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https://www.readbyqxmd.com/read/28344971/how-to-train-a-cell-cutting-edge-molecular-tools
#1
REVIEW
Jakub Czapiński, Michał Kiełbus, Joanna Kałafut, Michał Kos, Andrzej Stepulak, Adolfo Rivero-Müller
In biological systems, the formation of molecular complexes is the currency for all cellular processes. Traditionally, functional experimentation was targeted to single molecular players in order to understand its effects in a cell or animal phenotype. In the last few years, we have been experiencing rapid progress in the development of ground-breaking molecular biology tools that affect the metabolic, structural, morphological, and (epi)genetic instructions of cells by chemical, optical (optogenetic) and mechanical inputs...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28339751/changes-in-secondhand-smoke-exposure-after-smoke-free-legislation-spain-2006-2011
#2
Esteve Fernández, Marcela Fu, Mónica Pérez-Ríos, Anna Schiaffino, Xisca Sureda, María J López
Introduction: In 2011, the Spanish partial smoke-free legislation was extended to affect all enclosed settings, including hospitality venues and selected outdoor areas. This study evaluated the change in self-reported exposure to secondhand smoke among the adult, non-smoking population. Methods: Two cross-sectional surveys were conducted on nationally representative samples of the adult (≥18 years) non-smoking Spanish population. One was conducted in 2006 (6 months after the first ban) and the other in 2011, 6 months after the new ban was implemented...
February 28, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28331833/survey-of-spatial-distribution-of-vector-borne-disease-in-neighborhood-dogs-in-southern-brazil
#3
Caroline Constantino, Edson Ferraz Evaristo de Paula, Ana Pérola Drulla Brandão, Fernando Ferreira, Rafael Felipe da Costa Vieira, Alexander Welker Biondo
Neighborhood dogs may act as reservoirs and disseminators of vector-borne diseases in urban areas. Accordingly, the aim of this study was to ascertain the health status and the vector-borne pathogens infecting dogs living in public areas with high levels of human movement in the city of Curitiba, southern Brazil. Blood samples from 21 neighborhood dogs that were found in nine of 22 bus stations and two public parks were subjected to a complete blood cell (CBC) count, serum biochemical profiling, a commercial rapid ELISA test and a commercial real-time PCR panel of vector-borne diseases...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28329930/-commuting-mode-specific-exposure-to-pm-2-5-in-urban-area-of-guangzhou
#4
X J Lyu, Z H Li, X Li, W L Zeng, P Yang, Q X Lin, J Y Zheng, X L Du, Y Z Gu, Y Q Zhao, R S Xie, T Liu, H L Lin, W J Ma
Objective: To find the differences in PM(2.5) exposure level in the context of four commuting modes (by walk, bicycle, bus and subway) in Guangzhou. Methods: The PM(2.5) exposure assessment was carried out from January to December 2015 in Guangzhou. PM(2.5) was measured by using SidePak individual dust meter (AM510, TSI Inc. USA) with time interval of 1 minute. Our measurement was taken on Monday, Wednesday, Friday and Sunday in the second week of each month and the samples were collected in the morning (07:00-09:00), afternoon (11:00-13:00) and evening (17:00-19:00)...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28318430/factors-contributing-to-intercity-commercial-bus-drivers-crash-involvement-risk
#5
Mohammad Mehdi Besharati, Ali Tavakoli Kashani
The aim of this study was to examine the influence of demographic, environmental and occupational factors as well as behavioural characteristics of intercity bus drivers, on their crash involvement risk. A total number of 107 intercity bus drivers from Tehran, Iran were participated in the study. Logistic regression model suggested that smokers, those who drive during night to morning, less experienced drivers as well as those who operate older buses are more likely to be involved in crashes. In addition, one unit increase in the weekly driving hours might significantly increase the drivers' crash involvement risk...
March 20, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28316645/neighborhood-sociodemographics-and-change-in-built-infrastructure
#6
Jana A Hirsch, Geoffrey F Green, Marc Peterson, Daniel A Rodriguez, Penny Gordon-Larsen
While increasing evidence suggests an association between physical infrastructure in neighbourhoods and health outcomes, relatively little research examines how neighbourhoods change physically over time and how these physical improvements are spatially distributed across populations. This paper describes the change over 25 years (1985-2010) in bicycle lanes, off-road trails, bus transit service, and parks, and spatial clusters of changes in these domains relative to neighbourhood sociodemographics in four U...
2017: Journal of Urbanism
https://www.readbyqxmd.com/read/28303741/weight-of-the-evidence-evaluation-of-2-4-d-potential-for-interactions-with-the-estrogen-androgen-and-thyroid-pathways-and-steroidogenesis
#7
B H Neal, J Bus, M S Marty, K Coady, A Williams, J Staveley, J C Lamb
A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality in vitro, in vivo ecotoxicological and in vivo mammalian toxicological studies. Epidemiological studies were also considered. Toxicokinetic data provided the basis for determining rational cutoffs above which exposures were considered irrelevant to humans based on exceeding thresholds for saturation of renal clearance (TSRC); extensive human exposure and biomonitoring data support that these boundaries far exceed human exposures and provide ample margins of exposure...
