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shawn ahmed

Saleem I Abdulrauf, Ahmed M Ashour, Eric Marvin, Jeroen Coppens, Brian Kang, Tze Yu Yeh Hsieh, Breno Nery, Juan R Penanes, Aysha K Alsahlawi, Shawn Moore, Hussam Abou Al-Shaar, Joanna Kemp, Kanika Chawla, Nanthiya Sujijantarat, Alaa Najeeb, Nadeem Parkar, Vilaas Shetty, Tina Vafaie, Jastin Antisdel, Tony A Mikulec, Randall Edgell, Jonathan Lebovitz, Matt Pierson, Paulo Henrique Pires de Aguiar, Paula Buchanan, Angela Di Cosola, George Stevens
INTRODUCTION: Numerical classification systems for the internal carotid artery (ICA) are available, but modifications have added confusion to the numerical systems. Furthermore, previous classifications may not be applicable uniformly to microsurgical and endoscopic procedures. The purpose of this study was to develop a clinically useful classification system. MATERIALS AND METHODS: We performed cadaver dissections of the ICA in 5 heads (10 sides) and evaluated 648 internal carotid arteries with computed tomography angiography...
July 2016: Journal of Craniovertebral Junction and Spine
Mohamed S Ebeida, Ahmad A Rushdi, Muhammad A Awad, Ahmed H Mahmoud, Dong-Ming Yan, Shawn A English, John D Owens, Chandrajit L Bajaj, Scott A Mitchell
We introduce an algorithmic framework for tuning the spatial density of disks in a maximal random packing, without changing the sizing function or radii of disks. Starting from any maximal random packing such as a Maximal Poisson-disk Sampling (MPS), we iteratively relocate, inject (add), or eject (remove) disks, using a set of three successively more-aggressive local operations. We may achieve a user-defined density, either more dense or more sparse, almost up to the theoretical structured limits. The tuned samples are conflict-free, retain coverage maximality, and, except in the extremes, retain the blue noise randomness properties of the input...
August 2016: Computer Graphics Forum: Journal of the European Association for Computer Graphics
Shawn Wen, Kelly E Harvard, Cara Smith Gueye, Sara E Canavati, Arna Chancellor, Be-Nazir Ahmed, John Leaburi, Dysoley Lek, Rinzin Namgay, Asik Surya, Garib D Thakur, Maxine Anne Whittaker, Roly D Gosling
BACKGROUND: Significant progress has been made in reducing the malaria burden in the Asia Pacific region, which is aggressively pursuing a 2030 regional elimination goal. Moving from malaria control to elimination requires National Malaria Control Programmes (NMCPs) to target interventions at populations at higher risk, who are often not reached by health services, highly mobile and difficult to test, treat, and track with routine measures, and if undiagnosed, can maintain parasite reservoirs and contribute to ongoing transmission...
2016: Malaria Journal
Sheikh Sohail Ahmed, Shawn R Hicks, James E Slaven, Mara E Nitu
OBJECTIVE: Sedation may be needed for safe, effective completion of pediatric dental procedures. Procedural sedation is performed in a children's hospital based dental office. The three sedation approaches: a propofol-only (P-O) approach (2-3 mg/kg titrated to the needed level of sedation), an approach that includes either i.v. ketamine (K+P) (0.25 or 0.5 mg/kg) or i.v. fentanyl (F+P) (0.5-1 mcg/kg) prior to propofol administration. We sought to determine safety and efficacy of various propofol based sedation protocols...
2016: Journal of Clinical Pediatric Dentistry
A Razzaque Ahmed, Shawn Shetty, Srini Kaveri, Zachary S Spigelman
BACKGROUND: Bullous pemphigoid is an autoimmune blistering skin disease that predominantly affects the elderly. Conventional therapy using high-dose systemic corticosteroids and immunosuppressive agents can be ineffective in some patients and produce adverse events and relapses. Hence, alternate therapies are required. OBJECTIVE: The clinical outcomes of patients with extensive, recalcitrant bullous pemphigoid treated with a combination therapy of rituximab (RTX) and intravenous immunoglobulin were evaluated...
April 2016: Journal of the American Academy of Dermatology
Taksim Ahmed, Amany O Kamel, Shawn D Wettig
Nonviral gene therapy using gemini surfactants is a unique approach to medicine that can be adapted toward the treatment of various diseases. Recently, gemini surfactants have been utilized as candidates for the formation of nonviral vectors. The chemical structure of the surfactant (variations in the alkyl tail length and spacer/head group) and the resulting physicochemical properties of the lipoplexes are critical parameters for efficient gene transfection. Moreover, studying the interaction of the surfactant with DNA can help in designing an efficient vector and understanding how transfection complexes overcome various cellular barriers...
