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https://www.readbyqxmd.com/read/29244002/higher-recall-in-metagenomic-sequence-classification-exploiting-overlapping-reads
#1
Samuele Girotto, Matteo Comin, Cinzia Pizzi
BACKGROUND: In recent years several different fields, such as ecology, medicine and microbiology, have experienced an unprecedented development due to the possibility of direct sequencing of microbioimic samples. Among problems that researchers in the field have to deal with, taxonomic classification of metagenomic reads is one of the most challenging. State of the art methods classify single reads with almost 100% precision. However, very often, the performance in terms of recall falls at about 50%...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243742/corrigendum-a-comprehensive-infrastructure-for-big-data-in-cancer-research-accelerating-cancer-research-and-precision-medicine
#2
Izumi V Hinkson, Tanja M Davidsen, Juli D Klemm, Ishwar Chandramouliswaran, Anthony R Kerlavage, Warren A Kibbe
[This corrects the article on p. 83 in vol. 5, PMID: 28983483.].
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29243558/ex-vivo-and-in-vivo-genome-editing-a-regulatory-scientific-framework-from-early-development-to-clinical-implementation
#3
Houria Bachtarzi
Recent advances in human genome science have paved the way to a new class of human gene therapies based on gene editing, with the potential to provide a long-lasting curative strategy for many debilitating and complex disorders, for which there is an unmet medical need. Therapeutic genome editing encompasses both ex vivo and in vivo gene correction modalities, for which similar and also application-specific considerations apply, which dictate the overall strategy to be followed from a scientific, clinical and regulatory perspective...
December 15, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29243338/a-partially-linear-additive-model-for-clustered-proportion-data
#4
Weihua Zhao, Heng Lian, Dipankar Bandyopadhyay
Proportion data with support lying in the interval [0,1] are a commonplace in various domains of medicine and public health. When these data are available as clusters, it is important to correctly incorporate the within-cluster correlation to improve the estimation efficiency while conducting regression-based risk evaluation. Furthermore, covariates may exhibit a nonlinear relationship with the (proportion) responses while quantifying disease status. As an alternative to various existing classical methods for modeling proportion data (such as augmented Beta regression) that uses maximum likelihood, or generalized estimating equations, we develop a partially linear additive model based on the quadratic inference function...
December 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29240330/regulating-black-box-medicine
#5
W Nicholson Price
Data drive modern medicine. And our tools to analyze those data are growing ever more powerful. As health data are collected in greater and greater amounts, sophisticated algorithms based on those data can drive medical innovation, improve the process of care, and increase efficiency. Those algorithms, however, vary widely in quality. Some are accurate and powerful, while others may be riddled with errors or based on faulty science. When an opaque algorithm recommends an insulin dose to a diabetic patient, how do we know that dose is correct? Patients, providers, and insurers face substantial difficulties in identifying high-quality algorithms; they lack both expertise and proprietary information...
2017: Michigan Law Review
https://www.readbyqxmd.com/read/29239965/videolaryngoscopy-for-physician-based-prehospital-emergency-intubation-a-prospective-randomized-multicenter-comparison-of-different-blade-types-using-a-p-advance-c-mac-system-and-kingvision
#6
Erol Cavus, Sebastian Janssen, Florian Reifferscheid, Amke Caliebe, Andreas Callies, Martin von der Heyden, Peer G Knacke, Volker Doerges
BACKGROUND: Videolaryngoscopy is a valuable technique for endotracheal intubation. When used in the perioperative period, different videolaryngoscopes vary both in terms of technical use and intubation success rates. However, in the prehospital environment, the relative performance of different videolaryngoscopic systems is less well studied. METHODS: We conducted this prospective, randomized, multicenter study at 4 German prehospital emergency medicine centers...
December 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29234856/modified-island-technique-for-prominent-ears
#7
Horacio F Mayer, Hugo D Loustau
There have been several methods described for the correction of prominent ears, including techniques that excise, bend, suture, score, or cut the auricular cartilage. The Island Technique, proposed by Pitanguy, is based on the creation of a cartilage island to define the antihelix and correct the conchoscaphal angle. Visibility of sharp edges has been the main criticism of this technique. To avoid them, we advise performing an internal bevel incision to round off the edges and achieve a more natural look. Also, sometimes prominent ears are asymmetric with different conchoscaphal angles, determining a residual but protruding upper pole, thus requiring different treatment on each side...
