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https://www.readbyqxmd.com/read/28938612/magnetic-resonance-imaging-tracking-and-assessing-repair-function-of-the-bone-marrow-mesenchymal-stem-cells-transplantation-in-a-rat-model-of-spinal-cord-injury
#1
Hongwu Zhang, Liqin Wang, Shihong Wen, Qingfeng Xiang, Xianhong Xiang, Caixia Xu, Yong Wan, Jingnan Wang, Bin Li, Yiqian Wan, Zhiyun Yang, David Y B Deng
The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936962/-evaluation-of-the-effect-of-a-new-fixation-tape-for-tracheal-catheter-in-intensive-care-patients
#2
Limin Chen, Ruihong Liu, Biyu Shen, Lingling Wang, Zhiming Cui, Guanhua Xu
OBJECTIVE: To evaluate the effect of a new type of fixation tape for tracheal catheter in intensive care patients. METHODS: A purposive sampling study was conducted. Ninety patients experienced oral tracheal intubation for mechanical ventilation, and admitted to respiratory intensive care unit (ICU) of the Second Affiliated Hospital of Nantong University from November 2015 to February 2017 were enrolled. All the patients were randomly (random number) divided into the control group and the observation group with 45 patients in each group...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936052/outcome-of-descemet-stripping-automated-endothelial-keratoplasty-in-failed-penetrating-keratoplasty
#3
Abdulrahman S Khairallah
PURPOSE: The purpose of this study was to report the outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) surgeries in eyes with failed penetrating keratoplasty (PKP). METHODS: This was a retrospective, noncomparative, descriptive case series. Patients who underwent DSAEK following PKP from January 2007 to December 2012 were reviewed. Data were collected on best-corrected visual acuity (BCVA) before and 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years following DSAEK...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28934371/some-like-it-hot-repeat-migration-and-residency-of-whale-sharks-within-an-extreme-natural-environment
#4
David P Robinson, Mohammed Y Jaidah, Steffen S Bach, Christoph A Rohner, Rima W Jabado, Rupert Ormond, Simon J Pierce
The Arabian Gulf is the warmest sea in the world and is host to a globally significant population of the whale shark Rhincodon typus. To investigate regional whale shark behaviour and movements, 59 satellite-linked tags were deployed on whale sharks in the Al Shaheen area off Qatar from 2011-14. Four different models of tag were used throughout the study, each model able to collect differing data or quantities of data. Retention varied from one to 227 days. While all tagged sharks crossed international maritime boundaries, they typically stayed within the Arabian Gulf...
2017: PloS One
https://www.readbyqxmd.com/read/28933725/integrins-and-exosomes-a-dangerous-liaison-in-cancer-progression
#5
REVIEW
Mayra Paolillo, Sergio Schinelli
Integrin activity and function is classically related to the bi-directional regulation of cell-extracellular matrix (ECM) contacts that regulate a number of cell pathways linked to cell adhesion, cell detachment from ECM, cell migration, and anoikis. Interestingly, emerging data continue to uncover new roles for integrins in cancer-relevant pathways, particularly concerning the regulation of immune cell activity in the tumor niche, like myeloid cell differentiation and function and, very recently, the regulation of metastatic processes by exosomes...
