keyword
https://read.qxmd.com/read/38458385/the-impact-of-patient-reported-frailty-on-cardiovascular-outcomes-in-elderly-patients-after-non-st-acute-coronary-syndrome
#1
JOURNAL ARTICLE
W W A van den Broek, M E Gimbel, R S Hermanides, C Runnett, R F Storey, P Knaapen, M E Emans, R M Oemrawsingh, J Cooke, G Galasko, R Walhout, M G Stoel, C von Birgelen, Paul F M M van Bergen, S L Brinckman, I Aksoy, A Liem, A W J Van't Hof, J W Jukema, A A C M Heestermans, D Nicastia, H Alber, D Austin, A Nasser, V Deneer, J M Ten Berg
BACKGROUND: As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess the impact of patient-reported frailty on the treatment and prognosis of elderly early survivors of non-ST-elevation acute coronary syndrome (NSTE-ACS). METHODS: Frailty data were obtained from two prospective trials, POPular Age and the POPular Age Registry, which both assessed elderly NSTE-ACS patients. Frailty was assessed one month after admission with the Groningen Frailty Indicator (GFI) and was defined as a GFI-score of 4 or higher...
March 7, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38168768/vitamin-b-12-produced-by-gut-bacteria-modulates-cholinergic-signalling
#2
JOURNAL ARTICLE
Woo Kyu Kang, Jeremy T Florman, Antonia Araya, Bennett W Fox, Andrea Thackeray, Frank C Schroeder, Albertha J M Walhout, Mark J Alkema
A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B12 -producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host Caenorhabditis elegans. Here we demonstrate that vitamin B12 reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/S-adenosylmethionine cycle in the intestine...
January 2, 2024: Nature Cell Biology
https://read.qxmd.com/read/37880368/disruption-of-sugar-nucleotide-clearance-is-a-therapeutic-vulnerability-of-cancer-cells
#3
JOURNAL ARTICLE
Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim
Identifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge1 . Here we report a therapeutic vulnerability in a sugar nucleotide biosynthetic pathway that can be exploited in cancer cells with only a limited impact on normal cells. A systematic examination of conditionally essential metabolic enzymes revealed that UXS1, a Golgi enzyme that converts one sugar nucleotide (UDP-glucuronic acid, UDPGA) to another (UDP-xylose), is essential only in cells that express high levels of the enzyme immediately upstream of it, UGDH...
October 25, 2023: Nature
https://read.qxmd.com/read/37801396/a-bacterial-pathogen-induces-developmental-slowing-by-high-reactive-oxygen-species-and-mitochondrial-dysfunction-in-caenorhabditis-elegans
#4
JOURNAL ARTICLE
Zeynep Mirza, Albertha J M Walhout, Victor Ambros
Host-pathogen interactions are complex by nature, and the host developmental stage increases this complexity. By utilizing Caenorhabditis elegans larvae as the host and the bacterium Pseudomonas aeruginosa as the pathogen, we investigated how a developing organism copes with pathogenic stress. By screening 36 P. aeruginosa isolates, we found that the CF18 strain causes a severe but reversible developmental delay via induction of reactive oxygen species (ROS) and mitochondrial dysfunction. While the larvae upregulate mitophagy, antimicrobial, and detoxification genes, mitochondrial unfolded protein response (UPRmt ) genes are repressed...
October 4, 2023: Cell Reports
https://read.qxmd.com/read/37768542/treatment-of-elderly-patients-with-non-st-elevation-myocardial-infarction-the-nationwide-popular-age-registry
#5
JOURNAL ARTICLE
Marieke E Gimbel, Dean R P P Chan Pin Yin, Wout W A van den Broek, Renicus S Hermanides, Floris Kauer, Annerieke H Tavenier, Dirk Schellings, Stijn L Brinckman, Salem H K The, Martin G Stoel, Ton A C M Heestermans, Saman Rasoul, Mireille E Emans, Machiel van de Wetering, Paul F M M van Bergen, Ronald Walhout, Debby Nicastia, Ismail Aksoy, Arnoud van 't Hof, Paul Knaapen, Cees-Joost Botman, Anho Liem, Cornelis de Nooijer, Joyce Peper, Johannes C Kelder, Jurriën M Ten Berg
OBJECTIVE: We describe the current treatment of elderly patients with non-ST-elevation myocardial infarction (NSTEMI) enrolled in a national registry. METHODS: The POPular AGE registry is a prospective, multicentre study of patients ≥ 75 years of age presenting with NSTEMI, performed in the Netherlands. Management was at the discretion of the treating physician. Cardiovascular events consisted of cardiovascular death, myocardial infarction and ischaemic stroke...
