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Indirect restorations

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https://www.readbyqxmd.com/read/28799512/modulation-of-gabaa-receptors-in-the-treatment-of-epilepsy
#1
Eleonora Palma, Gabriele Ruffolo, Pierangelo Cifelli, Cristina Roseti, Erwin A van Vliet, Eleonora Aronica
BACKGROUND: A variety of evidence suggested that an imbalance in excitatory and inhibitory neurotransmission could be one of the pathophysiological mechanisms underlying the occurrence and progression of seizures. Understanding the causes of this imbalance may provide essential insight into the basic mechanisms of epilepsy and may uncover novel targets for future drug therapies. Accordingly, GABA is the most important inhibitory neurotransmitter in the CNS and its receptors (e.g., GABAARs) can still be relevant targets of new antiepileptic drugs (AEDs)...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28790019/neuronal-firing-activity-in-the-basal-ganglia-after-striatal-transplantation-of-dopamine-neurons-in-hemiparkinsonian-rats
#2
Regina Rumpel, Mesbah Alam, Lisa M Schwarz, Andreas Ratzka, Xingxing Jin, Joachim K Krauss, Claudia Grothe, Kerstin Schwabe
The loss of nigral dopaminergic neurons and the resulting dopamine (DA) depletion in the striatum (STR) lead to altered neuronal activity and enhanced beta activity in various regions of the basal ganglia (BG) motor loop in patients with Parkinson's disease and in rodents in the 6-hydroxydopamine (6-OHDA)-lesioned rat model. Intrastriatal DA graft implantation has been shown to re-innervate the host brain and restore DA input. Here, DA cell grafts were implanted into the STR of 6-OHDA-lesioned rats and the effect on neuronal activity under urethane anesthesia (1...
August 5, 2017: Neuroscience
https://www.readbyqxmd.com/read/28781073/accuracy-of-stereolithography-additive-casts-used-in-a-digital-workflow
#3
Hiba Al-Imam, Mia Gram, Ana R Benetti, Klaus Gotfredsen
STATEMENT OF PROBLEM: Despite the increasing demand for a digital workflow in the fabrication of indirect restorations, information on the accuracy of the resulting definitive casts is limited. PURPOSE: The purpose of this in vitro study was to compare the accuracy of definitive casts produced with digital scans and conventional impressions. MATERIAL AND METHODS: Chamfer preparations were made on the maxillary right canine and second molar of a typodont...
August 4, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28777394/in-vitro-evaluation-of-onlay-restorations-on-primary-teeth
#4
Kadriye G U Güzel, Ayşe C Altun, Zuhal Kırzıoğlu
PURPOSE: Many novel materials have been developed such as composite resin, ceramic, zircon or metal-supported ceramic for use in aesthetic restoration of primary teeth and permanent teeth with extensive crown damage. The aim of the present study was to compare microtensile bond strengths on materials using the microtensile bond strength test. MATERIALS AND METHODS: The microtensile bond strength on the primary tooth dentin was measured on extracted primary teeth using an indirect method and fracture patterns were evaluated...
August 2, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28775252/conflict-between-conservation-and-development-cash-forest-encroachment-in-asian-elephant-distributions
#5
Peng Liu, Hui Wen, Franziska K Harich, Changhuan He, Lanxin Wang, Xianming Guo, Jianwei Zhao, Aidong Luo, Hongpei Yang, Xiao Sun, Yang Yu, Shaobo Zheng, Jing Guo, Li Li, Li Zhang
Over the last 4 decades, China has undergone major economic development, resulting in considerable impacts on its wildlife populations and habitats. It is essential to quantify the conflict between development and conservation to assist with policy-making because forestry policies and market trends affected indirectly the distribution of Asian elephants. Here, we mapped the historical distribution of elephants versus human land use. Elephant distributions appear to occur in unbroken natural forests only. However, over the 40-year period, the distribution ranges have become smaller and fragmented, with natural forest area also declining by 16%...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765222/role-of-fatty-acid-kinase-in-cellular-lipid-homeostasis-and-saers-dependent-virulence-factor-expression-in-staphylococcus-aureus
#6
Megan E Ericson, Chitra Subramanian, Matthew W Frank, Charles O Rock
The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown. Fatty acid (FA) kinase is a two-component enzyme system required for extracellular FA uptake and SaeRS activity. Here, we demonstrate the existence of an intracellular nonesterified FA pool in S. aureus that is elevated in strains lacking FA kinase activity. SaeRS-mediated transcription is restored in FA kinase-negative strains when the intracellular FA pool is reduced either by growth with FA-depleted bovine serum albumin to extract the FA into the medium or by the heterologous expression of Neisseria gonorrhoeae acyl-acyl carrier protein synthetase to activate FA for phospholipid synthesis...
