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https://www.readbyqxmd.com/read/28539035/the-performance-of-serum-biomarkers-for-predicting-fibrosis-in-patients-with-chronic-viral-hepatitis
#1
Chang Seok Bang, Ha Yan Kang, Gyu Ho Choi, Suk Bae Kim, Wonae Lee, Il Han Song
Background/Aims: The invasiveness of a liver biopsy and its inconsistent results have prompted efforts to develop noninvasive tools to evaluate the severity of chronic hepatitis. This study was intended to assess the performance of serum biomarkers for predicting liver fibrosis in patients with chronic viral hepatitis. Methods: A total of 302 patients with chronic hepatitis B or C, who had undergone liver biopsy, were retrospectively enrolled. We investigated the diagnostic accuracy of several clinical factors for predicting advanced fibrosis (F≥3)...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28539007/videolaryngoscopy-versus-direct-laryngoscopy-for-tracheal-intubation-in-children-excluding-neonates
#2
REVIEW
Ibtihal S Abdelgadir, Robert S Phillips, Davinder Singh, Michael P Moncreiff, Joanne L Lumsden
BACKGROUND: Direct laryngoscopy is the method currently used for tracheal intubation in children. It occasionally offers unexpectedly poor laryngeal views. Indirect laryngoscopy involves visualizing the vocal cords by means other than obtaining a direct sight, with the potential to improve outcomes. We reviewed the current available literature and performed a meta-analysis to compare direct versus indirect laryngoscopy, or videolaryngoscopy, with regards to efficacy and adverse effects...
May 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28538993/fefsem-neuronal-response-during-combined-volitional-and-reflexive-pursuit
#3
Leah Bakst, Jérome Fleuriet, Michael J Mustari
Although much is known about volitional and reflexive smooth eye movements individually, much less is known about how they are coordinated. It is hypothesized that separate cortico-ponto-cerebellar loops subserve these different types of smooth eye movements. Specifically, the MT-MST-DLPN pathway is thought to be critical for ocular following eye movements, whereas the FEF-NRTP pathway is understood to be vital for volitional smooth pursuit. However, the role that these loops play in combined volitional and reflexive behavior is unknown...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28538992/intercepting-a-moving-target-on-line-or-model-based-control
#4
Huaiyong Zhao, William H Warren
When walking to intercept a moving target, people take an interception path that appears to anticipate the target's trajectory. According to the constant bearing strategy, the observer holds the bearing direction of the target constant based on current visual information, consistent with on-line control. Alternatively, the interception path might be based on an internal model of the target's motion, known as model-based control. To investigate these two accounts, participants walked to intercept a moving target in a virtual environment...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28538981/association-of-streptococcal-throat-infection-with-mental-disorders-testing-key-aspects-of-the-pandas-hypothesis-in-a-nationwide-study
#5
Sonja Orlovska, Claus Høstrup Vestergaard, Bodil Hammer Bech, Merete Nordentoft, Mogens Vestergaard, Michael Eriksen Benros
Importance: Streptococcal infection has been linked with the development of obsessive-compulsive disorder (OCD) and tic disorders, a concept termed pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). However, previous studies of this association have been small, and the results have been conflicting. Objective: To investigate the risk of mental disorders, specifically OCD and tic disorders, after a streptococcal throat infection...
May 24, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28538980/downregulation-of-lysyl-oxidase-protects-retinal-endothelial-cells-from-high-glucose-induced-apoptosis
#6
Dongjoon Kim, Robert P Mecham, Philip C Trackman, Sayon Roy
Purpose: To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods: Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG medium and transfected with LOX small interfering RNA (siRNA), scrambled siRNA as control, or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538978/the-characteristics-of-deep-optic-nerve-head-morphology-in-myopic-normal-tension-glaucoma
#7
Jong Chul Han, Eun Jung Lee, Si Bum Kim, Changwon Kee
Purpose: To investigate the relationship between axial length (AL) and deep optic nerve head (ONH) structure and to evaluate the characteristics of deep ONH structures in myopic normal tension glaucoma (NTG). Methods: The following parameters were assessed using spectral-domain optical coherence tomography (SD-OCT): externally oblique border tissue (EOBT) length, ONH tilt angle, optic canal (OC) obliqueness, and β-zone peripapillary atrophy (PPA). In addition, the angular location of the maximal value of each parameter and retinal nerve fiber layer (RNFL) defect were measured using infrared and red-free photos...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538949/the-follicular-skin-microbiome-in-patients-with-hidradenitis-suppurativa-and-healthy-controls
#8
Hans Christian Ring, Jonathan Thorsen, Ditte M Saunte, Berit Lilje, Lene Bay, Peter Theut Riis, Niels Larsen, Lee O'Brien Andersen, Henrik V Nielsen, Iben M Miller, Thomas Bjarnsholt, Kurt Fuursted, Gregor Borut Jemec
Importance: Although the pathogenesis of hidradenitis suppurativa (HS) remains enigmatic, several factors point to potential involvement of the cutaneous microbiome. Insight into the cutaneous microbiome in HS using next-generation sequencing may provide novel data on the microbiological diversity of the skin. Objective: To investigate the follicular skin microbiome in patients with HS and in healthy controls. Design, Setting, and Participants: This case-control study obtained punch biopsy specimens from patients with HS (lesional and nonlesional) and healthy controls between October 1, 2014, and August 1, 2016...
