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https://www.readbyqxmd.com/read/28350760/involvement-of-hsp70-and-ho-1-in-the-protective-effects-of-raloxifene-on-multiple-organ-dysfunction-syndrome-by-endotoxemia-in-ovariectomized-rats
#1
Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam, Yen-Mei Lee
OBJECTIVE: Accumulating evidence demonstrates that raloxifene, a selective estrogen receptor modulator, possesses anti-inflammatory action. This study evaluates the preventive effects of long-term treatment of raloxifene on acute inflammation and multiple organ dysfunction syndrome (MODS) in ovariectomized (OVX) rats with endotoxemia and its underlying mechanism of action. METHODS: Adult female rats were OVX bilaterally to induce estrogen insufficiency. OVX rats were administered with raloxifene (1 mg/kg, gavage, once daily) for 8 weeks, beginning 1 week after surgery, followed by induction of sepsis via intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg) for 4 hours...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28346465/sept12-phosphorylation-results-in-loss-of-the-septin-ring-sperm-annulus-defective-sperm-motility-and-poor-male-fertility
#2
Yi-Ru Shen, Han-Yu Wang, Yung-Che Kuo, Shih-Chuan Shih, Chun-Hua Hsu, Yet-Ran Chen, Shang-Rung Wu, Chia-Yih Wang, Pao-Lin Kuo
Septins are critical for numerous cellular processes through the formation of heteromeric filaments and rings indicating the importance of structural regulators in septin assembly. Several posttranslational modifications (PTMs) mediate the dynamics of septin filaments in yeast. However, little is known about the role of PTMs in regulating mammalian septin assembly, and the in vivo significance of PTMs on mammalian septin assembly and function remains unknown. Here, we showed that SEPT12 was phosphorylated on Ser198 using mass spectrometry, and we generated SEPT12 phosphomimetic knock-in (KI) mice to study its biological significance...
March 27, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28344416/one-year-outcomes-of-acute-decompensated-systolic-heart-failure-in-taiwan-lessons-from-tsoc-hfref-registry
#3
Hung-Yu Chang, Chun-Chieh Wang, Yen-Wen Wu, Pao-Hsien Chu, Chih-Cheng Wu, Chih-Hsin Hsu, Ming-Shien Wen, Wen-Chol Voon, Wei-Shiang Lin, Jin-Long Huang, Shyh-Ming Chen, Ning-I Yang, Heng-Chia Chang, Kuan-Cheng Chang, Shih-Hsien Sung, Kou-Gi Shyu, Jiunn-Lee Lin, Guang-Yuan Mar, Kuei-Chuan Chan, Jen-Yuan Kuo, Ji-Hung Wang, Zhih-Cherng Chen, Wei-Kung Tseng, Wen-Jin Cherng, Wei-Hsian Yin
BACKGROUND: Heart failure (HF) is a global health problem. The Taiwan Society of Cardiology-Heart Failure with reduced Ejection Fraction (TSOC-HFrEF) registry was a multicenter, observational survey of patients admitted with HFrEF in Taiwan. The aim of this study was to report the one-year outcome in this large-cohort of hospitalized patients presenting with acute decompensated HFrEF. METHODS: Patients hospitalized for acute HFrEF were recruited in 21 hospitals in Taiwan...
March 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28342993/teratogenic-responses-of-zebrafish-embryos-to-decabromodiphenyl-ether-bde-209-in-the-presence-of-nano-sio2-particles
#4
Shu-Ju Chao, Chin Pao Huang, Pei-Chung Chen, Chihpin Huang
This study investigated the influence of nano-SiO2 particles (nSiO2) on the teratogenic responses of zebrafish embryos to decabromodiphenyl ether (BDE-209). Zebrafish embryos were exposed to BDE-209 in the absence and presence of nSiO2 for 96 h post fertilization (hpf). Results showed that formation of nSiO2-BDE-209 associates promoted both extracellular and intracellular uptake of BDE-209 by zebrafish embryos, thereby increasing the bioconcentration of BDE-209 on the chorion surface and the embryos. Results also showed embryos delay hatching temporarily when co-exposure to BDE-209 and nSiO2 at 60 hpf...