August 1, 2017: MBio
https://www.readbyqxmd.com/read/28754911/chondroitin-sulfate-disaccharides-modified-the-structure-and-function-of-the-murine-gut-microbiome-under-healthy-and-stressed-conditions
#7
Fang Liu, Na Zhang, Zhaojie Li, Xiong Wang, Hongjie Shi, Changhu Xue, Robert W Li, Qingjuan Tang
Chondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disaccharides supplementation for 16 days significantly reduced blood LPS in the mice experiencing exhaustive exercise stress. CS disaccharides partially restored total fecal short-chain fatty acids from the level significantly repressed in mice under the stress...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28752912/functional-analysis-of-the-cyclophilin-ppib-role-in-bacterial-cell-division
#8
Aggeliki Skagia, Chrysoula Zografou, Anastasia Venieraki, Costas Fasseas, Panagiotis Katinakis, Maria Dimou
Escherichia coli PpiB is a peptidyl-prolyl cis/trans isomerase (PPIase, EC: 5.2.1.8) with chaperone activity. Here, we show that the ΔppiB deletion strain and the PpiB over-expression wild-type strain are both characterized by defects in cell division involving milder or severe cell filamentation, respectively. Using various PpiB mutants, we show that the PPIase activity of PpiB is necessary for the observed cell filamentation, whereas other structural features apart from the active site are also important for this phenotype...
July 28, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28750105/additive-manufacturing-techniques-in-prosthodontics-where-do-we-currently-stand-a-critical-review
#9
Nawal Alharbi, Daniel Wismeijer, Reham B Osman
PURPOSE: The aim of this article was to critically review the current application of additive manufacturing (AM)/3D-printing techniques in prosthodontics and to highlight the influence of various technical factors involved in different AM technologies. MATERIALS AND METHODS: A standard approach of searching MEDLINE, EMBASE, and Google Scholar databases was followed. The following search terms were used: (Prosth* OR Restoration) AND (Prototype OR Additive Manufacture* OR Compute* OR 3D-print* OR CAD/CAM) AND (Dentistry OR Dental)...
July 27, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28748270/color-difference-of-composite-resins-after-cementation-with-different-shades-of-resin-luting-cement
#10
Esra Cengiz, Sevcan Kurtulmus-Yilmaz, Izgen Karakaya, Huseyin Aktore
The purpose of this study was to evaluate the color difference of nanohybrid and ormocer-based composite resins with different thicknesses when 4 different shades of resin luting cement were used. 56 disc specimens of each composite resin (Aelite aesthetic enamel, Ceram-X mono) with 0.5 and 1 mm thicknesses were fabricated. Baseline color measurements were performed using a clinical spectrophotometer. The specimens of each thicknesses of each resin were randomly divided into 4 groups according to the shades of resin luting cement (white/A1, yellow/universal/A3, transparent and white opaque) (n = 7)...
