Maya V Voronina, Anastasia S Frolova, Ekaterina P Kolesova, Nikita A Kuldyushev, Alessandro Parodi, Andrey A Zamyatnin
Cellular survival hinges on a delicate balance between accumulating damages and repair mechanisms. In this intricate equilibrium, oxidants, currently considered physiological molecules, can compromise vital cellular components, ultimately triggering cell death. On the other hand, cells possess countermeasures, such as autophagy, which degrades and recycles damaged molecules and organelles, restoring homeostasis. Lysosomes and their enzymatic arsenal, including cathepsins, play critical roles in this balance, influencing the cell's fate toward either apoptosis and other mechanisms of regulated cell death or autophagy...
April 6, 2024: International Journal of Molecular Sciences