keyword
https://read.qxmd.com/read/38542175/chronic-rhinosinusitis-microbiological-etiology-potential-genetic-markers-and-diagnosis
#1
REVIEW
Michał Michalik, Beata Krawczyk
Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available biomarkers. Ongoing scientific research is increasingly based on simple and objective analytical methods, including sensors, detection with PCR, and sequencing...
March 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541788/robotic-assisted-epicardial-hybrid-ablation-and-left-appendage-closure-in-persistent-atrial-fibrillation-first-european-experience
#2
JOURNAL ARTICLE
Alfonso Agnino, Laura Giroletti, Ascanio Graniero, Piersilvio Gerometta, Matteo Parrinello, Giovanni Albano, Eduardo Celentano, Ernesto Cristiano, Giuseppe Nasso, Natasja M S de Groot
Background: Pulmonary vein isolation is currently considered to be the gold standard for ablating paroxysmal atrial fibrillation. However, its efficacy is limited in patients with persistent atrial fibrillation. The convergent procedure has emerged as a hybrid ablation. This study aims, for the first time in the literature, to introduce a hybrid approach that includes epicardial ablation with cutting-edge robotic technology and subsequent electrophysiological study to verify and an endocardial ablation to complete the ablation lines...
March 8, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541174/the-effectiveness-of-biological-agents-on-chronic-rhinosinusitis-with-nasal-polyposis-in-patients-with-comorbid-asthma-a-multicenter-real-life-study-from-t%C3%A3-rkiye
#3
MULTICENTER STUDY
Meryem Demir, Ceyda Tunakan Dalgic, Emine Nihal Mete Gokmen, Recep Savas, Suleyman Eroglu, Guzin Ozden, Cihan Orcen, Gulden Pacaci Cetin, Bahar Arslan, Ferda Bilgir, Gokten Bulut, Nurullah Yekta Akcam, Semiha Ozgul, Pamir Cerci, Raif Coskun, Sercan Gode, Insu Yilmaz, Aytul Zerrin Sin
Background and Objectives : Real-life data on the efficacy of biologic agents (BAs) on asthma-comorbid CRSwNP are needed. Our primary goal is to investigate the effects of BAs on CRSwNP symptoms, as well as endoscopic and tomography scores. Our secondary goal is to show a reduction in the frequency of acute sinusitis exacerbations and the need for surgery. Materials and Methods : We conducted a multicenter, retrospective, real-life study. We screened the patients with asthma-comorbid CRSwNP treated with omalizumab or mepolizumab...
March 8, 2024: Medicina
https://read.qxmd.com/read/38533169/from-pansinusitis-to-cerebritis-due-to-eikenella-corrodens
#4
Adriana América Silva, Inês Zão, João A Louro, Eduarda Pereira, Elisabete Monteiro
Meningitis is a rare but possible complication of sinusitis. We present a case of a 21-year-old woman with a history of fever, headache and nasal obstruction who presented at the emergency department with psychomotor agitation. Orotracheal intubation and invasive mechanical ventilation were given to protect airway. Blood analysis showed leukocytosis and elevated C-reactive protein. Cerebral and maxillofacial computed tomography (CT) demonstrated pansinusitis with gas foci more prominent in the left frontal sinus with an area of ​​bone rarefaction on the posterior wall with possible communication with the cranial cavity...
February 2024: Curēus
https://read.qxmd.com/read/38527834/-clinical-features-and-risk-factors-for-invasive-fungal-sinusitis-after-allogeneic-hematopoietic-stem-cell-transplantation
#5
JOURNAL ARTICLE
H X Fu, J J Li, Y Y Zhang, Y Q Sun, X D Mo, T T Han, J Kong, M Lyu, W Han, H Chen, Y Y Chen, F R Wang, C H Yan, Y Chen, J Z Wang, Y Wang, L P Xu, X J Huang, X H Zhang
Objective: To analyze the clinical characteristics and outcomes of patients with invasive fungal sinusitis (invasive fungal rhinosinusitis, IFR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and explored the risk factors for IFR after allo-HSCT. Methods: Nineteen patients with IFR after allo-HSCT at Peking University People's Hospital from January 2012 to December 2021 were selected as the study group, and 95 patients without IFR after allo-HSCT during this period were randomly selected as the control group (1:5 ratio) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38526695/pilonidal-sinus-an-overview-of-historical-and-current-management-modalities
#6
REVIEW
Adrian Tam, Christopher J Steen, Jonathan Chua, Raymond J Yap
Pilonidal disease is a common condition that commonly affects the younger adult population and is often seen in both the general practice and the hospital setting. Multiple treatment methods have gained and lost popularity over the last several decades, but more recent intervention principles show promising results. This article details the different methods of managing acute and chronic pilonidal disease ranging from treatments in the primary care setting to those in hospital theatres, with special attention to newer modalities of minimally invasive interventions...
