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https://www.readbyqxmd.com/read/29677629/effects-of-gastric-bypass-surgery-followed-by-supervised-physical-training-on-inflammation-and-endothelial-function-a-randomized-controlled-trial
#1
Charlotte Røn Stolberg, Lene Hymøller Mundbjerg, Peter Funch-Jensen, Bibi Gram, Else-Marie Bladbjerg, Claus Bogh Juhl
BACKGROUND AND AIMS: Obesity and physical inactivity are both associated with low-grade inflammation and endothelial dysfunction. Bariatric surgery improves markers of inflammation and endothelial function, but it is unknown if physical training after bariatric surgery can improve these markers even further. Therefore, we aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) followed by physical training on markers of low-grade inflammation and endothelial function. METHODS: Sixty patients approved for RYGB underwent examinations pre-surgery, 6, 12, and 24 months post-surgery...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677363/the-effect-of-denatured-lysozyme-on-human-corneal-epithelial-cells
#2
David J McCanna, Sarah Oh, Junghee Seo, Chantal Coles-Brennan, Zohra Fadli, Lakshman N Subbaraman, Lyndon W Jones
Purpose: During contact lens wear, the amount of lysozyme deposited on contact lenses varies depending on the lens material. The binding of lysozyme to some contact lens materials may result in a conformational change that denatures the protein to an inactive form. This investigation evaluated the effect that denatured lysozyme has on human corneal epithelial cells (HCECs) by measuring cell viability and the release of inflammatory cytokines. Methods: HCECs were exposed to lysozyme that was denatured to various activity levels...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677198/impact-of-selected-amino-acids-of-hp0377-helicobacter-pylori-thiol-oxidoreductase-on-its-functioning-as-a-ccmg-cytochrome-c-maturation-protein-and-dsb-disulfide-bond-isomerase
#3
Magdalena Joanna Grzeszczuk, Aleksandra Bąk, Anna Marta Banaś, Paweł Urbanowicz, Stanislaw Dunin-Horkawicz, Artur Gieldon, Cezary Czaplewski, Adam Liwo, Elżbieta K Jagusztyn-Krynicka
Helicobacter pylori HP0377 is a thiol oxidoreductase, a member of the CcmG family involved in cytochrome biogenesis, as previously shown by in vitro experiments. In this report, we document that HP0377 also acts in vivo in the cytochrome assembly process in Bacillus subtilis, where it complements the lack of ResA. However, unlike other characterized proteins in this family, HP0377 is a dithiol reductase and isomerase. We elucidated how the amino acid composition of its active site modulates its functionality...
2018: PloS One
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#4
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676956/high-intensity-interval-training-after-stroke-an-opportunity-to-promote-functional-recovery-cardiovascular-health-and-neuroplasticity
#5
Jennifer Crozier, Marc Roig, Janice J Eng, Marilyn MacKay-Lyons, Joyce Fung, Michelle Ploughman, Damian M Bailey, Shane N Sweet, Nicholas Giacomantonio, Alexander Thiel, Michael Trivino, Ada Tang
INTRODUCTION: Stroke is the leading cause of adult disability. Individuals poststroke possess less than half of the cardiorespiratory fitness (CRF) as their nonstroke counterparts, leading to inactivity, deconditioning, and an increased risk of cardiovascular events. Preserving cardiovascular health is critical to lower stroke risk; however, stroke rehabilitation typically provides limited opportunity for cardiovascular exercise. Optimal cardiovascular training parameters to maximize recovery in stroke survivors also remains unknown...
April 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29676732/donated-chemical-probes-for-open-science
#6
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29675670/principles-of-exercise-prescription-and-how-they-influence-exercise-induced-changes-of-transcription-factors-and-other-regulators-of-mitochondrial-biogenesis
#7
REVIEW
Cesare Granata, Nicholas A Jamnick, David J Bishop
Physical inactivity represents the fourth leading risk factor for mortality, and it has been linked with a series of chronic disorders, the treatment of which absorbs ~ 85% of healthcare costs in developed countries. Conversely, physical activity promotes many health benefits; endurance exercise in particular represents a powerful stimulus to induce mitochondrial biogenesis, and it is routinely used to prevent and treat chronic metabolic disorders linked with sub-optimal mitochondrial characteristics. Given the importance of maintaining a healthy mitochondrial pool, it is vital to better characterize how manipulating the endurance exercise dose affects cellular mechanisms of exercise-induced mitochondrial biogenesis...
