: To summarize short-term effectiveness, safety, and cost of using infliximab biosimilar (IFX-B) drugs, (Inflectra™ and Remsima™) compared to originator infliximab (IFX-O) (Remicade®) in biologic naive pediatric inflammatory bowel disease in the United Kingdom. METHODS: Prospective audit of patients starting anti-TNF therapy. Disease severity, response to treatment, and remission rate was measured by Pediatric Crohn's Disease Activity Index (PCDAI) and/or Physician Global Assessment (PGA)...
April 23, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29628151/safety-of-a-two-dose-investigational-hepatitis-b-vaccine-hbsag-1018-using-a-toll-like-receptor-9-agonist-adjuvant-in-adults
#3
Randall Hyer, Darren K McGuire, Biao Xing, Sam Jackson, Robert Janssen
BACKGROUND: Hepatitis B virus infection remains an important global public health problem. Approved alum-adjuvanted vaccines are well tolerated but require three doses and have reduced immunogenicity in adults. A two-dose vaccine containing hepatitis B surface antigen combined with a novel, Toll-like receptor 9 agonist adjuvant (HBsAg-1018 [HEPLISAV-B®]) has demonstrated significantly higher seroprotection rates than a three dose vaccine. METHODS: A post hoc analysis compared the safety of HBsAg-1018 with HBsAg-Eng (Engerix-B®), in three randomized, observer-blinded, active-controlled, multi-center phase 3 trials in adults...
April 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29613968/dosimetry-based-treatment-for-graves-disease
#4
Steve L Hyer, Brenda Pratt, Matthew Gray, Sarah Chittenden, Yong Du, Clive L Harmer, Glenn D Flux
OBJECTIVE: The aim of this retrospective study was to assess the long-term outcome of a personalized dosimetry approach in Graves' disease aiming to render patients euthyroid from a planned thyroid absorbed dose of 60 Gy. PATIENTS AND METHODS: A total of 284 patients with Graves' disease were followed prospectively following administration of radioiodine calculated to deliver an absorbed dose of 60 Gy. Patients with cardiac disease were excluded. Outcomes were analysed at yearly intervals for up to 10 years with a median follow-up of 37...
April 2, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29487509/enduring-effects-of-paternal-deprivation-in-california-mice-peromyscus-californicus-behavioral-dysfunction-and-sex-dependent-alterations-in-hippocampal-new-cell-survival
#5
Erica R Glasper, Molly M Hyer, Terrence J Hunter
Early-life experiences with caregivers can significantly affect offspring development in human and non-human animals. While much of our knowledge of parent-offspring relationships stem from mother-offspring interactions, increasing evidence suggests interactions with the father are equally as important and can prevent social, behavioral, and neurological impairments that may appear early in life and have enduring consequences in adulthood. In the present study, we utilized the monogamous and biparental California mouse ( Peromyscus californicus )...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29361841/cross-sectional-analysis-of-the-distal-fibular-intramedullary-canal-a-cadaveric-evaluation
#6
Mark A Prissel, Justin L Daigre, Roberto A Brandão, Terrence M Philbin, Christopher F Hyer, Gregory C Berlet
Fractures of the distal fibula secondary to rotational ankle injuries are one of the most common injuries requiring surgical intervention. The aim of this study was to describe the anatomy of the distal fibular medullary canal as a means of aiding in surgical management with an intramedullary device. Twenty fresh cadaveric below-knee specimens (group 1, 10 in 2015, group 2, 10 in 2016) were dissected to expose the distal fibular. Fifteen (10 mm each) segments were sectioned with a sagittal saw from the distal tip proximally and measured with a digital caliper...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29334375/a-small-molecule-inhibitor-of-the-ubiquitin-activating-enzyme-for-cancer-treatment
#7
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amidon, Neil F Bence
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (formerly known as MLN7243) as a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade...
February 2018: Nature Medicine
https://www.readbyqxmd.com/read/29233051/analyses-of-complaints-investigations-of-allegations-and-deficiency-citations-in-united-states-nursing-homes
#8
Kevin E Hansen, Kathryn Hyer, Amanda A Holup, Kelly M Smith, Brent J Small
Quality of care in nursing homes has been evaluated from varying perspectives, but few studies analyze complaints made to surveyors. This study analyzed complaints, investigations, and citations for nursing homes nationwide. Using the complaint and survey data sets, analyses match nursing home complaints with findings of investigations conducted. Results showed the average complaint rate was 13.3 complaints per 100 residents and that 43.2% of complaint allegations were substantiated, with complaints about care and services provided being the most prevalent...