March 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340526/an-experimental-study-on-flow-and-heat-transfer-characteristics-of-ethanol-polyalphaolefin-nanoemulsion-flowing-through-circular-minichannels
#5
Vu Trinh, Jiajun Xu
This work experimentally studied the convective flow and heat transfer characteristics of a novel nanostructured heat transfer fluid: "ethanol/polyalphaolefin nanoemulsion" flowing through 12 circular minichannels of 1-mm diameter each. Ethanol/polyalphaolefin nanoemulsion is a thermodynamically stable system formed by dispersing ethanol into a mixture of "polyalphaolefin (PAO)" and surfactants. In this study, ethanol/PAO nanoemulsion is used as the working fluid to study the effect of ethanol nanodroplets on its convective flow and heat transfer characteristics...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28334752/monitoring-the-consistency-quality-and-antioxidant-activity-of-da-hong-pao-teas-by-hplc-fingerprinting
#6
Lin Wang, Ting Yan, Lanping Yang, Kexia Zhang, Jingming Jia
In the present study, a high performance liquid chromatography (HPLC) method was developed and validated for fingerprint profiling to evaluate the quality consistency of the Da Hong Pao tea. The chromatographic separation was performed on a USA Waters C18 column (4.6 mm × 250 mm, 5 μm, Waters-XBridge Shield RP 18) with gradient elution. The column temperature was maintained at 30°C and the detection wavelength was set at 278 nm. The results demonstrated that the developed HPLC method achieved the desired linearity, precision, accuracy and limit of quantification...
February 18, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28329222/effect-of-daptomycin-dose-on-the-outcome-of-vancomycin-resistant-daptomycin-susceptible-enterococcus-faecium-bacteremia
#7
Yu-Chung Chuang, Hsin-Yi Lin, Pao-Yu Chen, Chi-Ying Lin, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang
Background.: Treatment options for vancomycin-resistant enterococci (VRE) bloodstream infection (BSI) are limited. Daptomycin, although not currently approved for this indication, is frequently used for the treatment of VRE-BSI. Its optimal dose still needs to be determined. Methods.: We conducted a prospective, observational, cohort study during 2010-2015. We included patients who received a daptomycin dose of ≥6 mg/kg for the treatment of VRE-BSI caused by daptomycin-susceptible VRE...
January 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328861/relationship-between-anesthesia-and-postoperative-endophthalmitis-a-retrospective-study
#8
Hou-Chuan Lai, Wei-Cheng Tseng, Shu-I Pao, Chih-Shung Wong, Ren-Chih Huang, Wei-Hung Chan, Zhi-Fu Wu
Previous study showed that patients under general anesthesia (GA) had nasopharyngeal secretions on the face at the end of ocular surgery, especially in propofol-based total intravenous anesthesia (TIVA), it might induce postoperative endophthalmitis. Therefore, we conducted a retrospective study to compare the incidence of endophthalmitis after ocular surgery under topical, inhalation anesthesia, and propofol-based TIVA in our medical center from 2011 to 2015.A total of 21,032 patients were included, and we evaluated epidemiologic factors, systemic diseases, other ocular pathologic characteristics, complications during the surgery, technique of ocular surgery, method of antibiotic prophylaxis, vitreous culture, and vision outcome in these patients...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327943/whole-genome-sequencing-of-chinese-clearhead-icefish-protosalanx-hyalocranius
#9
Kai Liu, Dongpo Xu, Jia Li, Chao Bian, Jinrong Duan, Yanfeng Zhou, Minying Zhang, Xinxin You, Yang You, Jieming Chen, Hui Yu, Gangchun Xu, Di-An Fang, Jun Qiang, Shulun Jiang, Jie He, Junmin Xu, Qiong Shi, Zhiyong Zhang, Pao Xu
Background: Chinese clearhead icefish, Protosalanx hyalocranius , is a representative icefish species with economic importance and special appearance. Due to its great economic values in China, the fish was introduced into Lake Dianchi and several other lakes from the Lake Taihu half a century ago. Similar to the Sinocyclocheilus cavefish, the clearhead icefish has certain cavefish-like traits, such as transparent body and nearly scaleless skin. Here, we provide the whole genome sequence of this surface-dwelling fish and generated a draft genome assembly, aiming at exploring molecular mechanisms for the biological interests...
