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https://www.readbyqxmd.com/read/29145509/untargeted-mass-spectrometry-discloses-plasma-solute-levels-poorly-controlled-by-hemodialysis
#1
Tammy L Sirich, Pavel A Aronov, Jonathan Fullman, Khanh Nguyen, Natalie S Plummer, Timothy W Meyer
Many solutes have been reported to remain at higher plasma levels relative to normal than the standard index solute urea in hemodialysis patients. Untargeted mass spectrometry was employed to compare solute levels in plasma and plasma ultrafiltrate of hemodialysis patients and normal subjects. Quantitative assays were employed to check the accuracy of untargeted results for selected solutes and additional measurements were made in dialysate and urine to estimate solute clearances and production. Comparison of peak areas indicated that many solutes accumulated to high levels in hemodialysis patients, with average peak areas in plasma ultrafiltrate of dialysis patients being more than 100 times greater than those in normals for 123 features...
2017: PloS One
https://www.readbyqxmd.com/read/29141481/liposome-supported-peritoneal-dialysis-in-rat-amitriptyline-exposure-with-and-without-intravenous-lipid-emulsion
#2
Robin Chapman, Martyn Harvey, Paul Davies, Zimei Wu, Grant Cave
INTRODUCTION: Liposome supported peritoneal dialysis is a recently described technique which may eventually be applicacle in the clinical scenario of the intoxicated patient. We evaluated the hypothesis that intravenous injection lipid emulsion (ILE) would augment acidic pH gradient liposome supported peritoneal dialysis (LSPD). METHODS: Orogastrically amitriptyline dosed rats were treated with either NaHCO3 intravenously and standard intraperitoneal dialysate (A); NaHCO3 intravenously and LSPD (B); or ILE and LSPD (C)...
November 15, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29133076/comparison-of-the-hemodynamic-tolerance-and-the-biological-parameters-of-four-acetate-free-hemodialysis-methods
#3
George Kosmadakis, Enrique Da Costa Correia, Julie Albaret, Frédéric Somda, Didier Aguilera
PURPOSE: Acetate in hemodialysis solutions exerts inflammatory, vasodilatatory and cardio-depressive effects. Citrate has been proposed as an optimal substitute. The aim of the present trial was the comparison of the hemodynamic and biological parameters on a group of patients dialysed consecutively with 4 acetate-free haemodialysis techniques. METHODS: In a prospective crossover manner, we measured the hemodynamic and biological effects of four acetate-free hemodialysis methods: he acetate-free biofiltration with variable potassium (AFBK) and three methods with a citrate buffer: onventional hemodialysis (HD), on-line hemodiafiltration (HDF) and on-line hemofiltration (HF)...
November 10, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29132247/management-of-a-rare-case-with-severe-hydrofluoric-acid-burns-important-roles-of-neutralizers-and-continuous-renal-replacement-therapy
#4
Yuanhai Zhang, Xingang Wang, Yuezhen Liu, Xinhua Jiang, Chunjiang Ye, Liangfang Ni, Liping Zhang, Jianfen Zhang, Bin Xu, Chunmao Han
Hydrofluoric acid (HF), a dangerous inorganic acid, is widely used in various industries and in daily life. Chemical burns caused by HF exposure occur more frequently in some regions worldwide. It has been reported that some cases with HF burns can be lethal due to the hypertoxicity of HF. In this article, we present a case of a 24-year-old worker who suffered HF burns by 53% HF solution to his face, neck, and nasal cavity. This patient quickly developed electrolyte disturbance, that is, hypocalcemia, and hypopotassemia, and myocardial injury after exposure...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29127845/highly-sensitive-determination-of-alendronate-in-human-plasma-and-dialysate-using-metal-free-hplc-ms-ms
#5
Miho Yamada, Xiao-Pen Lee, Masaya Fujishiro, Ken Iseri, Makoto Watanabe, Hiroshi Sakamaki, Naoki Uchida, Takaaki Matsuyama, Takeshi Kumazawa, Haruo Takahashi, Akira Ishii, Keizo Sato
A highly sensitive method was developed for the analysis of alendronate in human plasma and dialysate using MonoSpin™ SAX(®) extraction and metal-free high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) following methylation with trimethylsilyldiazomethane. The chromatographic separation of the derivatives for alendronate and alendronate-d6 was achieved on an L-column2 ODS metal-free column (50 mm  ×  2 mm i.d., particle size 3 µm) with a linear gradient elution system composed of 10 mM ammonium acetate (pH 6...
