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Indirect restorations

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https://www.readbyqxmd.com/read/28645637/antimicrobial-and-biological-activity-of-leachate-from-light-curable-pulp-capping-materials
#1
Maria Teresa Arias-Moliz, Cher Farrugia, Christie Y K Lung, Pierre Schembri Wismayer, Josette Camilleri
OBJECTIVES: Characterization of a number of pulp capping materials and assessment of the leachate for elemental composition, antimicrobial activity and cell proliferation and expression. METHODOLOGY: Three experimental light curable pulp-capping materials, Theracal and Biodentine were characterized by scanning electron microscopy, energy dispersive spectroscopy and X-ray diffraction. The elemental composition of the leachate formed after 24hours was assessed by inductively coupled plasma (ICP)...
June 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28643165/molecularly-targeted-therapies-for-p53-mutant-cancers
#2
REVIEW
Dekuang Zhao, William M Tahaney, Abhijit Mazumdar, Michelle I Savage, Powel H Brown
The tumor suppressor p53 is lost or mutated in approximately half of human cancers. Mutant p53 not only loses its anti-tumor transcriptional activity, but also often acquires oncogenic functions to promote tumor proliferation, invasion, and drug resistance. Traditional strategies have been taken to directly target p53 mutants through identifying small molecular compounds to deplete mutant p53, or to restore its tumor suppressive function. Accumulating evidence suggest that cancer cells with mutated p53 often exhibit specific functional dependencies on secondary genes or pathways to survive, providing alternative targets to indirectly treat p53-mutant cancers...
June 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28642922/universal-cements-dual-activated-and-chemically-activated
#3
Eliane de Lima, Ricardo Santos, Márcia Durão, Armiliana Nascimento, Rodivan Braz
Objective: The aim of the present study was to assess the bond strength of universal cements cured either dually or chemically only. Methods: Three cements were assessed using different types of application: dual activated (DA) or chemically activated (CA). In total 80 dentin blocks were used, obtained through the enamel wear of the lingual and buccal surfaces of bovine incisors. Standard cone-shaped cavity preparations were created using diamond burs. Subsequently, indirect restoration blocks were designed with Filtek Z350 (3M ESPE) composite resin...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642558/no-differences-in-longevity-of-direct-and-indirect-composite-restorations
#4
Marie A Congiusta
Data sourcesMedline, Cochrane Library, Web of Science, Scopus, Latin American and Caribbean Health Sciences (LILACS), Brazilian Library of Dentistry (BBO), clinicaltrials.gov and SIGLE databases.Study selectionOnly randomised clinical trials were considered that compared direct vs indirect composite restorations, with or without cusp involvement, having a follow-up period of two years or greater.Data extraction and synthesisTwo reviewers selected studies for inclusion, abstracted data and assessed risk of bias...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28638554/effect-of-professional-dental-prophylaxis-on-the-surface-gloss-and-roughness-of-cad-cam-restorative-materials
#5
Toshiko Sugiyama, Atsushi Kameyama, Tomoka Enokuchi, Akiko Haruyama, Aoi Chiba, Setsuko Sugiyama, Makoto Hosaka, Toshiyuki Takahashi
BACKGROUND: This study aimed to evaluate the effect of dental prophylaxis on the surface gloss and roughness of different indirect restorative materials for computer-aided design/computer-aided manufacturing (CAD/CAM): two types of CAD/CAM composite resin blocks (Shofu Block HC and Estelite Block) and two types of CAD/CAM ceramic blocks (IPS Empress CAD and Celtra DUO). MATERIAL AND METHODS: After polishing the CAD/CAM blocks and applying prophylaxis pastes, professional dental prophylaxis was performed using four different experimental protocols (n = 5 each): mechanical cleaning with Merssage Regular for 10 s four times (Group 1); four cycles of mechanical cleaning with Merssage Regular for 10 s and Merssage Fine for 10 s (Group 2); four cycles of mechanical cleaning with Merssage Regular for 10 s and Merssage Fine for 30 s (Group 3); and mechanical cleaning with Merssage Fine for 10 s four times (Group 4)...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28637240/tfeb-activation-restores-migration-ability-to-tsc1-deficient-adult-neural-stem-progenitor-cells
#6
Alessandro Magini, Alice Polchi, Danila Di Meo, Giuseppina Mariucci, Krizia Sagini, Federico De Marco, Tommaso Cassano, Stefano Giovagnoli, Diego Dolcetta, Carla Emiliani
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations in either of two genes, TSC1 or TSC2, resulting in the constitutive activation of the mammalian target of rapamycin complex 1 (mTORC1). mTOR inhibitors are now considered the treatment of choice for TSC disease. A major pathological feature of TSC is the development of subependymal giant cell astrocytomas (SEGAs) in the brain. Nowadays, it is thought that SEGAs could be a consequence of aberrant aggregation and migration of neural stem/progenitor cells (NSPCs)...
