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https://www.readbyqxmd.com/read/29151199/loneliness-in-older-adults-living-with-hiv
#1
Meredith Greene, Nancy A Hessol, Carla Perissinotto, Roland Zepf, Amanda Hutton Parrott, Cameron Foreman, Robert Whirry, Monica Gandhi, Malcolm John
We conducted a cross-sectional study among HIV-positive adults age ≥ 50 in San Francisco to evaluate the frequency of loneliness, characteristics of those who reported loneliness, and the association of loneliness with functional impairment and health-related quality of life (HRQoL). Participants (N = 356) were predominately male (85%); 57% were white; median age was 56. 58% reported any loneliness symptoms with 24% reporting mild, 22% moderate and 12% severe loneliness. Lonely participants were more likely to report depression, alcohol and tobacco use, and have fewer relationships...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29151177/mechanisms-of-drought-induced-dissipation-of-excitation-energy-in-sun-and-shade-adapted-drought-tolerant-mosses-studied-by-fluorescence-yield-change-and-global-and-target-analysis-of-fluorescence-decay-kinetics
#2
Hisanori Yamakawa, Ivo H M van Stokkum, Ulrich Heber, Shigeru Itoh
Some mosses stay green and survive long even under desiccation. Dissipation mechanisms of excess excitation energy were studied in two drought-tolerant moss species adapted to contrasting niches: shade-adapted Rhytidiadelphus squarrosus and sun-adapted Rhytidium rugosum in the same family. (1) Under wet conditions, a light-induced nonphotochemical quenching (NPQ) mechanism decreased the yield of photosystem II (PSII) fluorescence in both species. The NPQ extent saturated at a lower illumination intensity in R...
November 18, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29151048/early-vasopressor-use-following-traumatic-injury-a-systematic-review
#3
Mathieu Hylands, Augustin Toma, Nicolas Beaudoin, Anne Julie Frenette, Frédérick D'Aragon, Émilie Belley-Côté, Emmanuel Charbonney, Morten Hylander Møller, Jon Henrik Laake, Per Olav Vandvik, Reed Alexander Siemieniuk, Bram Rochwerg, François Lauzier, Robert S Green, Ian Ball, Damon Scales, Srinivas Murthy, Joey S W Kwong, Gordon Guyatt, Sandro Rizoli, Pierre Asfar, François Lamontagne
OBJECTIVES: Current guidelines suggest limiting the use of vasopressors following traumatic injury; however, wide variations in practice exist. Although excessive vasoconstriction may be harmful, these agents may help reduce administration of potentially harmful resuscitation fluids. This systematic review aims to compare early vasopressor use to standard resuscitation in adults with trauma-induced shock. DESIGN: Systematic review. DATA SOURCES: We searched MEDLINE, EMBASE, ClinicalTrials...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150994/combating-the-spread-of-ineffective-medical-procedures-a-lesson-learned-from-multiple-sclerosis
#4
Ari J Green, Hooman Kamel, S Andrew Josephson
No abstract text is available yet for this article.
November 18, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29150930/photoautotrophic-production-of-macular-pigment-in-a-chlamydomonas-reinhardtii-strain-generated-by-using-dna-free-crispr-cas9-rnp-mediated-mutagenesis
#5
Kwangryul Baek, Jihyeon Yu, Jooyeon Jeong, Sang Jun Sim, Sangsu Bae, EonSeon Jin
Lutein and zeaxanthin are dietary carotenoids reported to be protective against age-related macular degeneration. Recently, the green alga Chlamydomonas reinhardtii has received attention as a photosynthetic cell factory, but the potential of this alga for carotenoid production has not yet been evaluated. In this study, we selected the C. reinhardtii CC-4349 strain as the best candidate among seven laboratory strains tested for carotenoid production. A knock-out mutant of the zeaxanthin epoxidase gene induced by preassembled DNA-free CRISPR-Cas9 ribonucleoproteins in the CC-4349 strain had a significantly higher zeaxanthin content (56-fold) and productivity (47-fold) than the wild type without the reduction in lutein level...
