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https://www.readbyqxmd.com/read/29353431/sensitive-electrochemical-detection-of-microrna-21-based-on-propylamine-functionalized-mesoporous-silica-with-glucometer-readout
#1
Kun Deng, Yong Zhang, Xuedong Tong
A new homogeneous electrochemical sensing system was developed for sensitive detection of microRNA-21 (miRNA-21) based on target-induced glucose release from propylamine-functionalized mesoporous silica nanoparticle (MSN) with glucometer readout. Glucose molecules (as the signal tracers) were initially gated into the pores through the interaction of the negatively charged anchor DNA with the aminated MSN. Upon addition of target miRNA, the analyte competitively hybridized with anchor DNA to form the RNA-DNA duplex, thus resulting in detachment of anchor DNA from the MSN accompanying the pore opening...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29352711/gold-cleaning-methods-for-preparation-of-cell-culture-surfaces-for-self-assembled-monolayers-of-zwitterionic-oligopeptides
#2
Junko Enomoto, Tatsuto Kageyama, Dina Myasnikova, Kisaki Onishi, Yuka Kobayashi, Yoko Taruno, Takahiro Kanai, Junji Fukuda
Self-assembled monolayers (SAMs) have been used to elucidate interactions between cells and material surface chemistry. Gold surfaces modified with oligopeptide SAMs exhibit several unique characteristics, such as cell-repulsive surfaces, micropatterns of cell adhesion and non-adhesion regions for control over cell microenvironments, and dynamic release of cells upon external stimuli under culture conditions. However, basic procedures for the preparation of oligopeptide SAMs, including appropriate cleaning methods of the gold surface before modification, have not been fully established...
January 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29352520/ipragliflozin-improves-mitochondrial-abnormalities-in-renal-tubules-induced-by-a-high-fat-diet
#3
Susumu Takagi, Jinpeng Li, Yuta Takagaki, Munehiro Kitada, Kyoko Nitta, Toshiyuki Takasu, Keizo Kanasaki, Daisuke Koya
OBJECTIVE: Complete mechanisms of reno-protective effects of SGLT2 inhibitors have not been elucidated yet. Mitochondrial biogenesis is regulated by membrane GTPases, such as Opa1 and Mfn2. Here, we investigated whether SGLT2 inhibition in mice fed with a high-fat diet (HFD) improved mitochondrial morphology and restored mitochondrial biogenesis-related molecules. MATERIALS AND METHODS: Mice were fed in control diet or HFD with or without ipragliflozin treatment...
January 20, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29352506/patterns-of-burns-and-scalds-in-mongolian-children-a-hospital-based-prospective-study
#4
Gunsmaa Gerelmaa, Badarch Tumen-Ulzii, Shinji Nakahara, Masao Ichikawa
OBJECTIVE: To describe the circumstances of burn injury occurrence among Mongolian children and the products involved. METHODS: Study participants were children aged 15 years and younger who were admitted to the Burn Unit of the National Trauma Orthopedic Research Center from August 2015 to July 2016. We collected data on participant demographics and the etiology and clinical features of their burn injuries, and we analyzed the data based on the NOMESCO Classification model...
January 20, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29352407/-rhegmatogenous-retinal-detachment-epidemiology-and-risk-factors
#5
N E Bechrakis, A Dimmer
The incidence of rhegmatogenous retinal detachment in the European population is approximately 10 cases per 100,000 inhabitants per year and reaches a peak in the 6th and 7th decades of life, mostly in atemporal association with posterior vitreous body detachment. Known risk factors include myopia and higher axial length of the eye, male gender, previous trauma and vitreoretinal degeneration or dystrophy. In recent years, an increase in the risk of rhegmatogenous retinal detachment following cataract surgery was also found, especially after capsule rupture and vitreous body loss...
January 19, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29350687/intraocular-currents-bernoulli-s-principle-and-non-drainage-scleral-buckling-for-rhegmatogenous-retinal-detachment
#6
D Wong, Y K Chan, T Bek, I Wilson, E Stefánsson
For many years, it is not fully understood how non-drainage scleral buckling surgery brings about spontaneous reattachment of the detached retina when retinal breaks remain open at the end of surgery. Various explanations have been put forward, but none more interesting than the effect of fluid currents associated with eye movements. One such explanation involved the physics of the Bernoulli's principle. Daniel Bernoulli was an eighteenth century Swiss mathematician and he described an equation based on the conservation of energy...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29349026/arthroscopic-management-of-posterior-instability-due-to-floating-posterior-inferior-glenohumeral-ligament-lesions
#7
Lawrence O'Malley, Eric D Field, Larry D Field
The "floating" posterior inferior glenohumeral ligament (floating PIGHL) is an uncommon cause of posterior shoulder instability. This pathologic lesion, defined as detachment of both the origin of the PIGHL (posterior Bankart lesion) and insertion of the of the PIGHL from its humeral head insertion site, often results in significant and persistent shoulder instability symptoms. An effective surgical technique for arthroscopic repair of a floating PIGHL lesion is described and demonstrated.