September 28, 2023: Netherlands Heart Journal
https://read.qxmd.com/read/37691135/group-schema-therapy-for-cluster-c-personality-disorders-a-multicentre-open-pilot-study
#6
JOURNAL ARTICLE
Carlijn J M Wibbelink, Anne-Sophie S M Venhuizen, Raoul P P P Grasman, Nathan Bachrach, Charlotte van den Hengel, Sandy Hudepohl, Liselotte Kunst, Hinde de Lange, Mark A Louter, Suzy J M A Matthijssen, Arita Schaling, Simone Walhout, Karen Renske Wichers, Arnoud Arntz
BACKGROUND: Group schema therapy (GST) is increasingly popular as a treatment for personality disorders (PDs), including Cluster-C PDs. Individual ST has proven to be effective for Cluster-C PD patients, while the evidence for GST is limited. This study aimed to investigate the effectiveness of GST for Cluster-C PD. Moreover, differences between the specific Cluster-C PDs (avoidant PD, dependent PD and obsessive-compulsive PD) were explored. METHODS: A multicentre open trial was conducted, including 137 patients with a Cluster-C PD (avoidant PD: n = 107, dependent PD: n = 11 and obsessive-compulsive PD: n = 19)...
September 10, 2023: Clinical Psychology & Psychotherapy
https://read.qxmd.com/read/37685517/conservative-versus-invasive-strategy-in-elderly-patients-with-non-st-elevation-myocardial-infarction-insights-from-the-international-popular-age-registry
#7
JOURNAL ARTICLE
Wout W A van den Broek, Marieke E Gimbel, Dean R P P Chan Pin Yin, Jaouad Azzahhafi, Renicus S Hermanides, Craig Runnett, Robert F Storey, David Austin, Rohit Oemrawsingh, Justin Cooke, Gavin Galasko, Ronald J Walhout, Dirk A A M Schellings, Stijn L Brinckman, Hong Kie The, Martin G Stoel, Antonius A C M Heestermans, Debby Nicastia, Mireille E Emans, Arnoud W J van 't Hof, Hannes Alber, Robert Gerber, Paul F M M van Bergen, Ismail Aksoy, Abdul Nasser, Paul Knaapen, Cees-Joost Botman, Anho Liem, Johannes C Kelder, Jurriën M Ten Berg
This registry assessed the impact of conservative and invasive strategies on major adverse clinical events (MACE) in elderly patients with non-ST-elevation myocardial infarction (NSTEMI). Patients aged ≥75 years with NSTEMI were prospectively registered from European centers and followed up for one year. Outcomes were compared between conservative and invasive groups in the overall population and a propensity score-matched (PSM) cohort. MACE included cardiovascular death, acute coronary syndrome, and stroke...
August 22, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37527905/impact-of-recurrent-ischaemic-and-bleeding-events-on-quality-of-life-in-patients-with-acute-coronary-syndrome-insights-from-the-force-acs-registry
#8
JOURNAL ARTICLE
Niels M R van der Sangen, Jaouad Azzahhafi, Dean R P P Chan Pin Yin, Senna Rayhi, Victoria M van Weede, Ronald J Walhout, Melvyn Tjon Joe Gin, Ron Pisters, Deborah M Nicastia, Jorina Langerveld, Georgios J Vlachojannis, Rutger J van Bommel, Yolande Appelman, José P S Henriques, Jurriën Ten Berg, Wouter Kikkert
OBJECTIVE: Patients with acute coronary syndrome (ACS) remain at high risk for recurrent ischaemic and bleeding events during follow-up. Our study aimed to quantify and compare the impact of these adverse events on quality of life (QoL). METHODS: Data from patients with ACS prospectively enrolled in the FORCE-ACS registry between January 2015 and December 2019 were used for this study. The primary ischaemic and bleeding events of interest were hospital readmission for ACS and Bleeding Academic Research Consortium type 2 or 3 bleeding during 12 months follow-up...
August 2023: Open Heart
https://read.qxmd.com/read/37119809/a-transcriptional-cofactor-regulatory-network-for-the-c-elegans-intestine
#9
JOURNAL ARTICLE
Brent B Horowitz, Shivani Nanda, Albertha J M Walhout
Chromatin modifiers and transcriptional cofactors (collectively referred to as CFs) work with DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular eukaryotes, distinct tissues each execute their own gene expression program for accurate differentiation and subsequent functionality. While the function of TFs in differential gene expression has been studied in detail in many systems, the contribution of CFs has remained less explored. Here we uncovered the contributions of CFs to gene regulation in the Caenorhabditis elegans intestine...