November 18, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29150895/rapid-and-green-determination-of-58-fragrance-allergens-in-plush-toys
#6
Zhijuan Wang, Qing Zhang, Haiyu Li, Qing Lv, Wan Wang, Hua Bai
This paper presents a simple, rapid, and green method based on a static headspace gas chromatography with mass spectrometry for determining 58 fragrance allergens in plush toys. This study is the first to meet the requirement for simultaneously determining 66 fragrances, except for eight natural extracts restricted by the European Toy Safety Directive 2009/48/EC. A minimal amount of sample (20 mg) and acetone solvent (20 μL) were placed in a headspace vial. A gas-solid equilibration of fragrances between the headspace and the sample was achieved within 10 min under the vapor atmosphere of acetone at 200°C, which allowed the fragrances in the sample to be measured by gas chromatography with mass spectrometry...
November 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29150738/the-autism-family-experience-questionnaire-afeq-an-ecologically-valid-parent-nominated-measure-of-family-experience-quality-of-life-and-prioritised-outcomes-for-early-intervention
#7
Kathy Leadbitter, Catherine Aldred, Helen McConachie, Ann Le Couteur, Dharmi Kapadia, Tony Charman, Wendy Macdonald, Erica Salomone, Richard Emsley, Jonathan Green
There is a lack of measures that reflect the intervention priorities of parents of children with autism spectrum disorder (ASD) and that assess the impact of interventions on family experience and quality of life. The Autism Family Experience Questionnaire (AFEQ) was developed through focus groups and online consultation with parents, and reflected parental priorities. It was then administered to the parents of children enrolled in the Pre-school Autism Communication Trial and its 6-year follow-up study. The AFEQ showed good convergent validity with well-established measures of child adaptive functioning, parental mental health and parental wellbeing...
November 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29150635/one-pot-synthesis-of-trifunctional-chitosan-edta-%C3%AE-cyclodextrin-polymer-for-simultaneous-removal-of-metals-and-organic-micropollutants
#8
Feiping Zhao, Eveliina Repo, Dulin Yin, Li Chen, Simo Kalliola, Juntao Tang, Evgenia Iakovleva, Kam Chiu Tam, Mika Sillanpää
The global contamination of water resources with inorganic and organic micropollutants, such as metals and pharmaceuticals, poses a critical threat to the environment and human health. Herein, we report on a bio-derived chitosan-EDTA-β-cyclodextrin (CS-ED-CD) trifunctional adsorbent fabricated via a facile and green one-pot synthesis method using EDTA as a cross-linker, for the adsorption of toxic metals and organic micropollutants from wastewater. In this system, chitosan chain is considered as the backbone, and the immobilized cyclodextrin cavities capture the organic compounds via host-guest inclusion complexation, while EDTA-groups complex metals...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150611/uplift-of-the-central-transantarctic-mountains
#9
Phil Wannamaker, Graham Hill, John Stodt, Virginie Maris, Yasuo Ogawa, Kate Selway, Goran Boren, Edward Bertrand, Daniel Uhlmann, Bridget Ayling, A Marie Green, Daniel Feucht
The Transantarctic Mountains (TAM) are the world's longest rift shoulder but the source of their high elevation is enigmatic. To discriminate the importance of mechanical vs. thermal sources of support, a 550 km-long transect of magnetotelluric geophysical soundings spanning the central TAM was acquired. These data reveal a lithosphere of high electrical resistivity to at least 150 km depth, implying a cold stable state well into the upper mantle. Here we find that the central TAM most likely are elevated by a non-thermal, flexural cantilever mechanism which is perhaps the most clearly expressed example anywhere...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29150562/the-role-of-mhc-e-in-t-cell-immunity-is-conserved-among-humans-rhesus-macaques-and-cynomolgus-macaques
#10
Helen L Wu, Roger W Wiseman, Colette M Hughes, Gabriela M Webb, Shaheed A Abdulhaqq, Benjamin N Bimber, Katherine B Hammond, Jason S Reed, Lina Gao, Benjamin J Burwitz, Justin M Greene, Fidel Ferrer, Alfred W Legasse, Michael K Axthelm, Byung S Park, Simon Brackenridge, Nicholas J Maness, Andrew J McMichael, Louis J Picker, David H O'Connor, Scott G Hansen, Jonah B Sacha
MHC-E is a highly conserved nonclassical MHC class Ib molecule that predominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell regulation. However, MHC-E also binds pathogen-derived peptide Ags for presentation to CD8(+) T cells. Given this role in adaptive immunity and its highly monomorphic nature in the human population, HLA-E is an attractive target for novel vaccine and immunotherapeutic modalities. Development of HLA-E-targeted therapies will require a physiologically relevant animal model that recapitulates HLA-E-restricted T cell biology...
