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Indirect restorations

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https://www.readbyqxmd.com/read/29341474/effect-of-staining-beverages-on-color-and-translucency-of-cad-cam-composites
#1
S H Q Quek, A U J Yap, V Rosa, K B C Tan, K H Teoh
This study investigated the color (ΔE) and translucency changes (ΔTP) of CAD/CAM composites after exposure to staining solutions using both spectrophotometer and shade-matching device. Direct (Filtek Z350XT [ZT]), indirect (Shofu Ceramage [CE]) and CAD/CAM (Shofu HC Block [HC], Lava Ultimate [LU], Vita Enamic [EN]) composite specimens measuring 12 × 14 × 1.5 mm were fabricated, divided into five groups (n = 8), and immersed in cola, tea, coffee, red wine, distilled water (control) at 37°C for 7 days...
January 17, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29339083/mirna15a-regulates-insulin-signal-transduction-in-the-retinal-vasculature
#2
Youde Jiang, Li Liu, Jena J Steinle
We previously reported that tumor necrosis factor alpha (TNFα) could inhibit insulin signal transduction in retinal cells. We recently found that miR15a/16 also reduced TNFα in retinal endothelial cells (REC) and in vascular specific miR15a/16 knockout mice. Since in silico programs suggested that miR15a could directly bind the insulin receptor, we wanted to determine whether miR15a altered insulin signal transduction. We used a luciferase-based binding assay to determine whether miR15a directly bound the insulin receptor...
January 12, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29337054/deficiency-of-primary-cilia-in-kidney-epithelial-cells-induces-epithelial-to-mesenchymal-transition
#3
Sang Jun Han, Jin Ki Jung, Seung-Soon Im, Seong-Ryong Lee, Byeong-Churl Jang, Kwon Moo Park, Jee In Kim
Primary cilium is a microtubule-based non-motile organelle that plays critical roles in kidney pathophysiology. Our previous studies revealed that the lengths of primary cilia decreased upon renal ischemia/reperfusion injury and oxidative stress, and restored with recovery. Here, we tested the hypothesis that lack of primary cilium causes epithelial to mesenchymal transition (EMT) of kidney tubule cells. We investigated the alteration of length of primary cilia in TGF-β-induced EMT via visualization of primary cilia by fluorescence staining against acetylated α-tubulin...
January 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330607/river-continuity-restoration-and-diadromous-fishes-much-more-than-an-ecological-issue
#4
H Drouineau, C Carter, M Rambonilaza, G Beaufaron, G Bouleau, A Gassiat, P Lambert, S le Floch, S Tétard, E de Oliveira
Ecosystem fragmentation is a serious threat to biodiversity and one of the main challenges in ecosystem restoration. River continuity restoration (RCR) has often targeted diadromous fishes, a group of species supporting strong cultural and economic values and especially sensitive to river fragmentation. Yet it has frequently produced mixed results and diadromous fishes remain at very low levels of abundance. Against this background, this paper presents the main challenges for defining, evaluating and achieving effective RCR...
January 12, 2018: Environmental Management
https://www.readbyqxmd.com/read/29325036/evaluation-of-left-atrial-linear-ablation-using-contiguous-and-optimized-radiofrequency-lesions-the-aline-study
#5
Michael Wolf, Milad El Haddad, Joël Fedida, Philippe Taghji, Katarina Van Beeumen, Teresa Strisciuglio, Jan De Pooter, Caroline Lepièce, Yves Vandekerckhove, René Tavernier, Mattias Duytschaever, Sébastien Knecht
Aims: Achieving block across linear lesions is challenging. We prospectively evaluated radiofrequency (RF) linear ablation at the roof and mitral isthmus (MI) using point-by-point contiguous and optimized RF lesions. Methods and results: Forty-one consecutive patients with symptomatic persistent AF underwent stepwise contact force (CF)-guided catheter ablation during ongoing AF. A single linear set of RF lesions was delivered at the roof and posterior MI according to the 'Atrial LINEar' (ALINE) criteria, i...
