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Chronic daily headache

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https://www.readbyqxmd.com/read/29774174/outpatient-interventions-that-may-enhance-the-care-of-a-patient-with-co-existing-moyamoya-and-down-syndromes
#1
Anita Lwanga, Waldo Herrera, Katya Cruz Madrid, Antony Irungu
Moyamoya vasculopathy is a condition of chronic, progressive occlusion of the distal internal carotid arteries and the Circle of Willis. The resultant ischemia produces compensatory angiogenesis and the growth of a network of collateral blood vessels, which on angiography resemble a "puff of smoke" or "moyamoya" in Japanese. The objective of this case report is to describe the clinical course of a patient with Down and moyamoya syndromes and to enlighten clinicians about strategies that can be taken to enhance the care of similar patients...
March 16, 2018: Curēus
https://www.readbyqxmd.com/read/29766926/new-daily-persistent-headache-an-evolving-entity
#2
REVIEW
Ravi Uniyal, Vimal Kumar Paliwal, Sucharita Anand, Paurush Ambesh
New daily persistent headache (NDPH) is characterized by an abrupt onset of headache that becomes a daily entity, is unremitting and continuous from the onset, and lasts for more than 3 months. Dr Walter Vanast first described NDPH in the year 1986. Originally, it was proposed as a chronic daily headache but it was placed under "other primary headaches" in the International Classification of Headache Disorder Second Edition (ICHD 2nd edition). However, with evolving literature and better understanding of its clinical characteristics, it was classified as a "chronic daily headache" in the ICHD 3rd edition beta...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29754329/efficacy-and-safety-of-sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-large-real-life-results-of-patients-with-chronic-hepatitis-c-genotype-4
#3
Adel Abdel-Moneim, Alaa Aboud, Mohamed Abdel-Gabaar, Mohamed I Zanaty, Mohamed Ramadan
BACKGROUND AND AIM: Clinical studies evaluating the efficacy of daclatasvir (DCV) for treatment of chronic hepatitis C virus (HCV) genotype 4 (GT4) infection are scarce. This study aims to evaluate the efficacy and safety of DCV plus sofosbuvir (SOF) with or without ribavirin (RBV) for treatment of Egyptian patients infected with HCV GT4. METHODS: Between April 2016 and March of 2017, a large cohort of 946 patients with chronic HCV GT4 was enrolled for completing the treatment...
May 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29737529/posttraumatic-headache-classification-by-symptom-based-clinical-profiles
#4
Sylvia Lucas, Andrew H Ahn
There are currently no accepted therapies for posttraumatic headache (PTH). In order to meet the urgent need for effective therapies for PTH, we must continue to address fundamental gaps in our understanding of the clinical course and impact of PTH. Here we examine the existing schema used to characterize the clinical characteristics of PTH, including the International Classification of Headache Disorders (ICHD). There remain unresolved questions about whether to classify patients based on the extent of brain injury or on clinical symptom profiles...
May 8, 2018: Headache
https://www.readbyqxmd.com/read/29736067/mix-headache-a-valid-clinical-entity
#5
Tapas Kumar Aich, Uttam Gupta, Sandip Subedi
Background: Chronic daily headache (CDH) patients respond better with a combination of anti-migraine and anti-stress medications, irrespective of clinical diagnosis of chronic migraine (CM) or chronic tension-type headache (CTTH). Hypothesis: "CDH: Mix headache" type is a valid clinical entity. Materials and Methods: A total of 70 participants fulfilling the diagnosis of "primary CDH", aged between 15 and 55 years were taken up for the present study...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29722276/sustained-reductions-in-migraine-days-moderate-to-severe-headache-days-and-days-with-acute-medication-use-for-hfem-and-cm-patients-taking-fremanezumab-post-hoc-analyses-from-phase-2-trials
#6
Rashmi B Halker Singh, Ernesto Aycardi, Marcelo E Bigal, Pippa S Loupe, Mirna McDonald, David W Dodick
Background In phase 2 and 3 studies, fremanezumab, a monoclonal CGRP antibody, was an effective preventive treatment for high-frequency episodic migraine (HFEM) and chronic migraine (CM). Objective Post-hoc analyses evaluated population-wise 50%, 75% and 100% responder rates, and the extent to which individual responders sustained a 50%, 75% and 100% reduction in migraine days, moderate-to-severe (M/S) headache days and days of acute medication use during all three treatment months of the fremanezumab phase 2 studies...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29680161/anticipation-in-a-family-with-primary-familial-brain-calcification-caused-by-an-slc20a2-variant
#7
Takuya Konno, Patrick R Blackburn, Todd D Rozen, Jay A van Gerpen, Owen A Ross, Paldeep S Atwal, Zbigniew K Wszolek
AIM OF THE STUDY: To describe a family with primary familial brain calcification (PFBC) due to SLC20A2 variant showing possible genetic anticipation. MATERIALS AND METHODS: We conducted historical, genealogical, clinical, and radiologic studies of a family with PFBC. Clinical evaluations including neurological examination and head computed tomography (CT) scans of a proband and her father were performed. They provided additional information regarding other family members...
