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https://www.readbyqxmd.com/read/29351716/effect-of-metformin-on-glycemic-control-in-patients-with-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#1
Haiyang Meng, Ailing Zhang, Yan Liang, Jie Hao, Xiaojian Zhang, Jingli Lu
BACKGROUND: For T1D patients, adding metformin to insulin therapies is thought to improve blood glucose levels, but current evidence does not support this clinical benefit. Additional data from large clinical trials are now available; therefore, we conducted a meta-analysis of studies on assessing the efficacy and adverse effects of metformin. METHODS: We searched the MEDLINE, EMBASE and Cochrane Library databases for data from randomized controlled trials (RCTs)...
January 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29351636/effectiveness-of-respiratory-syncytial-virus-immunoprophylaxis-on-bronchiolitis-hospitalizations-among-high-risk-infants
#2
Pingsheng Wu, Gabriel J Escobar, Tebeb Gebretsadik, Kecia N Carroll, Sherian X Li, Eileen M Walsh, Edward F Mitchel, Chantel Sloan, William D Dupont, Chang Yu, Jeffrey R Horner, Tina V Hartert
We sought to determine the real-world effectiveness of respiratory syncytial virus (RSV) immunoprophylaxis in a population-based cohort to inform policy. The study population included infants born 1996-2008 and enrolled in Kaiser Permanente Northern California. During the RSV season (November-March), RSV immunoprophylaxis administration and the following 30 days were defined as RSV immunoprophylaxis protected period(s), and all other days as unprotected period(s). Bronchiolitis hospitalizations were determined using the International Classification of Diseases Ninth Revision codes during RSV season...
January 17, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29351629/housing-conditions-and-risk-of-physical-function-limitations-a-prospective-study-of-community-dwelling-older-adults
#3
Bibiana Pérez-Hernández, Esther Lopez-García, Auxiliadora Graciani, José Luis Ayuso-Mateos, Fernando Rodríguez-Artalejo, Esther García-Esquinas
Background: Poor housing conditions have been associated with an increased risk of morbidity and mortality in old age. Methods: Prospective cohort of 1602 older adults followed from 2012 to 2015. Poor conditions were defined as living in a walk-up building, lacking piped hot water or heating, feeling frequently cold at home, lacking a bathtub/shower, a refrigerator, a washing machine, an own room or a landline. Frailty was assessed with the Fried criteria, lower extremities performance with the Short Physical Performance Battery (SPPB), and disability in instrumental activities of daily living (IADL) with the Lawton and Brody questionnaire...
January 17, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29351163/comparison-of-the-force-velocity-and-power-time-curves-between-the-concentric-only-and-eccentric-concentric-bench-press-exercises
#4
Alejandro Pérez-Castilla, Paul Comfort, John J McMahon, Francisco Luis Pestaña-Melero, Amador García-Ramos
The aim of this study was to compare the temporal and mechanical variables between the concentric-only and eccentric-concentric bench press (BP) variants. Twenty-one men (age: 22.0±4.2 years, body mass: 73.4±7.7 kg, height: 177.2±8.0 cm; one-repetition maximum [1RM]: 1.12±0.12 kg⋅kg) were evaluated during the concentric-only and eccentric-concentric BP variants using 80% 1RM. Temporal (concentric phase duration, propulsive phase duration, and time to reach the maximum values of force, velocity, and power) and mechanical variables (force, velocity, and power), determined using a linear velocity transducer, were compared between both BP variants...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29351157/association-between-cotinine-verified-smoking-status-and-risk-of-colorectal-neoplasia
#5
Nam Hee Kim, Yoon Suk Jung, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
GOALS: We evaluated the association of urinary cotinine-verified smoking status with the risk of colorectal neoplasia (CRN). BACKGROUND: Many studies have reported the association between the risk of CRN and smoking status, based on self-reported questionnaires. Although self-reported smoking status may be inaccurate, to our knowledge, no study has yet assessed the association between objective biomarkers of tobacco exposure and the risk of CRN. STUDY: A cross-sectional study was conducted on 96,806 asymptomatic examinees who underwent colonoscopy and urinary cotinine measurements as part of a health check-up...
