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https://www.readbyqxmd.com/read/28528307/extracellular-atp-is-a-key-modulator-of-alveolar-bone-loss-in-periodontitis
#1
REVIEW
Itzhak Binderman, Nasir Gadban, Avinoam Yaffe
Periodontal diseases are initiated by pathogenic bacterial biofilm activity that induces a host inflammatory cells immune response, degradation of dento gingival fibrous tissue and its detachment from root cementum. It is well accepted, that osteoclastic alveolar bone loss is governed exclusively through secretion of proinflammatory cytokines. Nevertheless, our findings suggest that once degradation of collagen fibers by MMPs occurs, a drop of cellular strains cause immediate release of ATP from marginal gingival fibroblasts, cell deformation and influx of Ca+2...
May 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28528012/impact-of-total-pars-plana-vitrectomy-on-postoperative-complications-in-aphakic-snap-on-type-1-boston-keratoprosthesis
#2
Victor L Perez, Ella H Leung, Audina M Berrocal, Thomas A Albini, Jean Marie Parel, Guillermo Amescua, Eduardo C Alfonso, Tayyeba K Ali, Allister Gibbons
PURPOSE: To determine the impact of total pars plana vitrectomies (PPVs) with peripheral shaving of the vitreous base on the rates of postoperative complications in patients with aphakic, snap-on type I Boston keratoprostheses (KPros). DESIGN: Retrospective, consecutive case series. PARTICIPANTS: A total of 48 eyes in 46 patients with implantation of aphakic, snap-on type 1 Boston KPros performed at a tertiary care facility between January 1, 2007, and December 31, 2013, were included...
May 17, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28527785/the-effectiveness-of-a-fixed-dose-combination-pour-on-formulation-of-1-25-fipronil-and-2-5-fluazuron-against-economically-important-ectoparasites-and-associated-pharmacokinetics-in-cattle
#3
Welber Daniel Zanetti Lopes, Rafael Marin Chiummo, Luis Fernando Vettorato, Daniel de Castro Rodrigues, Rafael Bazaglia Sonada
The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R...
May 17, 2017: Parasitology International
https://www.readbyqxmd.com/read/28527713/stability-or-instability-in-avoidant-personality-disorder-mode-fluctuations-within-schema-therapy-sessions
#4
Ofer Peled, Eran Bar-Kalifa, Eshkol Rafaeli
BACKGROUND AND OBJECTIVES: Avoidant personality disorder (APD) is among the most prevalent personality disorders, but has received relatively little empirical attention. This study aims to characterize the frequency, intensity, and fluctuation patterns seen in the modes (self-states) of APD clients over the course of schema therapy (ST), a psychotherapy approach developed especially for personality disorders. METHOD: The newly-developed client mode rating scale (CMRS) was used to code every 5-min segment (n = 645) of 60 ST sessions...
May 6, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28527466/highly-excited-electronic-image-states-of-metallic-nanorings
#5
Christian Fey, Henrik Jabusch, Johannes Knörzer, Peter Schmelcher
We study electronic image states around a metallic nanoring and show that the interplay between the attractive polarization force and a repulsive centrifugal force gives rise to Rydberg-like image states trapped several nanometers away from the surface. The nanoring is modeled as a perfectly conducting isolated torus whose classical electrostatic image potential is derived analytically. The image states are computed via a two-dimensional finite-difference scheme as solutions of the effective Schrödinger equation describing the outer electron subject to this image potential...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527437/ab-initio-study-of-the-neutral-and-anionic-alkali-and-alkaline-earth-hydroxides-electronic-structure-and-prospects-for-sympathetic-cooling-of-oh
#6
Milaim Kas, Jérôme Loreau, Jacques Liévin, Nathalie Vaeck
We have performed a systematic ab initio study on alkali and alkaline earth hydroxide neutral (MOH) and anionic (MOH(-)) species where M = Li, Na, K, Rb, Cs or Be, Mg, Ca, Sr, Ba. The CCSD(T) method with extended basis sets and Dirac-Fock relativistic effective core potentials for the heavier atoms has been used to study their equilibrium geometries, interaction energies, electron affinities, electric dipole moment, and potential energy surfaces. All neutral and anionic species exhibit a linear shape with the exception of BeOH, BeOH(-), and MgOH(-), for which the equilibrium structure is found to be bent...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527031/choroidal-thickness-in-chronic-rhegmatogenous-retinal-detachment-before-and-after-surgery-and-comparison-with-acute-cases
#7
Isil Sayman Muslubas, Mumin Hocaoglu, Mehmet Giray Ersoz, Serra Arf, Murat Karacorlu
PURPOSE: To evaluate subfoveal choroidal thickness (SCT) in cases with chronic rhegmatogenous retinal detachment (RRD), before and after pars plana vitrectomy, and cases with acute RRD using optical coherence tomography. METHODS: This retrospective study included 24 eyes with chronic RRD and 26 eyes with recent-onset RRD. Best corrected visual acuity, intraocular pressure, and SCT were measured and compared between the two groups. Of 24 eyes with chronic RRD, 11 had primary pars plana vitrectomy...