April 11, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29663115/sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-for-treatment-of-chronic-hcv-genotype-4-patients-real-life-experience
#8
G Shiha, R Soliman, M ElBasiony, A A Hassan, N N H Mikhail
INTRODUCTION: New regimens involving direct-acting antiviral agents have recently been approved for the treatment of HCV. Our aim was to assess the efficacy and safety of 12 or 24 weeks of Sofosbuvir 400 mg plus Daclatasvir 60 mg, with or without ribavirin (800-1000 mg) in treating chronic hepatitis C genotype 4 patients. METHODS: This is an open-label observational study that describes the effect of 12 week or 24 weeks of daily oral Sofosbuvir (SOF) 400 mg plus Daclatasvir (DCV) 60 mg with or without ribavirin (RBV) with dose adjustment if indicated...
April 16, 2018: Hepatology International
https://www.readbyqxmd.com/read/29651369/unusual-relapse-of-chronic-lymphocytic-leukemia-after-remission
#9
Wajeeha Rizvi, Quoc Truong
Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia with over 20,000 estimated cases in 2017. Leukemic involvement of the nervous system from CLL causing neurologic symptoms is reported in only about one percent of patients. Unfortunately, there is no current standard therapy for the treatment of CLL leptomeningeal disease. In this case, we discuss an unusual presentation of CLL leptomeningeal disease misdiagnosed as chronic rebound headache. A 61-year-old female was diagnosed with Rai stage I CLL in 2002...
February 9, 2018: Curēus
https://www.readbyqxmd.com/read/29642749/chronic-migraine-a-process-of-dysmodulation-and-sensitization
#10
Min Su, Shengyuan Yu
Chronic migraine is a common chronic daily headache featured by frequent headache attacks with at least 15 headache days per month, which brings great disease burden to both the sufferers and the society. Transformed from episodic migraine, the pathophysiology of chronic migraine is not fully understood, even though several risk factors have been associated with migraine progression. Recent studies have identified both structural and functional alterations in some brain regions of chronic migraine patients indicating that maladaptation of the top-down pain modulation and subsequent sensitization of trigeminal system may be important in the pathogenesis of chronic migraine...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29610631/the-effect-of-propofol-on-chronic-headaches-in-patients-undergoing-endoscopy
#11
David Giampetro, Victor Ruiz-Velasco, Ashlee Pruett, Matthew Wicklund, Robert Knipe
Objective: This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background: Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods: We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29575668/early-management-of-medication-overuse-headache-patients-results-from-a-multicentric-clinical-study
#12
Ilenia Corbelli, Paola Sarchielli, Paolo Eusebi, Letizia Maria Cupini, Stefano Caproni, Paolo Calabresi
BACKGROUND: Educational intervention has proved to be effective in reducing drug abuse in uncomplicated medication overuse headache (MOH). This ancillary of SAMOHA multicentre study aimed to assess any differences in phenotypic characteristics, type and amount of drugs overused and comorbidities between MOH patients who respond to a simple advice and those who did not. METHODS: Demographic and clinical headache data of the last three months before enrollment of patients were collected; patients were then asked to fill out a daily headache diary for 4 weeks...
March 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29567798/ponatinib-efficacy-and-safety-in-philadelphia-chromosome-positive-leukemia-final-5-year-results-of-the-phase-2-pace-trial
#13
Jorge E Cortes, Dong-Wook Kim, Javier Pinilla-Ibarz, Philipp D le Coutre, Ronald Paquette, Charles Chuah, Franck E Nicolini, Jane F Apperley, H Jean Khoury, Moshe Talpaz, Daniel J DeAngelo, Elisabetta Abruzzese, Delphine Rea, Michele Baccarani, Martin C Müller, Carlo Gambacorti-Passerini, Stephanie Lustgarten, Victor M Rivera, Frank G Haluska, François Guilhot, Michael W Deininger, Andreas Hochhaus, Timothy P Hughes, Neil P Shah, Hagop M Kantarjian
Ponatinib has potent activity against native and mutant BCR-ABL1, including BCR-ABL1T315I The pivotal phase 2 PACE trial evaluated efficacy and safety of ponatinib at a starting dose of 45 mg once daily in 449 patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia resistant/intolerant to dasatinib or nilotinib, or with BCR ABL1T315I This analysis focuses on chronic-phase CML (CP-CML) patients (n=270) with 56.8-month median follow-up. Among 267 evaluable patients, 60%, 40%, and 24% achieved major cytogenetic response (MCyR), major molecular response (MMR), and MR4...
