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Indirect restorations

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https://www.readbyqxmd.com/read/27932519/host-plants-indirectly-influence-plant-virus-transmission-by-altering-gut-cysteine-protease-activity-of-aphid-vectors
#1
Patricia V Pinheiro, Murad Ghanim, Mariko M Matsuda Alexander, Ana Rita Rebelo, Rogerio S Santos, Benjamin C Orsburn, Stewart Gray, Michelle Cilia
The green peach aphid, Myzus persicae, is a vector of the Potato leafroll virus (PLRV, Luteoviridae), transmitted exclusively by aphids in a circulative manner. PLRV transmission efficiency was significantly reduced when a clonal lineage of M. persicae was reared on turnip as compared to the weed physalis, a transient effect caused by a host-switch response. A trend of higher PLRV titer in physalis-reared aphids as compared to turnip-reared aphids was observed at 24h and 72h after virus acquisition. The major difference in the proteomes of these aphids was the upregulation of predicted lysosomal enzymes, in particular the cysteine protease cathepsin B (cathB), in aphids reared on turnip...
December 8, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27916652/exploring-pericyte-and-cardiac-stem-cell-secretome-unveils-new-tactics-for-drug-discovery
#2
REVIEW
Georgina M Ellison-Hughes, Paolo Madeddu
Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair...
December 1, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27916455/phosphodiesterase-10a-inhibition-improves-cortico-basal-ganglia-function-in-huntington-s-disease-models
#3
Vahri Beaumont, Sheng Zhong, Hai Lin, WenJin Xu, Amyaouch Bradaia, Esther Steidl, Melanie Gleyzes, Kristian Wadel, Bruno Buisson, Fernando E Padovan-Neto, Shreaya Chakroborty, Karen M Ward, John F Harms, Jose Beltran, Mei Kwan, Afshin Ghavami, Jenny Häggkvist, Miklós Tóth, Christer Halldin, Andrea Varrone, Christoph Schaab, J Nikolaj Dybowski, Sarah Elschenbroich, Kimmo Lehtimäki, Taneli Heikkinen, Larry Park, James Rosinski, Ladislav Mrzljak, Daniel Lavery, Anthony R West, Christopher J Schmidt, Margaret M Zaleska, Ignacio Munoz-Sanjuan
Huntington's disease (HD) symptoms are driven to a large extent by dysfunction of the basal ganglia circuitry. HD patients exhibit reduced striatal phoshodiesterase 10 (PDE10) levels. Using HD mouse models that exhibit reduced PDE10, we demonstrate the benefit of pharmacologic PDE10 inhibition to acutely correct basal ganglia circuitry deficits. PDE10 inhibition restored corticostriatal input and boosted cortically driven indirect pathway activity. Cyclic nucleotide signaling is impaired in HD models, and PDE10 loss may represent a homeostatic adaptation to maintain signaling...
November 25, 2016: Neuron
https://www.readbyqxmd.com/read/27896143/new-avenues-for-reducing-intensive-care-needs-in-patients-with-chronic-spinal-cord-injury
#4
EDITORIAL
Pierre A Guertin
Relatively soon after their accident, patients suffering a spinal cord injury (SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27892837/conservative-anterior-partial-coverage-cad-cam-restoration
#5
J T May
Computer-aided design and manufacturing technology enables practitioners to create, in a single appointment, indirect restorations that are esthetic and functionally unique to the patient's situation. The popular effort to perform minimally invasive dentistry using digital techniques with chairside milling can lead dentists to novel individualized restorative treatment. This article demonstrates a conservative anterior partial coverage restoration, utilizing both digital technology and chairside ceramic characterization to achieve an optimal esthetic outcome while preserving healthy tooth structure...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27890355/the-effects-of-cavity-margin-angles-and-bolus-stiffness-on-the-mechanical-behavior-of-indirect-resin-composite-class-ii-restorations
#6
Pietro Ausiello, Stefano Ciaramella, Franklin Garcia-Godoy, Antonio Gloria, Antonio Lanzotti, Saverio Maietta, Massimo Martorelli
OBJECTIVE: To study the influence of the different class II mesio-occlusal-distal (MOD) cavity shape on the stress and strain distributions in adhesive indirect restorations, using numerical finite element analysis (FEA). To investigate the relationship between restored teeth failure and stiffness of food, three values of Young's modulus were used for the food. METHODS: A 3D model of a sound lower molar and three class II MOD cavities with different shape were created...