December 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29234442/the-association-of-quantitative-facial-color-features-with-cold-pattern-in-traditional-east-asian-medicine
#8
Sujeong Mun, Ilkoo Ahn, Siwoo Lee
Introduction: Facial diagnosis is a major component of the diagnostic method in traditional East Asian medicine. We investigated the association of quantitative facial color features with cold pattern using a fully automated facial color parameterization system. Methods: The facial color parameters of 64 participants were obtained from digital photographs using an automatic color correction and color parameter calculation system. Cold pattern severity was evaluated using a questionnaire...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233408/structured-academic-discussions-through-an-online-education-specific-platform-to-improve-pharm-d-students-learning-outcomes
#9
Srikanth Kolluru, James T Varughese
OBJECTIVE: To facilitate active academic discussions using an online, education-centered platform and reinforce concepts, in order to improve overall course outcomes. MATERIALS AND METHODS: A third year integrated pharmacotherapy course was enrolled on an online searchable platform, Piazza®, to facilitate academic discussions. Students could ask, answer, and explore content, and build on submitted answers in wiki style in collaboration. Instructor posted learning objectives, endorsed student responses with correct answers and led follow-up discussions...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233367/electronic-cigarette-use-knowledge-and-perceptions-among-health-professional-students
#10
Amy M Franks, William A Hawes, Keith R McCain, Nalin Payakachat
INTRODUCTION: Our study evaluated the electronic cigarette (e-cigarette) use, knowledge, and perceptions of health professional students enrolled in one of five colleges at a single academic health center. METHODS: A 56-item survey was conducted to examine the use, knowledge, and perceptions of e-cigarettes among health professional students. An e-cigarette knowledge score was calculated according to correct responses to eight true-false survey items, with possible scores ranging from zero to eight points...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29231801/correction-journal-of-aerosol-medicine-and-pulmonary-drug-delivery-2017-30-1-53-63-doi-10-1089-jamp-2015-1282
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29231178/internal-structure-and-swelling-behaviour-of-i-in-silico-i-microgel-particles
#12
Lorenzo Rovigatti, Nicoletta Gnan, Emanuela Zaccarelli
Microgels are soft colloids that, in virtue of their polymeric nature, can react to external stimuli such as temperature or pH by changing their size. The resulting swelling/deswelling transition can be exploited in fundamental research as well as for many diverse practical applications, ranging from art restoration to medicine. Such an extraordinary versatility stems from the complex internal structure of the individual microgels, each of which is a crosslinked polymer network. Here we employ a recently-introduced computational method to generate realistic microgel configurations and look at their structural properties, both in real and Fourier space, for several temperatures across the volume phase transition as a function of the crosslinker concentration and of the confining radius employed during the ``in-silico'' synthesis...
December 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29230871/prospective-motion-correction-enables-highest-resolution-time-of-flight-angiography-at-7t
#13
Hendrik Mattern, Alessandro Sciarra, Frank Godenschweger, Daniel Stucht, Falk Lüsebrink, Georg Rose, Oliver Speck
PURPOSE: Higher magnetic field strengths enable time-of-flight (TOF) angiography with higher resolution to depict small-vessel pathologies. However, this potential is limited by the subject's ability to remain motionless. Even small-scale, involuntary motion can degrade vessel depiction, thus limiting the effective resolution. The aim of this study was to overcome this resolution limit by deploying prospectively motion-corrected (PMC) TOF. METHODS: An optical, marker-based, in-bore tracking system was used to update the imaging volume prospectively according to the subject's head motion...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29230656/development-of-gate-monte-carlo-simulation-for-a-csi-pixelated-gamma-camera-dedicated-to-high-resolution-animal-spect
#14
Payvand Taherparvar, Alireza Sadremomtaz
GATE is currently considered in scintigraphic imaging as a powerful tool to develop, design and optimize nuclear medicine modalities. This paper describes the GATE simulation of a pixelated gamma camera which is dedicated to high resolution of small animals imaging. It consists of a CsI(Na) crystal array coupled to position sensitive photomultiplier tube. The simulation model includes photon tracking through low energy high resolution hexagonal parallel holes collimator, CsI(Na) pixelated crystal, back-compartment, and camera shielding...
