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https://www.readbyqxmd.com/read/28524835/collapsin-response-mediator-protein-2-induced-retinal-ischemic-injury-in-a-novel-mice-model-of-ocular-ischemia-syndrome
#1
Yu Wang, Xiao-Lei Wang, Guo-Li Xie, Hong-Yang Li, Yan-Ling Wang
BACKGROUND: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury. We determined whether CRMP2 modulates ischemic injury in the retinal of Ocular ischemic syndrome (OIS). This study was to explore the molecular mechanisms underlying OIS in a novel mice model. METHODS: Experiments were performed on adult male C57/BL6 mice that received bilateral internal carotid arteries ligation for 1, 2, or 4 weeks. The mice received injection of calpeptin group before occlusion for 4 weeks or not...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28524150/-functional-examinations-of-visual-channels-clinical-aspects
#2
M V Zueva, I V Tsapenko, E P Lantukh, N M Maglakelidze
The review discusses literature data on the clinical relevance of functional assessment of magno- (M), parvo- (P), and koniocellular (K) pathways. It also covers the differential contribution of the M, P, and K channels to visual impairments and how it determines the prognosis, early diagnosis, and treatment choice in patients with neurodegenerative diseases of the retina and brain. Selective changes in the performance of the visual channels are investigated by the example of glaucoma and optic neuritis in multiple sclerosis (MS) patients...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28523457/retinal-pigmentary-changes-in-chronic-uveitis-mimicking-retinitis-pigmentosa
#3
D Damla Sevgi, Samaneh Davoudi, Jason Comander, Lucia Sobrin
PURPOSE: To present retinal pigmentary changes mimicking retinitis pigmentosa (RP) as a finding of advanced uveitis. METHODS: We retrospectively reviewed charts of patients without a family history of inherited retinal degenerations who presented with retinal pigment changes and signs of past or present intraocular inflammation. Comprehensive eye examination including best-corrected visual acuity, slit-lamp examination and dilated fundus examination was performed on all patients in addition to color fundus photography, optical coherence tomography, fluorescein angiography (FA), and full-field electroretinogram testing...
May 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28516000/role-of-a-dual-splicing-and-amino-acid-code-in-myopia-cone-dysfunction-and-cone-dystrophy-associated-with-l-m-opsin-interchange-mutations
#4
Scott H Greenwald, James A Kuchenbecker, Jessica S Rowlan, Jay Neitz, Maureen Neitz
PURPOSE: Human long (L) and middle (M) wavelength cone opsin genes are highly variable due to intermixing. Two L/M cone opsin interchange mutants, designated LIAVA and LVAVA, are associated with clinical diagnoses, including red-green color vision deficiency, blue cone monochromacy, cone degeneration, myopia, and Bornholm Eye Disease. Because the protein and splicing codes are carried by the same nucleotides, intermixing L and M genes can cause disease by affecting protein structure and splicing...
May 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28513254/peripapillary-sparing-in-rdh12-associated-leber-congenital-amaurosis
#5
Aakriti Garg, Winston Lee, Jesse D Sengillo, Rando Allikmets, Kartik Garg, Stephen H Tsang
BACKGROUND: Peripapillary sparing is a characteristic that is traditionally described as pathognomonic for Stargardt disease. MATERIALS AND METHODS: We present a multimodal assessment of four Leber congenital amaurosis (LCA) cases with congenital macular atrophy and severely attenuated electroretinogram findings caused by bilallelic mutations in RDH12. RESULTS: Fundus autofluorescence imaging revealed a general loss of retinal pigment epithelium across the macula except for the peripapillary region in both eyes of all patients...
May 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28512427/long-term-clinical-course-in-a-patient-with-complete-congenital-stationary-night-blindness
#6
Kentaro Kurata, Katsuhiro Hosono, Yoshihiro Hotta
BACKGROUND: This report describes a 45-year-old man with complete congenital stationary night blindness (CSNB1) who has been followed up for 38 years. CASE: The patient first visited our hospital as a 7-year-old boy with a complaint of low visual acuity. Best corrected visual acuity (BCVA) was 0.5 in the right eye and 0.6 in the left eye. The refractive error was approximately -5.0 D in both eyes. The fundus showed only myopic changes. A bright-flash electroretinogram (ERG) revealed a negative configuration...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28508299/intensity-response-function-of-the-photopic-negative-response-phnr-effect-of-age-and-test-retest-reliability
#7
Nabin R Joshi, Emma Ly, Suresh Viswanathan
PURPOSE: To assess the effect of age and test-retest reliability of the intensity response function of the full-field photopic negative response (PhNR) in normal healthy human subjects. METHODS: Full-field electroretinograms (ERGs) were recorded from one eye of 45 subjects, and 39 of these subjects were tested on two separate days with a Diagnosys Espion System (Lowell, MA, USA). The visual stimuli consisted of brief (<5 ms) red flashes ranging from 0.00625 to 6...
May 15, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28504202/corrigendum-to-the-rod-driven-a-wave-of-the-dark-adapted-mammalian-electroretinogram-progress-in-retinal-and-eye-research-volume-39-march-2014-pages-1-22
#8
REVIEW
John G Robson, Laura J Frishman
No abstract text is available yet for this article.