February 2016: Nanomedicine
Taksim Ahmed, Amany O Kamel, Shawn D Wettig
Nonviral gene delivery, provides distinct treatment modalities for the inherited and acquired diseases, relies upon the encapsulation of a gene of interest, which is then ideally delivered to the target cells. Variations in the chemical structure of gemini surfactants and subsequent physicochemical characteristics of the gemini-based lipoplexes and their impact on efficient gene transfection were assessed in part I, which was published in first March 2016 issue of Nanomedicine (1103). In order to design an efficient vector using gemini surfactants, the interaction of the surfactant with DNA and other components of the delivery system must be characterized, and more critically, well understood...
February 2016: Nanomedicine
Jessica D Sims, Jae Youn Hwang, Shawn Wagner, Felix Alonso-Valenteen, Chris Hanson, Jan Michael Taguiam, Richard Polo, Ira Harutyunyan, Gevorg Karapetyan, Karn Sorasaenee, Ahmed Ibrahim, Eduardo Marban, Rex Moats, Harry B Gray, Zeev Gross, Lali K Medina-Kauwe
Water-soluble corroles with inherent fluorescence can form stable self-assemblies with tumor-targeted cell penetration proteins, and have been explored as agents for optical imaging and photosensitization of tumors in pre-clinical studies. However, the limited tissue-depth of excitation wavelengths limits their clinical applicability. To examine their utility in more clinically-relevant imaging and therapeutic modalities, here we have explored the use of corroles as contrast enhancing agents for magnetic resonance imaging (MRI), and evaluated their potential for tumor-selective delivery when encapsulated by a tumor-targeted polypeptide...
November 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
William H Goodson, Leroy Lowe, David O Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K Charles, Andrew R Collins, Andrew Ward, Anna C Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J Barclay, Binhua P Zhou, Carmen Blanco-Aparicio, Carolyn J Baglole, Chenfang Dong, Chiara Mondello, Chia-Wen Hsu, Christian C Naus, Clement Yedjou, Colleen S Curran, Dale W Laird, Daniel C Koch, Danielle J Carlin, Dean W Felsher, Debasish Roy, Dustin G Brown, Edward Ratovitski, Elizabeth P Ryan, Emanuela Corsini, Emilio Rojas, Eun-Yi Moon, Ezio Laconi, Fabio Marongiu, Fahd Al-Mulla, Ferdinando Chiaradonna, Firouz Darroudi, Francis L Martin, Frederik J Van Schooten, Gary S Goldberg, Gerard Wagemaker, Gladys N Nangami, Gloria M Calaf, Graeme Williams, Gregory T Wolf, Gudrun Koppen, Gunnar Brunborg, H Kim Lyerly, Harini Krishnan, Hasiah Ab Hamid, Hemad Yasaei, Hideko Sone, Hiroshi Kondoh, Hosni K Salem, Hsue-Yin Hsu, Hyun Ho Park, Igor Koturbash, Isabelle R Miousse, A Ivana Scovassi, James E Klaunig, Jan Vondráček, Jayadev Raju, Jesse Roman, John Pierce Wise, Jonathan R Whitfield, Jordan Woodrick, Joseph A Christopher, Josiah Ochieng, Juan Fernando Martinez-Leal, Judith Weisz, Julia Kravchenko, Jun Sun, Kalan R Prudhomme, Kannan Badri Narayanan, Karine A Cohen-Solal, Kim Moorwood, Laetitia Gonzalez, Laura Soucek, Le Jian, Leandro S D'Abronzo, Liang-Tzung Lin, Lin Li, Linda Gulliver, Lisa J McCawley, Lorenzo Memeo, Louis Vermeulen, Luc Leyns, Luoping Zhang, Mahara Valverde, Mahin Khatami, Maria Fiammetta Romano, Marion Chapellier, Marc A Williams, Mark Wade, Masoud H Manjili, Matilde E Lleonart, Menghang Xia, Michael J Gonzalez, Michalis V Karamouzis, Micheline Kirsch-Volders, Monica Vaccari, Nancy B Kuemmerle, Neetu Singh, Nichola Cruickshanks, Nicole Kleinstreuer, Nik van Larebeke, Nuzhat Ahmed, Olugbemiga Ogunkua, P K Krishnakumar, Pankaj Vadgama, Paola A Marignani, Paramita M Ghosh, Patricia Ostrosky-Wegman, Patricia A Thompson, Paul Dent, Petr Heneberg, Philippa Darbre, Po Sing Leung, Pratima Nangia-Makker, Qiang Shawn Cheng, R Brooks Robey, Rabeah Al-Temaimi, Rabindra Roy, Rafaela Andrade-Vieira, Ranjeet K Sinha, Rekha Mehta, Renza Vento, Riccardo Di Fiore, Richard Ponce-Cusi, Rita Dornetshuber-Fleiss, Rita Nahta, Robert C Castellino, Roberta Palorini, Roslida Abd Hamid, Sabine A S Langie, Sakina E Eltom, Samira A Brooks, Sandra Ryeom, Sandra S Wise, Sarah N Bay, Shelley A Harris, Silvana Papagerakis, Simona Romano, Sofia Pavanello, Staffan Eriksson, Stefano Forte, Stephanie C Casey, Sudjit Luanpitpong, Tae-Jin Lee, Takemi Otsuki, Tao Chen, Thierry Massfelder, Thomas Sanderson, Tiziana Guarnieri, Tove Hultman, Valérian Dormoy, Valerie Odero-Marah, Venkata Sabbisetti, Veronique Maguer-Satta, W Kimryn Rathmell, Wilhelm Engström, William K Decker, William H Bisson, Yon Rojanasakul, Yunus Luqmani, Zhenbang Chen, Zhiwei Hu
