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https://www.readbyqxmd.com/read/27905344/concurrent-retinitis-pigmentosa-and-pigmented-paravenous-retinochoroidal-atrophy-phenotypes-in-the-same-patient
#1
Dhanashree Ratra, Dhileesh P Chandrasekharan, P Aruldas, Vineet Ratra
We report a unique case of a patient with retinitis pigmentosa (RP) phenotype in one eye and pigmented paravenous retinochoroidal atrophy (PPRCA) phenotype in the other eye. We describe in detail the symptoms, clinical findings, and investigations done for a 32-year-old Indian woman. This patient had phenotypical picture resembling typical RP in the right eye, with characteristic symptoms of night blindness and constricted field of vision and a nonrecordable electroretinogram (ERG). The left eye of the same patient revealed typical PPRCA phenotype, with no night blindness, normal field, and normal ERG...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27899086/closantel-a-veterinary-drug-with-potential-severe-morbidity-in-humans
#2
Seyed Ali Tabatabaei, Mohammad Soleimani, Mohammad Reza Mansouri, Ahmad Mirshahi, Bahman Inanlou, Mojtaba Abrishami, Ahmad Reza Pakrah, Hamideh Masarat
BACKGROUND: Closantel is a halogenated salicylanilide with a potent anti parasitic activity. It is widely used in management of parasitic infestation in animals, but is contraindicated in humans. CASE PRESENTATION: A 34-year-old man with depression was referred to our center with progressive loss of vision in both eyes 10 days after unintentional ingestion of three 500 mg tablets of Closantel. On fundus examination, left optic disc margin was blurred. His bilateral visual acuity was no light perception (NLP) despite prescribed IV erythropoietin injections 20,000 units daily for 3 days and 1gr intravenous methylprednisolone acetate for 3 days followed by 1 mg/kg oral prednisolone...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27898981/macular-features-in-retinitis-pigmentosa-correlations-among-ganglion-cell-complex-thickness-capillary-density-and-macular-function
#3
Lisa Toto, Enrico Borrelli, Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Paolo Carpineto, Leonardo Mastropasqua
Purpose: To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). Methods: Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG)...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27893096/chemogenetic-activation-of-iprgcs-drives-changes-in-dark-adapted-scotopic-electroretinogram
#4
Nina Milosavljevic, Annette E Allen, Jasmina Cehajic-Kapetanovic, Robert J Lucas
Purpose: The purpose of this study was to investigate the impact of activating melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) on dark-adapted (scotopic) electroretinograms (ERG). Methods: We used mice (Opn4Cre/+) expressing cre recombinase in melanopsin-expressing cells for a targeted gene delivery of a chemogenetic Gq-coupled receptor, hM3Dq, to ipRGCs. Intraperitoneal injection of clozapine N-oxide (CNO) at 5 mg/kg was used for acute activation of hM3Dq and thus excitation of ipRGCs in darkness...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27881907/retinal-safety-of-intravitreal-rtpa-in-healthy-rats-and-under-excitotoxic-conditions
#5
Alejandra Daruich, Jérôme Parcq, Kimberley Delaunay, Marie-Christine Naud, Quentin Le Rouzic, Emilie Picard, Patricia Crisanti, Denis Vivien, Marianne Berdugo, Francine Behar-Cohen
PURPOSE: Intravitreal recombinant tissue plasminogen activator (rtPA) is used off-label for the surgical management of submacular hemorrhage, a severe complication of neovascular age-related macular degeneration. rtPA is approved for coronary and cerebral thrombolysis. However, in ischemic stroke rtPA is known to increase excitotoxic neural cell death by interacting with the N-methyl-D-aspartate (NMDA) receptor. We therefore investigated the retinal toxicity of rtPA in healthy rats and in a model of NMDA-induced retinal excitotoxicity...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27870802/intravitreal-infliximab-in-refractory-uveitis-in-behcet-s-disease-a-safety-and-efficacy-clinical-study
#6
Mostafa M E Hamza, Tamer A Macky, Mohamed Karim Sidky, Gaafar Ragab, Mahmoud M Soliman
PURPOSE: To assess the safety and efficacy of intravitreal infliximab (1 mg/0.05 mL) in patients with refractory posterior uveitis in Behcet's disease. METHODS: Twenty patients were included in this study. Best corrected visual acuity (BCVA), vitreous haze (graded 0-4), vasculitis, retinitis, and papillopathy (presence or absence) were assessed at baseline, Day 1 and Week 2, 4, 6, 8, 12, and 18. Optical coherence tomography (OCT) central foveal thickness, fluorescein angiography, and flash electroretinogram were done at baseline and 4, 12, and 18 weeks...
December 2016: Retina
https://www.readbyqxmd.com/read/27862073/n-methyl-n-nitrosourea-induces-retinal-degeneration-in-the-rat-via-the-inhibition-of-nf-%C3%AE%C2%BAb-activation
#7
Yu Xiong, Hong-Pei Ji, Wei-Tao Song, Ye-Wei Yin, Chao-Hua Xia, Bei Xu, Yi Xu, Xiao-Bo Xia
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration. Adult rats received a single intraperitoneal injection of MNU (60 mg/kg bodyweight). Hematoxylin and eosin staining demonstrated progressive outer nuclear layer (ONL) loss after MNU treatment...
