keyword
https://read.qxmd.com/read/38528752/incorporating-a-hemodialysis-filter-into-a-commercial-normothermic-perfusion-system-to-facilitate-long-term-preservation-of-human-split-livers
#1
JOURNAL ARTICLE
Joanna Huang, Ngee-Soon Lau, Mark Ly, Daniel Babekuhl, Paul Yousif, Ken Liu, Geoff McCaughan, Michael Crawford, Carlo Pulitano
BACKGROUND: Normothermic machine perfusion (NMP) allows for the assessment and resuscitation of ex-vivo human livers prior to transplantation. Commercially available NMP systems are closed circuits that accumulate metabolic waste and cytokines over time, potentially limiting organ preservation times. Dialysis has been proposed as a method to remove waste and excess fluid from such systems. This study aimed to demonstrate the utility of integrating dialysis into a commercially available system by quantifying solute removal...
March 25, 2024: Artificial Organs
https://read.qxmd.com/read/38515354/picc-insertion-and-veins-of-the-arm-size-variation-during-dialysis-treatment-a-prospective-observational-study
#2
JOURNAL ARTICLE
Elena Ajello, Antonio Arresta, Riccardo Rutili, Salvatore Aronica, Rigo Lorenzo, Elia Monti, Martina Galletti, Luigi Cannizzo, Luciano Giannini, Alberto Lucchini, Federico Pieruzzi, Stefano Elli
BACKGROUND: Peripherally Inserted Central Catheters play an increasingly important role in Central Venous Access Devices. However, the use of these devices should be carefully considered in specific situations such as central catheterisation in patients with chronic kidney disease. When evaluating the feasibility of placement for a patient undergoing dialysis, the relationship between changes in circulating volume before and after dialysis treatment, and potential variations in the size of deep veins in the upper limbs, should be considered...
March 22, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38511218/anti-diabetic-properties-of-brewer-s-spent-yeast-peptides-in-vitro-in-silico-and-ex-vivo-study-after-simulated-gastrointestinal-digestion
#3
JOURNAL ARTICLE
Marilin E Aquino, Silvina R Drago, Fermín Sánchez de Medina, Olga Martínez-Augustin, Raúl E Cian
Brewer's spent yeast (BSY) hydrolysates are a source of antidiabetic peptides. Nevertheless, the impact of in vitro gastrointestinal digestion of BSY derived peptides on diabetes has not been assessed. In this study, two BSY hydrolysates were obtained ( H1 and H2 ) using β-glucanase and alkaline protease, with either 1 h or 2 h hydrolysis time for H1 and H2 , respectively. These hydrolysates were then subjected to simulated gastrointestinal digestion (SGID), obtaining dialysates D1 and D2 , respectively...
March 21, 2024: Food & Function
https://read.qxmd.com/read/38510194/increased-levels-of-a-mycophenolic-acid-metabolite-in-patients-with-kidney-failure-negatively-affect-cardiomyocyte-health
#4
JOURNAL ARTICLE
Eva Harlacher, Corinna Schulte, Sonja Vondenhoff, Philippe Schmitt-Kopplin, Philippe Diederich, Christian Hemmers, Julia Moellmann, Julia Wollenhaupt, Rogier Veltrop, Erik Biessen, Michael Lehrke, Björn Peters, Georg Schlieper, Christoph Kuppe, Jürgen Floege, Vera Jankowski, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Chronic kidney disease (CKD) significantly increases cardiovascular risk and mortality, and the accumulation of uremic toxins in the circulation upon kidney failure contributes to this increased risk. We thus performed a screening for potential novel mediators of reduced cardiovascular health starting from dialysate obtained after hemodialysis of patients with CKD. The dialysate was gradually fractionated to increased purity using orthogonal chromatography steps, with each fraction screened for a potential negative impact on the metabolic activity of cardiomyocytes using a high-throughput MTT-assay, until ultimately a highly purified fraction with strong effects on cardiomyocyte health was retained...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38506151/peritoneal-phosphate-clearance-determinants-and-association-with-mortality
#5
JOURNAL ARTICLE
Jinping Li, Wenyu Zhang, Xichao Wang, Na Sun, Lei Li, Wenxiu Chang
BACKGROUND: Dialytic phosphate removal is a cornerstone of the management of hyperphosphatemia in peritoneal dialysis (PD) patients, but the influencing factors on peritoneal phosphate clearance (PPC) are incompletely understood. Our objective was to explore clinically relevant factors associated with PPC in patients with different PD modality and peritoneal transport status and the association of PPC with mortality. METHODS: This is a cross-sectional and prospective observational study...