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28538948/exploring-audiologists-language-and-hearing-aid-uptake-in-initial-rehabilitation-appointments
#9
Anna Sciacca, Carly Meyer, Katie Ekberg, Caitlin Barr, Louise Hickson
Purpose: The study aimed (a) to profile audiologists' language during the diagnosis and management planning phase of hearing assessment appointments and (b) to explore associations between audiologists' language and patients' decisions to obtain hearing aids. Method: Sixty-two audiologist-patient dyads participated. Patient participants were aged 55 years or older. Hearing assessment appointments were audiovisually recorded and transcribed for analysis. Audiologists' language was profiled using two measures: general language complexity and use of jargon...
May 23, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28538925/diet-and-body-fat-in-adolescence-and-early-adulthood-a-systematic-review-of-longitudinal-studies
#10
Bruna Celestino Schneider, Samuel Carvalho Dumith, Silvana Paiva Orlandi, Maria Cecília Formoso Assunção
Adipose tissue is a vital component of the human body, but in excess, it represents a risk to health. According to the World Health Organization, one of the main factors determining excessive body adiposity is the dietary habit. This systematic review investigated longitudinal studies that assessed the association between diet and body fat in adolescents and young adults. Twenty-one relevant papers published between 2001 and 2015 were selected. The most used method for estimating body fat was the body mass index (15 studies)...
May 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28538878/hidradenitis-suppurativa-epidemiological-study-of-cases-diagnosed-at-a-dermatological-reference-center-in-the-city-of-bauru-in-the-brazilian-southeast-state-of-s%C3%A3-o-paulo-between-2005-and-2015
#11
Tatiana Cristina Pedro Cordeiro de Andrade, Bruna Cortinóvis Vieira, Agnes Mayumi Nakano Oliveira, Tábata Yamasaki Martins, Tatiane Meira Santiago, Antônio Carlos Ceribelli Martelli
Background: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present. Objective: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge about the disease. Methods: This cross-sectional descriptive study with retrospective analysis of medical records of 194 patients diagnosed with hidrosadenitis in a dermatological reference center in the city of Bauru (SP) between 2005 and 2015...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538877/effects-of-isotretinoin-on-the-olfactory-function-in-patients-with-acne
#12
Demet Kartal, Mehmet Yaşar, Levent Kartal, Ibrahim Özcan, Murat Borlu
Background: Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice. Objective: This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy. Methods: Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538875/particular-characteristics-of-atopic-eczema-in-tropical-environments-the-tropical-environment-control-for-chronic-eczema-and-molecular-assessment-teccema-cohort-study
#13
Jorge Sánchez, Andrés Sánchez, Ricardo Cardona
Background: Atopic dermatitis is a prevalent health problem in the world. Allergic sensitization is an important risk factor, but the roles of other factors, inherent in tropic region, are unknown. Objective: A cohort study was designed in a tropical city to investigate molecular and environmental risk factors for eczema, considering as particular features perennial exposure to mites, poor living conditions and others tropical characteristics. Methods: 433 patients were included at baseline and biological samples were collected during 24 months of follow-up...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28538838/relationship-between-matrix-metalloproteinases-and-the-occurrence-and-development-of-ovarian-cancer
#14
Y Zhang, Q Chen
Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high expression in ovarian cancer tissues. MMPs are considered to be related to the occurrence, development, invasion and metastasis of ovarian cancer. Moreover, some studies have discovered that the unbalance between MMPs and tissue inhibitor of metalloproteinases (TIMPs) are associated with the malignant phenotype of tumors. This review summarizes the latest research progress of MMPs in ovarian cancer...