March 22, 2018: Blood
https://www.readbyqxmd.com/read/29565948/a-randomized-double-blind-study-of-the-effects-of-a-sustained-release-formulation-of-sodium-nitrite-sr-nitrite-on-patients-with-diabetic-neuropathy
#14
Amol Soin, Glen Bock, Anthony Giordano, Chirag Patel, David Drachman
BACKGROUND: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain. OBJECTIVES: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation. STUDY DESIGN: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29561944/treatment-of-chikungunya-chronic-arthritis-a-systematic-review
#15
REVIEW
Gabriella Maria Pitt Gameiro Sales, Izabel Crystine Pereira Barbosa, Laura Maia Sampaio Canejo Neta, Paloma Lopes de Melo, Raphael de Azevedo Leitão, Hugo Moura de Albuquerque Melo
INTRODUCTION: Chikungunya (CHIK) is a tropical arbovirus, transmitted by the female mosquito Aedes aegypti and Aedes albopictus. In Brazil, there have been cases reported since 2014. The initial manifestations of this virus are sudden onset high fever, headache, chills, rashes, myalgia and intense joint pain. Usually, CHIK presents the acute and chronic phases, the latter characterized by bilateral polyarthralgia, which can last for months or even years. During this period, autoimmune diseases can be triggered, making the picture even more complicated...
January 2018: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29560128/first-in-human-phase-1-study-of-the-btk-inhibitor-gdc-0853-in-relapsed-or-refractory-b-cell-nhl-and-cll
#16
John C Byrd, Stephen Smith, Nina Wagner-Johnston, Jeff Sharman, Andy I Chen, Ranjana Advani, Bradley Augustson, Paula Marlton, S Renee Commerford, Kwame Okrah, Lichuan Liu, Elaine Murray, Elicia Penuel, Ashley F Ward, Ian W Flinn
GDC-0853 is a selective, reversible, and non-covalent inhibitor of Bruton's tyrosine kinase (BTK) that does not require interaction with the Cys481 residue for activity. In this first-in-human phase 1 study we evaluated safety, tolerability, pharmacokinetics, and activity of GDC-0853 in patients with relapsed or refractory non-Hodgkin lymphoma (NHL) or chronic lymphocytic leukemia (CLL). Twenty-four patients, enrolled into 3 cohorts, including 6 patients who were positive for the C481S mutation, received GDC-0853 at 100, 200, or 400 mg once daily, orally...
February 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29559871/radiofrequency-ablation-of-pericranial-nerves-for-treating-headache-conditions-a-promising-option-for-patients
#17
Alaa Abd-Elsayed, Laura Kreuger, Shawna Wheeler, Janet Robillard, Susanne Seeger, Douglas Dulli
Background: Chronic daily headache, including chronic migraine, can be challenging to treat. Medications often only provide limited improvement, and surgical interventions can be associated with significant adverse effects. We present our experience with using radiofrequency ablation (RFA) for pericranial nerves to treat chronic headache conditions. Methods: This retrospective analysis included patients who received RFA for pericranial nerves to treat chronic daily headache conditions from January 1, 2015 to June 1, 2016...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29556851/novel-interventional-nonopioid-therapies-in-headache-management
#18
REVIEW
Omar Viswanath, Roxanna Rasekhi, Rekhaben Suthar, Mark R Jones, Jacquelin Peck, Alan D Kaye
PURPOSE OF REVIEW: Headaches encompass a broad-based category of a symptom of pain in the region of the head or neck. For those patients who unfortunately do not obtain relief from conservative treatment, interventional techniques have been developed and are continuing to be refined in an attempt to treat this subset of patients with the goal of return of daily activities. This investigation reviews various categories of headaches, their pathophysiology, and types of interventional treatments currently available...
March 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29554316/concurrent-placement-of-bilateral-suboccipital-and-supraorbital-nerve-stimulators-using-on-q-tunneler-technical-note
#19
Lara Massie, Rushna Ali, Konstantin V Slavin, Jason M Schwalb
BACKGROUND: Stimulation of the occipital and supraorbital nerves is used to treat chronic migraine refractory to medical management. Placement of cranial leads is often challenging due to the rigid Touhy needle included in the kit for its placement. OBJECTIVE: To report the first case of concurrent placement of bilateral supraorbital (SNS) and occipital nerve stimulators (ONS) from a unilateral approach using the On-Q* Tunneler, (Halyard Health, Alpharetta, Georgia) a flexible, blunt tipped plastic tunneler with a tear-away sheath...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29545691/cervical-extension-traction-as-part-of-a-multimodal-rehabilitation-program-relieves-whiplash-associated-disorders-in-a-patient-having-failed-previous-chiropractic-treatment-a-cbp-%C3%A2-case-report
#20
Miles O Fortner, Paul A Oakley, Deed E Harrison
[Purpose] To present the case of the non-surgical restoration of cervical lordosis in a patient suffering from chronic whiplash syndrome including chronic neck pain and daily headaches resulting from previous whiplash. [Subject and Methods] A 31 year old female presented with a chief complaint of chronic neck pain and headaches for 12 years, correlating temporally with a sustained whiplash. These symptoms were not significantly relieved by previous chiropractic spinal manipulative therapy. The patient had cervical hypolordosis and was treated with Chiropractic BioPhysics® protocol including extension exercises, manual adjustments and cervical extension traction designed to increase the cervical lordosis...
February 2018: Journal of Physical Therapy Science
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