July 26, 2017: Odontology
https://www.readbyqxmd.com/read/28743131/the-spatial-extent-of-epiretinal-electrical-stimulation-in-the-healthy-mouse-retina
#11
Zohreh Hosseinazdeh, Archana Jalligampala, Eberhart Zrenner, Daniel Lleweylln Rathbun
BACKGROUND/AIMS: Retinal prostheses use electrical stimulation to restore functional vision to patients blinded by retinitis pigmentosa. A key detail is the spatial pattern of ganglion cells activated by stimulation. Therefore, we characterized the spatial extent of network-mediated electrical activation of retinal ganglion cells (RGCs) in the epiretinal monopolar electrode configuration. METHODS: Healthy mouse RGC activities were recorded with a micro-electrode array (MEA)...
July 26, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/28736604/comparison-between-three-glass-fiber-post-cementation-techniques
#12
Guido Migliau, Luca Piccoli, Stefano Di Carlo, Giorgio Pompa, Laith Konstantinos Besharat, Marco Dolci
OBJECTIVE: The aim of this experimental study was to compare the traditional cement systems with those of the latest generation, to assess if indeed these could represent of viable substitutes in the cementation of indirect restorations, and in the specific case of endodontic posts. METHODS: The assessment of the validity of the cementing methods was performed according to the test of the push-out, conducted on sections obtained from the roots of treated teeth. The samples were divided into three groups...
January 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/28731178/microrna-379-acts-as-a-tumor-suppressor-in-non-small-cell-lung-cancer-by-targeting-the-igf%C3%A2-1r-mediated-akt-and-erk-pathways
#13
Fangzheng Zhou, Long Nie, Dali Feng, Siyan Guo, Ren'na Luo
Lung cancer is one of the most common types of malignancy in humans and is a leading cause of cancer-related deaths among men and women worldwide. Aberrantly expressed microRNAs in non-small cell lung cancer (NSCLC) contribute to tumor occurrence and development as either tumor suppressors or promoters. MicroRNA-379 (miR‑379) is dysregulated in several types of human cancer. However, its expression pattern, role and underlying mechanism in NSCLC progression and metastasis are poorly understood. In this study, assay of reverse transcription-quantitative polymerase chain reaction showed that miR‑379 was downregulated in both NSCLC tissue and cell lines...
September 2017: Oncology Reports
https://www.readbyqxmd.com/read/28729383/definitions-and-end-points-for-interventional-studies-for-arteriovenous-dialysis-access
#14
Gerald A Beathard, Charmaine E Lok, Marc H Glickman, Ahmed A Al-Jaishi, Donna Bednarski, David L Cull, Jeffery H Lawson, Timmy C Lee, Vandana D Niyyar, Donna Syracuse, Scott O Trerotola, Prabir Roy-Chaudhury, Surendra Shenoy, Margo Underwood, Haimanot Wasse, Karen Woo, Theodore H Yuo, Thomas S Huber
This paper is part of the Clinical Trial Endpoints for Dialysis Vascular Access Project of the American Society of Nephrology Kidney Health Initiative. The purpose of this project is to promote research in vascular access by clarifying trial end points which would be best suited to inform decisions in those situations in which supportive clinical data are required. The focus of a portion of the project is directed toward arteriovenous access. There is a potential for interventional studies to be directed toward any of the events that may be associated with an arteriovenous access' evolution throughout its life cycle, which has been divided into five distinct phases...
July 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28729119/effect-of-restorations-using-a-flowable-resin-composite-in-non-carious-cervical-lesions-a-systematic-review-and-meta-analysis
#15
REVIEW
Anna Szesz, Sibelli Parreiras, Eveline Martini, Alessandra Reis, Alessandro Loguercio
OBJECTIVES: To answer the following PICO question (participant, intervention, comparator and outcome): Does flowable resin composite restorations compared with regular resin composites improve the marginal adaptation, marginal discoloration and retention rates of restorations placed in non-carious cervical lesions [NCCLs] of adults?, through a systematic review and meta-analysis. SOURCE: MEDLINE, Scopus, Web of Science, LILACS, BBO, Cochrane Library and SIGLE were searched without restrictions, as well as the abstracts of the IADR, clinical trials registries, dissertations and theses in May 2016 (updated in April 2017)...
