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Indirect restorations

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https://www.readbyqxmd.com/read/28216846/three-dimensional-finite-element-analysis-of-the-stress-distribution-pattern-in-a-mandibular-first-molar-tooth-restored-with-five-different-restorative-materials
#1
Kathleen Manuela D'souza, Meena Ajay Aras
INTRODUCTION: Badly broken or structurally compromised posterior teeth are frequently associated with crown/root fracture. Numerous restorative materials have been used to fabricate indirect full-coverage restorations for such teeth. This study aims to evaluate and compare the effect of restorative materials on the stress distribution pattern in a mandibular first molar tooth, under varying loading conditions and to compare the stress distribution pattern in five commonly used indirect restorative materials...
January 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28213983/no-evidence-of-indirect-resin-composite-restorations-lasting-longer-than-direct-resin-composite-restorations-in-posterior-teeth
#2
Romina Brignardello-Petersen
No abstract text is available yet for this article.
February 14, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28212163/multiple-organ-dysfunction-in-children-mechanically-ventilated-for-acute-respiratory-failure
#3
Scott L Weiss, Lisa A Asaro, Heidi R Flori, Geoffrey L Allen, David Wypij, Martha A Q Curley
OBJECTIVES: The impact of extrapulmonary organ dysfunction, independent from sepsis and lung injury severity, on outcomes in pediatric acute respiratory failure is unclear. We sought to determine the frequency, timing, and risk factors for extrapulmonary organ dysfunction and the independent association of multiple organ dysfunction syndrome with outcomes in pediatric acute respiratory failure. DESIGN: Secondary observational analysis of the Randomized Evaluation of Sedation Titration for Respiratory Failure cluster-randomized prospective clinical trial conducted between 2009 and 2013...
February 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28192403/a-double-negative-feedback-loop-between-epcam-and-erk-contributes-to-the-regulation-of-epithelial-mesenchymal-transition-in-cancer
#4
N V Sankpal, T P Fleming, P K Sharma, H J Wiedner, W E Gillanders
Epithelial-mesenchymal transition (EMT) is an important biological process that has been implicated in cancer metastasis. Epithelial cell adhesion molecule (EpCAM) is expressed at the basolateral membrane of most normal epithelial cells but is overexpressed in many epithelial cancers. In our studies on the role of EpCAM in cancer biology, we observed that EpCAM expression is decreased in mesenchymal-like primary cancer specimens in vivo and following induction of EMT in cancer cell lines in vitro. Extracellular signal-related kinase (ERK) is a key regulator of EMT...
February 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28182314/exotic-weeds-and-fluctuating-microclimate-can-constrain-native-plant-regeneration-in-urban-forest-restoration
#5
K J Wallace, Daniel C Laughlin, Bruce D Clarkson
Restoring forest structure and composition is an important component of urban land management, but we lack clear understanding of the mechanisms driving restoration success. Here we studied two indicators of restoration success in temperate rainforests: native tree regeneration and epiphyte colonization. We hypothesized that ecosystem properties such as forest canopy openness, abundance of exotic herbaceous weeds, and the microclimate directly affect the density and diversity of native tree seedlings and epiphytes...
February 9, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28174053/effect-of-different-surface-treatment-techniques-on-the-repair-strength-of-indirect-composites
#6
B A C Loomans, M E Mesko, R R Moraes, J Ruben, E M Bronkhorst, T Pereira-Cenci, M C D N J M Huysmans
OBJECTIVES: Composite resin restorations present high survival rates and when a failure occurs repair is often possible. The aim of this study was to assess the effect of various repair techniques on indirect restorations. METHODS: LAVA Ultimate (3M), and Clearfil Estenia blocks (Kuraray) were repaired with our without surface roughness treatments, silane application and artificial ageing. Micro-shear bond stress tests were performed, while cohesive strength served as positive control...
February 4, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28159339/effect-of-different-treatments-on-the-flexural-strength-of-fully-versus-partially-stabilized-monolithic-zirconia
#7
Taiseer A Sulaiman, Aous A Abdulmajeed, Khalil Shahramian, Lippo Lassila
STATEMENT OF PROBLEM: Recent monolithic zirconia materials used for indirect restorations are predominantly fully stabilized zirconia with claims of enhanced optical properties. These restorations may behave differently from the conventional partially stabilized zirconia restorations, which may negatively affect some of the core properties required for restoration success. PURPOSE: The purpose of this in vitro study was to evaluate and compare the effects of staining, airborne-particle abrasion, and artificial aging on the flexural strength of fully and partially stabilized zirconia material...