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29347941/a-five-year-retrospective-study-of-the-epidemiological-characteristics-and-visual-outcomes-of-pediatric-ocular-trauma
#8
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29347633/stochastic-thermodynamics-of-interacting-degrees-of-freedom-fluctuation-theorems-for-detached-path-probabilities
#9
Jannik Ehrich, Andreas Engel
Systems with interacting degrees of freedom play a prominent role in stochastic thermodynamics. Our aim is to use the concept of detached path probabilities and detached entropy production for bipartite Markov processes and elaborate on a series of special cases including measurement-feedback systems, sensors, and hidden Markov models. For these special cases we show that fluctuation theorems involving the detached entropy production recover known results which have been obtained separately before. Additionally, we show that the fluctuation relation for the detached entropy production can be used in model selection for data stemming from a hidden Markov model...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347598/electric-generation-and-ratcheted-transport-of-contact-charged-drops
#10
Charles A Cartier, Jason R Graybill, Kyle J M Bishop
We describe a simple microfluidic system that enables the steady generation and efficient transport of aqueous drops using only a constant voltage input. Drop generation is achieved through an electrohydrodynamic dripping mechanism by which conductive drops grow and detach from a grounded nozzle in response to an electric field. The now-charged drops are transported down a ratcheted channel by contact charge electrophoresis powered by the same voltage input used for drop generation. We investigate how the drop size, generation frequency, and transport velocity depend on system parameters such as the liquid viscosity, interfacial tension, applied voltage, and channel dimensions...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347496/kinetics-of-lipid-nanoparticle-mediated-intracellular-mrna-delivery-and-function
#11
Vladimir P Zhdanov
mRNA delivery into cells forms the basis for one of the new and promising ways to treat various diseases. Among suitable carriers, lipid nanoparticles (LNPs) with a size of about 100 nm are now often employed. Despite high current interest in this area, the understanding of the basic details of LNP-mediated mRNA delivery and function is limited. To clarify the kinetics of mRNA release from LNPs, the author uses three generic models implying (i) exponential, (ii) diffusion-controlled, and (iii) detachment-controlled kinetic regimes, respectively...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346488/a-subretinal-cell-delivery-method-via-suprachoroidal-access-in-minipigs-safety-and-surgical-outcomes
#12
Marc D de Smet, Jessica L Lynch, Nadine S Dejneka, Michael Keane, I John Khan
Purpose: This study evaluated a new subretinal method for delivery of human or pig umbilical tissue-derived cells (hUTC or pUTC, respectively) using a novel subretinal injection cannula and suprachoroidal approach in Göttingen minipig eyes. hUTC (palucorcel) are currently under development for treating geographic atrophy in humans. Methods: Twenty-four Göttingen minipigs (divided into eight groups) were subretinally administered palucorcel, pUTC, or vehicle. In some cases, fluorescently labeled cells and vehicle were administered...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29346241/chronic-central-serous-chorioretinopathy-early-and-late-morphological-and-functional-changes-after-verteporfin-photodynamic-therapy
#13
Pierluigi Iacono, Massimiliano Tedeschi, Barbara Boccassini, Adele Chiaravalloti, Monica Varano, Mariacristina Parravano
PURPOSE: To describe early and late morphological and functional changes in subjects receiving photodynamic therapy (PDT) for chronic central serous chorioretinopathy. METHODS: Patients with chronic central serous chorioretinopathy were prospectively enrolled and received standard PDT. At the baseline examination, each subject underwent complete ophthalmological examination, including best-corrected visual acuity (BCVA) assessment, fluorescein angiography and indocyanine green angiography, spectral domain optical coherence tomography, and microperimetry...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346130/reply-management-of-descemet-membrane-detachment-after-forceps-birth-injury
#14
Jack S Parker, John S Parker, Gerrit R J Melles
No abstract text is available yet for this article.