November 13, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27843226/validity-and-cost-effectiveness-of-cone-adaptation-test-as-a-screening-tool-to-detect-retinitis-pigmentosa
#8
Rahul Deshpande, Prajakta Save, Madan Deshpande, Mahadev Shegunashi, Marium Chougule, Rajiv Khandekar
BACKGROUND: The cone adaptation test is to detect retinitis pigmentosa (RP) cases confirmed by electroretinogram (ERG). We present the validity and cost-effectiveness of cone adaptation test as a screening tool for detecting RP. METHODS: This cross-sectional study was conducted between November 2013 and December 2013. All RP cases diagnosed by ophthalmologists of H. V. Desai Eye Hospital in the last 5 years were participated in this study. The cone adaptation test was done in photopic and scotopic illumination...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27833968/posterior-vitreous-detachment-and-macular-anatomical-changes-a-tomographic-electroretinographic-study
#9
Alin Ştefan Ştefănescu-Dima, Cornelia Andreea Corîci, Maria Rodica Mănescu, Teodor Nicuşor Sas, Maria Iancău, Carmen LuminiŢa Mocanu
AIM: Posterior vitreous detachment (PVD) is a physiological phenomenon due to aging characterized by separation of the vitreous cortex from the retina and may induce a variety of pathological events at the vitreoretinal junction. The aim of this study is to highlight in vivo anatomical and functional changes in early stages of PVD allowing the correct treatment. MATERIAL AND METHODS: Non-consecutive case series; optical coherence tomography (OCT) relies on analyzing the reflectivity of coherent light from different anatomical interfaces within posterior vitreous and retinal histological layers, thus acquiring transverse sections through vitreoretinal interface, sensory retina, retinal pigment epithelium and choroid...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27831552/knockout-of-ccr2-alleviates-photoreceptor-cell-death-in-rodent-retina-exposed-to-chronic-blue-light
#10
Zizhong Hu, Yi Zhang, Junling Wang, Pingan Mao, Xuehua Lv, Songtao Yuan, Zhengru Huang, Yuzhi Ding, Ping Xie, Qinghuai Liu
Age-related macular degeneration (AMD), the leading cause of visual loss after the age of 60 years, is a degenerative retinal disease involving a variety of environmental and hereditary factors. Although it has been implicated that immune system is involved in the disease progression, the exact role that microglia has is still unclear. Here we demonstrated that knockout of Ccr2 gene could alleviate photoreceptor cell death in mice retinas exposed to chronic blue light. In Ccr2(-/-) mice, a damaged microglia recruitment was shown in retina and this could protect the visual function in electroretinogram and alleviate the photoreceptor apoptosis, which thus helped attenuate the blue light-induced retinopathy...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27820927/south-american-weakly-electric-fish-gymnotiformes-are-long-wavelength-sensitive-cone-monochromats
#11
Da-Wei Liu, Ying Lu, Hong Young Yan, Harold H Zakon
Losses of cone opsin genes are noted in animals that are nocturnal or rely on senses other than vision. We investigated the cone opsin repertoire of night-active South American weakly electric fish. We obtained opsin gene sequences from genomic DNA of 3 gymnotiforms (Eigenmannia virescens, Sternopygus macrurus, Apteronotus albifrons) and the assembled genome of the electric eel (Electrophorus electricus). We identified genes for long-wavelength-sensitive (LWS) and medium-wavelength-sensitive cone opsins (RH2) and rod opsins (RH1)...
November 8, 2016: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/27820752/electronegative-electroretinogram-in-achromatopsia
#12
Craig S Schallhorn, David B Granet, Henry A Ferreyra
PURPOSE: To report novel electroretinographic findings in a genetically confirmed case of achromatopsia. METHODS: A patient with a history of childhood nystagmus, photoaversion, and absent color vision was examined. Electroretinography and fundus examination were performed under anesthesia at the time of corrective surgery for nystagmus. Genomic DNA isolated from peripheral blood was directly sequenced for variations in the CNGA3 and CNGB3 genes. RESULTS: Ophthalmoscopic examination revealed no distinct abnormalities...