July 17, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28725366/vegetation-structure-and-photosynthesis-respond-rapidly-to-restoration-in-young-coastal-fens
#16
Anna M Laine, Anne Tolvanen, Lauri Mehtätalo, Eeva-Stiina Tuittila
Young coastal fens are rare ecosystems in the first stages of peatland succession. Their drainage compromises their successional development toward future carbon (C) reservoirs. We present the first study on the success of hydrological restoration of young fens. We carried out vegetation surveys at six young fens that represent undrained, drained, and restored management categories in the Finnish land uplift coast before and after restoration. We measured plant level carbon dioxide (CO2) assimilation and chlorophyll fluorescence (Fv/Fm) from 17 most common plant species present at the sites...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28721994/evaluation-of-marginal-and-internal-gaps-of-metal-ceramic-crowns-obtained-from-conventional-impressions-and-casting-techniques-with-those-obtained-from-digital-techniques
#17
Rathika Rai, S Arun Kumar, R Prabhu, Ranjani Thillai Govindan, Faiz Mohamed Tanveer
BACKGROUND: Accuracy in fit of cast metal restoration has always remained as one of the primary factors in determining the success of the restoration. A well-fitting restoration needs to be accurate both along its margin and with regard to its internal surface. AIM: The aim of the study is to evaluate the marginal fit of metal ceramic crowns obtained by conventional inlay casting wax pattern using conventional impression with the metal ceramic crowns obtained by computer-aided design and computer-aided manufacturing (CAD/CAM) technique using direct and indirect optical scanning...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28708240/comparative-analysis-of-general-dental-practitioners-fees-and-scheduled-fees-for-root-canal-treatment-and-coronal-restorations-in-the-adult-population-of-sweden-a-five-year-follow-up-of-data-from-the-swedish-dental-register
#18
E Wigsten, T Kvist, V S Dawson, P-E Isberg, H Fransson
AIM: To investigate the fees charged by Swedish dentists for root fillings, coronal restorations and further dental interventions during a follow-up period of 5-6 years. METHODOLOGY: A total of 248,299 root fillings were linked with the tooth, the patient and the provider and entered into the Swedish Social Insurance Agency register in 2009. The data register also recorded the subsidy-based (scheduled) fee and the fee actually charged for the root fillings. Fees charged for direct or indirect coronal restorations and additional interventions during the follow-up period were also recorded...
July 14, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28701516/blocking-tgf-%C3%AE-and-%C3%AE-catenin-epithelial-crosstalk-exacerbates-ckd
#19
Stellor Nlandu-Khodo, Surekha Neelisetty, Melanie Phillips, Marika Manolopoulou, Gautam Bhave, Lauren May, Peter E Clark, Haichun Yang, Agnes B Fogo, Raymond C Harris, M Mark Taketo, Ethan Lee, Leslie S Gewin
The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many different cellular effects depending on the target cell type. To investigate how TGF-β signaling in the proximal tubule, a key target and mediator of CKD, alters the response to CKD, we injured mice lacking the TGF-β type 2 receptor specifically in this epithelial segment...
July 12, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28697086/use-of-volar-plate-for-indirect-coronal-plane-reduction-in-an-intraarticular-distal-radius-fracture
#20
Rebecca Senehi, Tyani D Luo, Alejandro Marquez-Lara, Arun Aneja, Hoyt R Beard, Eben A Carroll
Management of intraarticular distal radius fractures requires precise reconstruction of the articular surface to optimize outcomes. Treatment goals also include restoration of alignment, rotation, and angulation in both the coronal and sagittal planes of the metaphyseal component of these fractures. Surgical management with open reduction and internal fixation with a volar plate is often the preferred method of open treatment. However, a variety of different techniques have been described, and the preferred technique may be determined on an individual basis by the fracture characteristics, patient-dependent factors, or surgeon experience...
August 2017: Journal of Orthopaedic Trauma
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