March 2, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28298370/alcohol-policy-changes-and-22-year-trends-in-individual-alcohol-consumption-in-a-swiss-adult-population-a-1993-2014-cross-sectional-population-based-study
#8
Shireen Dumont, Pedro Marques-Vidal, Thierry Favrod-Coune, Jean-Marc Theler, Jean-Michel Gaspoz, Barbara Broers, Idris Guessous
OBJECTIVE: Evidence on the impact of legislative changes on individual alcohol consumption is limited. Using an observational study design, we assessed trends in individual alcohol consumption of a Swiss adult population following the public policy changes that took place between 1993 and 2014, while considering individual characteristics and secular trends. DESIGN: Cross-sectional study. SETTING: Swiss general adult population. PARTICIPANTS: Data from 18 963 participants were collected between 1993 and 2014 (aged 18-75 years)...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28293047/personality-driving-behavior-and-mental-disorders-factors-as-predictors-of-road-traffic-accidents-based-on-logistic-regression
#9
Seyyed Salman Alavi, Mohammad Reza Mohammadi, Hamid Souri, Soroush Mohammadi Kalhori, Fereshteh Jannatifard, Ghazal Sepahbodi
BACKGROUND: The aim of this study was to evaluate the effect of variables such as personality traits, driving behavior and mental illness on road traffic accidents among the drivers with accidents and those without road crash. METHODS: In this cohort study, 800 bus and truck drivers were recruited. Participants were selected among drivers who referred to Imam Sajjad Hospital (Tehran, Iran) during 2013-2015. The Manchester driving behavior questionnaire (MDBQ), big five personality test (NEO personality inventory) and semi-structured interview (schizophrenia and affective disorders scale) were used...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28284131/decision-support-for-environmental-management-of-industrial-non-hazardous-secondary-materials-new-analytical-methods-combined-with-simulation-and-optimization-modeling
#10
Keith W Little, Nadeesha H Koralegedara, Coleen M Northeim, Souhail R Al-Abed
Non-hazardous solid materials from industrial processes, once regarded as waste and disposed in landfills, offer numerous environmental and economic advantages when put to beneficial uses (BUs). Proper management of these industrial non-hazardous secondary materials (INSM) requires estimates of their probable environmental impacts among disposal as well as BU options. The U.S. Environmental Protection Agency (EPA) has recently approved new analytical methods (EPA Methods 1313-1316) to assess leachability of constituents of potential concern in these materials...
March 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28282961/pedestrians-in-traffic-environments-ultrafine-particle-respiratory-doses
#11
Maurizio Manigrasso, Claudio Natale, Matteo Vitali, Carmela Protano, Pasquale Avino
Particulate matter has recently received more attention than other pollutants. PM10 and PM2.5 have been primarily monitored, whereas scientists are focusing their studies on finer granulometric sizes due both to their high number concentration and their high penetration efficiency into the respiratory system. The purpose of this study is to investigate the population exposure to UltraFine Particles (UFP, submicrons in general) in outdoor environments. The particle number doses deposited into the respiratory system have been compared between healthy individuals and persons affected by Chronic Obstructive Pulmonary Disease (COPD)...
March 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28279581/exposure-of-in-pram-babies-to-airborne-particles-during-morning-drop-in-and-afternoon-pick-up-of-school-children
#12
Prashant Kumar, Ioar Rivas, Lovish Sachdeva
In-pram babies are more susceptible to air pollution effects, yet studies assessing their exposure are limited. We measured size-resolved particle mass (PMC; 0.25-32 μm) and number (PNC; 0.2-1 μm) concentrations on a 2.7 km route. The instruments were placed inside a baby pram. The route passed through 4 traffic intersections (TIs) and a bus stand. A total of ∼87 km road length was covered through 64 trips, made during school drop-in (morning) and pick-up (afternoon) hours. The objectives were to assess PMC and PNC exposure to in-pram babies at different route segments, understand their physicochemical characteristics and exposure differences between in-pram babies and adults carrying them...
March 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28274811/iarc-use-of-oxidative-stress-as-key-mode-of-action-characteristic-for-facilitating-cancer-classification-glyphosate-case-example-illustrating-a-lack-of-robustness-in-interpretative-implementation
#13
James S Bus
The International Agency for Research on Cancer (IARC) has formulated 10 key characteristics of human carcinogens to incorporate mechanistic data into cancer hazard classifications. The analysis used glyphosate as a case example to examine the robustness of IARC's determination of oxidative stress as "strong" evidence supporting a plausible cancer mechanism in humans. The IARC analysis primarily relied on 14 human/mammalian studies; 19 non-mammalian studies were uninformative of human cancer given the broad spectrum of test species and extensive use of formulations and aquatic testing...