May 11, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28501709/calcium-ion-coordinated-dexamethasone-supramolecular-hydrogel-as-therapeutic-alternative-for-control-of-non-infectious-uveitis
#9
Wei Wu, Zhaoliang Zhang, Taotao Xiong, Wenguang Zhao, Rou Jiang, Hao Chen, Xingyi Li
Supramolecular hydrogel formed by the self-assembly of therapeutic agents have received considerable attention due to its high drug payload, carrier-free features. Herein, we constructed a dexamethasone sodium phosphate (Dex) supramolecular hydrogel in combination of Dex and calcium ion (Ca(2+)) and further demonstrated its therapeutic efficacy in the control of ocular inflammation. The developed supramolecular hydrogel was thoroughly characterized by rheology, TEM, FTIR and XRD. Calcium ions and Dex concentration had markedly influence on the sol-gel transition behavior of hydrogel and the proposed Dex supramolecular hydrogel displayed thixotropic property...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28494494/multifocal-erg-responses-in-subjects-with-a-history-of-preterm-birth
#10
Pablo Altschwager, Anne Moskowitz, Anne B Fulton, Ronald M Hansen
Purpose: The purpose of this study is to assess cone-mediated central retinal function in children with a history of preterm birth, including subjects with and without retinopathy of prematurity (ROP). The multifocal electroretinogram (mfERG) records activity of the postreceptor retinal circuitry. Methods: mfERG responses were recorded to an array of 103 hexagonal elements that subtended 43° around a central fixation target. The amplitude and latency of the first negative (N1) and first positive (P1) response were evaluated in six concentric rings centered on the fovea...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28494212/retinal-toxicity-of-acai-fruit-euterpe-oleracea-dye-concentrations-in-rabbits-basic-principles-of-a-new-dye-for-chromovitrectomy-in-humans
#11
Rafael R Caiado, Cristiane S Peris, Acácio Alves Souza Lima-Filho, Joao Guilherme Palma Urushima, Eduardo Novais, Emmerson Badaró, André Maia, Rita Sinigaglia-Coimbra, Sung Eun S Watanabe, Eduardo B Rodrigues, Michel Eid Farah, Mauricio Maia
PURPOSE: Evaluate toxicity of acai fruit (Euterpe oleracea) dye concentrations in a rabbit model. METHODS: Rabbits were injected intravitreously with 10%, 25%, and 35% acai dye concentrations. Control eyes received balanced salt solution (BSS). Electroretinogram (ERG), fundus imaging, fluorescein angiography (FA), optical coherence tomography (OCT), and light and transmission electron microscopy (LM/TEM) were performed. RESULTS: Fundus imaging showed increased vitreous opacity with increased dye concentrations...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28491470/effect-of-active-and-passive-smoking-on-retinal-nerve-fibre-layer-and-ganglion-cell-complex
#12
Amany Abd El-Fattah El-Shazly, Yousra Ahmed Thabet Farweez, Lamia Salah Elewa, Yasser Abdelmageuid Elzankalony, Botheina Ahmed Thabet Farweez
Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28491467/association-between-asymptomatic-unilateral-internal-carotid-artery-stenosis-and-electrophysiological-function-of-the-retina-and-optic-nerve
#13
Anna Machalińska, Aleksandra Kowalska-Budek, Miłosz Piotr Kawa, Arkadiusz Kazimierczak, Krzysztof Safranow, Marta Kirkiewicz, Grażyna Wilk, Wojciech Lubiński, Piotr Gutowski, Bogusław Machaliński
Purpose. This study was designed to assess retinal and optic nerve bioelectrical function in patients with unilateral asymptomatic but hemodynamically significant internal carotid artery stenosis (ICAS). Methods. Forty-two subjects with a diagnosis of unilateral ICAS and 34 controls were analyzed. Full-field electroretinogram (ERG), pattern electroretinogram (PERG), and pattern visual-evoked potentials, as well as optical coherence tomography and ophthalmological examination, were performed. Data analysis included eyes ipsilateral to ICAS (EIS) and eyes contralateral to ICAS (ECS)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28490646/a-missense-mutation-in-grm6-reduces-but-does-not-eliminate-mglur6-expression-or-rod-depolarizing-bipolar-cell-function
#14
Neal S Peachey, Nazarul Hasan, Bernard FitzMaurice, Samantha Burrill, Gobinda Pangeni, Son Yong Karst, Laura Reinholdt, Melissa L Berry, Marge Strobel, Ronald George Gregg, Maureen A McCall, Bo Chang
GRM6 encodes the metabotropic glutamate receptor 6 (mGluR6) used by retinal depolarizing bipolar cells (DBCs). Mutations in GRM6 lead to DBC dysfunction, and underlie the human condition autosomal recessive complete congenital stationary night blindness. Mouse mutants for Grm6 are important models for this condition. Here we report a new Grm6 mutant, identified in an electroretinogram (ERG) screen of mice maintained at The Jackson Laboratory. The Grm6(nob8) mouse has a reduced amplitude b-wave component of the ERG, which reflects light-evoked DBC activity...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28487632/nicotinamide-and-wld-s-act-together-to-prevent-neurodegeneration-in-glaucoma
#15
