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https://www.readbyqxmd.com/read/27909065/cdk5-directly-targets-nuclear-p21cip1-and-promotes-cancer-cell-growth
#1
Pao-Hsuan Huang, Mei-Chih Chen, Yu-Ting Peng, Wei-Hsiang Kao, Chih-Hsiang Chang, Yun-Chi Wang, Chih-Ho Lai, Jer-Tsong Hsieh, Jo-Hsin Wang, Yueh-Tsung Lee, Eugene Lin, Chia-Herng Yue, Hsin-Yi Wang, Shuen-Chi You, Ho Lin
The significance of Cdk5 in cell-cycle control and cancer biology has gained increased attention. Here we report the inverse correlation between the protein levels of Cdk5 and p21(CIP1) from cell-based and clinical analysis. Mechanistically, we identify that Cdk5 overexpression triggers the proteasome-dependent degradation of p21(CIP1) through a S130 phosphorylation in a Cdk2-independent manner. Besides, the evidence from cell-based and clinical analysis shows that Cdk5 primarily regulates nuclear p21(CIP1) protein degradation...
December 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27908572/significant-treatment-effect-of-add-on-ketamine-anesthesia-in-electroconvulsive-therapy-in-depressive-patients-a-meta-analysis
#2
Dian-Jeng Li, Fu-Chiang Wang, Che-Sheng Chu, Tien-Yu Chen, Chia-Hung Tang, Wei-Cheng Yang, Philip Chik-Keung Chow, Ching-Kuan Wu, Ping-Tao Tseng, Pao-Yen Lin
Add-on ketamine anesthesia in electroconvulsive therapy (ECT) has been studied in depressive patients in several clinical trials with inconclusive findings. Two most recent meta-analyses reported insignificant findings with regards to the treatment effect of add-on ketamine anesthesia in ECT in depressive patients. The aim of this study is to update the current evidence and investigate the role of add-on ketamine anesthesia in ECT in depressive patients via a systematic review and meta-analysis. We performed a thorough literature search of the PubMed and ScienceDirect databases, and extracted all relevant clinical variables to compare the antidepressive outcomes between add-on ketamine anesthesia and other anesthetics in ECT...
November 28, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27905061/one-third-of-hips-after-periacetabular-osteotomy-survive-30-years-with-good-clinical-results-no-progression-of-arthritis-or-conversion-to-tha
#3
Till Dominic Lerch, Simon Damian Steppacher, Emanuel Francis Liechti, Moritz Tannast, Klaus Arno Siebenrock
BACKGROUND: Since its first description in 1984, periacetabular osteotomy (PAO) has become an accepted treatment for hip dysplasia. The 30-year survivorship with this procedure has not been reported. Because these patients are often very young at the time of surgery, long-term followup and identification of factors associated with poor outcome could help to improve patient selection. QUESTIONS/PURPOSES: Looking at the initial group of patients with hip dysplasia undergoing PAO at the originator's institution, we asked: (1) What is the cumulative 30-year survival rate free from conversion to THA, radiographic progression of osteoarthritis, and/or a Merle d'Aubigné-Postel score < 15? (2) Did hip function improve and pain decrease? (3) Did radiographic osteoarthritis progress? (4) What are the factors associated with one or more of the three endpoints: THA, radiographic progression of osteoarthritis, and/or Merle d'Aubigné-Postel score < 15? METHODS: We retrospectively evaluated the first 63 patients (75 hips) who underwent PAO for hip dysplasia between 1984 and 1987...