December 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29225676/association-between-insulin-resistance-and-preeclampsia-in-obese-non-diabetic-women-receiving-metformin
#9
Jyoti Balani, Steve Hyer, Argyro Syngelaki, Ranjit Akolekar, Kypros H Nicolaides, Antoinette Johnson, Hassan Shehata
Objectives: To examine whether the reduced incidence of preeclampsia in non-diabetic obese pregnant women treated with metformin is mediated by changes in insulin resistance. Methods: This was a secondary analysis of obese pregnant women in a randomised trial (MOP trial). Fasting plasma glucose and insulin were measured in 384 of the 400 women who participated in the MOP trial. Homeostasis model assessment of insulin resistance (HOMA-IR) was compared in the metformin and placebo groups and in those that developed preeclampsia versus those that did not develop preeclampsia...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29189085/sharing-end-of-life-care-preferences-with-family-members-who-has-the-discussion-and-who-does-not
#10
Lindsay J Peterson, Debra Dobbs, Hongdao Meng, Alyssa Gamaldo, Kevin O'Neil, Kathryn Hyer
BACKGROUND: Research suggests that greater engagement in family discussions concerning end-of-life (EOL) care preferences could improve advance care planning and EOL outcomes. However, a substantial number of people have not had such discussions. OBJECTIVE: The study's objective was to understand attitudes and experiences influencing engagement in discussions of EOL care preferences with family members, including the role of healthcare providers in such discussions...
November 30, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29172847/synergies-resulting-from-a-systems-biology-approach-integrating-radiation-epidemiology-and-radiobiology-to-optimize-protection-of-the-public-after-exposure-to-low-doses-of-ionizing-radiation
#11
Nicholas Dainiak, Ludwig E Feinendegen, Randall N Hyer, Paul A Locke, Alan E Waltar
No abstract text is available yet for this article.
January 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29161471/peer-to-peer-mentoring-for-african-american-women-with-lupus-a-feasibility-pilot
#12
Edith M Williams, J Madison Hyer, Ramakrishnan Viswanathan, Trevor D Faith, Delia Voronca, Mulugeta Gebregzaibher, Jim C Oates, Leonard Egede
OBJECTIVE: To examine the feasibility and potential benefits of peer mentoring to improve the disease self-management and quality of life of individuals with systemic lupus erythematosus (SLE). METHODS: Peer mentors were trained and paired with up to three mentees to receive self-management education and support by telephone over 12 weeks. This study took place at an academic teaching hospital in Charleston, South Carolina. Seven quads consisting of one peer mentor and three mentees were matched based on factors such as age, area of residence, marital and work status...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29156168/new-fixation-methods-for-the-treatment-of-the-diabetic-foot-beaming-external-fixation-and-beyond
#13
REVIEW
Roberto A Brandão, Jeffrey S Weber, David Larson, Mark A Prissel, Patrick E Bull, Gregory C Berlet, Christopher F Hyer
Surgical correction of complex foot and ankle deformities secondary to Charcot neuroarthropathy remains a significant surgical challenge. New technological advancements in hardware have allowed for the use of augmented fixation techniques in midfoot deformity correction, including the use of indication-specific locking plates and beaming techniques that offer enhanced stability. Severe hindfoot deformity management can employ the use of internal fixation, including intramedullary hindfoot nails and circular external fixation frames for limb salvage...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29154697/rate-of-subtalar-joint-arthrodesis-after-retrograde-tibiotalocalcaneal-arthrodesis-with-intramedullary-nail-fixation-evaluation-of-the-rain-database
#14
Michael Dujela, Christopher F Hyer, Gregory C Berlet
BACKGROUND: Hindfoot arthritis or significant deformity involving the ankle and subtalar joint (STJ) is a disabling condition with few salvage options. Many surgeons note a decreased STJ fusion rate compared with ankle union when a retrograde nail construct is used. The purpose of this study was to report the STJ fusion rate of tibiotalocalcaneal (TTC) arthrodesis with retrograde nail. METHODS: A chart and radiographic review was performed. TTC fusions performed in patients with osteoarthritis, posttraumatic arthritis, or deformity correction with retrograde nail fixation were included...
November 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29126857/impact-of-endogenous-progesterone-on-reactivity-to-yohimbine-and-cocaine-cues-in-cocaine-dependent-women
#15
Megan M Moran-Santa Maria, Brian J Sherman, Kathleen T Brady, Nathaniel L Baker, J Madison Hyer, Chantelle Ferland, Aimee L McRae-Clark
BACKGROUND AND OBJECTIVE: Data from clinical and preclinical models of relapse suggest that progesterone attenuates cocaine-seeking behavior. In a recent study, we found that cocaine-dependent women reported greater subjective responses to cues that were preceded by a stressor than cocaine-dependent men. The objective of this study was to examine the impact of endogenous progesterone on the subjective and endocrine responses to a drug-paired cue that was preceded by a stressor in cocaine-dependent women...