May 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28526550/impact-of-first-eye-versus-second-eye-cataract-surgery-on-visual-function-and-quality-of-life
#8
Nakul S Shekhawat, Michael V Stock, Elizabeth F Baze, Mary K Daly, David E Vollman, Mary G Lawrence, Amy S Chomsky
PURPOSE: To compare the impact of first eye versus second eye cataract surgery on visual function and quality of life. DESIGN: Cohort study. PARTICIPANTS: A total of 328 patients undergoing separate first eye and second eye phacoemulsification cataract surgeries at 5 veterans affairs centers in the United States. Patients with previous ocular surgery, postoperative endophthalmitis, postoperative retinal detachment, reoperation within 30 days, dementia, anxiety disorder, hearing difficulty, or history of drug abuse were excluded...
May 16, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28526303/the-use-of-biobrane-%C3%A2-for-wound-coverage-in-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#9
Alan D Rogers, Erin Blackport, Robert Cartotto
INTRODUCTION: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN. METHODS: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted...
May 16, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28525931/innovative-delivery-method-using-a-detachable-device-to-deliver-a-large-polyglycolic-acid-sheet-to-a-gastric-ulcer-perforation
#10
Hirohito Mori, Hideki Kobara, Asadur Rahman, Noriko Nishiyama, Akira Nishiyama, Yasuyuki Suzuki, Tsutomu Masaki
No abstract text is available yet for this article.
May 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28525682/secondary-sulcus-fixed-foldable-iol-implantation-with-25-g-infusion-in-patients-with-previous-ppv-after-open-globe-injury
#11
Tiangeng He, Caiyun You, Song Chen, Xiangda Meng, Yuanyuan Liu, Hua Yan
PURPOSE: To evaluate the safety and efficacy of secondary sulcus-fixed foldable intraocular lens (IOL) implantation through a clear corneal incision with 25-G infusion in patients with previous pars plana vitrectomy (PPV) after open-globe injury, and to analyze postoperative outcomes and prognostic factors of treatment. METHODS: Clinical data of 89 eyes of 89 patients with open-globe injury who underwent secondary sulcus-fixed foldable IOL implantation through a clear corneal incision with 25-G infusion after vitrectomy in our hospital between January 2008 and June 2015 were retrospectively analyzed...
May 16, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#12
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28525466/facet-preserving-technique-by-en-bloc-flavectomy-in-microscopic-posterior-decompression-surgery-for-lumbar-spinal-stenosis-semicircumferential-decompression-scd
#13
Yasushi Fujiwara, Hideki Manabe, Tadayoshi Sumida, Bunichiro Izumi, Kazuyoshi Nakanishi, Nobuhiro Tanaka, Nobuo Adachi
Posterior decompression surgery which enlarges the spinal canal in cases with lumbar spinal stenosis is the most fundamental technique in spine surgery, but controversy still remains for the exact technique. Because nerve roots run under the ventral side on the superior articular process (SAP), achieving both facet joint preservation and nerve root decompression is problematic. In conventional laminotomies or laminectomies, medial facetectomies are performed to decompress the nerve root, but it is ideal to preserve the facet joints completely for preserving joint stability...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28524883/occurrence-rate-of-retinal-detachment-after-small-gauge-vitrectomy-for-idiopathic-epiretinal-membrane
#14
J Marie-Louise, E Philippakis, A Darugar, R Tadayoni, B Dupas
PurposeTo assess the occurrence rate of retinal detachment (RD) after small gauge vitrectomy for idiopathic epiretinal membrane (ERM).Patients and methodsRetrospective observational case series. The records of consecutive patients operated on for idiopathic ERM using small gauge pars plana vitrectomy between August 2012 and December 2014 with at least a 1-year follow-up were reviewed. All patients were contacted by phone to assess the occurrence of RD during the post-operative follow-up. The main outcome was the occurrence of RD...