March 25, 2024: Updates in Surgery
https://read.qxmd.com/read/38525891/the-topos-study
#7
JOURNAL ARTICLE
Tim Sebastian, Stefano Barco, Davide Voci, Michael Lichtenberg, Oliver Schlager, Houman Jalaie, Rick de Graaf, Christian Erbel, Alexander Massmann, Marc Schindewolf, David Spirk
<b/> Background : We aimed to study the long-term safety and efficacy of oblique venous stents for post-thrombotic syndrome (PTS) with iliac vein compression. Patients and methods : In the multinational, prospective, single-arm TOPOS study, PTS patients scheduled for endovascular therapy with the sinus-Obliquus® stent and optional distal extension with the sinus-Venous® or sinus-XL Flex® stent were enrolled at eight European vascular centres between October 2016 and December 2020. The primary outcome was primary stent patency at 24 months, and secondary outcomes included the clinical course of PTS (Villalta score, revised Venous Clinical Severity Score [rVCSS], Visual Analog Scale [VAS] of pain), quality of life changes (Chronic Venous Insufficiency Quality of Life Questionnaire, CIVIQ-20), and device-related complications...
March 25, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38525870/clinical-outcomes-associated-with-orphenadrine-deliberate-self-poisoning-a-retrospective-poisons-centre-study
#8
JOURNAL ARTICLE
Nina Dhaliwal, Darren M Roberts
INTRODUCTION: Orphenadrine overdoses can cause antimuscarinic toxicity, respiratory failure, refractory seizures and cardiotoxicity. The dose-toxicity relationship is poorly defined. Orphenadrine is marketed as immediate and sustained release formulations, and it is not known how the formulation impacts on toxicity. We determined the clinical toxicity of orphenadrine in patients referred to a regional poisons centre. METHODS: Retrospective case series of patients in New South Wales with orphenadrine deliberate self-poisoning from January 2016 to April 2022 referred to the New South Wales Poisons Information Centre...
March 25, 2024: Clinical Toxicology
https://read.qxmd.com/read/38524028/a-rare-case-of-fungal-osteomyelitis-of-the-distal-tibia-in-a-pediatric-patient
#9
Syed Faisal Afaque, Udit Agrawal, Dilip K Shankhwar, Suresh Chand, Vikas Verma
Staphylococcus aureus infection is the most common cause of osteomyelitis. Over 100,000 fungal species have been described; only 150 are pathogenic to humans. These opportunistic infections frequently enter the body due to a decrease in host defense or through an invasive gateway, such as a dental extraction or skin discontinuity due to trauma. Symptoms and radiological examination often mimic those of other etiologies, which can lead to substantial delays in treatment. Our case is a 13-year-old healthy boy with no history of immune incompetency who presented to us with complaints of pain and swelling over his left ankle and leg with an on-and-off history of fever for 15 days...
February 2024: Curēus
https://read.qxmd.com/read/38523980/myocardial-bridging-of-mid-left-anterior-descending-artery-lad-presenting-as-transient-left-bundle-branch-block-during-nuclear-stress-test
#10
Kai Shiang Lin, Adam Kurnick, Ridhima Goel, Igal Gorbut, Adam Friedman, Ezra Schrem, Samy I McFarlane, Inna Bukharovich
Transient left bundle branch block occurring during a nuclear stress test in the setting of myocardial bridging is a relatively rare finding. We report a case of a 75-year-old male who presented with typical stable angina. Serial troponins were negative, and the electrocardiogram revealed normal sinus rhythm with left ventricular hypertrophy and T-wave inversions in the lateral leads. The nuclear stress test was non-ischemic but showed a transient left bundle branch block associated with chest pain and shortness of breath that occurred right after the administration of regadenoson...