June 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28636984/whether-low-dose-metronomic-oral-cyclophosphamide-improves-the-response-to-docetaxel-in-first-line-treatment-of-non-triple-negative-metastatic-breast-cancer
#7
Jian Zhang, Leiping Wang, Zhonghua Wang, Biyun Wang, Jun Cao, Fangfang Lv, Sheng Zhang, Zhimin Shao, Xichun Hu
Oral metronomic chemotherapy may target tumor cells indirectly via antiangiogenic activity, restoration of anticancer immune response, or induction of tumor dormancy. We initiated the single-center, randomized, open-label, phase II study to determine whether the addition of metronomic cyclophosphamide to docetaxel (T) (w/o trastuzumab) improves overall response rate (ORR) as first-line treatment among patients with non-triple-negative metastatic breast cancer (MBC). Eligible patients with previously untreated non-triple-negative MBC were randomly assigned (1:1) to receive 3-weekly cycles of Metro-TC (T 75mg/m2, d1 plus oral cyclophosphamide 50 mg daily) or T alone...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28633768/comparing-different-surgical-techniques-for-addressing-the-posterior-malleolus-in-supination-external-rotation-ankle-fractures-and-the-need-for-syndesmotic-screw-fixation
#8
Mengnai Li, Rachel C Collier, Brian W Hill, Nathaniel Slinkard, Thuan V Ly
Trimalleolar ankle fractures are unstable injuries with possible syndesmotic disruption. Recent data have described inherent morbidity associated with screw fixation of the syndesmosis, including the potential for malreduction, hardware irritation, and post-traumatic arthritis. The posterior malleolus is an important soft tissue attachment for the posterior inferior syndesmosis ligament. We hypothesized that fixation of a sizable posterior malleolar (PM) fracture in supination external rotation type IV (SER IV) ankle fractures would act to stabilize the syndesmosis and minimize or eliminate the need for trans-syndesmotic fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28620335/a-different-way-to-stay-in-touch-with-urban-nature-the-perceived-restorative-qualities-of-botanical-gardens
#9
Giuseppe Carrus, Massimiliano Scopelliti, Angelo Panno, Raffaele Lafortezza, Giuseppe Colangelo, Sabine Pirchio, Francesco Ferrini, Fabio Salbitano, Mariagrazia Agrimi, Luigi Portoghesi, Paolo Semenzato, Giovanni Sanesi
Botanical gardens represent interesting arenas for research in environmental psychology and environment-behavior relations. They can be considered a very particular type of restorative environment and also have a relevant social function for the promotion of a more sustainable lifestyle in current societies. In this paper, we present a study assessing the relationship between the perceived restorativeness, the psychological and physical benefits experienced, and the subjective well-being reported by visitors of botanical gardens in four different cities in Italy (N = 127)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28606868/vitamin-d-endocrinology-of-bone-mineralization
#10
REVIEW
Marjolein van Driel, Johannes P T M van Leeuwen
Bone is a dynamic tissue that is strongly influenced by endocrine factors to restore the balance between bone resorption and bone formation. Bone formation involves the mineralization of the extracellular matrix formed by osteoblasts. In this process the role of vitamin D (1α,25(OH)2D3) is both direct and indirect. The direct effects are enabled via the Vitamin D Receptor (VDR); the outcome is dependent on the presence of other factors as well as origin of the osteoblasts, treatment procedures and species differences...