January 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29351029/factors-associated-with-adherence-to-nasoalveolar-molding-nam-by-caregivers-of-infants-born-with-cleft-lip-and-palate
#6
Nick O Esmonde, Judah S Garfinkle, Yiyi Chen, William E Lambert, Anna A Kuang
OBJECTIVE: Identify factors associated with adherence to nasoalveolar molding (NAM) therapy. DESIGN: Retrospective case-control study. SETTING: Tertiary referral center. PATIENTS, PARTICIPANTS: Infants with cleft lip, with or without cleft palate, referred for NAM. One hundred thirty-five patients met criteria. MAIN OUTCOME MEASURE(S): Adherence to NAM therapy, defined as continuous use of the appliance and attendance of NAM adjustment visits...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350775/randomized-trial-of-transcranial-dc-stimulation-for-post-stroke-dysphagia
#7
Sonja Suntrup-Krueger, Corinna Ringmaier, Paul Muhle, Andreas Wollbrink, Andre Kemmling, Uta Hanning, Inga Claus, Tobias Warnecke, Inga Teismann, Christo Pantev, Rainer Dziewas
OBJECTIVE: We evaluated whether transcranial direct current stimulation (tDCS) is able to enhance dysphagia rehabilitation following stroke. Besides relating clinical effects with neuroplastic changes in cortical swallowing processing we aimed to identify factors influencing treatment success. METHODS: In this double-blind, randomized study 60 acute dysphagic stroke patients received contralesional anodal (1 mA, 20 min) or sham tDCS on four consecutive days. Swallowing function was thoroughly assessed before and after the intervention using the validated Fiberoptic Endoscopic Dysphagia Severity Scale (FEDSS) and clinical assessment...
January 19, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29350756/cytocompatibility-of-biodentine-and-iroot-fs-with-human-periodontal-ligament-cells-an-in-vitro-study
#8
T Luo, J Liu, Y Sun, Y Shen, L Zou
AIM: To evaluate the cytocompatibility of Biodentine and iRoot FS with human periodontal ligament cells (hPDLCs). METHODOLOGY: hPDLCs were characterized by flow cytometry and immunocytochemical analysis. hPDLC adhesion was assessed by scanning electron microscopy at day 3; proliferation by live/dead assay at day 1, 3 and 7; and osteogenic differentiation by alkaline phosphatase (ALP) activity staining, ALP quantification analysis and qRT-PCR at day 7 and 14. Data were analysed with ANOVA and independent sample t-tests with SPSS 21...
January 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29350485/purification-of-glutathione-s-transferase-enzyme-from-quail-liver-tissue-and-inhibition-effects-of-3ar-4s-7r-7as-2-4-e-3-aryl-acryloyl-phenyl-3a-4-7-7a-tetrahydro-1h-4-7-methanoisoindole-1-3-2h-dione-derivatives-on-the-enzyme-activity
#9
Yusuf Temel, Umit M Koçyigit, M Şerif Taysı, Faik Gökalp, Meliha Burcu Gürdere, Yakup Budak, Mustafa Ceylan, İlhami Gülçin, Mehmet Çiftci
The use of quail meat and eggs has made this animal important in recent years, with its low cost and high yields. Glutathione S-transferases (GST, E.C.2.5.1.18) are an important enzyme family, which play a critical role in detoxification system. In our study, GST was purified from quail liver tissue with 47.88-fold purification and 12.33% recovery by glutathione agarose affinity chromatography. The purity of enzyme was checked by SDS-PAGE method and showed a single band. In addition, inhibition effects of (3aR,4S,7R,7aS)-2-(4-((E)-3-(aryl)acryloyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7methanoisoindole-1,3(2H)-dion derivatives (1a-g) were investigated on the enzyme activity...
January 19, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29350413/occupational-exposure-to-extremely-low-frequency-magnetic-fields-and-the-risk-of-als-a-systematic-review-and-meta-analysis
#10
Anke Huss, Susan Peters, Roel Vermeulen
We performed a meta-analysis to examine associations of occupational exposure to extremely-low frequency magnetic fields (ELF-MF) with amyotrophic lateral sclerosis (ALS). Epidemiologic studies were identified in EMBASE and MEDLINE, in reference lists and a specialist database. We included studies that reported risk estimates of ALS in association with occupational ELF-MF exposure. Summary relative risks (RR) or odds ratios (OR) were obtained with random effect meta-analysis, and analyses were stratified by type of exposure assessment...