May 18, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28538836/establishment-of-patient-derived-tumor-xenograft-pdtx-models-using-samples-from-ct-guided-percutaneous-biopsy
#15
Y-P Zhuang, Y-P Zhu, H-Y Wang, L Sun, J Zhang, Y-P Hao, L Wang
This study aimed to investigate the feasibility of the establishment of a human cancer xenograft model using samples from computed tomography (CT)-guided percutaneous biopsy. Fresh tumor tissues obtained from 10 cancer patients by CT-guided percutaneous biopsy were subcutaneously inoculated into NOD-Prkdcem26Il2rgem26Nju (NCG) mice to establish human patient-derived tumor xenograft (PDTX) models. The formation of first and second generation xenografts was observed, and tumor volume was recorded over time. Tumor tissue consistency between the PDTX model and primary tumors in patients was compared using H&E staining and immunohistochemistry...
May 18, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28538833/research-about-suppression-effect-and-auditory-processing-in-individuals-who-stutter
#16
Cláudia Fassin Arcuri, Ana Maria Schiefer, Marisa Frasson de Azevedo
Purpose: To verify the auditory processing abilities and occurrence of the suppression effect of Otoacoustic Emissions (OAE) in individuals who stutter. Methods: The study sample comprised 15 adult individuals who stutter, aged 18-40 years, with stuttering severity ranging from mild to severe, paired according to gender, age, and schooling with individuals without speech complaint or disorder. All participants underwent conventional clinical evaluation, specific stuttering assessment, and basic (audiometry, imitanciometry, and measurement of acoustic reflexes) and specific (auditory processing evaluation and measurement of suppression effect of OAEs) audiological assessments...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28538830/subjective-memory-complaints-and-their-relation-with-verbal-fluency-in-active-older-people
#17
Flavia Rodrigues Bernardes, Camila Kretzer Machado, Monique Coan Souza, Marcos José Machado, Aline Megumi Arakawa Belaunde
Purpose: To verify subjective memory complaints and their relation to verbal fluency in older people participating in community groups. Methods: An epidemiological quantitative study performed in community groups for older people in Florianópolis, state of Santa Catarina, Brazil. Data were collected by structured interview using the Memory Complaint Questionnaire (MAC-Q) and the Verbal Fluency Test (VFT) by semantic categories "animals/minute". For an inferential descriptive analysis, data with p < 5% were considered...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28538828/families-perception-of-children-adolescents-with-language-impairment-through-the-international-classification-of-functioning-disability-and-health-icf-cy
#18
Daniele Theodoro Ostroschi, Maria de Lurdes Zanolli, Regina Yu Shon Chun
Purpose: To investigate the perception of family members regarding linguistic conditions and social participation of children and adolescents with speech and language impairments using the International Classification of Functioning, Disability and Health - Children and Youth Version (ICF-CY). Methods: Quali-quantitative approach research, in which a survey of medical records of 24 children/adolescents undergoing speech-language therapy and interviews with their family members was conducted...
May 22, 2017: CoDAS
https://www.readbyqxmd.com/read/28538823/family-health-team-reports-of-conduct-on-child-hearing-loss
#19
Jullyane Florencio Pachêco da Silva, Cleide Fernandes Teixeira, Maria Luiza Lopes Timóteo de Lima, Fabiana de Oliveira Silva Sousa, Silvana Maria Sobral Griz
Purpose: To analyze the performance of family health teams toward the suspicion and identification of child hearing loss. Methods: This is a case study. Data were collected in three focus groups with three family health teams of a health district in the metropolitan area of Recife, Brazil. All data were transcribed and analyzed based on the interview analysis model of condensation of meanings. Results: The family health professionals investigated made use of some resources to assess child reaction to sound stimuli, but they were mostly unaware of risk indicators for hearing loss and presented doubts about conducting referrals...
May 15, 2017: CoDAS
https://www.readbyqxmd.com/read/28538822/association-between-harmful-oral-habits-and-the-structures-and-functions-of-the-stomatognathic-system-perception-of-parents-guardians
#20
Thayse Steffen Pereira, Fabiana de Oliveira, Maria Cristina de Almeida Freitas Cardoso
Purpose: To verify the occurrence and associate the presence and duration of harmful oral habits with the structures and functions of the stomatognathic system. Methods: This is a cross-sectional, exploratory study. Participants' participation was formalized by the signing of an Informed Consent Form. The non-probabilistic sample comprised 289 children aged one to 12 years assisted at a Family Health Strategy unit. The data were obtained through a questionnaire to identify harmful oral habits applied to the children's parents and/or guardians...
May 15, 2017: CoDAS
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