Valeria Aguillon-Rodriguez, Dora Angelaki, Hannah Bayer, Niccolo Bonacchi, Matteo Carandini, Fanny Cazettes, Gaelle Chapuis, Anne K Churchland, Yang Dan, Eric Dewitt, Mayo Faulkner, Hamish Forrest, Laura Haetzel, Michael Häusser, Sonja B Hofer, Fei Hu, Anup Khanal, Christopher Krasniak, Ines Laranjeira, Zachary F Mainen, Guido Meijer, Nathaniel J Miska, Thomas D Mrsic-Flogel, Masayoshi Murakami, Jean-Paul Noel, Alejandro Pan-Vazquez, Cyrille Rossant, Joshua Sanders, Karolina Socha, Rebecca Terry, Anne E Urai, Hernando Vergara, Miles Wells, Christian J Wilson, Ilana B Witten, Lauren E Wool, Anthony M Zador
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements of mouse behavior. Here, we show that a standardized task to probe decision-making in mice produces reproducible results across multiple laboratories. We adopted a task for head-fixed mice that assays perceptual and value-based decision making, and we standardized training protocol and experimental hardware, software, and procedures...
May 20, 2021: ELife