March 20, 2024: Seminars in Dialysis
https://read.qxmd.com/read/38506130/the-revival-of-sorbents-in-chronic-dialysis-treatment
#6
REVIEW
Jeroen Peter Kooman
Interest in the use of sorbents in chronic dialysis treatment has undergone a revival in the last decades, for which two major factors are responsible. The first is the potential of sorbents as adjunct therapy for the removal of substances that are difficult to remove by conventional dialysis therapies. The second is their use in regeneration of dialysate, which is of pivotal importance in the design of portable or even wearable treatments, next to the potential for reducing water use during conventional dialysis treatment...
March 20, 2024: Seminars in Dialysis
https://read.qxmd.com/read/38504636/prevention-of-dialysis-disequilibrium-syndrome-in-children-with-advanced-uremia-with-a-structured-hemodialysis-protocol-a-quality-improvement-initiative-study
#7
JOURNAL ARTICLE
Sidharth Kumar Sethi, Valerie Luyckx, Timothy Bunchman, Aishwarya Nair, Shyam Bihari Bansal, Bryce Pember, Kritika Soni, Savita, Dinesh Kumar Yadav, Vivek Sharma, Khalid Alhasan, Rupesh Raina
BACKGROUND: Dialysis disequilibrium syndrome (DDS) is a rare but significant concern in adult and pediatric patients undergoing dialysis initiation with advanced uremia or if done after an interval. It is imperative to gain insights into the epidemiological patterns, pathophysiological mechanisms, and preventive strategies aimed at averting the onset of this ailment. DESIGN: Prospective observational quality improvement initiative cohort study. SETTING AND PARTICIPANTS: A prospective single-center study involving 50 pediatric patients under 18 years recently diagnosed with chronic kidney disease stage V with blood urea ≥200 mg/dL, admitted to our tertiary care center for dialysis initiation from January 2017 to October 2023...
March 20, 2024: Hemodialysis International
https://read.qxmd.com/read/38499459/plasma-exchange-for-the-management-of-digoxin-toxicity-in-an-individual-with-an-acute-kidney-injury-a-case-report
#8
JOURNAL ARTICLE
Hannah Preston, Emma Cannon, Simon Watson
Digoxin toxicity can be life-threatening. Digoxin-specific antibody (DSA) fragments are used in severe digoxin toxicity, binding to serum-free digoxin and enabling increased renal excretion. In severe renal impairment, clearance of these complexes is prolonged, leading to rebound toxicity. Digoxin and DSA complexes are not dialysable. We present a case of a gentleman with severe digoxin toxicity and acute kidney injury (AKI). Despite receiving DSA doses, his digoxin levels rebounded and symptoms persisted. Based on published case reports, plasma exchange (PEX) after further dosing was arranged...
March 18, 2024: Journal of the Royal College of Physicians of Edinburgh
https://read.qxmd.com/read/38490516/role-of-peritoneal-equilibration-test-in-assessing-folate-transport-during-peritoneal-dialysis
#9
JOURNAL ARTICLE
Yu-Ling Lin, Yi-Che Lee, Chih-Chung Lee, Mei-Hsuan Wu
BACKGROUND: Low plasma folate levels have been reported in patients undergoing hemodialysis and peritoneal dialysis (PD) in clinical studies. However, folate transport has never been mentioned as a factor contributing to low plasma folate levels in patients undergoing PD. The peritoneal equilibrium test (PET) assesses the plasma creatinine level and glucose transport abilities. This study aimed to evaluate the association between plasma folate levels and folate transport during PD based on PET grades...
March 13, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38488040/microdialysis-coupled-with-droplet-microfluidics-and-mass-spectrometry-for-determination-of-neurotransmitters-in-vivo-with-high-temporal-resolution
#10
JOURNAL ARTICLE
Shane S Wells, Ian J Bain, Alec C Valenta, Ashley E Lenhart, Daniel J Steyer, Robert T Kennedy
Monitoring the concentration fluctuations of neurotransmitters in vivo is valuable for elucidating the chemical signals that underlie brain functions. Microdialysis sampling is a widely used tool for monitoring neurochemicals in vivo . The volume requirements of most techniques that have been coupled to microdialysis, such as HPLC, result in fraction collection times of minutes, thus limiting the temporal resolution possible. Further the time of analysis can become long for cases where many fractions are collected...