November 3, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27803852/therapeutic-effects-of-mesenchymal-stem-cells-administered-at-later-phase-of-recurrent-experimental-autoimmune-uveitis
#13
Ping-Ting Zhao, Ling-Jun Zhang, Hui Shao, Ling-Ling Bai, Bo Yu, Chang Su, Li-Jie Dong, Xun Liu, Xiao-Rong Li, Xiao-Min Zhang
AIM: To test the therapeutic effects of delayed treatment of mesenchymal stem cells (MSCs) in recurrent experimental autoimmune uveitis (rEAU). METHODS: The efficacy of different regimens of MSC administration in rEAU were tested by evaluation of clinical and pathological intraocular inflammation, as well as retinal structural and functional integrity using optical coherence tomography (OCT) and electroretinogram (ERG). The retinal sections were also immunostained with antibodies to glial fibrillary acidic protein (GFAP) and rhodopsin (RHO)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800277/objective-determination-of-retinal-function-in-bietti-crystalline-retinopathy
#14
Dorukcan Akıncıoğlu, Ümit Yolcu, Abdullah İlhan, Fatih Çakır Gündoğan
A 44-year-old female patient without any known systemic or ocular disease presented with progressive visual loss and night vision disturbance. Visual acuity was 0.6 in the right eye and 0.2 in the left eye. Tiny, yellow crystalline deposits were seen on fundus examination. In addition, areas of retinal pigment epithelium and choriocapillaris atrophy were detected. Rod and cone responses were depressed in full-field flash electroretinogram. Multifocal electroretinogram testing showed severe foveal function disturbance with less severe but still depressed responses toward the periphery...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800268/occult-macular-dystrophy
#15
Işıl Sayman Muslubaş, Serra Arf, Mümin Hocaoğlu, Hakan Özdemir, Murat Karaçorlu
Occult macular dystrophy is an inherited macular dystrophy characterized by a progressive decline of bilateral visual acuity with normal fundus appearance, fluorescein angiogram and full-field electroretinogram. This case report presents a 20-year-old female patient with bilateral progressive decline of visual acuity for six years. Her visual acuity was 3-4/10 in both eyes. Anterior segment and fundus examination, fluorescein angiogram and full-field electroretinogram were normal. She could read all Ishihara pseudoisochromatic plates...
April 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27799745/pathophysiology-of-visual-disorders-induced-by-phosphodiesterase-inhibitors-in-the-treatment-of-erectile-dysfunction
#16
REVIEW
Marilita M Moschos, Eirini Nitoda
AIM: The aim of this review was to summarize the ocular action of the most common phosphodiesterase (PDE) inhibitors used for the treatment of erectile dysfunction and the subsequent visual disorders. METHOD: This is a literature review of several important articles focusing on the pathophysiology of visual disorders induced by PDE inhibitors. RESULTS: PDE inhibitors have been associated with ocular side effects, including changes in color vision and light perception, blurred vision, transient alterations in electroretinogram (ERG), conjunctival hyperemia, ocular pain, and photophobia...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27799733/steady-state-pattern-electroretinogram-and-frequency-doubling-technology-in-anisometropic-amblyopia
#17
Costantino Schiavi, Filippo Tassi, Alessandro Finzi, Ernesto Strobbe, Mauro Cellini
BACKGROUND: Steady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes. METHODS: Fifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT. RESULTS: The amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27799729/single-flash-electroretinograms-of-mature-cataractous-and-fellow-eyes
#18
Yasuyuki Yamauchi, Jun-Ichi Mochizuki, Akito Hirakata, Shigekazu Uda
BACKGROUND: It is generally stated that opacities of the ocular media, including senile cataract, have little effect on the electrical responses of the retina. However, lower amplitudes and longer implicit times are sometimes observed in electroretinograms (ERGs) of patients with mature cataract. METHODS: Single flash ERGs of mature cataractous eyes with decimal visual acuity less than 0.1 were compared with those of the fellow eyes with decimal visual acuity better than 0...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27793487/unilateral-retinitis-pigmentosa-a-case-report
#19
C Nazar, M Feldman, R González, R Espinoza
CLINICAL CASE: A 27-year-old woman with a history of nyctalopia and constriction of visual field of the right eye. The ophthalmological examination showed a visual field and electroretinogram that were compatible with unilateral retinitis pigmentosa (RP). After a one year follow-up, the unilateral condition remained. DISCUSSION: Unilateral retinitis pigmentosa is a rare condition, with a frequency between 0.2%-5% of the RP. It mainly affects women and older age groups than bilateral RP...
October 25, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27792813/asymmetrical-functional-deficits-of-on-and-off-retinal-processing-in-the-mdx3cv-mouse-model-of-duchenne-muscular-dystrophy
#20
Tina I Tsai, Mirella Telles Salgueiro Barboni, Balázs Vince Nagy, Michel J Roux, Alvaro Rendon, Dora Fix Ventura, Jan Kremers
Purpose: The dystrophin mouse mutant mdx3Cv exhibits scotopic electroretinograpic (ERG) abnormalities, which resemble clinical changes observed in Duchenne muscular dystrophy (DMD) patients. In the present study, ERGs obtained from mdx3Cv and their wild-type littermates under scotopic, mesopic, and photopic conditions were analyzed to provide further insight on the affected retinal pathways, and to compare them with human data. Methods: Electroretinograms of mdx3Cv (n = 9) and age-matched C57BL/6J mice (n = 10) included the scotopic full-field flash (for outer retinal deficits in rod pathway), scotopic threshold response (for inner retinal integrity), photopic flash, sinusoidal flicker (for outer retinal deficits in cone pathway), mesopic rapid-on/-off sawtooth flicker, and photopic long-duration flash measurements (for separate ON-/OFF-responses under different conditions)...
October 1, 2016: Investigative Ophthalmology & Visual Science
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