April 19, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29675026/multiplex-cytokine-analysis-of-aqueous-humor-in-juvenile-idiopathic-arthritis-associated-anterior-uveitis-with-or-without-secondary-glaucoma
#8
Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M Koch, Philipp S Müther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten Heinz
Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674335/although-coronary-mortality-has-decreased-rates-of-cardiovascular-disease-remain-high-21-years-of-follow-up-comparing-cohorts-of-men-born-in-1913-with-men-born-in-1943
#9
Michael Fu, Annika Rosengren, Erik Thunström, Zacharias Mandalenakis, Lennart Welin, Kenneth Caidahl, Aldina Pivodic, You Zhong, Constantinos Ergatoudes, David Morales, Catharina Welin, Kurt Svärdsudd, Mikael Dellborg, Per-Olof Hansson
BACKGROUND: Despite a decline in mortality rates from cardiovascular disease (CVD) in the past few decades, the burden of CVD in a contemporary population remains inadequately addressed. Therefore, this study was aimed to investigate secular trends in mortality from coronary artery disease and all-cause mortality over 2 decades, by comparing 2 cohorts of men born 30 years apart and evaluate the prediction of the risk of CVD and all-cause death in a contemporary random sample of Swedish men...
April 19, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29674316/activation-of-renal-clc-k-chloride-channels-depends-on-an-intact-n-terminus-of-their-accessory-subunit-barttin
#10
Daniel Wojciechowski, Stefan Thiemann, Christina Schaal, Alina Rahtz, Jeanne de la Roche, Birgit Begemann, Toni Becher, Martin Fischer
ClC-K channels belong to the CLC family of chloride channels and chloride/proton antiporters. They contribute to sodium chloride reabsorption in Henle's loop of the kidney and to potassium secretion into the endolymph by the stria vascularis of the inner ear. Their accessory subunit barttin stabilizes the ClC-K/barttin complex, promotes its insertion into the surface membrane, and turns the pore-forming subunits into a conductive state. Barttin mutations cause Bartter syndrome type IV, a salt wasting nephropathy with sensorineural deafness...
April 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29673126/overexpression-of-hace1-in-gastric-cancer-inhibits-tumor-aggressiveness-by-impeding-cell-proliferation-and-migration
#11
Ying-Ling Chen, Dong-Ping Li, Hong-Yue Jiang, Yang Yang, Li-Li Xu, Shun-Cai Zhang, Hong Gao
HACE1 E3 ligase was discovered to be down-regulated in several cancers while its role in regulating tumors was merely understood. This study aimed to explore the specific effect of HACE1 played in gastric tumorigenesis and its potential mechanism. HACE1's expression was found significantly lower in gastric cancer tissues compared with the adjacent normal tissues (P < 0.001). Its protein level in gastric cancer negatively correlated to tumor pathological differentiation (P = 0.019). And in gastric cancer patients with TNM I-IIIa, those with lower HACE1 protein level had poorer overall survival (P = 0...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29672997/sexual-activity-and-quality-of-life-in-japanese-pelvic-organ-prolapse-patients-after-transvaginal-mesh-surgery
#12
Manami Kinjo, Yasukuni Yoshimura, Yasuhide Kitagawa, Takatsugu Okegawa, Kikuo Nutahara
AIM: This study aimed to evaluate sexual activity and quality of life (QOL) after transvaginal mesh (TVM) surgery in Japanese patients with pelvic organ prolapse (POP). The objective cure rate and associated complications were also investigated. METHODS: The cases of patients who underwent TVM surgery were retrospectively analyzed. QOL was assessed using the Prolapse Quality of Life Questionnaire (P-QOL), and sexual function was evaluated using the Female Sexual Function Index (FSFI) before surgery and 12 months after surgery...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29672972/metabolomic-profiling-and-biological-investigation-of-the-marine-sponge-derived-bacterium-rhodococcus-sp-ua13
#13
Yasmin Elsayed, John Refaat, Usama Ramadan Abdelmohsen, Eman Maher Othman, Helga Stopper, Mostafa Ahmed Fouad
INTRODUCTION: Marine sponge-associated actinomycetes are potent sources of bioactive natural products of pharmaceutical significance. They also contributed to the discovery of several clinically relevant antimicrobials. OBJECTIVE: To apply the non-targeted metabolomics approach in chemical profiling of the sponge-derived bacterium Rhodococcus sp. UA13, formerly recovered from the Red Sea sponge Callyspongia aff. Implexa, along with testing for the anti-infective potential of its different fractions...
April 19, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29672683/daily-internet-time-towards-an-evidence-based-recommendation
#14
André Berchtold, Christina Akre, Yara Barrense-Dias, Grégoire Zimmermann, Joan-Carles Surís
Background: Since 2001, a recommendation of no more than 2 h per day of screen time for children 2 years of age or older was adopted in many countries. However, this recommendation was rarely examined empirically. The goal of the present study was to question this recommendation in today's connected world. Methods: We used data from the ado@internet.ch survey (spring 2012), a representative sample of 8th graders in the Canton of Vaud, Switzerland (n = 2942, 50.6% female)...