January 31, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28157652/neuroprotective-effect-of-chrysin-on-hyperammonemia-mediated-neuroinflammatory-responses-and-altered-expression-of-astrocytic-protein-in-the-hippocampus
#8
Renuka Mani, Vijayakumar Natesan, Ramakrishnan Arumugam
Neuroinflammation is an innate immune response in the central nervous system (CNS) against metabolic and pathogenic toxic wastes. The main hypothesis implies that a state of hyperammonemia which is accountable for both direct and indirect modification in ammonia metabolism with an elevated production of inflammatory cytokines. This study was constructed to explore the modulating effect of chrysin on rudimentary pathophysiologic mechanisms of ammonium chloride (NH4Cl) mediated neuroinflammation in the experimental hyperammonemic rats...
January 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28154997/risk-associated-with-perioperative-red-blood-cell-transfusion-in-cranial-surgery
#9
Jonathan A Cohen, Nima Alan, Andreea Seicean, Robert J Weil
We assessed the impact of intra- and postoperative RBC transfusion on postoperative morbidity and mortality in cranial surgery. A total of 8924 adult patients who underwent cranial surgery were identified in the 2006-2011 American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database. Patients undergoing a biopsy, radiosurgery, or outpatient surgery were excluded. Propensity scores were calculated according to demographic variables, comorbidities, and preoperative laboratory values...
February 3, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28140497/invasive-rodents-have-multiple-indirect-effects-on-seabird-island-invertebrate-food-web-structure
#10
Joshua Thoresen, David Towns, Sebastian Leuzinger, Mel Durrett, Christa P H Mulder, David A Wardle
Burrowing seabirds that nest on islands transfer nutrients from the sea, disturb the soil through burrowing, damage tree foliage when landing, and thereby modify the surface litter. However, seabirds are in decline worldwide, as are their community- and ecosystem-level impacts, primarily due to invasive predatory mammals. The direct and indirect effects of seabird decline on communities and ecosystems are inherently complex. Here we employed network analysis, as a means of simplifying ecological complexity, to better understand the effects seabird loss may have on island invertebrate communities...
January 31, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28138889/denitrification-potential-of-riparian-soils-in-relation-to-multiscale-spatial-environmental-factors-a-case-study-of-a-typical-watershed-china
#11
Jianbing Wei, Hao Feng, Quanguo Cheng, Shiqian Gao, Haiyan Liu
The objective of this study was to test the hypothesis that environmental regulators of riparian zone soil denitrification potential differ according to spatial scale within a watershed; consequently, a second objective was to provide spatial strategies for conserving and restoring the purification function of runoff in riparian ecosystems. The results show that soil denitrification in riparian zones was more heterogeneous at the profile scale than at the cross-section and landscape scales. At the profile scale, biogeochemical factors (including soil total organic carbon, total nitrogen, and nitrate-nitrogen) were the major direct regulators of the spatial distribution of soil denitrification enzyme activity (DEA)...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28138031/anti-kit-monoclonal-antibody-treatment-enhances-the-anti-tumor-activity-of-immune-checkpoint-inhibitors-by-reversing-tumor-induced-immunosuppression
#12
Andrew J Garton, Scott Seibel, Lori Lopresti-Morrow, Linda Crew, Neal Janson, Sreekala Mandiyan, E Sergio Trombetta, Shannon Pankratz, Theresa M LaVallee, Richard Gedrich
The receptor tyrosine kinase KIT is an established oncogenic driver of tumor growth in certain tumor types including gastrointestinal stromal tumors (GIST), in which constitutively active mutant forms of KIT represent an actionable target for small molecule tyrosine kinase inhibitors. There is also considerable potential for KIT to influence tumor growth indirectly based on its expression and function in cell types of the innate immune system, most notably mast cells. We have evaluated syngeneic mouse tumor models for anti-tumor effects of an inhibitory KIT monoclonal antibody (mAb), dosed either alone or in combination with immune checkpoint inhibitors...
January 30, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28132874/glycation-inhibitors-extend-yeast-chronological-lifespan-by-reducing-advanced-glycation-end-products-and-by-back-regulation-of-proteins-involved-in-mitochondrial-respiration
#13
Rubina S Kazi, Reema M Banarjee, Arati B Deshmukh, Gouri V Patil, Mashanipalya G Jagadeeshaprasad, Mahesh J Kulkarni
: Advanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose)...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28126243/the-effect-of-curing-conditions-on-the-dentin-bond-strength-of-two-dual-cure-resin-cements
#14
Atsuko Tagami, Rena Takahashi, Toru Nikaido, Junji Tagami
PURPOSE: The purpose of this study was to determine the effect of the curing condition (i.e., the curing mode and restoration thickness) on the tensile bond strength of a dual-cure resin cement applied to dentin. METHODS: Indirect composite resin disks (1, 2, and 3mm in thickness) were prepared. The irradiance of a halogen light curing unit through each disk was measured by a curing radiometer. A measurement was also taken for the condition with no disk. Following this, two dual-cure resin cements, Panavia F2...