November 30, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27899857/worse-prognosis-in-heart-failure-patients-with-30-day-readmission
#4
Ying-Chang Tung, Shing-Hsien Chou, Kuan-Liang Liu, I-Chang Hsieh, Lung-Sheng Wu, Chia-Pin Lin, Ming-Shien Wen, Pao-Hsien Chu
BACKGROUND: Heart failure (HF) readmission results in substantial expenditure on HF management. This study aimed to evaluate the readmission rate, outcome, and predictors of HF readmission. METHODS: Patients with reduced left ventricular ejection fraction (LVEF < 40%) who were admitted for acute decompensation of de novo HF were enrolled to analyze readmission rate, mortality and predictors of readmission. RESULTS: A total of 433 de novo HF patients with LVEF < 40% were enrolled during the period August 2013 to December 2014...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27894546/innovative-design-of-closing-loops-producing-an-optimal-force-system-applicable-in-the-0-022-in-bracket-slot-system
#5
Mayumi Sumi, Yoshiyuki Koga, Jun-Ya Tominaga, Ryo Hamanaka, Hiroya Ozaki, Pao-Chang Chiang, Noriaki Yoshida
INTRODUCTION: Most closing loops designed for producing higher moment-to-force (M/F) ratios require complex wire bending and are likely to cause hygiene problems and discomfort because of their complicated configurations. We aimed to develop a simple loop design that can produce optimal force and M/F ratio. METHODS: A loop design that can generate a high M/F ratio and the ideal force level was investigated by varying the portion and length of the cross-sectional reduction of a teardrop loop and the loop position...
December 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27893158/articular-cartilage-scores-in-cranial-cruciate-ligament-deficient-dogs-with-or-without-bucket-handle-tears-of-the-medial-meniscus
#6
Kathryn Kaufman, Brian S Beale, Howard D Thames, W Brian Saunders
OBJECTIVE: To compare articular cartilage scores in cranial cruciate ligament (CCL)-deficient dogs with or without concurrent bucket handle tears (BHT) of the medial meniscus. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned dogs treated with arthroscopy and tibial plateau leveling osteotomy or extracapsular repair for complete CCL rupture (290 stifles from 264 dogs). METHODS: Medical records and arthroscopic images were reviewed...
November 28, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27891031/spinal-compression-fractures-due-to-pregnancy-associated-osteoporosis
#7
R Krishnakumar, Arun T Kumar, Mathew John Kuzhimattam
OBJECTIVES: To report on unique cases of spinal compression fractures due to pregnancy-associated osteoporosis (PAO) and to suggest a satisfactory treatment modality. MATERIALS AND METHODS: A single-center retrospective study. We reviewed the data of 535 patients with osteoporotic spinal compression fractures over a period of 5-year. Two patients who developed spinal compression fractures due to PAO were identified and treated. RESULTS: The clinical presentation and blood investigations ruled out other causes of osteoporosis...
October 2016: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/27887570/metamis-a-metagenomic-microbial-interaction-simulator-based-on-microbial-community-profiles
#8
Grace Tzun-Wen Shaw, Yueh-Yang Pao, Daryi Wang
BACKGROUND: The complexity and dynamics of microbial communities are major factors in the ecology of a system. With the NGS technique, metagenomics data provides a new way to explore microbial interactions. Lotka-Volterra models, which have been widely used to infer animal interactions in dynamic systems, have recently been applied to the analysis of metagenomic data. RESULTS: In this paper, we present the Lotka-Volterra model based tool, the Metagenomic Microbial Interacticon Simulator (MetaMIS), which is designed to analyze the time series data of microbial community profiles...
November 25, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27881074/changes-of-gonadotropin-releasing-hormone-receptor-2-during-the-anadromous-spawning-migration-in-coilia-nasus
#9
Jin-Rong Duan, Di-An Fang, Min-Ying Zhang, Kai Liu, Yan-Feng Zhou, Dong-Po Xu, Pao Xu, Da-Peng Li
BACKGROUND: An increase in the activity of the pituitary-gonad axis (PG-axis) and gonad development are essential for the onset of spawning migration in teleosts. In the fish Coilia nasus, gonad development and spawning migration up the Yangtze River occurs by the end of each summer. We hypothesized that gonadotropin releasing hormones receptor 2 (GnRH-R2), which together produce a signal that interacts with the PG-axis, may help to regulate spawning migration processes. RESULTS: In this regard, we (1) characterized the gonadosomatic index (GSI) in the anadromous fish C...