January 8, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29322934/computational-analysis-reveals-the-coupling-between-bistability-and-the-sign-of-a-feedback-loop-in-a-tgf-%C3%AE-1-activation-model
#6
Huipeng Li, Lakshmi Venkatraman, Balakrishnan Chakrapani Narmada, Jacob K White, Hanry Yu, Lisa Tucker-Kellogg
BACKGROUND: Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an ordinary differential equation (ODE) model was published showing that the net activation of TGF-β1 depends on the balance between two antagonistic sub-pathways. RESULTS: Through modeling the effects of perturbations that affect both sub-pathways, we revealed that bistability is coupled with the signs of feedback loops in the model...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29313809/parp1-facilitates-ep300-recruitment-to-the-promoters-of-the-subset-of-rbl2-dependent-genes
#7
Agnieszka Robaszkiewicz, Ewelina Wiśnik, Zsolt Regdon, Kinga Chmielewska, László Virág
Differentiation of human monocytes is associated with proliferation arrest resulting from activation of the inter alia retinoblastoma protein family of gene repressors, which target gene promoters in an E2F-dependent manner. To investigate RBL2 contribution to defining monocyte phenotype and function, we used primer libraries. We identified genes encoding two surface receptors (CXCR1 and IL17RE) and two TLR signaling mediators (CD86 and NFKB2) that are repressed by the RBL2-E2F4-HDAC1-BRM complex. Surprisingly, PARP1 co-regulated 24 out of the 28 identified genes controlled by RBL2...
December 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29311433/local-viscoelastic-response-of-direct-and-indirect-dental-restorative-composites-measured-by-afm
#8
Laura Grattarola, Giacomo Derchi, Alberto Diaspro, Carla Gambaro, Marco Salerno
We investigated the viscoelastic response of direct and indirect dental restorative composites by the novel technique of AM-FM atomic force microscopy. We selected four composites for direct restorations (Adonis, Optifil, EPH, CME) and three composites for indirect restorations (Gradia, Estenia, Signum). Scanning electron microscopy with micro-analysis was also used to support the results. The mean storage modulus of all composites was in the range of 10.2-15.2 GPa. EPH was the stiffest (p<0.05 vs. all other composites but Adonis and Estenia), while no significant difference was observed between direct and indirect group (p≥0...
December 31, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29300949/summer-flowering-cover-crops-support-wild-bees-in-vineyards
#9
Houston Wilson, Jessica S Wong, Robbin W Thorp, Albie F Miles, Kent M Daane, Miguel A Altieri
Agricultural expansion and intensification negatively affect pollinator populations and has led to reductions in pollination services across multiple cropping systems. As a result, growers and researchers have utilized the restoration of local and landscape habitat diversity to support pollinators, and wild bees in particular. Although a majority of studies to date have focussed on effects in pollinator-dependent crops such as almond, tomato, sunflower, and watermelon, supporting wild bees in self-pollinated crops, such as grapes, can contribute to broader conservation goals as well as provide other indirect benefits to growers...
December 30, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29284099/replacement-of-a-missing-maxillary-central-incisor-using-a-direct-fiber-reinforced-fixed-dental-prosthesis-a-case-report
#10
M F Romero, F J Haddock, W W Brackett
The use of the direct fiber-reinforced fixed dental prosthesis (FDP) restorative technique presented in this article will result in an ideal restoration considering both esthetics and function in a single appointment. Although indirect techniques are available and may be used, they are time-consuming, resulting in higher cost; therefore, a simplified approach combining a prebonded fiber-reinforced mesh with a sculptable micro-hybrid composite will deliver an acceptable esthetic result with proper function.