January 23, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28123635/bmsc-paracrine-activity-attenuates-interleukin-1%C3%AE-induced-inflammation-and-apoptosis-in-rat-af-cells-via-inhibiting-relative-nf-%C3%AE%C2%BAb-signaling-and-the-mitochondrial-pathway
#15
Jinquan Hu, Qiang Yan, Changgui Shi, Ye Tian, Peng Cao, Wen Yuan
We previously showed that bone mesenchymal stem cells (BMSCs) inhibit interleukin-1 beta (IL-1β) induced degenerative effects in NP cells by their paracrine activity, but the anti-inflammatory and anti-apoptotic effect of BMSC paracrine activity and the relative signaling pathway were not further investigated in annulus fibrosus (AF) cells. In this study, AF cells were exposed to IL-1β, which was applied to mimic intervertebral disc degeneration (IDD) in vitro. Indirect co-culture with BMSCs in a transwell co-culture system reduced the activity of nuclear factor-κB-p65 (NF-κB-p65) through the restoration of its inhibitor IκBa...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28115548/the-fatty-acid-regulator-fadr-influences-the-expression-of-the-virulence-cascade-in-the-el-tor-biotype-of-vibrio-cholerae-by-modulating-the-levels-of-toxt-via-two-different-mechanisms
#16
Gabriela Kovacikova, Wei Lin, Ronald K Taylor, Karen Skorupski
: FadR is a master regulator of fatty acid (FA) metabolism that coordinates the pathways of FA degradation and biosynthesis in enteric bacteria. We show here that a ΔfadR mutation in the El Tor biotype of Vibrio cholerae prevents the expression of the virulence cascade by influencing both the transcription and post-translational regulation of the master virulence regulator ToxT. FadR is a transcriptional regulator that represses the expression of genes involved in FA degradation, activates the expression of genes involved in unsaturated FA (UFA) biosynthesis and also activates the expression of two operons involved in saturated FA (SFA) biosynthesis...
January 23, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28101525/untangling-basal-ganglia-network-dynamics-and-function-role-of-dopamine-depletion-and-inhibition-investigated-in-a-spiking-network-model
#17
Mikael Lindahl, Jeanette Hellgren Kotaleski
The basal ganglia are a crucial brain system for behavioral selection, and their function is disturbed in Parkinson's disease (PD), where neurons exhibit inappropriate synchronization and oscillations. We present a spiking neural model of basal ganglia including plausible details on synaptic dynamics, connectivity patterns, neuron behavior, and dopamine effects. Recordings of neuronal activity in the subthalamic nucleus and Type A (TA; arkypallidal) and Type I (TI; prototypical) neurons in globus pallidus externa were used to validate the model...
November 2016: ENeuro
https://www.readbyqxmd.com/read/28092679/genome-wide-analysis-of-p53-regulated-transcription-in-myc-driven-lymphomas
#18
C Tonelli, M J Morelli, A Sabò, A Verrecchia, L Rotta, T Capra, S Bianchi, S Campaner, B Amati
The tumour suppressor p53 is a transcription factor that controls cellular stress responses. Here, we dissected the transcriptional programmes triggered upon restoration of p53 in Myc-driven lymphomas, based on the integrated analysis of p53 genomic occupancy and gene regulation. p53 binding sites were identified at promoters and enhancers, both characterized by the pre-existence of active chromatin marks. Only a small fraction of these sites showed the 20 base-pair p53 consensus motif, suggesting that p53 recruitment to genomic DNA was primarily mediated through protein-protein interactions in a chromatin context...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28089332/lithium-silicate-endocrown-fabricated-with-a-cad-cam-system-a-functional-and-esthetic-protocol
#19
Leonardo Fernandes da Cunha, Carla Castiglia Gonzaga, Janes Francio Pissaia, Gisele Maria Correr
An endocrown restoration is an alternative approach to complete crowns with intraradicular cores or dowels for the restoration of endodontically treated teeth. Endocrowns conserve tooth structure and require fewer dental visits. This approach has been widely used, and various materials and techniques have been reported. Computer-aided design and computer-aided manufacturing (CAD-CAM) systems can generate and store libraries of teeth with various anatomies in their database, and diagnostic tooth waxing may not be required...
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28078716/incorporating-food-web-dynamics-into-ecological-restoration-a-modeling-approach-for-river-ecosystems
#20
J Ryan Bellmore, Joseph R Benjamin, Michael Newsom, Jennifer A Bountry, Daniel Dombroski
Restoration is frequently aimed at the recovery of target species, but also influences the larger food web in which these species participate. Effects of restoration on this broader network of organisms can influence target species both directly and indirectly via changes in energy flow through food webs. To help incorporate these complexities into river restoration planning we constructed a model that links river food web dynamics to in-stream physical habitat and riparian vegetation conditions. We present an application of the model to the Methow River, Washington (USA), a location of on-going restoration aimed at recovering salmon...
January 12, 2017: Ecological Applications: a Publication of the Ecological Society of America
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