Pete A Williams, Jeffrey M Harder, Nicole E Foxworth, Brynn H Cardozo, Kelly E Cochran, Simon W M John
Glaucoma is a complex neurodegenerative disease characterized by progressive visual dysfunction leading to vision loss. Retinal ganglion cells are the primary affected neuronal population, with a critical insult damaging their axons in the optic nerve head. This insult is typically secondary to harmfully high levels of intraocular pressure (IOP). We have previously determined that early mitochondrial abnormalities within retinal ganglion cells lead to neuronal dysfunction, with age-related declines in NAD (NAD(+) and NADH) rendering retinal ganglion cell mitochondria vulnerable to IOP-dependent stresses...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28480027/effects-of-hydrogen-rich-saline-on-endotoxin-induced-uveitis
#16
Wei-Ming Yan, Lei Zhang, Tao Chen, Guan-Hua Zhao, Pan Long, Jing An, Zuo-Ming Zhang
The therapeutic effects of hydrogen-rich saline (HRS) have been reported for a wide range of diseases mainly via selectively reducing the amount of reactive oxygen species. Oxidative stress plays an important role in the pathogenesis of uveitis and endotoxin-induced uveitis (EIU). In this study, we investigated whether HRS can mitigate EIU in rats. Sprague-Dawley rats were randomly divided into Norm group, Model group, HRS group, dexamethasone (DEX) group, and rats in the latter three groups were injected with equal amount of lipopolysaccharide (LPS) to induce EIU of different severities (by 1 mg/kg of LPS, or 1/8 mg/kg of LPS)...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28475715/reep6-deficiency-leads-to-retinal-degeneration-through-disruption-of-er-homeostasis-and-protein-trafficking
#17
Smriti A Agrawal, Thomas Burgoyne, Aiden Eblimit, James Bellingham, David A Parfitt, Amelia Lane, Ralph Nichols, Chinwe Asomugha, Matthew J Hayes, Peter M Munro, Mingchu Xu, Keqing Wang, Clare E Futter, Yumei Li, Rui Chen, Michael E Cheetham
Retinitis pigmentosa (RP) is the most common form of inherited retinal dystrophy. We recently identified mutations in REEP6, which encodes the receptor expression enhancing protein 6, in several families with autosomal recessive RP. REEP6 is related to the REEP and Yop1p family of ER shaping proteins and potential receptor accessory proteins, but the role of REEP6 in the retina is unknown. Here we characterise the disease mechanisms associated with loss of REEP6 function using a Reep6 knockout mouse generated by CRISPR/Cas9 gene editing...
May 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28451988/correlation-of-macular-structure-and-function-in-a-boy-with-primary-foveomacular-retinitis-and-sequence-of-changes-over-5%C3%A2-years
#18
Anurag Badhani, Tapas Ranjan Padhi, Gopal Krishna Panda, Sujoy Mukherjee, Taraprasad Das, Subhadra Jalali
PURPOSE: To describe the clinical characteristics, macular structure and function, and to document sequential changes over 5 years in a 10-year-old boy with bilateral primary foveomacular retinitis. METHODS: A 10-year-old boy presented with sudden onset scotoma in both eyes, experienced after getting up from bed on a non-eclipse day. He persistently denied direct sun-gazing. He neither had any significant systemic illness, nor was using any medications. In addition to a detailed examination at presentation that included fundus fluorescein angiogram (FFA), electroretinogram (ERG), pattern ERG and electrooculogram (EOG), he was examined periodically for 5 years with Humphrey visual field (HVF), spectral domain optical coherence tomogram (SDOCT), Amsler grid charting and multifocal ERG...
April 27, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28451987/erg-and-other-discriminators-between-advanced-hydroxychloroquine-retinopathy-and-retinitis-pigmentosa
#19
Archana A Nair, Michael F Marmor
PURPOSE: To study whether the ERG and other clinical findings help to distinguish between advanced hydroxychloroquine (HCQ) retinopathy and pericentral or diffuse retinitis pigmentosa (RP) with similar fundus appearance. METHODS: We conducted a retrospective analysis of patients with advanced HCQ retinopathy (n = 11), pericentral RP (n = 8) and diffuse RP (n = 8). Pericentral RP was defined as having limited fundus damage and relatively normal flicker ERG time-to-peak...
April 27, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28451649/objective-measures-of-visual-function-in-papilledema
#20
Heather E Moss
Visual function is an important parameter to consider when managing patients with papilledema. Though the current standard of care uses standard automated perimetry (SAP) to obtain this information, this test is inherently subjective and prone to patient errors. Objective visual function tests including the visual evoked potential, pattern electroretinogram, photopic negative response of the full field electroretinogram, and pupillary light response have the potential to replace or supplement subjective visual function tests in papilledema management...
August 2016: Adv Ophthalmol Optom
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