April 17, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29672347/transconjunctival-triamcinolone-injection-for-upper-lid-retraction-in-thyroid-eye-disease-a-new-injection-method
#15
Stephanie Ming Young, Yoon-Duck Kim, Stephanie S Lang, Kyung In Woo
PURPOSE: To evaluate the role of transconjunctival triamcinolone acetonide (TA) injection in the management of upper eyelid retraction in thyroid eye disease. METHODS: Retrospective interventional review of all patients who underwent transconjunctival TA injection (40 mg/mL) for thyroid eye disease-related upper eyelid retraction from January 2010 to December 2016 in a single tertiary institution. The present study comprised 2 groups: Patients receiving only TA injection (group 1), and patients receiving both TA injection and other immunosuppressive therapy (group 2)...
April 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29672262/the-roadmap-for-harmonization-status-of-the-international-consortium-for-harmonization-of-clinical-laboratory-results
#16
Gary L Myers, W Greg Miller
The International Consortium for Harmonization of Clinical Laboratory Results (ICHCLR) was established to fulfill recommendations identified by an international conference convened to review the available infrastructure and challenges in achieving harmonization of results among different measurement procedures. The specific objectives of the ICHCLR are to: prioritize measurands by medical importance, coordinate the work of different organizations, and stimulate development of technical and regulatory processes to achieve harmonization...
April 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29672015/zebrafish-based-discovery-of-antiseizure-compounds-from-the-red-sea-pseurotin-a-2-and-azaspirofuran-a
#17
Daniëlle Copmans, Mostafa Rateb, Jioji N Tabudravu, Mercedes Pérez-Bonilla, Nina Dirkx, Riccardo Vallorani, Caridad Diaz, José Pérez Del Palacio, Alan J Smith, Rainer Ebel, Fernando Reyes, Marcel Jaspars, Peter A M de Witte
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further development. Within the framework of this project, seven known heterospirocyclic γ-lactams, namely, pseurotin A, pseurotin A2 , pseurotin F1, 11- O-methylpseurotin A, pseurotin D, azaspirofuran A, and azaspirofuran B, were isolated from the bioactive marine fungus Aspergillus fumigatus, and their antiseizure activity was evaluated in the larval zebrafish pentylenetetrazole (PTZ) seizure model...
April 19, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29671967/awareness-of-participaction-among-canadian-adults-a-seven-year-cross-sectional-follow-up
#18
John C Spence, Guy Faulkner, Eun-Young Lee, Tanya Berry, Christine Cameron, Sameer Deshpande, Amy E Latimer-Cheung, Ryan E Rhodes, Mark S Tremblay
INTRODUCTION: In this cross-sectional follow-up study, we explored Canadian's awareness of ParticipACTION and their levels of physical activity (PA) after seven years of campaigns. METHODS: A population-based survey was conducted with 7282 adults over a period of 14 months from February 2014 to May 2015. The survey consisted of questions on the 2014-2015 Physical Activity Monitor relating to awareness and knowledge of ParticipACTION. Weighted logistic models were constructed to examine whether awareness was associated with PA-related beliefs, intentions, and leisure time physical activity (LTPA)...
April 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29671966/perceptions-of-organizational-capacity-to-promote-physical-activity-in-canada-and-participaction-s-influence-five-years-after-its-relaunch-a-qualitative-study
#19
Subha Ramanathan, Guy Faulkner, Tanya Berry, Sameer Deshpande, Amy E Latimer-Cheung, Ryan E Rhodes, John C Spence, Mark S Tremblay
INTRODUCTION: ParticipACTION is a Canadian physical activity communications and social marketing organization relaunched in 2007. The purpose of this study was to qualitatively investigate organizational capacity for physical activity promotion among Canadian organizations, and the influence of ParticipACTION on capacity five years after relaunch. METHODS: Using a purposive sampling strategy, semi-structured telephone interviews were conducted with 44 key informants representing national, provincial, and local organizations with a mandate to promote physical activity...
April 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29671585/ligand-triggered-structural-changes-in-the-m2-muscarinic-acetylcholine-receptor
#20
Mireia Jiménez-Rosés, Minos-Timotheos Matsoukas, Gianluigi Caltabiano, Arnau Cordomí
Τhe muscarinic M2 acetylcholine receptor, one of the few G protein-coupled receptors that has not only been crystallized in both active and inactive conformations, but also in the presence of a positive allosteric modulator, is an interesting system to study the molecular mechanisms of GPCR activation and ligand allosterism. Here, we have employed molecular dynamics (MD) simulations (adding to 14μs in total) to study conformational changes triggered by the inverse agonist R-(-)-3-quinuclidinyl-benzilate (QNB) in the structure of the active M2 muscarinic (PBD id 4MQS) after replacement of the agonist iperoxo by the inverse agonist QNB...
April 19, 2018: Journal of Chemical Information and Modeling
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