March 15, 2024: Analyst
https://read.qxmd.com/read/38483736/expression-and-significance-of-sirt6-in-human-peritoneal-dialysis-effluents-and-peritoneal-mesothelial-cells
#11
JOURNAL ARTICLE
Shuai-Shuai Shi, Yi-Qiang Zhang, Lu-Qi Zhang, Yun-Feng Li, Xiao-Shuang Zhou, Rong-Shan Li
Sirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal dialysis (PD) remains unclear. We collected 110 PD patients with a duration of PD for more than 3 months and studied the influence of PD duration and history of peritonitis on SIRT6 levels in PD effluents (PDEs). We also analyzed the relationship between SIRT6 levels in PDEs and transforming growth factor beta 1 (TGF-β1), IL-6, PD duration, peritoneal function, PD ultrafiltration (UF), and glucose exposure...
March 14, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38478218/negligible-in-vitro-recovery-of-macromolecules-from-microdialysis-using-100%C3%A2-kda-probes-and-dextran-in-perfusion-fluid
#12
JOURNAL ARTICLE
Spille Dorothee, G Sørensen, L R Olsen, J F Bastlund, F Sotty, D Belling, M H Olsen, T I Mathiesen, K Møller, F Larsen, P Birkeland
Microdialysis is applied in neurointensive care to monitor cerebral glucose metabolism. If recoverable, macromolecules may also serve as biomarkers in brain disease and provide clues to their passage across the blood-brain barrier. Our study aimed to investigate the in vitro recovery of human micro- and macromolecules using microdialysis catheters and perfusion fluids approved for clinical use. In vitro microdialysis of a bulk solution containing physiological or supraphysiological concentrations of glucose, lactate, pyruvate, human IgG, serum albumin, and hemoglobin was performed using two different catheters and perfusion fluids...
March 13, 2024: Neurochemical Research
https://read.qxmd.com/read/38477224/the-futility-of-post-haemodialysis-blood-glucose-levels-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Jing Zhang, Richard K Le Leu, Qunyan Xu, Paul Bennett
BACKGROUND: Frequent blood glucose tests are performed for people with diabetes receiving haemodialysis. OBJECTIVES: To determine the rate of out-of-range post-haemodialysis blood glucose levels that are clinically acted upon, the intervention and outcome of each intervention, and the associations between post-haemodialysis blood glucose levels and relevant clinical predictors. DESIGN: 12-month retrospective cohort medical record review in one Australian haemodialysis centre...
March 13, 2024: Journal of Renal Care
https://read.qxmd.com/read/38468417/treatment-of-severe-hyponatremia-with-continuous-renal-replacement-therapy-a-case-and-review-of-corrective-strategies
#14
Paul J Der Mesropian, Shawn Phillips, Martha Naber, Sunjeev Konduru, Gulvahid Shaikh, Krishnakumar Hongalgi
Treatment of severely hyponatremic patients with continuous renal replacement therapy (CRRT) presents a unique challenge given the lack of commercial options for hypotonic replacement solutions or dialysate. We report the case of a 55-year-old male who presented with profound, symptomatic hyponatremia in the setting of acute kidney injury (AKI). The patient was found to have a serum sodium concentration of 97 mEq/L because of free water retention that occurred during severe AKI from viral gastroenteritis and rhabdomyolysis...
March 11, 2024: Hemodialysis International
https://read.qxmd.com/read/38465136/metastatic-calcinosis-cutis-unusual-locations-in-end-stage-renal-disease
#15
Jc Charm C Asoy, Justin Luke D Yap
Metastatic calcinosis cutis is a rare consequence of end-stage renal disease (ESRD), which occurs due to elevated levels of serum phosphorus and abnormal phosphate and calcium metabolism, leading to the precipitation and deposition of calcium in the cutaneous and subcutaneous tissues. This paper reports the case of a 33-year-old male with ESRD and a six-year history of hemodialysis treatment who presented with multiple areas of gradually enlarging, lobulated calcified soft tissue masses observed bilaterally at the level of the acromioclavicular joint and superomedial aspect of the right thigh, extensively involving the perineal region and the right superior anterior chest wall...