November 24, 2016: BMC Developmental Biology
https://www.readbyqxmd.com/read/27880017/comparison-of-the-outcomes-of-free-jejunal-flap-reconstructions-of-pharyngoesophageal-defects-in-hypopharyngeal-cancer-and-corrosive-injury-patients
#10
Mu-Han Hsieh, Yun-Tai Yang, Yueh-Ju Tsai, Yur-Ren Kuo, Pao-Yuan Lin
INTRODUCTION: Free jejunal flap is one of the optimal choices for restoring upper digestive tract. The purpose of this study was to introduce the treatment strategies and to compare the outcomes of free jejunal flap for pharyngoesophageal reconstruction between hypopharyngeal cancer and chemical corrosive injured esophagus. METHODS: From 2001 to 2012, patients who had been received esophageal reconstruction by free jejunal flap for pharyngoesophageal defect were divided into squamous cell carcinoma (SCC) group and corrosive chemical injury (CCI) group...
November 23, 2016: Microsurgery
https://www.readbyqxmd.com/read/27878856/a-semiparametric-mixture-cure-survival-model-for-left-truncated-and-right-censored-data
#11
Chyong-Mei Chen, Pao-Sheng Shen, James Cheng-Chung Wei, Lichi Lin
In follow-up studies, the disease event time can be subject to left truncation and right censoring. Furthermore, medical advancements have made it possible for patients to be cured of certain types of diseases. In this article, we consider a semiparametric mixture cure model for the regression analysis of left-truncated and right-censored data. The model combines a logistic regression for the probability of event occurrence with the class of transformation models for the time of occurrence. We investigate two techniques for estimating model parameters...
November 23, 2016: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/27876077/post-traumatic-acute-kidney-injury-a-cross-sectional-study-of-trauma-patients
#12
Wei-Hung Lai, Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Pao-Jen Kuo, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hsiao-Yun Hsieh
BACKGROUND: The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock at a Level I trauma center. METHODS: Detailed data of 78 trauma patients with AKI and 14,504 patients without AKI between January 1, 2009 and December 31, 2014 were retrieved from the Trauma Registry System...
November 22, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27869214/irradiance-dependent-uvb-photocarcinogenesis
#13
Cheng-Che E Lan, Ching-Shuang Wu, Shu-Mei Huang, Chin-Han Wu, Hsiao-Chi Lai, Yu-Ting Peng, Pao-Sheng Hou, Hui-Jun Yang, Gwo-Shing Chen
Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867861/intraoperative-neural-monitoring-in-thyroid-surgery-lessons-learned-from-animal-studies
#14
REVIEW
Che-Wei Wu, Gregory W Randolph, I-Cheng Lu, Pi-Ying Chang, Yi-Ting Chen, Pao-Chu Hun, Yi-Chu Lin, Gianlorenzo Dionigi, Feng-Yu Chiang
Recurrent laryngeal nerve (RLN) injury remains a significant morbidity associated with thyroid and parathyroid surgery. In the past decade, surgeons have increasingly used intraoperative neural monitoring (IONM) as an adjunct technique for localizing and identifying the RLN, detecting RLN injury, and predicting the outcome of vocal cord function. In recent years, many animal studies have investigated common pitfalls and new applications of IONM. For example, the use of IONM technology in animal models has proven valuable in studies of the electrophysiology of RLN injury...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27863446/glutathione-transferase-p1-1-as-an-arsenic-drug-sequestering-enzyme
#15
Lorien J Parker, Alessio Bocedi, David B Ascher, Jade B Aitken, Hugh H Harris, Mario Lo Bello, Giorgio Ricci, Craig J Morton, Michael W Parker
Arsenic-based compounds are paradoxically both poisons and drugs. Glutathione transferase (GSTP1-1) is a major factor in resistance to such drugs. Here we describe using crystallography, X-ray absorption spectroscopy, mutagenesis, mass spectrometry and kinetic studies how GSTP1-1 recognizes the drug phenylarsine oxide (PAO). In conditions of cellular stress where glutathione (GSH) levels are low, PAO crosslinks C47 to C101 of the opposing monomer, a distance of 19.9 Å, and causes a dramatic widening of the dimer interface by ∼10 Å...