July 26, 2017: Cancers
https://www.readbyqxmd.com/read/28933699/pyoderma-gangrenosum-an-uncommon-case-report-and-review-of-the-literature
#6
António Carlos Lemos, Debora Aveiro, Natália Santos, Vítor Marques, Luís Filipe Pinheiro
BACKGROUND: Pyoderma gangrenosum (PG) is a rare ulcerative condition that is diagnostically and therapeutically challenging, as debridement leads to ulcer deterioration (pathergy phenomenon); immunosuppression is considered the gold standard therapy. CASE REPORT: The authors present the case of a 42-year-old woman with PG and uncontrolled iatrogenic diabetes, secondary to a total pancreatectomy performed in another hospital in 1998 due to nesidioblastosis. In 2008, she was referred to the diabetic foot consultation at Centro Hospitalar Tondela-Viseu (Viseu, Portugal) due to an infected wound on the left leg thought to be related to a trauma from footwear, but the injury worsened despite treatment...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28933041/macular-hole-caused-by-retained-subfoveal-perfluorocarbon-that-subsequently-closed-after-its-spontaneous-resolution-a-case-report
#7
Reiko Tanabu, Yukihiko Suzuki, Kaori Suzuki, Shizuka Takahashi, Mitsuru Nakazawa, Hideyuki Mizutani
INTRODUCTION: To prevent local reduction in retinal function caused by retained subretinal perfluorocarbon liquid (PFCL), it has been noted that removal of PFCL under the fovea should be considered, with a vitrectomy selected for such removal. CASE REPORT: A vitrectomy was performed for traumatic retinal detachment during which PFCL was temporarily used as an intraocular tamponade for retina flattening. Following surgery, subfoveal PFCL was retained beneath the retina...
September 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28932912/behavioral-cognitive-and-emotional-coping-strategies-of-women-with-endometriosis-a-critical-narrative-review
#8
REVIEW
Cristina Zarbo, Agostino Brugnera, Luigi Frigerio, Chiara Malandrino, Massimo Rabboni, Emi Bondi, Angelo Compare
Endometriosis is a disabling and long-term medical condition affecting quality of life and mental health. Behavioral, cognitive, and emotional coping strategies, emotional intelligence, and metacognition could in part explain the link between the disease and impaired psychological and life functioning. This critical narrative review aimed at examining the state of the art of the relationships between endometriosis and these factors. According to PRISMA principles, we performed a systematic search for quantitative and qualitative studies on multiple electronic databases as regards coping strategies, emotional intelligence, and metacognition in women with endometriosis...
September 21, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28932485/incontinentia-pigmenti-in-a-child-with-suspected-retinoblastoma
#9
Stephanie J Weiss, Archana Srinivasan, Michael A Klufas, Carol L Shields
BACKGROUND: Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, findings include retinal vascular non-perfusion, occasionally with traction retinal detachment, retinal fibrosis, and retinal pigment epithelium defects. These findings can resemble retinoblastoma, especially when vitreoretinal fibrosis produces leukocoria. CASE REPORT: A 2-month-old girl born full-term presented with leukocoria, suspicious for retinoblastoma...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28931796/epidemiological-study-on-trichophyton-disseminating-from-the-feet-of-the-elderly
#10
Shusaku Suzuki, Yoko Mano, Nobuhiko Furuya, Katsumi Fujitani
OBJECTIVES: To grasp the colonization status of Trichophyton in terms of spreading rate, we investigated the intergenerational epidemiological difference in the spreading rate of Trichophyton from teenagers to the elderly aged over 65. In addition, the elderly people were divided into two groups: those living at nursing homes and those living at their homes. We compared the two groups in terms of the difference in the spreading rate of Trichophyton. METHODS: Spreading rate was investigated by identifying the fungi collected by the cotton swab sampling method...
2017: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/28931594/adhesion-force-and-attachment-lifetime-of-the-kif16b-px-domain-interaction-with-lipid-membranes
#11
Serapion Pyrpassopoulos, Henry Shuman, E Michael Ostap
KIF16B is a highly processive kinesin-3 family member that participates in the trafficking and tubulation of early endosomes along microtubules. KIF16B attaches to lipid cargos via a PX motif at its C-terminus, which has nanomolar affinity for bilayers containing phosphatidylinositol-3-phosphate (PI(3)P). As the PX domain has been proposed to be a primary mechanical anchor for the KIF16B-cargo attachment, we measured the adhesion forces and detachment kinetics of the PX domain as it interacts with membranes containing 2% PI(3)P and 98% phosphatidylcholine...