February 2024: Curēus
https://read.qxmd.com/read/38463843/partial-purification-and-characterization-of-protease-extracted-from-kinema
#16
JOURNAL ARTICLE
Dambar Bahadur Khadka, Tikaram Pahadi, Sunil Aryal, Dhan Bahadur Karki
Proteases are large group of highly demanded enzymes having huge application in food and pharmaceutical industries. Numerous sources, including plants, microorganisms, and animals, can be used to obtain protease. Due to its affordability and safety consideration, fermented foods have recently attracted more attention as a source of microbial protease. The present study aimed to extract protease from kinema , partially purify the extracted protease following dialysis after precipitation with ammonium sulfate, and determine general characteristics of protease...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38458357/staphylococcus-aureus-small-colony-variants-a-potentially-underestimated-microbiological-challenge-in-peritoneal-dialysis
#17
JOURNAL ARTICLE
Markus Obermueller, Ludwig Traby, Matthias Weiss-Tessbach, Richard Kriz, Kathrin Spettel, Lisa Schneider, Lena Hohl, Heinz Burgmann, Manuel Kussmann
INTRODUCTION: Peritonitis remains the major infectious complication in the setting of peritoneal dialysis (PD). Despite known only moderate pathogenicity, the most frequently detected pathogens in PD-related peritonitis are surprisingly coagulase-negative staphylococci. However, this could be explained, at least in part, by Staphylococcus aureus small colony variants (SCVs) induced by PD fluids (PDFs) and misidentified by routinely used microbiological methods. MATERIAL AND METHODS: Bacteria were exposed to commonly used PDFs in various regimens designed to simulate daily use as closely as possible...
March 6, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38446246/interdialytic-weight-gain-and-low-dialysate-sodium-concentration-in-patients-on-chronic-hemodialysis-a-systematic-review-and-meta-analysis
#18
REVIEW
Maurizio Bossola, Ilaria Mariani, Monica Sacco, Manuela Antocicco, Gilda Pepe, Enrico Di Stasio
PURPOSE: The present systematic review and meta-analysis aimed at evaluating the effect of low dialysate sodium concentration on interdialytic weight gain (IDWG) in chronic hemodialysis patients. METHODS: Studies were eligible for inclusion if they were English language papers published in a peer-reviewed journal and met the following inclusion criteria: (1) studies in adult patients (over 18 years of age), (2) included patients on chronic hemodialysis since at least 6 months; (3) compared standard (138-140 mmol/l) or high (> 140 mmol/l) dialysate sodium concentration with low (< 138 mmol/l) dialysate sodium concentration; (4) Included one outcome of interest: interdialytic weight gain...
March 6, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38446190/gh-and-igf-1-in-skin-interstitial-fluid-and-blood-are-associated-with-heat-loss-responses-in-exercising-young-adults
#19
JOURNAL ARTICLE
Gulinu Maimaituxun, Tatsuro Amano, Glen P Kenny, Toby Mündel, Masanobu Kajiki, Kaname Tagawa, Akira Katagiri, Yoko Tanabe, Koichi Watanabe, Takeshi Nishiyasu, Narihiko Kondo, Naoto Fujii
PURPOSE: Sweat glands and cutaneous vessels possess growth hormone (GH) and insulin-like growth factor 1 (IGF-1) receptors. Here, we assessed if exercise increases GH and IGF-1 in skin interstitial fluid, and whether baseline and exercise-induced increases in GH and IGF-1 concentrations in skin interstitial fluid/blood are associated with heat loss responses of sweating and cutaneous vasodilation. METHODS: Sixteen young adults (7 women) performed a 50-min moderate-intensity exercise bout (50% VO2peak ) during which skin dialysate and blood samples were collected...
March 6, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/38443857/the-association-between-new-inflammation-markers-and-frequent-peritoneal-dialysis-associated-peritonitis
#20
JOURNAL ARTICLE
Jing Tang, Dongxue Wang, Yun Chen, Jinhong Feng
OBJECTIVE: To validate an association between new inflammation and frequent peritoneal dialysis-associated peritonitis (PDAP). MATERIALS AND METHODS: In China, retrospective clinical data were collected on 208 patients who received continuous ambulatory peritoneal dialysis (CAPD) between 2010 and 2021. The patients were divided into two groups: non-frequent PDAP (the interval between two peritonitis episodes of more than one year) and frequent PDAP (the interval between two peritonitis episodes of less than one year)...
March 5, 2024: BMC Nephrology
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