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals...
June 2015: Carcinogenesis
Luciana E Leopold, Bree N Heestand, Soobin Seong, Ludmila Shtessel, Shawn Ahmed
Single-copy transgenes in Caenorhabditis elegans can be subjected to a potent, irreversible silencing process termed small RNA-induced epigenetic silencing (RNAe). RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that promote and respond to secondary small interfering RNA (siRNA) production. Here we define a related siRNA-mediated silencing process, termed "multigenerational RNAe," which can occur for transgenes that are maintained in a hemizygous state for several generations...
May 19, 2015: Proceedings of the National Academy of Sciences of the United States of America
A Razzaque Ahmed, Shawn Shetty
Rituximab is a chimeric monoclonal antibody that selectively binds to the CD20 molecule on B cells, resulting in their lysis. In autoimmune blistering diseases, the auto-antibody-producing B cells are destroyed and auto-antibody levels are reduced or eliminated. In the majority of patients, rituximab produces rapid clinical response and early resolution. In part, this accounts for the increased use of rituximab. Rituximab does not distinguish normal from pathologic B cells. Hence, shortly after its use, B-cell levels are zero and remain so for several months...
June 2015: American Journal of Clinical Dermatology
Rosemarie C D'Angelo, Maria Ouzounova, April Davis, Daejin Choi, Stevie M Tchuenkam, Gwangil Kim, Tahra Luther, Ahmed A Quraishi, Yasin Senbabaoglu, Sarah J Conley, Shawn G Clouthier, Khaled A Hassan, Max S Wicha, Hasan Korkaya
Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-renewal as well as in tumor development. However, the role of Notch signaling in breast cancer stem cells (CSC) remains to be determined. We utilized a lentiviral Notch reporter system to identify a subset of cells with a higher Notch activity (Notch(+)) or reduced activity (Notch(-)) in multiple breast cancer cell lines. Using in vitro and mouse xenotransplantation assays, we investigated the role of the Notch pathway in breast CSC regulation...
March 2015: Molecular Cancer Therapeutics
Kristine E Brown, Gustavo Chagoya, Shawn G Kwatra, Timothy Yen, Stephen T Keir, Mary Cooter, Katherine A Hoadley, Ahmed Rasheed, Eric S Lipp, Roger Mclendon, Francis Ali-Osman, Darell D Bigner, John H Sampson, Madan M Kwatra
The development of drugs to inhibit glioblastoma (GBM) growth requires reliable pre-clinical models. To date, proteomic level validation of widely used patient-derived glioblastoma xenografts (PDGX) has not been performed. In the present study, we characterized 20 PDGX models according to subtype classification based on The Cancer Genome Atlas criteria, TP53, PTEN, IDH 1/2, and TERT promoter genetic analysis, EGFR amplification status, and examined their proteomic profiles against those of their parent tumors...
June 2015: Journal of Neurochemistry
A Razzaque Ahmed, Shawn Shetty
Approximately 500 treatment recalcitrant pemphigus vulgaris patients have been treated with rituximab. They were treated according to the lymphoma protocol (N=224) or rheumatoid arthritis protocol (RAP) (N=209) patients. Others were treated with modifications or combinations of the two. The mean duration of follow-up with the lymphoma protocol was 28.9months and 21.9 in the rheumatoid arthritis protocol. The majority of the patients received corticosteroids and immunosuppressive therapy before, during, and after rituximab therapy...