May 19, 2017: Eye
https://www.readbyqxmd.com/read/28524199/multiple-electron-capture-from-isolated-protein-poly-anions-in-collision-with-slow-highly-charged-ions
#15
A R Milosavljević, P Rousseau, A Domaracka, B A Huber, A Giuliani
Collisions of 375 keV Xe(25+) ions with trapped mass/charge selected poly-anions of the cytochrome C protein (∼12.5 kDa) were studied by coupling a linear quadrupole ion trap with low-energy ion beam facility. Tandem mass spectra were recorded for the protein precursor charge states ranging from -9 to -17. The present work reports the first study of slow highly charged ion collisions with poly-anions. A high signal to noise ratio allowed the study of the intensity of single and multiple electron removal by a projectile, as well as associated neutral losses, as a function of the target charge state...
May 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28524134/-oct-morphometric-and-angiographic-parallels-between-different-variants-of-central-serous-chorioretinopathy
#16
I E Panova, T B Shaimov, V A Shaimova
Central serous chorioretinopathy (CSCR) is a frequent cause of vision deterioration. Often it is associated with type 1 neovascularization under the pigment retinal epithelium (RPE). Optical coherence tomography angiography (OCT-angiography) enables non-invasive and contrast-free detection of neovessels in any retinal layer, which makes the method appropriate for diagnostics in CSCR. AIM: to investigate OCT-morphometric and angiographic parallels between different CSCR courses. MATERIAL AND METHODS: The study included 37 patients with CSCR...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28523446/in-vitro-quantification-of-luminal-denudation-after-crimping-and-balloon-dilatation-of-endothelialized-covered-stents
#17
Shigeo Ichihashi, Frederic Wolf, Thomas Schmitz-Rode, Kimihiko Kichikawa, Stefan Jockenhoevel, Petra Mela
PURPOSE: Covered stents have been demonstrated to reduce restenosis; however, the membrane's limited biocompatibility can still lead to thrombus formation. To obtain optimal surface hemocompatibility, endothelialization of the luminal surface has been proposed. However, the effect of delivery procedures, such as crimping and balloon dilatation, on the endothelial layer has not been quantified. This study investigated the impact of such procedures on endothelialized covered stents in vitro...
May 18, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28523233/a-new-method-allowing-long-term-potentiation-recordings-in-hippocampal-organotypic-slices
#18
Paula Paci, Sylvain Gabriele, Laurence Ris
BACKGROUND: Hippocampal organotypic slices are used to improve the understanding of synaptic plasticity mechanisms because they allow longer term studies compared to acute slices. However, it is more delicate to keep cultures alive in the recording system outside in vitro conditions. Experiments from the organotypic cultures are common but the handling of slices is rarely described in the literature, even though tissue preservation is crucial. Instruments are sometimes required to extract the slices from the culture inserts but this approach is delicate and can lead to damage, given how strongly the slices are attached to the insert...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28523190/expression-of-upar-in-urinary-podocytes-of-patients-with-fabry-disease
#19
Hernán Trimarchi, Romina Canzonieri, Amalia Schiel, Juan Politei, Cristian Costales-Collaguazo, Aníbal Stern, Matías Paulero, Tatiana Rengel, Lara Valiño-Rivas, Mariano Forrester, Fernando Lombi, Vanesa Pomeranz, Romina Iriarte, Alexis Muryan, Alberto Ortiz, María Dolores Sanchez-Niño, Elsa Zotta
Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure. We evaluated a potential mechanism of podocyte detachment via the expression of the urokinase-type Plasminogen Activator Receptor (uPAR) in urinary podocytes of Fabry patients. Methods. This is a cross-sectional study that included controls (n = 20) and Fabry patients (n = 44) either untreated (n = 23) or treated with agalsidase-β (n = 21)...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28522152/anti-trypanosomal-activity-of-cationic-n-heterocyclic-carbene-gold-i-complexes
#20
Isabel Winter, Julia Lockhauserbäumer, Gertrud Lallinger-Kube, Rainer Schobert, Klaus Ersfeld, Bernhard Biersack
Two gold(I) N-heterocyclic carbene complexes 1a and 1b were tested for their anti-trypanosomal activity against Trypanosoma brucei parasites. Both gold compounds exhibited excellent anti-trypanosomal activity (IC50=0.9-3.0nM). The effects of the gold complexes 1a and 1b on the T. b. brucei cytoskeleton were evaluated. Rapid detachment of the flagellum from the cell body occurred after treatment with the gold complexes. In addition, a quick and complete degeneration of the parasitic cytoskeleton was induced by the gold complexes, only the microtubules of the detached flagellum remained intact...
May 15, 2017: Molecular and Biochemical Parasitology
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