November 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150516/drna-seq-implicates-sulfide-as-master-regulator-of-s-0-metabolism-in-chlorobaculum-tepidum-and-other-green-sulfur-bacteria
#11
Jacob M Hilzinger, Vidhyavathi Raman, Kevin E Shuman, Brian J Eddie, Thomas E Hanson
The green sulfur bacteria (Chlorobiaceae) are anaerobes that use electrons from reduced sulfur compounds (sulfide, S(0), and thiosulfate) as electron donors for photoautotrophic growth. Chlorobaculum tepidum, the model system for the Chlorobiaceae, both produces and consumes extracellular S(0) globules depending on the availability of sulfide in the environment. These physiological changes imply significant changes in gene regulation, which has been observed when sulfide is added to Cba. tepidum growing on thiosulfate...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150423/including-children-and-young-people-in-assessments-a-practical-guide
#12
Lydia M C Green, Amanda J Friend, Rebecca J M Bardgett, Jonathan C Darling
The ability to interact with children and young people (CYP), appropriately examine and competently interpret signs is an essential skill for many medical practitioners and allied healthcare professionals; yet, how do we ensure competence in our students and trainees? One method is to include CYP in both formative and summative assessments; this provides an invaluable opportunity for examiners not only to evaluate the clinical interaction but also to gain an understanding of the CYP experience and what characteristics they value in a 'good children's doctor'...
November 17, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29150378/enhanced-antibacterial-effects-of-green-synthesized-zno-nps-using-aristolochia-indica-against-multi-drug-resistant-bacterial-pathogens-from-diabetic-foot-ulcer
#13
Katherin Steffy, G Shanthi, Anson S Maroky, S Selvakumar
BACKGROUND: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India. METHODS: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value...
November 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29150258/a-spent-coffee-grounds-based-biorefinery-for-the-production-of-biofuels-biopolymers-antioxidants-and-biocomposites
#14
REVIEW
Sanjib Kumar Karmee
Spent coffee grounds are composed of lipid, carbohydrates, carbonaceous, and nitrogen containing compounds among others. Using n-hexane and n-hexane/isopropanol mixture highest oil yield was achived during soxhlet extraction of oil from spent coffee grounds. Alternatively, supercritical carbon dioxide can be employed as a green solvent for the extraction of oil. Using advanced chemical and biotechnological methods, spent coffee grounds are converted to various biofuels such as, biodiesel, renewable diesel, bioethanol, bioethers, bio-oil, biochar, and biogas...
November 14, 2017: Waste Management
https://www.readbyqxmd.com/read/29150257/utilization-of-organic-residues-using-heterotrophic-microalgae-and-insects
#15
REVIEW
Daniel Pleissner, Birgit A Rumpold
Various organic residues occur globally in the form of straw, wood, green biomass, food waste, feces, manure etc. Other utilization strategies apart from anaerobic digestion, composting and incineration are needed to make use of the whole potential of organic residues as sources of various value added compounds. This review compares the cultivation of heterotrophic microalgae and insects using organic residues as nutrient sources and illuminates their potential with regard to biomass production, productivity and yield, and utilization strategies of produced biomasses...