January 19, 2018: Bioelectromagnetics
https://www.readbyqxmd.com/read/29350403/influence-of-contrast-administration-on-computed-tomography-based-analysis-of-visceral-adipose-and-skeletal-muscle-tissue-in-clear-cell-renal-cell-carcinoma
#11
Michael T Paris, Helena F Furberg, Stacey Petruzella, Oguz Akin, Andreas M Hötker, Marina Mourtzakis
BACKGROUND: Computed tomography (CT) scans are being utilized to examine the influence of skeletal muscle and visceral adipose quantity and quality on health-related outcomes in clinical populations. However, little is known about the influence of contrast administration on these parameters. METHODS: Precontrast, arterial, and 3-minute postcontrast CT images of 45 patients with clear cell renal cell carcinoma were downloaded from The Cancer Imaging Archive and retrospectively analyzed for visceral adipose cross-sectional area (CSA) and density, and muscle CSA and density at the third lumbar vertebrae...
January 19, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29350400/feasibility-of-enteral-protein-supplementation-in-critically-ill-children
#12
Yara M F Moreno, Daniela B Hauschild, Mayara D Martins, Lori J Bechard, Nilesh M Mehta
BACKGROUND: We describe the protein type and concentration in standard enteral nutrition (EN) formulas and the effect of protein supplementation on the osmolality of standard formulas. We also aimed to examine factors associated with optimal protein delivery in critically ill children. METHODS: Protein content and other characteristics of pediatric EN formulas used worldwide were recorded. Factors associated with achievement of recommended protein delivery and tolerance of protein-supplemented formulas were recorded prospectively in a cohort of critically ill children...
January 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29350363/is-nighttime-laparoscopic-general-surgery-under-general-anesthesia-safe
#13
Ahmet Kemalettin Koltka, Mehmet İlhan, Achmet Ali, Ali Fuat Kaan Gök, Nükhet Sivrikoz, Teoman Hakan Yanar, Mustafa Kayıhan Günay, Cemalettin Ertekin
BACKGROUND: Fatigue and sleep deprivation can affect rational decision-making and motor skills, which can decrease medical performance and quality of patient care. The aim of the present study was to investigate the association between times of the day when laparoscopic general surgery under general anesthesia was performed and their adverse outcomes. METHODS: All laparoscopic cholecystectomies and appendectomies performed at the emergency surgery department of a tertiary university hospital from 01...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29350310/proanthocyanidins-and-the-risk-of-prostate-cancer-in-italy
#14
Delphine Praud, Maria Parpinel, Valentina Guercio, Cristina Bosetti, Diego Serraino, Gaetano Facchini, Maurizio Montella, Carlo La Vecchia, Marta Rossi
Proanthocyanidins are polymers of monomeric unit flavan-3-ols with antioxidant, anti-inflammatory and free radical scavenging activities. We investigated the association between proanthocyanidin intake and prostate cancer risk through data that were collected between 1991 and 2002 in an Italian case-control study, including a total of 1,294 incident, histologically confirmed cases of prostate cancer and 1,451 controls admitted to hospital for acute, non-neoplastic, and non-hormone-related diseases. We estimated odds ratios (ORs) and their 95% confidence intervals (CIs) using multiple logistic regression models, and computed energy-adjusted proanthocyanidin intakes using the residual method...
January 19, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29350266/normative-measurements-of-inferior-oblique-muscle-thickness-in-japanese-by-magnetic-resonance-imaging-using-a-new-technique
#15
Maria Suzanne Sabundayo, Hirohiko Kakizaki, Yasuhiro Takahashi
PURPOSE: To measure the thickness of the inferior oblique muscle (IOM) among Japanese by magnetic resonance imaging (MRI) using a new technique. METHODS: This retrospective observational study included 78 patients (36 males and 42 females) who underwent MRI for detection of a unilateral orbital lesion or examining causes of unilateral retrobulbar pain. The thickness of the IOM was measured on the side without the orbital lesion or symptom. On the quasi-sagittal plane through the optic nerve, the major and minor axes of the cross-section of the IOM were measured...