April 29, 2023: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/37043428/a-d-2-hydroxyglutarate-dehydrogenase-mutant-reveals-a-critical-role-for-ketone-body-metabolism-in-caenorhabditis-elegans-development
#10
JOURNAL ARTICLE
Olga Ponomarova, Hefei Zhang, Xuhang Li, Shivani Nanda, Thomas B Leland, Bennett W Fox, Alyxandra N Starbard, Gabrielle E Giese, Frank C Schroeder, L Safak Yilmaz, Albertha J M Walhout
In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism of D-2HG remains unclear in any organism. Here, we find that, in Caenorhabditis elegans, D-2HG is produced in the propionate shunt, which is transcriptionally activated when flux through the canonical, vitamin B12-dependent propionate breakdown pathway is perturbed...
April 2023: PLoS Biology
https://read.qxmd.com/read/36942755/systems-level-transcriptional-regulation-of-caenorhabditis-elegans-metabolism
#11
JOURNAL ARTICLE
Shivani Nanda, Marc-Antoine Jacques, Wen Wang, Chad L Myers, L Safak Yilmaz, Albertha Jm Walhout
Metabolism is controlled to ensure organismal development and homeostasis. Several mechanisms regulate metabolism, including allosteric control and transcriptional regulation of metabolic enzymes and transporters. So far, metabolism regulation has mostly been described for individual genes and pathways, and the extent of transcriptional regulation of the entire metabolic network remains largely unknown. Here, we find that three-quarters of all metabolic genes are transcriptionally regulated in the nematode Caenorhabditis elegans...
March 21, 2023: Molecular Systems Biology
https://read.qxmd.com/read/36844660/the-gendering-of-infectious-disease-classifying-male-and-female-causes-of-death-in-the-netherlands-and-norway-1880-1910
#12
JOURNAL ARTICLE
Hilde L Sommerseth, Evelien C Walhout
This article explores sex and gender patterns in mortality, based on individual-level causes of death (CODs) in two urban communities, obtained from civil and parish registers. By analysing CODs for the period 1880-1910 for Roosendaal (Netherlands) and Trondheim (Norway) we investigate how notions of sex and gender were reflected in cause-specific mortality rates for adults and in the registration of CODs by local authorities. Our findings show (i) excess male mortality among age group 15-70, (ii) airborne infectious diseases were responsible for most deaths in both cities, but did not show a distinct gender pattern, (iii) TB appeared to be more location-specific than gender-specific...
November 2022: Social History of Medicine: the Journal of the Society for the Social History of Medicine
https://read.qxmd.com/read/36734518/evolved-bacterial-resistance-to-the-chemotherapy-gemcitabine-modulates-its-efficacy-in-co-cultured-cells
#13
JOURNAL ARTICLE
Serkan Sayin, Brittany Rosener, Carmen G Li, Bao Ho, Olga Ponomarova, Doyle V Ward, Albertha J M Walhout, Amir Mitchell
Drug metabolism by the microbiome can influence anti-cancer treatment success. We previously suggested that chemotherapies with antimicrobial activity can select for adaptations in bacterial drug metabolism that can inadvertently influence the host's chemoresistance. We demonstrated that evolved resistance against fluoropyrimidine chemotherapy lowered its efficacy in worms feeding on drug-evolved bacteria (Rosener et al., 2020). Here we examine a model system that captures local interactions that can occur in the tumor microenvironment...
February 3, 2023: ELife
https://read.qxmd.com/read/36711629/a-transcriptional-cofactor-regulatory-network-for-the-c-elegans-intestine
#14
Brent B Horowitz, Shivani Nanda, Albertha J M Walhout
Chromatin modifiers and transcriptional cofactors (collectively referred to as CFs) work with DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular eukaryotes, distinct tissues each execute their own gene expression program for accurate differentiation and subsequent functionality. While the function of TFs in differential gene expression has been studied in detail in many systems, the contribution of CFs has remained less explored. Here we uncovered the contributions of CFs to gene regulation in the Caenorhabditis elegans intestine...
January 6, 2023: bioRxiv
https://read.qxmd.com/read/36440862/molecular-dynamics-simulations-of-rhodamine-b-zwitterion-diffusion-in-polyelectrolyte-solutions
#15
JOURNAL ARTICLE
Peter K Walhout, Zhe He, Bercem Dutagaci, Grzegorz Nawrocki, Michael Feig
Polyelectrolytes continue to find wide interest and application in science and engineering, including areas such as water purification, drug delivery, and multilayer thin films. We have been interested in the dynamics of small molecules in a variety of polyelectrolyte (PE) environments; in this paper, we report simulations and analysis of the small dye molecule rhodamine B (RB) in several very simple polyelectrolyte solutions. Translational diffusion of the RB zwitterion has been measured in fully atomistic, 2 μs long molecular dynamics simulations in four different polyelectrolyte solutions...