November 6, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29123839/relationship-between-nitrogen-loss-and-blood-urea-nitrogen-concentrations-in-patients-requiring-continuous-renal-replacement-therapy
#6
Takeaki Sato, Shigeki Kushimoto
Aim: It is well known that continuous renal replacement therapy (CRRT) produces some amount of nitrogen loss, but there are few tools that are easily applied to measure it. This study aimed to evaluate nitrogen loss using blood urea nitrogen (BUN) measurement in patients receiving CRRT. Methods: The subjects were 28 patients who received CRRT (except for liver failure) between 2010 and 2012. Nutrition data and nitrogen excretion in dialysate and urine were measured...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122381/the-dialyser-in-the-year-2017-much-more-than-a-membrane
#7
Rafael Pérez-García, Roberto Alcázar
No abstract text is available yet for this article.
November 6, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29122211/citrate-dialysate-does-not-induce-oxidative-stress-or-inflammation-in-vitro-as-compared-to-acetate-dialysate
#8
Rafael Pérez-García, Rafael Ramírez Chamond, Patricia de Sequera Ortiz, Marta Albalate, Marta Puerta Carretero, Mayra Ortega, M Caridad Ruiz Caro, Roberto Alcazar Arroyo
Increased acetataemia during haemodialysis sessions has been associated with a number of abnormalities, including increased oxidative stress, pro-inflammatory cytokines and nitric oxide synthesis. However, citric acid may play an alternative role to acetate as a dialysate stabiliser given that the effect of citrate on complement and leukocyte activation is different to that of acetate. The purpose of this study was to compare the inflammatory effect in immunocompetent blood cells of acetate dialysate and citrate dialysate...
November 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29109162/comparative-assessment-of-tedizolid-pharmacokinetics-and-tissue-penetration-between-diabetic-patients-with-wound-infections-and-healthy-volunteers-via-in-vivo-microdialysis
#9
Sean M Stainton, Marguerite L Monogue, Arlinda Baummer-Carr, Ashley K Shepard, James F Nugent, Joseph L Kuti, David P Nicolau
Herein, we present pharmacokinetic and tissue penetration data for oral tedizolid in hospitalized patients with diabetic foot infections (DFI) compared with healthy volunteers. Participants received oral tedizolid phosphate 200mg every 24 hours for 3 doses to achieve steady-state. A microdialysis catheter was inserted into the subcutaneous tissue near the margin of the wound for patients or into thigh tissue of volunteers. Following the 3(rd) dose, 12 blood and 14 dialysate fluid samples were collected over 24 hours to characterize tedizolid concentrations in plasma and interstitial extracellular fluid of soft tissue...