March 6, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28274757/an-evaluation-of-our-experience-in-position-verification-of-catheters-used-for-interstitial-high-dose-rate-brachytherapy-of-solitary-bladder-tumors
#14
S J E A Bus, N G Leus, B J Oosterveld, M P R Van Gellekom, G J M van de Loop, E M van der Steen-Banasik
PURPOSE: The goal of this study was to verify the position of catheters used over 4 days for brachytherapy of solitary bladder tumors. METHODS AND MATERIALS: The study covered three phases. Shifting of catheters was studied using daily position verification CT scans of 20 patients. The possibility to omit the CT scan on Day 2 by adding a loading margin of 4 mm on each side was studied using data of 5 patients. Whether the Day 4 verification CT scan could be omitted if this margin was used, was studied for another group of 10 patients, comparing the Day 3 treatment plan to the Day 4 CT scan...
March 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28269391/design-and-validation-of-a-wearable-drl-less-eeg-using-a-novel-fully-reconfigurable-architecture
#15
Ruhi Mahajan, Bashir I Morshed, Gavin M Bidelman
The conventional EEG system consists of a driven-right-leg (DRL) circuit, which prohibits modularization of the system. We propose a Lego-like connectable fully reconfigurable architecture of wearable EEG that can be easily customized and deployed at naturalistic settings for collecting neurological data. We have designed a novel Analog Front End (AFE) that eliminates the need for DRL while maintaining a comparable signal quality of EEG. We have prototyped this AFE for a single channel EEG, referred to as Smart Sensing Node (SSN), that senses brain signals and sends it to a Command Control Node (CCN) via an I2C bus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268670/a-distributed-current-stimulator-asic-for-high-density-neural-stimulation
#16
Jeong Hoan Park, Chaebin Kim, Seung-Hee Ahn, Tae Mok Gwon, Joonsoo Jeong, Sang Beom Jun, Sung June Kim
This paper presents a novel distributed neural stimulator scheme. Instead of a single stimulator ASIC in the package, multiple ASICs are embedded at each electrode site for stimulation with a high density electrode array. This distributed architecture enables the simplification of wiring between electrodes and stimulator ASIC that otherwise could become too complex as the number of electrode increases. The individual ASIC chip is designed to have a shared data bus that independently controls multiple stimulating channels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268203/effects-of-altruism-and-burnout-on-driving-behavior-of-bus-drivers
#17
Xia Shi, Liang Zhang
Personality traits predict driving behaviors. However, the mechanism underlying this relationship has not been adequately investigated in professional drivers. The current study investigated the relationship between altruistic personality and aberrant driving behaviors, and the potential role of burnout. A total of 194 bus drivers completed questionnaires including measures of altruism, burnout and aberrant driving behaviors (aggressive violations, ordinary violations, errors, and lapses). The results showed that altruism was negatively correlated with burnout, and with all the four subcategories of aberrant driving behavior...
March 4, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28262405/improving-the-accuracy-of-microelectrode-recording-in-deep-brain-stimulation-surgery-with-intraoperative-ct
#18
Ryan B Kochanski, Gian Pal, Sander Bus, Leo Verhagen Metman, Sepehr Sani
Microelectrode recording (MER) is used to confirm electrophysiological signals within intended anatomic targets during deep brain stimulation (DBS) surgery. We describe a novel technique called intraoperative CT-guided extrapolation (iCTE) to predict the intended microelectrode trajectory and, if necessary, make corrections in real-time before dural opening. Prior to dural opening, a guide tube was inserted through the headstage and rested on dura. Intraoperative CT (iCT) was obtained, and a trajectory was extrapolated along the path of the guide tube to target depth using targeting software...
March 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28261406/the-impact-of-see-the-city-you-serve-field-trip-an-educational-tool-for-teaching-social-determinants-of-health
#19
Aileen Y Chang, Tracie L Bass, Monique Duwell, Jeffrey S Berger, Raksha Bangalore, Nancy S Lee, Richard L Amdur, Marcus Andrews, Esme Fahnestock, Lamek Kahsay, Jehan El-Bayoumi
BACKGROUND : There has been limited evaluation of tools for teaching social determinants of health (SDOH). OBJECTIVE : We evaluated a field trip as a tool for teaching SDOH to incoming medical interns. METHODS : Incoming interns from The George Washington University participated in a bus field trip of Washington, DC, guided by community partners. The field trip introduced trainees to local neighborhoods. Pre- and postactivity surveys developed by the authors were analyzed using a Wilcoxon signed rank test...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28257819/in-vitro-and-ex-vivo-permeability-studies-of-paclitaxel-and-doxorubicin-from-drug-eluting-biodegradable-ureteral-stents
#20
Alexandre A Barros, Carlos Oliveira, Rui L Reis, Estevão Lima, Ana Rita C Duarte
A drug-eluting biodegradable ureteral stent (BUS) has been developed as a new approach for the treatment of urothelial tumors of upper urinary tract cancer. In a previous work, this system has proven to be a good carrier for anticancer drugs as a potential effective and sustainable intravesical drug delivery (IDD) system. BUS has revealed to reduce in 75% the viability of human urothelial cancer cells (T24) after 72 h of contact and demonstrated minimal cytotoxic effect on human umbilical vein endothelial cells (HUVECs) which were used as a control...
February 28, 2017: Journal of Pharmaceutical Sciences
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