January 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29284075/atraumatic-restorative-treatment-versus-conventional-restorative-treatment-for-managing-dental-caries
#11
REVIEW
Mojtaba Dorri, Maria José Martinez-Zapata, Tanya Walsh, Valeria Cc Marinho, Aubrey Sheiham Deceased, Carlos Zaror
BACKGROUND: Dental caries is a sugar-dependent disease that damages tooth structure and, due to loss of mineral components, may eventually lead to cavitation. Dental caries is the most prevalent disease worldwide and is considered the most important burden of oral health. Conventional treatment methods (drill and fill) involve the use of rotary burs under local anaesthesia. The need for an electricity supply, expensive handpieces and highly trained dental health personnel may limit access to dental treatment, especially in underdeveloped regions...
December 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29279548/concept-and-clinical-application-of-the-resin-coating-technique-for-indirect-restorations
#12
Toru Nikaido, Junji Tagami, Hirofumi Yatani, Chikahiro Ohkubo, Tomotaro Nihei, Hiroyasu Koizumi, Toshio Maseki, Yuichiro Nishiyama, Tomoyoshi Takigawa, Yuji Tsubota
The resin-coating technique is one of the successful bonding techniques used for the indirect restorations. The dentin surfaces exposed after cavity preparation are coated with a thin film of a coating material or a dentin bonding system combined with a flowable composite resin. Resin coating can minimize pulp irritation and improve the bond strength between a resin cement and tooth structures. The technique can also be applied to endodontically treated teeth, resulting in prevention of coronal leakage of the restorations...
December 27, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29277655/phosphatidylinositol-4-5-bisphosphate-cholesterol-and-fatty-acids-modulate-the-calcium-activated-chloride-channel-tmem16a-ano1
#13
José J De Jesús-Pérez, Silvia Cruz-Rangel, Ángeles E Espino-Saldaña, Ataúlfo Martínez-Torres, Zhiqiang Qu, H Criss Hartzell, Nancy E Corral-Fernandez, Patricia Pérez-Cornejo, Jorge Arreola
The TMEM16A-mediated Ca2+-activated Cl- current drives several important physiological functions. Membrane lipids regulate ion channels and transporters but their influence on members of the TMEM16 family is poorly understood. Here we have studied the regulation of TMEM16A by phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), cholesterol, and fatty acids using patch clamp, biochemistry and fluorescence microscopy. We found that depletion of membrane PI(4,5)P2 causes a decline in TMEM16A current that is independent of cytoskeleton, but is partially prevented by removing intracellular Ca2+...
December 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29251329/bet-bromodomain-inhibitor-jq1-modulates-microrna-expression-in-thyroid-cancer-cells
#14
Catia Mio, Ketty Conzatti, Federica Baldan, Lorenzo Allegri, Marialuisa Sponziello, Francesca Rosignolo, Diego Russo, Sebastiano Filetti, Giuseppe Damante
Anaplastic thyroid carcinoma (ATC) represents the most lethal thyroid cancer sub-type, currently unresponsive to standard treatments. Recently, bromodomain and extra-terminal (BET) proteins have emerged as attractive therapeutic targets in several diseases, including cancer. In different cancer models, the anti-neoplastic activity of BET inhibitors such as JQ1, I-BET762 and I-BET151 have already been established, due to both direct and indirect effects. miRNAs are 20-22 nucleotide transcriptional regulators which play important roles in proliferation, differentiation and apoptosis...
February 2018: Oncology Reports
https://www.readbyqxmd.com/read/29250522/fibromyalgia-syndrome-a-metabolic-approach-grounded-in-biochemistry-for-the-remission-of-symptoms
#15
Silvia Maria Lattanzio
Fibromyalgia syndrome (FMS) is a chronic, complex, and heterogeneous disorder of still poorly understood etiopathophysiology associated with important musculoskeletal widespread pain, fatigue, non-restorative sleep, and mood disturbances. It is estimated to afflict 2-3% of the worldwide population, with clean prevalence among women. The objective of this paper is to propose a novel treatment for symptomatic remission of FMS, grounded in biochemistry and consisting in the withdrawal from the diet of molecules that can indirectly trigger the symptoms...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29216369/the-pentatricopeptide-repeat-protein-mef31-is-required-for-editing-at-site-581-of-the-tatc-transcript-and-indirectly-influences-editing-at-site-586-of-the-same-transcript
#16
Anita Arenas-M, Enrique González-Durán, Isabel Gómez, Matthias Burger, Axel Brennicke, Mizuki Takenaka, Xavier Jordana
Pentatricopeptide repeat (PPR) proteins constitute the largest family of proteins in angiosperms and most members are predicted to play roles in the maturation of organellar RNAs. Here we describe the novel Mitochondrial Editing Factor 31 (MEF31), an E-PPR protein involved in editing at two near sites in the same transcript encoding subunit C of the twin-arginine translocation (tat) pathway. MEF31 is essential for editing at site tatC-581 and application of the recently proposed amino acid code for RNA recognition by PPR proteins supports the view that MEF31 directly targets this site by recognizing its cis sequence...