November 18, 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27862461/single-electron-transfer-between-cux2-and-thiols-determined-by-extended-x-ray-absorption-fine-structure-analysis-application-in-markovnikov-type-hydrothiolation-of-styrenes
#16
Hong Yi, Chunlan Song, Yiying Li, Chih-Wen Pao, Jyh-Fu Lee, Aiwen Lei
Transition-metal mediated C-S bond formation using thiol compounds has been widely used in recent years. However, there has been less focus on the interaction between the metal and thiol compounds. In this work, we have successfully evidenced the single-electron transfer between CuX2 and thiophenol utilizing EXAFS. The fitting EXAFS results reveal that two halide anions are coordinated with the Cu(I) center, whereas no sulfur atom is observed in the first coordination sphere. This Cu(I) ate complex serves as the key intermediate for the proton transfer in the application of Markovnikov-type hydrothiolation reactions...
November 10, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27860150/a-functionally-conserved-zn2-cys6-binuclear-cluster-transcription-factor-class-regulates-necrotrophic-effector-gene-expression-and-host-specific-virulence-of-two-major-pleosporales-fungal-pathogens-of-wheat
#17
Kasia Rybak, Pao Theen See, Huyen T T Phan, Robert A Syme, Caroline S Moffat, Richard P Oliver, Kar-Chun Tan
The fungus Parastagonospora nodorum is the causal agent of septoria nodorum blotch of wheat (Triticum aestivum). The interaction is mediated by multiple fungal necrotrophic effector-dominant host sensitivity gene interactions. The three best characterised effector-sensitivity gene systems are SnToxA-Tsn1, SnTox1-Snn1 and SnTox3-Snn3. These effector genes are highly expressed during early infection but expression decreases as the infection progresses to tissue necrosis and sporulation. However, the mechanism of regulation is unknown...
November 18, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27855320/mir-122-promotes-hepatic-antioxidant-defense-of-genetically-improved-farmed-tilapia-gift-oreochromis-niloticus-exposed-to-cadmium-by-directly-targeting-a-metallothionein-gene
#18
Jun Qiang, Yi-Fan Tao, Jie He, Pao Xu, Jin-Wen Bao, Yi-Lan Sun
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate target gene expression by binding to the 3'untranslated region (3'UTR) of the target mRNA. MiRNAs regulate a large variety of genes, including those involved in liver homeostasis and energy metabolism. Down-regulated levels of hepatic miR-122 were found in genetically improved farmed tilapia (GIFT, Oreochromis niloticus) exposed to cadmium (Cd) stress. Here, we report for the first time that reduction of miR-122 post-transcriptionally increased metallothionein (MT) mRNA levels by binding to its 3'UTR, as shown by a 3' UTR luciferase reporter assay...
November 9, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27854341/sept12-ndc1-complexes-are-required-for-mammalian-spermiogenesis
#19
Tsung-Hsuan Lai, Ying-Yu Wu, Ya-Yun Wang, Mei-Feng Chen, Pei Wang, Tsung-Ming Chen, Yi-No Wu, Han-Sun Chiang, Pao-Lin Kuo, Ying-Hung Lin
Male factor infertility accounts for approximately 50 percent of infertile couples. The male factor-related causes of intracytoplasmic sperm injection failure include the absence of sperm, immotile sperm, immature sperm, abnormally structured sperm, and sperm with nuclear damage. Our knockout and knock-in mice models demonstrated that SEPTIN12 (SEPT12) is vital for the formation of sperm morphological characteristics during spermiogenesis. In the clinical aspect, mutated SEPT12 in men results in oligozoospermia or teratozoospermia or both...
November 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27847763/preliminary-experience-with-vascular-plugs-for-parent-artery-occlusion-of-the-carotid-or-vertebral-arteries
#20
Woosung Lee, Yong Sam Shin, Kyung Hyun Kim, Yong Bae Kim, Chang-Ki Hong, Joonho Chung
OBJECTIVE: The purpose of this study was to report the authors' preliminary experience using the Amplatzer Vascular Plug (AVP) (St. Jude Medical, Plymouth, MN, USA) for parent artery occlusion of the internal carotid artery (ICA) or vertebral artery (VA). MATERIALS AND METHODS: Between September 2008 and December 2015, we performed 52 therapeutic parent artery occlusions (PAOs) by an endovascular technique. Among them, 10 patients underwent PAO of the carotid or vertebral arteries using AVPs...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
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