January 19, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29350064/comparison-of-hyaluronic-acid-based-micelles-and-polyethylene-glycol-based-micelles-on-reversal-of-multidrug-resistance-and-enhanced-anticancer-efficacy-in-vitro-and-in-vivo
#16
Jinling Wang, Ying Li, Lifang Wang, Xiaohui Wang, Pengfei Tu
Polyethylene glycol (PEG)-based block copolymer micelles and hyaluronic acid (HA)-based grafted copolymer micelles have been widely investigated in chemotherapy. In this study, to evaluate the differences among HA-based grafted polymer micelles, PEG-based block polymer micelles and the mixed of these two micelles in enhancing antitumor effects and overcoming MDR, two amphiphilic vitamin E succinate (VES) derivatives, HA VES (HA-g-VES) and PEG 2000 VES (TPGS2k), were applied as nanocarriers to prepare HA-VES micelles (HA-PMs), TPGS2k micelles (TPGS2k-PMs) and the mixed micelles (HA/TPGS2k-PMs) for the co-delivery of doxorubicin (DOX) and curcumin (Cur)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29349981/-clinical-results-in-early-and-mid-term-of-using-the-s-rom-femoral-stem-in-revision
#17
Shang Piao, Yong-Gang Zhou, Yin-Qiao Du, Hai-Yang Ma, Jing-Yang Sun, Zhi-Sen Gao, Ya-Wen Peng, Wen-Ming Wu
OBJECTIVE: To investigate and the clinical effect of S-ROM modular stem in femur reconstruction in hip revision arthroplasty. METHODS: From January 2008 to January 2016, 21 patients received revision hip arthroplasties using S-ROM stems. There were 5 males and 16 females with an average of 48.33 years old(range, 29 to 73 years old). There were 13 cases caused by aseptic loosening, 4 cases by infection, 2 cases by nonunion of sub-tuberosity osteotomy, 1 case for repeated dislocation, 1 case for traumatic great trochanter fracture...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349966/-a-medium-term-therapeutic-effects-of-anatomic-locking-plate-for-femoral-intertrochanteric-with-lateral-femoral-wall-fractures
#18
Jin-Wei Xu, Lei Han, Yun-Gen Hu, Wei-Li Fang, Bo Ji
OBJECTIVE: To retrospectively study medium term follow-up outcomes of the femoral intertrochanteric with lateral femoral wall fractures using anatomic locking plate fixation. METHODS: From June 2010 to January 2013, 18 cases of the unstable femoral intertrochanteric with lateral femoral wall fractures were treated with the anatomic locking plate, included 8 males and 10 females with an average age of 75.5 years ranging from 19 to 83 years old. There were 8 cases of traffic accident injuries, 6 cases of falls injuries, and 4 cases of falling from high place...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349954/-influence-on-coagulation-function-and-the-therapy-effect-of-damage-control-orthopaedics-for-unstable-pelvic-fractures-and-multiple-fractures-of-extremities
#19
Yan-Chao Li, Yong Liu, Bo Huang
OBJECTIVE: To retrospectively explore the effects of damage control orthopaedics concept on coagulation and curative effects in unstable pelvic fractures and multiple fractures of limbs. METHODS: From March 2014 to December 2015, 40 patients with unstable pelvic fractures and limbs multiple fractures in treatment group included 22 males and 18 females with an average age of (39.00±4.12) years old were treated with the damage control orthopaedics concept, the ISS score was (25...
March 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349823/tibolone-and-risk-of-gynecological-hormone-sensitive-cancer
#20
Ellen Christine Leth Løkkegaard, Lina Steinrud Mørch
Risk of ovarian cancer with hormone therapy is associated with use of both unopposed estrogen therapy and combined estrogen-progestin therapy, whereas for endometrial cancer addition of continuous progestin decreases the estrogen induced increased risk. Less is known about risk with use of tibolone; a synthetic steroid with estrogenic, progestagenic, and androgenic properties. We assessed these associations in a prospective cohort study, including all Danish women 50-79 years of age and followed 1995-2009. National Danish Registers captured individually updated exposure information, cancer cases including histology and confounding factors...
January 19, 2018: International Journal of Cancer. Journal International du Cancer
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