February 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29124779/prenatal-diethylstilbestrol-exposure-and-cancer-risk-in-women
#16
Rebecca Troisi, Elizabeth E Hatch, Linda Titus, William Strohsnitter, Mitchell H Gail, Dezheng Huo, Ervin Adam, Stanley J Robboy, Marianne Hyer, Robert N Hoover, Julie R Palmer
In the Diethylstilbestrol [DES] Combined Cohort Follow-up, the age- and calendar-year specific standardized incidence ratio [SIR] for clear cell adenocarcinoma [CCA] was 27.6 (95% confidence interval [CI] 7.51-70.6) for the exposed women. The SIR for breast cancer was 1.17 (95% CI 1.01-1.36) and the hazard ratio [HR] adjusted for birth year and cohort for comparison with the unexposed was 1.05 (95% CI 0.79-1.41). The SIR for pancreatic cancer was 2.43 (95% CI 1.21-4.34) and the adjusted HR for comparison with unexposed women was 7...
November 10, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29110501/first-metatarsal-head-osteochondral-defect-treatment-with-particulated-juvenile-cartilage-allograft-transplantation-a-case-series
#17
Bryan Van Dyke, Gregory C Berlet, Justin L Daigre, Christopher F Hyer, Terrence M Philbin
BACKGROUND: Focal damage to articular cartilage, also called an osteochondral defect (OCD), can be a cause of pain and decreased range of motion. Recent advancements have led to transplantation techniques using particulated juvenile articular cartilage allograft. This technique has been applied to the first metatarsal head to a very limited degree, with no published results to our knowledge. The aim of this study was to review the clinical results of patients who underwent particulated juvenile cartilage allograft implantation for first metatarsal head OCDs...
February 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29098941/efflux-transporter-breast-cancer-resistance-protein-dominantly-expresses-on-the-membrane-of-red-blood-cells-hinders-partitioning-of-its-substrates-into-the-cells-and-alters-drug-drug-interaction-profiles
#18
Pu Shi, Mingxiang Liao, Bei-Ching Chuang, Robert Griffin, Judy Shi, Marc Hyer, John K Fallon, Philip C Smith, Chao Li, Cindy Q Xia
1. Red blood cell (RBC) partitioning is important in determining pharmacokinetic and pharmacodynamic properties of a compound; however, active transport across RBC membranes is not well understood, particularly without transporter-related cell membrane proteomics data. 2. In this study, we quantified breast cancer resistance protein (BCRP/Bcrp) and MDR1/P-glycoprotein (P-gp) protein expression in RBCs from humans, monkeys, dogs, rats, and mice using nanoLC/MS/MS, and evaluated their effect on RBC partitioning and plasma exposure of their substrates...
November 3, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29090986/prophylactic-negative-pressure-wound-therapy-in-obese-patients-following-cesarean-delivery
#19
Maureen Ayers Looby, Rachel Isaksson Vogel, Ananta Bangdiwala, Barbara Hyer, Kamalini Das
OBJECTIVE: Negative pressure therapy (NPT) offers the potential to reduce infection in obese patients. The goal of this study was to explore the association between NPT use and infection after cesarean delivery among obese women. METHODS: We initiated a hospital protocol wherein women with a body mass index (BMI) of 40 kg/m2 or greater who delivered after January 1, 2011 were to receive NPT following cesarean section. A retrospective comparison of surgical site infection (SSI) in women receiving the intervention to a similar group with a BMI of 40 kg/m2 or greater, a historical control group of women who delivered before January 1, 2011...
October 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/29069384/a-prospective-cohort-study-of-prenatal-diethylstilbestrol-exposure-and-cardiovascular-disease-risk
#20
Rebecca Troisi, Linda Titus, Elizabeth E Hatch, Julie R Palmer, Dezheng Huo, William C Strohsnitter, Ervin Adam, Winnie Ricker, Marianne Hyer, Robert N Hoover
Purpose: Prenatal exposure to diethylstilbestrol (DES), a prototype endocrine-disrupting chemical, is associated with risk for adverse reproductive outcomes and cancer in women. We investigated whether cardiovascular disease (CVD) risk might also be greater in women prenatally exposed to DES. Methods: DES-exposed (n = 3941) and -unexposed (n = 1705) women participating in the Combined DES Cohort Follow-up Study were followed prospectively from 1994 to 2013. Prenatal DES exposure (or lack of exposure) was documented in the birth record or physician's note...
January 1, 2018: Journal of Clinical Endocrinology and Metabolism
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