January 17, 2018: Cornea
https://www.readbyqxmd.com/read/29345093/rapid-fabrication-of-detachable-three-dimensional-tissues-by-layering-of-cell-sheets-with-heating-centrifuge
#15
Yuji Haraguchi, Yuki Kagawa, Akiyuki Hasegawa, Hirotsugu Kubo, Tatsuya Shimizu
Confluent cultured cells on a temperature-responsive culture dish can be harvested as an intact cell sheet by decreasing temperature below 32°C. A three-dimensional (3-D) tissue can be fabricated by the layering of cell sheets. A resulting 3-D multi-layered cell sheet-tissue on a temperature-responsive culture dish can be also harvested without any damage by only temperature decreasing. For shortening the fabrication time of the 3-D multi-layered constructs, we attempted to layer cell sheets on a temperature-responsive culture dish with centrifugation...
January 18, 2018: Biotechnology Progress
https://www.readbyqxmd.com/read/29345000/cell-death-under-epithelial-mesenchymal-transition-control-in-prostate-cancer-therapeutic-response
#16
REVIEW
Diane Begemann, Harry Anastos, Natasha Kyprianou
Prostate cancer is a widespread problem among men, with >160 000 new cases in 2017 alone. Androgen deprivation therapy is commonly used in prostate cancer treatment to block androgens required for cancer growth, but disease relapse after androgen deprivation therapy is both common and severe. Changes in androgen receptor signaling from androgen deprivation therapy have been linked to therapeutic resistance and tumor progression. Resistant cells can become reprogrammed to undergo epithelial-mesenchymal transition, a phenotypic switch from benign, epithelial cells to a mobile cell with mesenchymal traits...
January 17, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29344770/sub-inner-limiting-membrane-hemorrhage-in-a-patient-with-terson-syndrome
#17
M Munteanu, C Rosca, H Stanca
PURPOSE: To report a case of bilateral Terson Syndrome with sub inner limiting membrane hemorrhage associated with a rare finding: perimacular fold. METHODS: The patient, a 34 years old female with aneurysmal subarachnoid hemorrhage and bilateral Terson syndrome was admitted to the Ophthalmology department, complaining of blurred vision. Core vitrectomy, hyaloid detachment, peeling of the ILM and aspiration of the sub inner limiting membrane hemorrhage was performed...
January 17, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29344481/choroidal-melanoma-mimicker-a-case-of-metastatic-clear-cell-renal-cell-carcinoma
#18
Chris B Komanski, Shaina M Rubino, Jacob C Meyer, Craig M Greven
Choroidal melanoma is the most common primary intraocular malignancy, yet metastatic disease remains the most common malignancy of the eye. Differentiating these entities is essential as treatment, systemic associations, and prognosis vary dramatically between the two. Established diagnostic criteria are accurate for the diagnosis of uveal melanoma. Yet, metastatic disease may be misdiagnosed as a uveal melanoma in rare cases. We report a case of metastatic clear-cell renal cell carcinoma masquerading as uveal melanoma...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344127/mechanisms-of-peritoneal-dissemination-in-gastric-cancer
#19
Feng Sun, Min Feng, Wenxian Guan
Peritoneal dissemination is the most frequent metastatic pattern of gastric cancer, but the mechanisms underlying peritoneal dissemination are yet to be elucidated. Paget's 'seed and soil' hypothesis is recognized as the fundamental theory of metastasis. The 'seeding' theory proposes that the formation of peritoneal dissemination is a multistep process, including detachment from the primary tumour, transmigration and attachment to the distant peritoneum, invasion into subperitoneal tissue and proliferation with blood vascular neogenesis...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343275/early-babesia-canis-transmission-in-dogs-within-24%C3%A2-h-and-8%C3%A2-h-of-infestation-with-infected-pre-activated-male-dermacentor-reticulatus-ticks
#20
Marie Varloud, Julian Liebenberg, Josephus Fourie
BACKGROUND: This study was designed to assess the ability of fed male Dermacentor reticulatus ticks to transmit Babesia canis to dogs after being detached from previous canine or ovine hosts. METHODS: The study was an exploratory, parallel group design conducted in two trials. All the animals were sero-negative for babesiosis prior to enrolment. In a first trial, donor dogs and donor sheep were infested with Babesia canis infected male and uninfected female ticks for 72 h...
January 17, 2018: Parasites & Vectors
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