June 9, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28599365/the-critical-role-of-local-policy-effects-in-arid-watershed-groundwater-resources-sustainability-a-case-study-in-the-minqin-oasis-china
#11
Yuanyuan Hao, Yaowen Xie, Jinhui Ma, Wenpei Zhang
Designed as a watershed groundwater restoration policy (WGRP), the Comprehensive Treatment Program of the Shiyang River Basin (CTSRB) was launched in 2006 to restore the groundwater resources in the Minqin oasis, northwestern China. This study sought to verify the recovery effects of CTSRB implementation from the perspective of groundwater depth. We reconstructed the spatio-temporal distribution of groundwater depth at interannual and pixel scales by using digital groundwater depth models (DGDMs), based on the ordinary kriging interpolation method...
June 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28599055/delivered-adipose-derived-stromal-cells-improve-host-derived-adipose-tissue-formation-in-composite-constructs-in-vivo
#12
Katharina Storck, Reyk Fischer, Maria Buchberger, Bernhard Haller, Sybille Regn
OBJECTIVES/HYPOTHESIS: Adipose tissue engineering aims to provide functional tissue surrogates for the restoration of soft tissue defects and contour deformities in the face. Many studies involve the delivery of cells; however, the impact and the exact role of the implanted cells is not yet fully elucidated. STUDY DESIGN: Animal research. METHODS: In this study, we used a mouse model for the development of volume-stable adipose tissue using polyurethane scaffolds combined with a long-term stable fibrin gel and adipose-derived stromal cells to investigate the influence of cell delivery on tissue development...
June 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28598969/cucurbitacin-e-reduces-obesity-and-related-metabolic-dysfunction-in-mice-by-targeting-jak-stat5-signaling-pathway
#13
Munazza Murtaza, Gulnaz Khan, Meha Fatima Aftab, Shabbir Khan Afridi, Safina Ghaffar, Ayaz Ahmed, Rahman M Hafizur, Rizwana Sanaullah Waraich
Several members of cucurbitaceae family have been reported to regulate growth of cancer by interfering with STAT3 signaling. In the present study, we investigated the unique role and molecular mechanism of cucurbitacins (Cucs) in reducing symptoms of metabolic syndrome in mice. Cucurbitacin E (CuE) was found to reduce adipogenesis in murine adipocytes. CuE treatment diminished hypertrophy of adipocytes, visceral obesity and lipogenesis gene expression in diet induced mice model of metabolic syndrome (MetS)...
2017: PloS One
https://www.readbyqxmd.com/read/28593704/fragmentation-increases-wind-disturbance-impacts-on-forest-structure-and-carbon-stocks-in-a-western-amazonian-landscape
#14
Naomi B Schwartz, María Uriarte, Ruth DeFries, Kristopher M Bedka, Katia Fernandes, Victor Gutiérrez-Vélez, Miguel A Pinedo-Vasquez
Tropical second-growth forests could help mitigate climate change, but the degree to which their carbon potential is achieved will depend on exposure to disturbance. Wind disturbance is common in tropical forests, shaping structure, composition, and function, and influencing successional trajectories. However, little is known about the impacts of extreme winds on second-growth forests in fragmented landscapes, though these ecosystems are often located in mosaics of forest, pasture, cropland, and other land cover types...
June 7, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28586234/the-direct-indirect-technique-for-composite-restorations-revisited
#15
André V Ritter, Newton Fahl, Marcos Vargas, Rodrigo R Maia
In the direct-indirect composite technique, composite is applied to a nonretentive tooth preparation (eg, a noncarious cervical lesion or a veneer/inlay/onlay preparation) without any bonding agent, sculpted to a primary anatomic form, and light-cured. The partially polymerized restoration is then removed from the preparation and finished and tempered extraorally chairside. The finished inlay is bonded to the preparation using a resin-based luting agent. Advantages of this technique include enhanced physical and mechanical properties afforded by the extraoral chairside tempering process because of increased monomer conversion, and greater operator control over the final marginal adaptation, surface finishing and polishing, and anatomy of the restoration, given that these elements are defined outside of the patient's mouth...