November 28, 2022: Journal of Physical Chemistry. B
https://read.qxmd.com/read/36209067/design-of-an-rct-on-cost-effectiveness-of-group-schema-therapy-versus-individual-schema-therapy-for-patients-with-cluster-c-personality-disorder-the-quest-clc-study-protocol
#16
JOURNAL ARTICLE
Iuno Z Groot, Anne-Sophie S M Venhuizen, Nathan Bachrach, Simone Walhout, Bregje de Moor, Kasper Nikkels, Susanne Dalmeijer, Myrte Maarschalkerweerd, Joël R van Aalderen, Hinde de Lange, Renske Wichers, Agatha Ph Hollander, Silvia M A A Evers, Raoul P P P Grasman, Arnoud Arntz
BACKGROUND: Given the high prevalence of Cluster-C Personality Disorders (PDs) in clinical populations, disease burden, high societal costs and poor prognosis of comorbid disorders, a major gain in health care can be achieved if Cluster-C PDs are adequately treated. The only controlled cost-effectiveness study published so far found Individual Schema Therapy (IST) to be superior to Treatment as Usual (TAU). Group ST (GST) might improve cost-effectiveness as larger numbers can be treated in (>50%) less time compared to IST...
October 8, 2022: BMC Psychiatry
https://read.qxmd.com/read/36151093/bacterial-diet-modulates-tamoxifen-induced-death-via-host-fatty-acid-metabolism
#17
JOURNAL ARTICLE
Cédric Diot, Aurian P García-González, Andre F Vieira, Melissa Walker, Megan Honeywell, Hailey Doyle, Olga Ponomarova, Yomari Rivera, Huimin Na, Hefei Zhang, Michael Lee, Carissa P Olsen, Albertha J M Walhout
Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis elegans, which does not have an ER ortholog. We find that different bacteria dramatically modulate tamoxifen toxicity in C. elegans, with a three-order of magnitude difference between animals fed Escherichia coli, Comamonas aquatica, and Bacillus subtilis. Remarkably, host fatty acid (FA) biosynthesis mitigates tamoxifen toxicity, and different bacteria provide the animal with different FAs, resulting in distinct FA profiles...
September 23, 2022: Nature Communications
https://read.qxmd.com/read/35847555/a-metabolic-regulatory-network-for-the-caenorhabditis-elegans-intestine
#18
JOURNAL ARTICLE
Sushila Bhattacharya, Brent B Horowitz, Jingyan Zhang, Xuhang Li, Hefei Zhang, Gabrielle E Giese, Amy D Holdorf, Albertha J M Walhout
Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations that affect the expression for a given gene or set of genes have not been available. Here, we use a gene-centered approach to derive a first-pass metabolic regulatory network for Caenorhabditis elegans by performing RNAi of more than 1,400 metabolic genes with a set of 19 promoter reporter strains that express a fluorescent protein in the animal's intestine...
August 19, 2022: IScience
https://read.qxmd.com/read/35794472/c-elegans-as-a-model-for-inter-individual-variation-in-metabolism
#19
JOURNAL ARTICLE
Bennett W Fox, Olga Ponomarova, Yong-Uk Lee, Gaotian Zhang, Gabrielle E Giese, Melissa Walker, Nicole M Roberto, Huimin Na, Pedro R Rodrigues, Brian J Curtis, Aiden R Kolodziej, Timothy A Crombie, Stefan Zdraljevic, L Safak Yilmaz, Erik C Andersen, Frank C Schroeder, Albertha J M Walhout
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic background, nutritional input, microbiota and other environmental factors1-4 . It is difficult to connect differences in metabolism to genomic variation and derive underlying molecular mechanisms in humans, owing to differences in diet and lifestyle, among others. Here we use the nematode Caenorhabditis elegans as a model to study inter-individual variation in metabolism. By comparing three wild strains and the commonly used N2 laboratory strain, we find differences in the abundances of both known metabolites and those that have not to our knowledge been previously described...
July 2022: Nature
https://read.qxmd.com/read/35563392/the-plasmid-pex18gm-indirectly-increases-caenorhabditis-elegans-fecundity-by-accelerating-bacterial-methionine-synthesis
#20
JOURNAL ARTICLE
Rui Guo, Gen Li, Leilei Lu, Shan Sun, Ting Liu, Mengsha Li, Yong Zheng, Albertha J M Walhout, Jun Wu, Huixin Li
Plasmids are mostly found in bacteria as extrachromosomal genetic elements and are widely used in genetic engineering. Exploring the mechanisms of plasmid-host interaction can provide crucial information for the application of plasmids in genetic engineering. However, many studies have generally focused on the influence of plasmids on their bacterial hosts, and the effects of plasmids on bacteria-feeding animals have not been explored in detail. Here, we use a "plasmid-bacteria- Caenorhabditis elegans " model to explore the impact of plasmids on their host bacteria and bacterivorous nematodes...
April 30, 2022: International Journal of Molecular Sciences
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