November 14, 2017: Waste Management
https://www.readbyqxmd.com/read/29150081/turning-over-a-new-leaf-bacteriocins-going-green
#16
Maarten G K Ghequire, René De Mot
Bacteriocins are potent antibacterial proteins that selectively kill phylogenetic relatives of the producer. Their polymorphic nature, most prominent in γ-Proteobacteria, offers potential for the design of customized bacteriocin cocktails targeting Gram-negative pathogens. As an alternative to recombinant production in bacteria, they are eligible for large-scale production in plants.
November 14, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29149913/subadditive-responses-to-extremely-short-blue-and-green-pulsed-light-on-visual-evoked-potentials-pupillary-constriction-and-electroretinograms
#17
Soomin Lee, Yuria Uchiyama, Yoshihiro Shimomura, Tetsuo Katsuura
BACKGROUND: The simultaneous exposure to blue and green light was reported to result in less melatonin suppression than monochromatic exposure to blue or green light. Here, we conducted an experiment using extremely short blue- and green-pulsed light to examine their visual and nonvisual effects on visual evoked potentials (VEPs), pupillary constriction, electroretinograms (ERGs), and subjective evaluations. METHODS: Twelve adult male subjects were exposed to three light conditions: blue-pulsed light (2...
November 17, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/29149898/detection-of-plasmodium-falciparum-male-and-female-gametocytes-and-determination-of-parasite-sex-ratio-in-human-endemic-populations-by-novel-cheap-and-robust-rtqpcr-assays
#18
Federica Santolamazza, Pamela Avellino, Giulia Siciliano, Franck Adama Yao, Fabrizio Lombardo, Jean Bosco Ouédraogo, David Modiano, Pietro Alano, Valentina Dianora Mangano
BACKGROUND: The presence of Plasmodium falciparum gametocytes in peripheral blood is essential for human to mosquito parasite transmission. The detection of submicroscopic infections with gametocytes and the estimation of the gametocyte sex ratio are crucial to assess the human host potential ability to infect mosquitoes and transmit malaria parasites. AIM AND OBJECTIVES: The aim of this work was to develop sensitive and cheap Real Time qPCR assays for large-scale epidemiological surveys, based on detection and amplification of gametocyte sex specific transcripts selected from the literature: the female-specific pfs25 and pf glycerol kinase (pfGK) and the male-specific pfs230p and pf13 transcripts...
November 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29149781/macrophages-from-behcet-s-disease-patients-express-decreased-level-of-aryl-hydrocarbon-receptor-ahr-mrna
#19
Mohammad Taghi Palizgir, Maryam Akhtari, Mahdi Mahmoudi, Shayan Mostafaei, Alireza Rezaeimanesh, Massoomeh Akhlaghi, Farhad Shahram
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, connecting environmental stimulators with the immune system. M1 macrophages are a part of immune system that contribute to the inflammatory events in the pathogenesis of Behcet's disease (BD). The effect of AHR on the macrophages in BD patients is still unclear. In this study, we investigated the mRNA expression of AHR in the monocyte-derived and M1 macrophages in active BD patients in comparison to healthy controls. Isolated monocytes from 10 healthy controls and 10 active BD patients were differentiated to macrophages by macrophage-colony stimulating factor (M-CSF) for 7 days...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29149679/innovative-urban-forestry-governance-in-melbourne-investigating-green-placemaking-as-a-nature-based-solution
#20
Natalie Marie Gulsrud, Kelly Hertzog, Ian Shears
A nature-based approach to climate resilience aims to challenge and re-frame conventional environmental management methods by refocusing solutions from technological strategies to socio-ecological principles such as human well-being and community-based governance models, thereby improving and legitimizing the delivery of ecosystem services (ES). There are, however, many challenges to applying a socio-ecological agenda to urban climate resilience and thereby re-framing ES delivery as community and people focused, a knowledge gap extensively outlined in the environmental governance literature...
November 14, 2017: Environmental Research
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