February 24, 2017: GigaScience
https://www.readbyqxmd.com/read/28323616/yap-is-essential-for-mechanical-force-production-and-epithelial-cell-proliferation-during-lung-branching-morphogenesis
#10
Chuwen Lin, Erica Yao, Kuan Zhang, Xuan Jiang, Stacey Croll, Katherine Thompson-Peer, Pao-Tien Chuang
Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties. In support of this model, mechanical force production is compromised and cell proliferation is reduced in Yap mutant lungs. We propose that defective force generation and insufficient epithelial cell number underlie the branching defects...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28322436/modelling-hydraulic-transport-and-anaerobic-uptake-by-paos-and-gaos-during-wastewater-feeding-in-ebpr-granular-sludge-reactors
#11
David G Weissbrodt, Christof Holliger, Eberhard Morgenroth
New-generation bioprocesses using granular sludge aim for a high-rate removal of nutrients from wastewater with low footprint. Achieving enhanced biological phosphorus removal (EBPR) relies on the design of sludge beds and wastewater feeding conditions to optimally load the biomass and to select for polyphosphate- (PAOs) over glycogen-accumulating organisms (GAOs) and other heterotrophs. A hydraulic-metabolic mathematical model was developed to elucidate the impact of hydraulic transport patterns and environmental conditions on the PAO/GAO competition during up-flow feeding through an EBPR granular sludge bed...
March 21, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28322328/5d-imaging-via-light-sheet-microscopy-reveals-cell-dynamics-during-the-eye-antenna-disc-primordium-formation-in-drosophila
#12
Yu Shan Huang, Hui Yu Ku, Yun Chi Tsai, Chin Hao Chang, Sih Hua Pao, Y Henry Sun, Arthur Chiou
5D images of engrailed (en) and eye gone (eyg) gene expressions during the course of the eye-antenna disc primordium (EADP) formation of Drosophila embryos from embryonic stages 13 through 16 were recorded via light sheet microscopy and analyzed to reveal the cell dynamics involved in the development of the EADP. Detailed analysis of the time-lapsed images revealed the process of EADP formation and its invagination trajectory, which involved an inversion of the EADP anterior-posterior axis relative to the body...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314450/conceptualization-of-success-in-young-adulthood
#13
REVIEW
Maryland Pao
Successful transition from childhood to adulthood is context and culture dependent. This article reviews concepts of mental health and theoretic constructs of successful adulthood that suggest intentional policies and practices are developed with a specific vision of success. Parents, educators, mental health professionals, and policymakers need to be cognizant of their assumptions and essential roles in these processes. The early development of illness may disrupt and alter the timelines of different developmental milestones and trajectories...
April 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28314208/long-term-effects-of-sulphide-on-the-enhanced-biological-removal-of-phosphorus-the-symbiotic-role-of-thiothrix-caldifontis
#14
F J Rubio-Rincón, L Welles, C M Lopez-Vazquez, M Nierychlo, B Abbas, M Geleijnse, P H Nielsen, M C M van Loosdrecht, D Brdjanovic
Thiothrix caldifontis was the dominant microorganism (with an estimated bio-volume of 65 ± 3%) in a lab-scale enhanced biological phosphorus removal (EBPR) system containing 100 mg of sulphide per litre in the influent. After a gradual exposure to the presence of sulphide, the EBPR system initially dominated by Candidatus Accumulibacter phosphatis Clade I (98 ± 3% bio-volume) (a known polyphosphate accumulating organism, PAO) became enriched with T. caldifontis. Throughout the different operating conditions studied, practically 100% phosphate removal was always achieved...
March 7, 2017: Water Research
https://www.readbyqxmd.com/read/28306752/structural-characterization-of-fluoride-species-in-shark-teeth
#15
Hsun-Hui Chang, Ming-Jou Chien, Chun-Chieh Kao, Yu-Jo Chao, Pao-Tao Yu, Chun-Yu Chang, Shing-Jong Huang, Yuan-Ling Lee, Jerry C C Chan
In shark teeth we have identified the species fluorapatite, hydroxyfluorapatite and its defect site, calcium fluoride, and potassium fluoride. Their relative amounts in teeth at different development stages have been quantified. Calcium fluoride and potassium fluoride may be associated with the fluoridation mechanism in shark teeth.