February 2024: Curēus
https://read.qxmd.com/read/38520981/risk-of-covid-19-in-pediatric-population-and-the-effects-of-covid-19-vaccination-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Kassandra Corona, Janisah Amirah I Saripada, Kendall Wermine, Sydney Seavey, Bibiana Toro Figueira, Joshua J LaHaye, Yuki Yoshiyasu, Shiva Daram, Brian McKinnon
OBJECTIVE: Prior studies have demonstrated the adverse effects of upper respiratory infections on the pediatric population, such as increased risk for acute otitis media (AOM). Other studies have noted decreased otitis media complaints during the COVID-19 pandemic. This project aims to identify whether individuals who tested positive for COVID-19 at the Emergency Department (ED) visit had an increased risk of developing severe complications. Additionally, we will study whether vaccination helped decrease following COVID-19 complications...
March 22, 2024: Auris, Nasus, Larynx
https://read.qxmd.com/read/38520324/evaluation-of-a-clinical-decision-support-system-and-an-automated-electronic-health-record-alert-on-outpatient-prescribing-of-cefdinir
#12
JOURNAL ARTICLE
Ashleah Courtney, Gregory Cook, Margarita Silio
Acute bacterial upper respiratory infections are common indications for antibiotics in pediatrics, and many prescriptions may be inappropriate. Novel approaches to outpatient antimicrobial stewardship interventions are needed. This quasi-experimental study of an order set and best practice advisory alert targeting cefdinir prescriptions demonstrated an 8.4% decrease in cefdinir prescribing (p=<0.001).
March 23, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38513110/contemporary-catheter-ablation-of-complex-atrial-tachycardias-after-prior-atrial-fibrillation-ablation-pulsed-field-versus-radiofrequency-current-energy-ablation-guided-by-high-density-mapping
#13
JOURNAL ARTICLE
Melanie A Gunawardene, Tim Harloff, Mario Jularic, Jannis Dickow, Rahin Wahedi, Omar Anwar, Peter Wohlmuth, Nele Gessler, Jens Hartmann, Stephan Willems
BACKGROUND: Catheter-ablation (CA) of post-ablation left-atrial tachycardias (LAT) can be challenging. So far, pulsed-field ablation (PFA) has not been compared to standard point-by-point radiofrequency-current (RFC) energy for LAT ablation. AIMS: To compare efficacy of PFA versus RFC in patients undergoing CA for LAT. METHODS: Consecutive patients undergoing LAT-CA were prospectively enrolled (09/2021-02/2023). After electro-anatomical high-density mapping, ablation with either a pentaspline PFA-catheter or RFC was performed...
March 21, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38510226/carotid-web-as-a-source-of-thromboembolism-in-a-young-african-american-female
#14
Eric Assid, Chad Hall, Mawadah Samad, Richard Zweifler
Background: Carotid webs are nonatherosclerotic fibrous bands that may alter hemodynamic flow and increase the risk of platelet aggregation, leading to thromboembolism in young, otherwise healthy individuals. Although rare, carotid webs are important causes of thromboembolic strokes and are often overlooked in the routine workup for a stroke. Treating physicians and radiologists must recognize and properly manage patients who present with carotid webs to prevent recurrent thromboembolism. Case Report: A healthy 30-year-old female presented with slurred speech and unilateral left upper and lower extremity numbness...
2024: Ochsner Journal
https://read.qxmd.com/read/38506028/-acute-and-chronic-rhinosinusitis-age-characteristics
#15
JOURNAL ARTICLE
S V Ryazantsev, I M Kirichenko, E L Savlevich, V I Popadyuk, N S Kozlova, A I Chernolev
Children's and adults' rhinosinusitis are two diseases that have both similarities and differences in anatomy, epidemiology, causes, pathogenesis, diagnosis and treatment. At the same rhinosinusitis is one of the most common in otorhinolaryngology's practice, both in children and adults. The of adults paranasal sinuses (PNS) anatomy differs from children's PNS anatomy. Although ostiomeatal complex occlusion is recognized as a major cause of poor ventilation and drainage of the adult paranasal sinuses, it does not have a strong effect on pediatric rhinosinusitis, but adenoids play a key role...