December 4, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29215493/minimally-invasive-lateral-lumbar-interbody-fusion-for-adult-spinal-deformity-clinical-and-radiological-efficacy-with-minimum-two-years-follow-up
#17
Hyung-Youl Park, Kee-Yong Ha, Young-Hoon Kim, Dong-Gune Chang, Sang-Il Kim, Jae-Won Lee, Joo-Hyun Ahn, Jong-Bin Kim
STUDY DESIGN: A retrospective cohort study OBJECTIVE.: To evaluate the clinical and radiological efficacies of supplementing minimally invasive lateral lumbar interbody fusion (LLIF) with open posterior spinal fusion (PSF) in adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA: Minimally invasive techniques have been increasingly applied for surgery of ASD. Few reports have been published that directly compare LLIF combined with PSF to conventional PSF for ASD...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29209553/antidyskinetic-treatment-with-mtep-affects-multiple-molecular-pathways-in-the-parkinsonian-striatum
#18
Jing-Ya Lin, Zhen-Guo Liu, Cheng-Long Xie, Lu Song, Ai-Juan Yan
Parkinson's disease is characterized by dopaminergic neuron loss and dopamine (DA) depletion in the striatum. Standard treatment is still focused on the restoration of dopamine with exogenous L-Dopa, which however causes L-Dopa-induced dyskinesia (LID). Several studies have shown that antagonism of the metabotropic glutamate receptor 5 alleviates LID, but the underlying mechanisms have remained unclear. We set out to determine where this alleviation may depend on restoring the equilibrium between the two main striatofugal pathways...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29209516/subretinal-fluid-application-to-close-a-refractory-full-thickness-macular-hole
#19
Carsten H Meyer, Robert Borny, Nicole Horchi
Background: To close a refractory full thickness macular hole (FTMH) by adjacent subretinal fluid application to release the elastic retina from the retinal pigment epithelium (RPE). Case presentation: A 83 years old patient presented an old FTMH with a diameter of 1444 μm. After confirming intraoperatively the complete release of the epiretinal membrane around the FTMH, we installed 3 small subretinal blebs around the hole, to release the adjacent retina from the RPE...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29205613/survival-of-extensive-restorations-in-primary-molars-15-year-practice-based-study
#20
Battsetseg Tseveenjav, Jussi Furuholm, Aida Mulic, Håkon Valen, Tuomo Maisala, Seppo Turunen, Sinikka Varsio, Merja Auero, Leo Tjäderhane
BACKGROUND: Caries decline in the western world is accompanied by strong polarization among children; 8% of Finnish 5-year-olds having 76% of untreated caries. This high caries risk group needs preventive and restorative strategies. AIM: To explore survival of extensive restorations in primary molars. DESIGN: This study was based on health records from 2002 to 2016 of children under 18 years. RESULTS: Of severely affected primary molars (n = 1061), 41% were restored with preformed metal crowns (PMCs), 38% with glass-ionomer cement (GIC)/polyacid-modified resin composite (PAMRC)/resin-modified GIC (RMGIC), and 21% with resin composites (RC)...
December 3, 2017: International Journal of Paediatric Dentistry
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