November 24, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27888084/are-locked-facets-a-contraindication-for-extreme-lateral-interbody-fusion
#7
Rodrigo Navarro-Ramirez, Gernot Lang, Yu Moriguchi, Eric Elowitz, Jose Alfredo Corredor, Mauricio J Avila, Alberto Gotfryd, Marjan Alimi, Lena Gandevia, Roger Härtl
BACKGROUND: Extreme lateral interbody fusion (ELIF) has gained popularity as a minimally invasive treatment allowing for indirect decompression of neural elements. However, evidence regarding the influence of facet degeneration (FD) and facet tropism (FT) towards indirect decompression is lacking. The aim of the study was to evaluate whether indirect decompression is impaired by FD and FT in patients undergoing ELIF. METHODS: 37 patients undergoing ELIF were included in a retrospective study...
November 22, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27885743/influence-of-polymerisation-method-and-type-of-fibre-on-fracture-strength-of-endodontically-treated-teeth
#8
Neslihan Tekçe, Kansad Pala, Safa Tuncer, Mustafa Demirci, Merve Efe Serim
The aim of this study was to investigate (i) the effect of direct or indirect polymerisation of adhesive-impregnated ribbon fibre under 4-mm bulk-filled composites on fracture strength; (ii) to compare polyethylene ribbon fibre-reinforcement composites with short fibre-reinforced composite; and (iii) the effectiveness of polyethylene ribbon fibre according to the restorative materials used (low-viscous bulk-fill composite, high-viscous flowable composite or conventional paste composite). Seventy molars were divided into seven groups; (groups 1-2) Ribbond-reinforced Surefil-SDR; (group 3) Ribbond-reinforced G Aenial Flo; (group 4) Ribbond-reinforced G Aenial Posterior; (group 5) short fibre-reinforced composite everX Posterior; (group 6) unfilled cavity; (group 7) intact teeth...
November 25, 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/27881324/bacterial-adhesion-on-direct-and-indirect-dental-restorative-composite-resins-an-in%C3%A2-vitro-study-on-a-natural-biofilm
#9
Giacomo Derchi, Michele Vano, Antonio Barone, Ugo Covani, Alberto Diaspro, Marco Salerno
STATEMENT OF PROBLEM: Both direct and indirect techniques are used for dental restorations. Which technique should be preferred or whether they are equivalent with respect to bacterial adhesion is unclear. PURPOSE: The purpose of this in vitro study was to determine the affinity of bacterial biofilm to dental restorative composite resins placed directly and indirectly. MATERIAL AND METHODS: Five direct composite resins for restorations (Venus Diamond, Adonis, Optifil, Enamel Plus HRi, Clearfil Majesty Esthetic) and 3 indirect composite resins (Gradia, Estenia, Signum) were selected...
October 27, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27875055/intraoral-repair-of-a-glass-ceramic-restoration-with-nanohybrid-ormocers-a-case-report
#10
Juergen Manhart, Iris Frasheri
The interest in repairing failed restorations has been growing; such a procedure may prolong the life span of defective direct and indirect dental restorations. The intraoral repair using resin-based composite materials has major benefits, as it preserves the main body of the restoration, avoids unnecessary removal of sound tooth structure, is an easy and fast treatment, avoids additional appointments, and is inexpensive. This case report demonstrates the use of nanohybrid Ormocer®, or organically modified ceramic, materials...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27859563/direct-estimation-of-tracer-kinetic-parameter-maps-from-highly-undersampled-brain-dynamic-contrast-enhanced-mri
#11
Yi Guo, Sajan Goud Lingala, Yinghua Zhu, R Marc Lebel, Krishna S Nayak
PURPOSE: The purpose of this work was to develop and evaluate a T1 -weighted dynamic contrast enhanced (DCE) MRI methodology where tracer-kinetic (TK) parameter maps are directly estimated from undersampled (k,t)-space data. THEORY AND METHODS: The proposed reconstruction involves solving a nonlinear least squares optimization problem that includes explicit use of a full forward model to convert parameter maps to (k,t)-space, utilizing the Patlak TK model. The proposed scheme is compared against an indirect method that creates intermediate images by parallel imaging and compressed sensing before to TK modeling...