June 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28581920/randomized-clinical-trial-to-evaluate-mta-indirect-pulp-capping-in-deep-caries-lesions-after-24-months
#16
U Koc Vural, A Kiremitci, S Gokalp
OBJECTIVE: This clinical study aimed to assess the efficacies of mineral trioxide aggregate (MTA) and calcium hydroxide [Ca(OH)2] in the treatment of deep carious lesions by the direct complete caries removal technique. METHODS AND MATERIALS: A total of 100 permanent molar/premolar teeth were capped with either Ca(OH)2 (n=49) or MTA (n=51) and restored with composite resin in 73 patients. Periapical radiographs were acquired prior to the treatment as well as at six, 12, and 24 months posttreatment...
June 5, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28579384/managing-molars-with-severe-molar-incisor-hypomineralization-a-cost-effectiveness-analysis-within-german-healthcare
#17
Karim Elhennawy, Paul-Georg Jost-Brinkmann, David John Manton, Sebastian Paris, Falk Schwendicke
OBJECTIVES: Dentists have a range of options for managing molars with severe molar-incisor hypomineralization (MIH), each with different long-term implications. The cost-effectiveness of managing molars with severe MIH was assessed. METHODS: A mixed public-private-payer perspective within German healthcare was adopted. Individuals with one to four severely MIH-affected molars were followed over their lifetime. We compared: (1) removal of the tooth/teeth and orthodontic alignment of the second and third molars (Ex/Ortho); (2) restoration of the tooth using resin composite (Comp); (3) restoration using an indirect metal crown after temporizing it using a preformed metal crown (PMC/IR)...
June 1, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28579353/in%C3%A2-vitro-differentiation-of-menstrual-blood-stem-cells-into-keratinocytes-a-potential-approach-for-management-of-wound-healing
#18
Maryam Akhavan-Tavakoli, Maryam Fard, Sayeh Khanjani, Sona Zare, Haleh Edalatkhah, Davood Mehrabani, Amir-Hassan Zarnani, Reza Shirazi, Somaieh Kazemnejad
The skin wounds caused by insults should be treated immediately to restore the functions and integrity. Recent studies suggest that stem cells-based therapies may be applicable in wound healing. Newly defined menstrual blood-derived stem cells (MenSCs) show high rate of cell proliferation and trans-differentiation potency to various cell types. However, MenSCs potential to generate keratinocyte for future therapeutic use of skin lesions has been remained to investigate. We cultivated MenSCs in the presence of isolated foreskin derived-keratinocytes using an indirect co-culture system and evaluated efficiency of this protocol to generate keratinocytes using immunofluorescent staining and Real Time PCR technique...
June 1, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28572811/direct-and-pollinator-mediated-effects-of-herbivory-on-strawberry-and-the-potential-for-improved-resistance
#19
Anne Muola, Daniela Weber, Lisa E Malm, Paul A Egan, Robert Glinwood, Amy L Parachnowitsch, Johan A Stenberg
The global decline in pollinators has partly been blamed on pesticides, leading some to propose pesticide-free farming as an option to improve pollination. However, herbivores are likely to be more prevalent in pesticide-free environments, requiring knowledge of their effects on pollinators, and alternative crop protection strategies to mitigate any potential pollination reduction. Strawberry leaf beetles (SLB) Galerucella spp. are important strawberry pests in Northern Europe and Russia. Given that SLB attack both leaf and flower tissue, we hypothesized pollinators would discriminate against SLB-damaged strawberry plants (Fragaria vesca, cultivar 'Rügen'), leading to lower pollination success and yield...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28572416/graduate-periodontics-programs-integration-of-implant-provisionalization-in-core-curricula-implementation-of-coda-standard-4-10-2-d
#20
Christopher A Barwacz, Ed Pantzlaff, Veerasathpurush Allareddy, Gustavo Avila-Ortiz
The aim of this descriptive study was to provide an overview of the status of implementation of Commission on Dental Accreditation (CODA) Standard 4-10.2.d (Provisionalization of Dental Implants) by U.S. graduate periodontics programs since its introduction in 2013. Surveys were sent in May 2015 to 56 accredited postdoctoral periodontics program directors to ascertain program director characteristics; status of planning, implementation, and curriculum resulting from adoption of Standard 4-10.2.d; preferred clinical protocols for implant provisionalization; interdisciplinary educational collaborators; and competency assessment mechanisms...
June 2017: Journal of Dental Education
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