2024: Vestnik Otorinolaringologii
https://read.qxmd.com/read/38504423/esophageal-perforation-presenting-initially-as-multiple-brain-abscesses-secondary-to-streptococcus-intermedius
#16
JOURNAL ARTICLE
Muhammed Yaman Swied, Mulham Alom, Obada Daaboul, Muaataz Azzawi, Abdul Swied
Brain abscess is a life-threatening infection that can occur secondary to contiguous or hematogenous spread. Several underlying conditions can lead to brain abscesses, such as dental infection, otitis media, sinusitis, and immunosuppression. Esophageal perforation leading to brain abscesses is extremely rare. We report a rare case of a 32-year-old man who presented to the emergency department with progressive headaches and upper-extremity weakness. Upon further evaluation, computed tomography (CT) revealed multiple brain abscesses secondary to Streptococcus intermedius infection...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38498565/outpatient-visits-and-antibiotic-use-due-to-higher-valency-pneumococcal-vaccine-serotypes
#17
JOURNAL ARTICLE
Laura M King, Kristin L Andrejko, Sarah Kabbani, Sara Y Tartof, Lauri A Hicks, Adam L Cohen, Miwako Kobayashi, Joseph A Lewnard
BACKGROUND: In 2022-2023, 15- and 20-valent pneumococcal conjugate vaccines (PCV15/PCV20) were recommended for infants. We aimed to estimate the incidence of outpatient visits and antibiotic prescriptions in U.S. children (≤17 years) from 2016-2019 for acute otitis media, pneumonia, and sinusitis associated with PCV15- and PCV20-additional (non-PCV13) serotypes to quantify PCV15/20 potential impacts. METHODS: We estimated the incidence of PCV15/20-additional serotype-attributable visits and antibiotic prescriptions as the product of all-cause incidence rates, derived from national healthcare surveys and MarketScan databases, and PCV15/20-additional serotype-attributable fractions...
March 18, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38498256/concurrent-spontaneous-coronary-dissection-and-reversible-cerebral-vasoconstriction-syndrome-during-postnatal-care
#18
JOURNAL ARTICLE
Sang Gon Yoon, Yeo-Jeong Song, Yun-Seok Song, Jino Park, Seunghwan Kim, Dong-Kie Kim, Ki-Hun Kim, Doo-Il Kim, Hyun Kuk Kim, Dong Ah Lee
BACKGROUND: Pregnancy-associated spontaneous coronary artery dissection (SCAD) and reversible cerebral vasoconstriction syndrome (RCVS) are rare conditions that may occur during pregnancy and the postpartum period. The coexistence of both diseases may pose a risk to patients, potentially resulting in a variety of complications and clinical manifestations. This is considered the first case of a patient who successfully recovered from a critical condition in the postpartum period, with contemporaneous SCAD and RCVS...
March 18, 2024: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/38496499/nasopharyngeal-metatranscriptomics-reveals-host-pathogen-signatures-of-pediatric-sinusitis
#19
Nooran AbuMazen, Vivian Chu, Manjot Hunjan, Briallen Lobb, Sojin Lee, Marcia Kurs-Lasky, John V Williams, William MacDonald, Monika Johnson, Jeremy A Hirota, Nader Shaikh, Andrew C Doxey
UNLABELLED: Acute sinusitis (AS) is the fifth leading cause of antibiotic prescriptions in children. Distinguishing bacterial AS from common viral upper respiratory infections in children is crucial to prevent unnecessary antibiotic use but is challenging with current diagnostic methods. Despite its speed and cost, untargeted RNA sequencing of clinical samples from children with suspected AS has the potential to overcome several limitations of other methods. However, the utility of sequencing-based approaches in analysis of AS has not been fully explored...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38496113/pediatric-cerebral-venous-sinus-thrombosis-a-case-report
#20
Pruthvi Patel, Shirley M Gandhi, Philip P Breton, Tetiana Litvinchuk
Cerebral venous sinus thrombosis (CVST) in infants is a rare vascular disorder that presents with nonspecific symptoms leading to a delay in diagnosis and treatment. Thrombus formation in the cerebral sinuses prevents blood from draining out of the brain leading to local and systemic complications. Here, we present an 11-week-old patient who presented to the emergency department (ED) with three days of lethargy, multiple episodes of projectile emesis, increased fussiness, and downward gaze. A CT scan demonstrated intraventricular hemorrhage (IVH) with acute hydrocephalus...
February 2024: Curēus
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