November 17, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27854220/-get-the-balance-right-pathological-significance-of-autophagy-perturbation-in-neuromuscular-disorders
#12
Perrine Castets, Stephan Frank, Michael Sinnreich, Markus A Rüegg
Recent research has revealed that autophagy, a major catabolic process in cells, is dysregulated in several neuromuscular diseases and contributes to the muscle wasting caused by non-muscle disorders (e.g. cancer cachexia) or during aging (i.e. sarcopenia). From there, the idea arose to interfere with autophagy or manipulate its regulatory signalling to help restore muscle homeostasis and attenuate disease progression. The major difficulty for the development of therapeutic strategies is to restore a balanced autophagic flux, due to the dynamic nature of autophagy...
May 27, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27837575/dreams-in-ancient-greek-medicine
#13
K Laios, M M Moschos, E Koukaki, E Vasilopoulos, M Karamanou, M-I Kontaxaki, G Androutsos
Dreams preoccupied the Greek and Roman world in antiquity, therefore they had a prominent role in social, philosophical, religious, historical and political life of those times. They were considered as omens and prophetic signs of future events in private and public life, and that was particularly accentuated when elements of actions which took place in the plot of dreams were associated directly or indirectly with real events. This is why it was important to use them in divination, and helped the growth of superstition and folklore believes...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27830175/a-total-economic-valuation-of-wetland-ecosystem-services-an-evidence-from-jagadishpur-ramsar-site-nepal
#14
Sony Baral, Bijendra Basnyat, Rajendra Khanal, Kalyan Gauli
Wetlands are the most productive ecosystem and provide wide arrays of wetland ecosystems (goods and services) to the local communities in particular and global communities in general. However, management of the wetland often does not remain priority and recognized as the unproductive waste land mainly due to poor realization of the economic value of the wetlands. Taking this into account, the study estimated the total economic value of the Jagadishpur Reservoir taking into account direct, indirect, and nonuse value...
2016: TheScientificWorldJournal
https://www.readbyqxmd.com/read/27830145/in-vitro-comparative-analysis-of-fracture-resistance-in-inlay-restoration-prepared-with-cad-cam-and-different-systems-in-the-primary-teeth
#15
Huseyin Simsek, Sera Derelioglu
Objective. The aim of this study was to compare to fracture resistance test of inlay restorations prepared using direct inlay technique (Gradia® Direct Composite) and Indirect Restoration System® (Gradia Indirect Composite) and CAD/CAD system (Vita Enamic® Block). Study Design. 48 noncarious extracted maxillary second primary molars were randomly divided into 4 groups with 12 in each group. All the teeth were prepared based on inlay class II preparations except for the control group. Other groups were restored with Gradia Direct Composite, Gradia Indirect Composite, and Vita Enamic Block, respectively...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27826624/mesenchymal-stem-cells-derived-from-normal-gingival-tissue-inhibit-the-proliferation-of-oral-cancer-cells-in-vitro-and-in-vivo
#16
Xiaoli Ji, Zhihui Zhang, Ying Han, Jiangyuan Song, Xiangliang Xu, Jianqiu Jin, Sha Su, Dongdong Mu, Xiaodan Liu, Si Xu, Hongwei Cui, Zhongfang Zhao, Yixiang Wang, Hongwei Liu