November 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29081657/comparative-analysis-of-the-long-term-effect-of-two-families-of-high-flux-polysulfone-dialysers-on-platelet-count-a-retrospective-cross-sectional-study
#10
Rosaria Del Giorno, Lorenzo Berwert, Silvio Pianca, Giorgia Bianchi, Olivier Giannini, Luca Gabutti
INTRODUCTION: Thrombocytopenia is a potential complication of hemodialysis (HD), and its occurrence has been described even with highly biocompatible polysulfone (PSf) membranes. Dialysis units routinely monitor platelet (PLT) count at the beginning of HD sessions. However, considering that the long-term effects on PLT count could easily be missed, the prevalence of HD-related thrombocytopenia could be underestimated. In the present study, we aimed to investigate the following: 1) the long-term impact of HD treatment on PLT count, comparing two families of dialysis membranes made up of similar PSfs; 2) whether the switch between the dialysis membranes studied significantly affects PLT count; and 3) the prevalence and the risk of HD-induced thrombocytopenia according to the dialysis membranes used...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29073536/intensive-care-unit-drug-costs-in-the-context-of-total-hospital-drug-expenditures-with-suggestions-for-targeted-cost-containment-efforts
#11
Shoroq M Altawalbeh, Melissa I Saul, Amy L Seybert, Joshua M Thorpe, Sandra L Kane-Gill
PURPOSE: To assess costs of intensive care unit (ICU) related pharmacotherapy relative to hospital drug expenditures, and to identify potential targets for cost-effectiveness investigations. We offer the unique advantage of comparing ICU drug costs with previously published data a decade earlier to describe changes over time. MATERIALS AND METHODS: Financial transactions for all ICU patients during fiscal years (FY) 2009-2012 were retrieved from the hospital's data repository...
October 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29064178/low-dialysate-potassium-concentration-is-associated-with-prolonged-recovery-time
#12
Antonia Harford, Ambreen Gul, Serena Cumber, Susan Paine, Ronald Schrader, Nicole Trujillo, Philip Zager
INTRODUCTION: Modifiable hemodialysis treatment parameters may impact patient reported outcomes, including recovery time. Answers to the recovery question may predict the impact of treatment parameters on clinical outcomes and health related quality of life. However, the reliability of answers to the recovery question after consecutive and nonconsecutive dialysis treatments in diverse populations has not been established. OBJECTIVE: To assess the reliability of this instrument and to determine if recovery time was associated with modifiable dialysis parameters, we conducted a quality assurance project in which we asked, "How long did it take you to recover from your last dialysis session?" after consecutive and nonconsecutive treatments...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29064175/verification-of-physicochemical-structures-of-dialysis-membrane-using-reversal-dialysis-technique
#13
Akihiro C Yamashita, Takahisa Ono, Narumi Tomisawa
OBJECTIVE: Solute removal performance of the dialyzer is closely related to physicochemical structures of the membrane. The objective of this study is to devise a new in vitro evaluation technique to directly correlate the physicochemical structures of the membrane to the dialysis performance. MATERIALS AND METHODS: Commercial 11 dialyzers with cellulose triacetate (CTA), ethylene vinylalcohol co-polymer (EVAL), asymmetry CTA (termed ATA), 4 polysulfone (PSf), polyether sulfone (PES), and 3 polyester polymer alloy (PEPA) membranes were employed for investigation...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29063343/acetaminophen-clearance-during-ex-vivo-continuous-renal-replacement-therapies
#14
Bridget A Scoville, Vera Vulaj, Bruce A Mueller, Gail M Annich, Deborah S Wagner
Intravenous acetaminophen is an adjuvant to opioid use in critically ill and surgical patients requiring continuous renal replacement therapy (CRRT). The objective of this study was to determine the ex vivo transmembrane clearance of intravenous acetaminophen during continuous hemofiltration and hemodialysis. Transmembrane clearance was assessed using a validated ex vivo bovine blood model for CRRT using an F8 or HF1400 hemodiafilter. Ultrafiltrate and dialysate flow rates were 1, 2, and 3 L/h. Urea and acetaminophen clearances were calculated and compared...