December 11, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29230023/pharmacogenetics-predictors-of-methylphenidate-efficacy-in-childhood-adhd
#15
N M Myer, J R Boland, S V Faraone
Stimulant medication has long been effective in treating attention-deficit/hyperactivity disorder (ADHD) and is currently the first-line pharmacological treatment for children. Both methylphenidate and amphetamine modulate extracellular catecholamine levels through interaction with dopaminergic, adrenergic and serotonergic system components; it is therefore likely that catecholaminergic molecular components influence the effects of ADHD treatment. Using meta-analysis, we sought to identify predictors of pharmacotherapy to further the clinical implementation of personalized medicine...
December 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29227257/world-and-national-experience-in-organization-of-prevention-of-cardiovascular-diseases
#16
А Biduchak, Zh Chornenka
The aim of the study was to examine the global, European and national experience in the implementation of preventive programs and to reveal their value in health, economy and social health development. The conducted research has found that the implementation of the national program, the correct methodological approach of the physician to evaluate risk factors, and implementing preventive measures of diseases of the circulatory system bring positive results (reduction of prevalence and incidence of cerebral stroke by 13,7% and 1,4%, respectively)...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29224269/-surgical-treatment-and-early-mid-follow-up-results-of-complete-atrioventricular-septal
#17
H J Cui, J Zhuang, J M Chen, J Z Cen, G Xu, S S Wen
Objective: To discuss the surgical treatment and early-mid follow-up results of complete atrioventricular septal defect (CAVSD). Methods: The clinic data of 235 cases of CAVSD underwent surgical treatment at Department of Cardiac Surgery, Guangdong General Hospital from June 2009 to June 2016 was analyzed retrospectively (104 male and 131 female patients). The patients were aged 18 days to 58 years (mid age 8.9 months) at surgery, and 2 cases of newborns (0.9%), 24 cases of 1 to 3 months (10.2%), 56 cases of 4 to 6 months (23...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29222708/correction-to-effect-of-renal-transplantation-on-cognitive-function-in-hemodialysis-patients-a-longitudinal-study
#18
Yogesh K Chhabra, Sanjay Sood, Omprakash Rathi, Sandeep Mahajan
In the original publication, the second author's affiliation was incorrectly published as "Department of Physiology, RAK College of Medical Sciences, Ras Al Khaimah, UAE". The correct affiliation should read as "Visiting Academic, Basic Medical Sciences Department, College of Medicine, University of Sharjah (UAE)".
December 8, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29218815/prospective-systemic-risk-analysis-of-the-dispensing-process-in-german-community-pharmacies
#19
Tatjana Stojković, Olaf Rose, Ronja Woltersdorf, Valentina Marinković, Tanja Manser, Ulrich Jaehde
BACKGROUND: Medicine dispensing represents an error-prone activity, carrying a considerable risk for patients. OBJECTIVE: To prospectively identify and prioritize potential failure modes in the medicine dispensing process as well as to develop corrective actions for patient safety improvement in German community pharmacies. METHOD: Failure mode and effects analysis was performed in 2 community pharmacies in North Rhine-Westphalia, Germany, in October 2016...
December 7, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29218605/oxymatrine-sensitizes-the-hacat-cells-to-the-ifn-%C3%AE-pathway-and-downregulates-mdc-icam-1-and-socs1-by-activating-p38-jnk-and-akt
#20
Chun-Jie Gao, Pei-Jun Ding, Li-Li Yang, Xu-Feng He, Meng-Jiao Chen, Dong-Ming Wang, Yan-Xin Tian, Hui-Min Zhang
Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. Activation of the IFN-γ and its downstream interleukin-12 (IL-12) pathway can correct these diseases. Suppressor of cytokine signaling 1 (SOCS1) is a cytokine signaling inhibitor that blocks downstream pathways of IFN-γ by blocking the mitogen-activated protein kinase (MAPK) and protein kinase B (Akt) signaling pathways...
December 7, 2017: Inflammation
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