The interplay between tumor cells and mesenchymal stem cells (MSCs) within tumor microenvironment plays a significant role in tumor development, and thus might be exploited for therapeutic intervention. In this study, we isolated MSCs from normal gingival tissue (GMSCs), and detected the effect of GMSCs on oral cancer cells via direct co-culture and indirect co-culture systems. The cell proliferation assay of direct co-culture showed that GMSCs could inhibit the growth of oral cancer cells. Conditioned medium derived from GMSCs (GMSCs-CM) also exerted an anticancer effect, which indicates that soluble factors in GMSCs-CM played a dominant role in GMSCs-induced cancer cell growth inhibition...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27823707/body-weight-and-basal-metabolic-rate-in-childhood-narcolepsy-a-longitudinal-study
#17
Zongwen Wang, Huijuan Wu, William S Stone, Jianhua Zhuang, Linli Qiu, Xing Xu, Yan Wang, Zhengqing Zhao, Fang Han, Zhongxin Zhao
OBJECTIVES: The aims of this study were to document the trajectory of weight gain and body mass index (BMI) in children with type 1 narcolepsy, and to analyze basal metabolic rate (BMR). METHODS: A total of 65 Chinese children with type 1 narcolepsy with a disease duration ≤12 months were included. In addition, 79 healthy age-matched students were enrolled as controls. Height and body weight were measured every six months for up to 36 months to calculate BMI growth...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27822572/indirect-zirconia-reinforced-lithium-silicate-ceramic-cad-cam-restorations-preliminary-clinical-results-after-12-months
#18
Moritz Zimmermann, Christina Koller, Albert Mehl, Reinhard Hickel
OBJECTIVE: No clinical data are available for the new computer-aided design/computer-assisted manufacture (CAD/CAM) material zirconia-reinforced lithium silicate (ZLS) ceramic. This study describes preliminary clinical results for indirect ZLS CAD/CAM restorations after 12 months. METHOD AND MATERIALS: Indirect restorations were fabricated, using the CEREC method and intraoral scanning (CEREC Omnicam, CEREC MCXL). Sixty-seven restorations were seated adhesively (baseline)...
November 7, 2016: Quintessence International
https://www.readbyqxmd.com/read/27812614/reliability-failure-probability-and-strength-of-resin-based-materials-for-cad-cam-restorations
#19
Kiatlin Lim, Adrian U-Jin Yap, Shruti Vidhawan Agarwalla, Keson Beng-Choon Tan, Vinicius Rosa
Objective: This study investigated the Weibull parameters and 5% fracture probability of direct, indirect composites, and CAD/CAM composites. Material and Methods: Discshaped (12 mm diameter x 1 mm thick) specimens were prepared for a direct composite [Z100 (ZO), 3M-ESPE], an indirect laboratory composite [Ceramage (CM), Shofu], and two CAD/CAM composites [Lava Ultimate (LU), 3M ESPE; Vita Enamic (VE), Vita Zahnfabrik] restorations (n=30 for each group). The specimens were polished, stored in distilled water for 24 hours at 37°C...
September 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/27811376/p-glycoprotein-mediated-chemoresistance-is-reversed-by-carbonic-anhydrase-xii-inhibitors
#20
Joanna Kopecka, Gregory M Rankin, Iris C Salaroglio, Sally-Ann Poulsen, Chiara Riganti
Carbonic anhydrase XII (CAXII) is a membrane enzyme that maintains pH homeostasis and sustains optimum P-glycoprotein (Pgp) efflux activity in cancer cells. Here, we investigated a panel of eight CAXII inhibitors (compounds 1-8), for their potential to reverse Pgp mediated tumor cell chemoresistance. Inhibitors (5 nM) were screened in human and murine cancer cells (colon, lung, breast, bone) with different expression levels of CAXII and Pgp. We identified three CAXII inhibitors (compounds 1, 2 and 4) that significantly (≥ 2 fold) increased the intracellular retention of the Pgp-substrate and chemotherapeutic doxorubicin, and restored its cytotoxic activity...
November 3, 2016: Oncotarget
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