October 23, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29060465/an-in-silico-method-to-predict-net-calcium-transfer-during-hemodialysis
#15
Vaibhav Maheshwari, Alhaji Cherif, Doris Fuertinger, Gudrun Schappacher-Tilp, Priscila Preciado, Stephan Thijssen, David A Bushinsky, Peter Kotanko
International guidelines for chronic hemodialysis patients suggest a dialysate calcium concentration between 1.25 and 1.5 mmol/L. However, it is not certain if these dialysate calcium levels result in net calcium transfer into the patient. With ubiquitous prevalence of vascular calcification in hemodialysis patients, it is pertinent to model the mass balance of calcium during dialysis. To this end, we developed a two compartmental patient model and spatiotemporal representation of dialyzer model to investigate and quantify the calcium mass balance during dialysis...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059342/mathematical-model-of-calcium-exchange-during-haemodialysis-using-a-citrate-containing-dialysate
#16
Julien Aniort, Laurent Chupin, Nicolae Cîndea
Calcium has two important roles in haemodialysis. It participates in the activation of blood coagulation and calcium intakes have a major impact on patient mineral and bone metabolism. The aim of this article is to propose a mathematical model for calcium ions concentration in a dialyzer during haemodialysis using a citrate dialysate. The model is composed of two elements. The first describes the flows of blood and dialysate in a dialyzer fibre. It was obtained by asymptotic analysis and takes into account the anisotropy of the fibres forming a dialyzer...
October 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29055386/peritoneal-dialysis-the-unique-features-by-compartmental-delivery-of-renal-replacement-therapy
#17
Tibor Fülöp, Lajos Zsom, Mihály B Tapolyai, Miklos Z Molnar, Sohail Abdul Salim, István Arany, Mehrdad Hamrahian, László Rosivall
Despite decades of research, the clinical efficacy of peritoneal dialysis (PD) remains enigmatic. We may wonder why the modality fail in some patients but perhaps the more proper question would be, why it works in so many? We know that the contribution of residual renal function (RRF), more so than in hemodialysis, is critically important to the well-being of many of the patients. Unique features of the modality include the relatively low volume of dialysate fluid needed to provide effective uremic control and the disproportionate tendency for both hypokalemia and hypoalbuminemia, when compared to hemodialysis...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29044780/-hot-versus-cold-behavioral-cognitive-styles-motivational-dopaminergic-versus-cognitive-cholinergic-processing-of-a-pavlovian-cocaine-cue-in-sign-and-goal-tracking-rats
#18
Kyle K Pitchers, Louisa F Kane, Youngsoo Kim, Terry E Robinson, Martin Sarter
Discrete Pavlovian reward cues acquire more potent incentive motivational properties (incentive salience), in some animals (sign-trackers; STs) compared to others (goal trackers; GTs). Conversely, GTs appear to be better than STs in processing more complex contextual cues, perhaps reflecting their relatively greater bias for goal-directed cue processing. Here we investigated the activity of two major prefrontal neuromodulatory input systems, dopamine (DA) and acetylcholine (ACh), in response to a discrete Pavlovian cue that was previously paired with cocaine administration in STs and GTs...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29044339/metabolic-acidosis-in-hemodialysis-patients-a-review
#19
Luiza Raksa Rezende, Pablo Brandão de Souza, Giselly Rosa Modesto Pereira, Jocemir Ronaldo Lugon
Metabolic acidosis is highly prevalent in hemodialysis patients. The disorder is associated with increased mortality and its deleterious effects are already present in the predialysis phase of chronic kidney disease. Metabolic acidosis has been linked to progression of chronic kidney disease, changes in protein and glucose metabolism, bone and muscle disorders and cardiovascular disease. At present, the control of metabolic acidosis in hemodialysis is mainly focused on the supply of bicarbonate during dialysis session, but further studies are needed to set the optimum target serum bicarbonate and the best concentration of the bicarbonate dialysate...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29033853/proinflammatory-effect-of-high-glucose-concentrations-on-hmrsv5-cells-via-the-autocrine-effect-of-hmgb1
#20
Yuening Chu, Yi Wang, Zhihuang Zheng, Yuli Lin, Rui He, Jun Liu, Xuguang Yang
Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD) using a glucose-based dialysate. Mesothelial cells (MCs) take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1) and interleukin 8 (IL-8). The apoptosis of MCs induced by high glucose levels also contributes to complications of PD...
2017: Frontiers in Physiology
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