April 2015: Autoimmunity Reviews
Aisa Sakaguchi, Peter Sarkies, Matt Simon, Anna-Lisa Doebley, Leonard D Goldstein, Ashley Hedges, Kohta Ikegami, Stacy M Alvares, Liwei Yang, Jeannine R LaRocque, Julie Hall, Eric A Miska, Shawn Ahmed
Germ cells are maintained in a pristine non-aging state as they proliferate over generations. Here, we show that a novel function of the Caenorhabditis elegans RNA interference proteins RNAi spreading defective (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature. rsd mutants cultured at high temperatures became progressively sterile and displayed loss of small interfering RNAs (siRNAs) that target spermatogenesis genes, simple repeats, and transposons. Desilencing of spermatogenesis genes occurred in late-generation rsd mutants, although defective spermatogenesis was insufficient to explain the majority of sterility...
October 14, 2014: Proceedings of the National Academy of Sciences of the United States of America
Amita A Desai, Lindsey M Thompson, Ahmed T Abdelmoity, Husam Kayyali, Shawn D St Peter
INTRODUCTION: The ketogenic diet is a treatment modality used for patients with refractory epilepsy. Development of cholelithiasis while on the ketogenic diet is a potential side effect that has been described in the literature. There however have not been any reports on the outcomes of continuing the diet after cholecystectomy. PATIENT: We present a 5-year-old boy with history of pharmacologically intractable epilepsy that was well controlled on the ketogenic diet...
September 2014: Pediatric Neurology
Rounak Nassirpour, Sachin Mathur, Mark M Gosink, Yizheng Li, Ahmed M Shoieb, Joanna Wood, Shawn P O'Neil, Bruce L Homer, Laurence O Whiteley
BACKGROUND: MicroRNAs (miRNAs) are small, non-coding RNAs that regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in many cellular processes and have been implicated in several diseases. Recent studies have reported significant levels of miRNAs in a variety of body fluids, raising the possibility that miRNAs could serve as useful biomarkers. Next-generation sequencing (NGS) is increasingly employed in biomedical investigations. Although concordance between this platform and qRT-PCR based assays has been reported in high quality specimens, information is lacking on comparisons in biofluids especially urine...
2014: BMC Genomics
Shawn E Nielsen, Imran Ahmed, Larry Cahill
Sex differences in emotional memory have received increasing interest over the past decade. However, to date, no work has explored how a postlearning stressor might modulate the influence of sex hormone status on memory for gist and peripheral detail in an emotional versus neutral context. Here, we tested 3 predictions. First, compared with naturally cycling (NC) women in the luteal phase, women on hormonal contraception (HC) would have significantly blunted hypothalamic-pituitary-adrenal reactivity to physical stress...
August 2014: Behavioral Neuroscience
Matt Simon, Peter Sarkies, Kohta Ikegami, Anna-Lisa Doebley, Leonard D Goldstein, Jacinth Mitchell, Aisa Sakaguchi, Eric A Miska, Shawn Ahmed
Defects in the Piwi/piRNA pathway lead to transposon desilencing and immediate sterility in many organisms. We found that the C. elegans Piwi mutant prg-1 became sterile after growth for many generations. This phenotype did not occur for RNAi mutants with strong transposon-silencing defects and was separable from the role of PRG-1 in transgene silencing. Brief periods of starvation extended the transgenerational lifespan of prg-1 mutants by stimulating the DAF-16/FOXO longevity transcription factor. Constitutive activation of DAF-16 via reduced daf-2 insulin/IGF-1 signaling immortalized prg-1 strains via RNAi proteins and histone H3 lysine 4 demethylases...
May 8, 2014: Cell Reports
Shawn Shetty, A R Ahmed
Normal antibodies and pathogenic autoantibodies are produced by B-cells and plasma cells. Rituximab is a chimeric monoclonal antibody that targets the CD20 molecule on cells that express them on their surface and kills them. Rituximab has been increasingly used to treat several autoimmune diseases. Studies on fatal outcomes associated with rituximab therapy are lacking. A comprehensive and detailed analysis in which the multiple factors that could contribute to a fatal outcome in all the autoimmune diseases in which rituximab has been used would be cumbersome, lack uniformity and would prove difficult in making certain definitive conclusions and comparisons, but more importantly it would not allow to provide specific precautions and recommendations to prevent mortality...
December 2013: Autoimmunity
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