September 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28931539/detachment-induced-e-cadherin-expression-promotes-3d-tumor-spheroid-formation-but-inhibits-tumor-formation-and-metastasis-of-lung-cancer-cells
#12
Phattrakorn Powan, Sudjit Luanpitpong, Xiaoqing He, Yon Rojanasakul, Pithi Chanvorachote
The interconversion between epithelial and mesenchymal is proposed to be a key machinery responsible for metastasis-related deaths. Likewise, cancer stem cells (CSCs) have been proposed to be a key driver of tumor metastasis. However, the linkage between the two events and their control mechanisms are unclear. We used a 3D tumor spheroid assay and other CSC-indicating assays to investigate the role of E-cadherin in CSC regulation and its association to epithelial to mesenchymal transition in lung cancer cells...
September 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28931008/biometric-and-structural-ocular-manifestations-of-marfan-syndrome
#13
Petra Gehle, Barbara Goergen, Daniel Pilger, Peter Ruokonen, Peter N Robinson, Daniel J Salchow
BACKGROUND: To study biometric and structural ocular manifestations of Marfan syndrome (MFS). METHODS: Observational, retrospective, comparative cohort study in a tertiary referral center on 285 MFS patients and 267 controls. Structural and biometric ocular characteristic were compared. RESULTS: MFS eyes were longer (axial length 24.25 ± 1.74 mm versus 23.89 ± 1.31 mm, p < 0.001) and had a flatter cornea than control eyes (mean keratometry 41...
2017: PloS One
https://www.readbyqxmd.com/read/28930802/morphologic-features-associated-with-fibrotic-scarring-after-anti-vascular-endothelial-growth-factor-therapy-in-polypoidal-choroidal-vasculopathy
#14
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Ye Ji Kim
PURPOSE: To investigate morphologic features associated with fibrotic scarring after anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy (PCV). METHODS: This retrospective study included 293 patients who had been diagnosed with PCV and treated with anti-vascular endothelial growth factor monotherapy during a 12-month follow-up period. Associations of morphologic features, including type of PCV, location of the polypoidal lesion, greatest linear dimension, largest polyp diameter, choroidal vascular hyperpermeability, pigment epithelial detachment, intraretinal fluid, and subretinal hyperreflective material (SHRM) with fibrotic scar at 12 months were analyzed...
September 19, 2017: Retina
https://www.readbyqxmd.com/read/28930777/endoscopic-delayed-breast-reconstruction-with-expanders-and-implants-via-the-axillary-incision-made-for-sentinel-lymph-node-biopsy-or-lymphadenectomy
#15
José Maria Serra-Mestre, Randolfo Fernandez Peñuela, Francesco DʼAndrea, Joan Maria Viñals, José Maria Serra-Renom
BACKGROUND: Classic techniques of delayed prosthetic breast reconstruction use the mastectomy scar as an access route. As a result, the filling of the expander must be postponed until the wounds have healed. This creates an asymmetry between the breasts with the volume changes caused by the filling of the expander, which may occur over several weeks and cause considerable discomfort. METHODS: Delayed breast reconstruction was performed via the axillary incision made for sentinel lymph node biopsy or lymphadenectomy with endoscopic assistance and detachment of the pectoralis major muscle...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28930649/ph-multistage-responsive-micellar-system-with-charge-switch-and-peg-layer-detachment-for-co-delivery-of-paclitaxel-and-curcumin-to-synergistically-eliminate-breast-cancer-stem-cells
#16
Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian
Several studies have demonstrated that cancer stem cells (CSCs) are responsible for replenishing bulk tumor cells, generating new tumors and causing metastasis and relapse. Although combination therapy with multiple chemotherapeutics is considered to be a promising approach for simultaneously eliminating non-CSCs and CSCs, it is difficult to deliver drugs into the inner region of a solid tumor where the CSCs are located due to a lack of capillaries. Here, we synthesized a pH-sensitive polymer, poly(ethylene glycol)-benzoic imine-poly(γ-benzyl-l-aspartate)-b-poly(1-vinylimidazole) block copolymer (PPBV), to develop a pH multistage responsive micellar system for co-delivering paclitaxel and curcumin and synergistically eliminating breast cancer stem cells (bCSCs) and non-bCSCs...