March 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28301536/prognostic-impact-of-peritonitis-in-hemodialysis-patients-a-national-wide-longitudinal-study-in-taiwan
#16
Yueh-An Lu, Kun-Hua Tu, Cheng-Chia Lee, Patricia W Wu, Chee-Jen Chang, Ya-Chung Tian, Chih-Wei Yang, Pao-Hsien Chu
BACKGROUND: Peritonitis has been independently associated with increased morbidity and mortality in peritoneal dialysis patients. However, there are few reports on peritonitis in hemodialysis patients. We aim at investigating both the risk profiles and prognostic impact of peritonitis in hemodialysis patients. METHODS: This nation-wide longitudinal study uses claims data obtained from the Taiwan National Health Insurance Research Database. A total of 80,733 incident hemodialysis patients of age ≥ 20 years without a history of peritonitis were identified between January 1, 1998 and December 31, 2009...
2017: PloS One
https://www.readbyqxmd.com/read/28300072/unravelling-the-hidden-link-of-lithium-halides-and-application-in-the-synthesis-of-organocuprates
#17
Hong Yi, Dali Yang, Jie Xin, Xiaotian Qi, Yu Lan, Yi Deng, Chih-Wen Pao, Jyh-Fu Lee, Aiwen Lei
As a versatile metal, copper has demonstrated a wide application in acting as both organometallic reagent and catalyst. Organocuprates are among the most used organometallic reagents in the formation of new carbon-carbon bonds in organic synthesis. Therefore, revealing the real structures of organocuprates in solution is crucial to provide insights into the reactivity of organocuprates. Here we provide several important insights into organocuprate chemistry. The main finding contains the following aspects. The Cu(0) particles were detected via the reduction of CuX by nBuLi or PhLi...
March 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28286465/evaluation-of-new-biphasic-calcium-phosphate-bone-substitute-rabbit-femur-defect-model-and-preliminary-clinical-results
#18
Yeong-Jang Chen, Jwo-Luen Pao, Chiang Sang Chen, Yu-Chun Chen, Chun-Chien Chang, Fang-Ming Hung, Chih-Hung Chang
Autogenous bone grafting, used to repair bone defects, is limited and the donor site can experience complications. Compared to autogenous bone graft, artificial bones have different porosity, which might make them suitable alternatives to bone grafts. Here, two porous biphasic calcium phosphate bone substitutes, namely Bicera™ and Triosite™, are used in an animal study and clinical practice to find a suitable porosity for implantation. Bicera™ and Triosite™ consist of 60 wt% hydroxyapatite and 40 wt% β-tricalcium phosphate, with the porosity of Bicera™ (82%) being higher than that of Triosite™ (70%)...
2017: Journal of Medical and Biological Engineering
https://www.readbyqxmd.com/read/28284729/effects-of-di-2-ethylhexyl-phthalate-exposure-on-1-2-dimethyhydrazine-induced-colon-tumor-promotion-in-rats
#19
Hsin-Pao Chen, Min-Hsiung Pan, Yuan-Yi Chou, Chieh Sung, Kuo-Hsin Lee, Chung-Man Leung, Ping-Chi Hsu
Di(2-ethylhexyl)phthalate (DEHP) may cause carcinogenicity in the liver; however, few have detailed on the potential effects of DEHP exposure on colorectal cancer. Male Sprague-Dawley rats received i.p. injections of 1,2-dimethylhydrazine (DMH) once-a-week for the first 4 weeks, and rats in each group were treated with DEHP through oral gavage daily for either 7, 10 or 15 weeks; after which, all rats were euthanized and their colons were assessed (a) morphologically for aberrant crypt foci (ACF) or tumors, (b) cytologically for mitotic index (MI), and (c) immunohistochemically for the expression of β-catenin, cyclooygenase (COX)-2, vascular endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), cyclin D1, and c-myc...
March 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28281124/major-pancreatic-duct-continuity-is-the-crucial-determinant-in-the-management-of-blunt-pancreatic-injury-a-pancreatographic-classification
#20
Being-Chuan Lin, Yon-Cheong Wong, Ray-Jade Chen, Nai-Jen Liu, Cheng-Hsien Wu, Tsann-Long Hwang, Yu-Pao Hsu
BACKGROUND: To evaluate the management and outcomes of blunt pancreatic injuries based on the integrity of the major pancreatic duct (MPD). METHODS: Between August 1996 and August 2015, 35 patients with blunt pancreatic injuries underwent endoscopic retrograde pancreatography (ERP). Medical charts were retrospectively reviewed for demography, ERP timing, imaging findings, management, and outcome. RESULTS: Of the 35 patients, 21 were men and 14 were women, with ages ranging from 11 to 70 years...
March 9, 2017: Surgical Endoscopy
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