September 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28930457/a-computational-investigation-of-the-geometrical-and-electronic-structures-of-vgen-0-n-1-4-clusters-by-density-functional-theory-and-multiconfigurational-casscf-caspt2-method
#17
Van Tan Tran, Minh Thao Nguyen, Quoc Tri Tran
Density functional theory and multiconfigurational CASSCF/CASPT2 method have been employed to study the low-lying states of VGen-/0 (n = 1 - 4) clusters. For VGe-/0 and VGe2-/0 clusters, the relative energies and geometrical structures of the low-lying states are reported at the CASSCF/CASPT2 level. For the VGe3-/0 and VGe4-/0 clusters, the computational results show that due to the large contribution of the Hartree-Fock exact exchange, the hybrid B3LYP, B3PW91, and PBE0 functionals overestimate the energies of the high-spin states as compared to the pure GGA BP86 and PBE functionals and the CASPT2 method...
September 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28930445/thermo-responsive-and-active-functional-fiber-mats-for-cultured-cell-recovery
#18
Wilaiporn Graisuwan, Songchan Puthong, Hui Zhao, Suda Kiatkamjornwong, Patrick Theato, Voravee P Hoven
Thermo-responsive and active functional fiber mats were prepared from random copolymer of poly(pentafluorophenyl acrylate-co-N-isopropylacrylamide) (P(PFPA-co-NIPAM)), which was synthesized by a controlled radical polymerization process based on reversible addition-fragmentation chain transfer (RAFT). As reactive sites, pentafluorophenyl ester (PFP) groups were incorporated in the copolymer to allow for a multiple post-polymerization modification. UV-crosslinkable moieties were first introduced by partially reacting PFP groups in the copolymer with ortho-nitrobenzyl (ONB)-protected diamine...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28930071/dynamics-of-the-ift-machinery-at-the-ciliary-tip
#19
Alexander Chien, Sheng Min Shih, Raqual Bower, Douglass Tritschler, Mary E Porter, Ahmet Yildiz
Intraflagellar transport (IFT) is essential for the elongation and maintenance of eukaryotic cilia and flagella. Due to the traffic jam of multiple trains at the ciliary tip, how IFT trains are remodeled in these turnaround zones cannot be determined by conventional imaging. Using Photogate, we visualized the full range of movement of single IFT trains and motors in Chlamydomonas flagella. Anterograde trains split apart and IFT complexes mix with each other at the tip to assemble retrograde trains. Dynein-1b is carried to the tip by kinesin-II as inactive cargo on anterograde trains...
September 20, 2017: ELife
https://www.readbyqxmd.com/read/28929240/a-casscf-caspt2-investigation-on-electron-detachments-from-scsi-n-n%C3%A2-%C3%A2-4-6-clusters
#20
Minh Thao Nguyen, Quoc Tri Tran, Van Tan Tran
In this work, the low-lying states of several isomers of ScSi n(-/0) (n = 4-6) were investigated with the B3LYP functional and CASPT2 method. The ground states of the anionic clusters were predicted to be the singlet states of the trigonal bipyramid ScSi4(-) (A-ScSi4(-)), the face-capped trigonal bipyramid ScSi5(-) (A-ScSi5(-)), and the pentagonal bipyramid ScSi6(-) (A-ScSi6(-)) isomer. Based on the anionic ground states, all the relevant electron detachment processes were identified. The corresponding adiabatic and vertical detachment energies (ADEs and VDEs) of the anionic clusters were computed at the CASPT2 level...
September 20, 2017: Journal of Molecular Modeling
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