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Keywords Mesial temporal lobe epilepsy ...

Mesial temporal lobe epilepsy and memory

https://read.qxmd.com/read/37421714/arousal-deregulation-in-the-co-shaping-of-neuropsychological-dysfunction-in-frontal-and-mesial-temporal-lobe-epilepsy
#21
JOURNAL ARTICLE
Katerina Poprelka, Panayiotis Patrikelis, Maria Takousi, Lambros Messinis, Theodoros Fasilis, Sofia Margariti, Evniki Ntinopoulou, Anastasia Verentzioti, Maria Stefanatou, Athanasia Alexoudi, Stefanos Korfias, Ioannis Zalonis, Stylianos Gatzonis
OBJECTIVE: Our work aims to investigate the role of physiological arousal in the expression of neuropsychological deficits in frontal lobe epilepsy (FLE) and mesial temporal lobe epilepsy (mTLE), by drawing on the Lurian theory of brain function. METHODS: For this study a total of 43 patients with focal onset epilepsy has been taken; twenty-four patients with FLE, 19 patients with mTLE and 26 healthy controls, all matched for age and education. Participants underwent a comprehensive neuropsychological assessment including various cognitive domains, such as attention, episodic memory, speed of information processing, response inhibition and mental flexibility, working memory, verbal fluency (phonological & semantic)...
August 2023: Epilepsy Research
https://read.qxmd.com/read/37405548/intracranial-neurofeedback-modulating-neural-activity-in-the-mesial-temporal-lobe-during-memory-encoding-a-pilot-study
#22
JOURNAL ARTICLE
Koji Koizumi, Naoto Kunii, Kazutaka Ueda, Kazuhiko Takabatake, Keisuke Nagata, Shigeta Fujitani, Seijiro Shimada, Masayuki Nakao
Removal of the mesial temporal lobe (MTL) is an established surgical procedure that leads to seizure freedom in patients with intractable MTL epilepsy; however, it carries the potential risk of memory damage. Neurofeedback (NF), which regulates brain function by converting brain activity into perceptible information and providing feedback, has attracted considerable attention in recent years for its potential as a novel complementary treatment for many neurological disorders. However, no research has attempted to artificially reorganize memory functions by applying NF before resective surgery to preserve memory functions...
July 5, 2023: Applied Psychophysiology and Biofeedback
https://read.qxmd.com/read/37391474/connectivity-alteration-in-thalamic-nuclei-and-default-mode-network-related-area-in-memory-processes-in-mesial-temporal-lobe-epilepsy-using-magnetoencephalography
#23
JOURNAL ARTICLE
Tomotaka Ishizaki, Satoshi Maesawa, Daisuke Nakatsubo, Hiroyuki Yamamoto, Jun Torii, Manabu Mutoh, Jun Natsume, Minoru Hoshiyama, Ryuta Saito
This work aimed to investigate the involvement of the thalamic nuclei in mesial temporal lobe epilepsy (MTLE) and identify the influence of interictal epileptic discharges on the neural basis of memory processing by evaluating the functional connectivity (FC) between the thalamic nuclei and default mode network-related area (DMNRA) using magnetoencephalography. Preoperative datasets of nine patients with MTLE with seizure-free status after surgery and those of nine healthy controls were analyzed. The FC between the thalamic nuclei (anterior nucleus [ANT], mediodorsal nucleus [MD], intralaminar nuclei [IL]), hippocampus, and DMNRA was examined for each of the resting, pre-spike, spike, and post-spike periods in the delta to ripple bands using magnetoencephalography...
June 30, 2023: Scientific Reports
https://read.qxmd.com/read/37347650/a-novel-geometry-based-analysis-of-hippocampal-morphometry-in-mesial-temporal-lobe-epilepsy
#24
JOURNAL ARTICLE
Laura Fischbach, Tobias Bauer, Kersten Diers, Juri-Alexander Witt, Mar Brugues, Valeri Borger, Martin Schidlowski, Attila Rácz, Tobias Baumgartner, Randi von Wrede, Daniel Paech, Bernd Weber, Alexander Radbruch, Hartmut Vatter, Albert J Becker, Hans-Jürgen Huppertz, Christoph Helmstaedter, Rainer Surges, Martin Reuter, Theodor Rüber
Hippocampal volumetry is an essential tool in researching and diagnosing mesial temporal lobe epilepsy (mTLE). However, it has a limited ability to detect subtle alterations in hippocampal morphometry. Here, we establish and apply a novel geometry-based tool that enables point-wise morphometric analysis based on an intrinsic coordinate system of the hippocampus. We hypothesized that this point-wise analysis uncovers structural alterations not measurable by volumetry, but associated with histological underpinnings and the neuropsychological profile of mTLE...
June 22, 2023: Human Brain Mapping
https://read.qxmd.com/read/37321319/temporopolar-amygdalohippocampectomy-for-mesial-temporal-lobe-epilepsy-a-2d-anatomical-operative-video
#25
Cleiton Formentin, Dayvid Leonardo de Castro Oliveira, Leo Gordiano Matias, Andrei Fernandes Joaquim, Helder Tedeschi, Enrico Ghizoni
Mesial temporal lobe epilepsy (MTLE) is the most frequent type of focal epilepsy in young adults and the most commonly reported in surgical series worldwide1,2 . When seizures become refractory to drug therapy, they are unlikely to remit spontaneously, and for those 30% of patients with epilepsy that are refractory to antiepileptic drugs, it is well stated that resection of the mesial temporal lobe structures provides great rate (70-80%) of seizure control3,4 . The transsylvian route for amygdalohippocampectomy has been used at our institution for many years, evolving from the first description of Yasargil through the inferior circular sulcus of insula to the most recent one through the amygdala trying to preserve the temporal stem5,6 ...
June 13, 2023: World Neurosurgery
https://read.qxmd.com/read/37257470/rhinal-and-hippocampal-event-related-potentials-as-epileptogenic-zone-markers-in-the-pre-surgical-evaluation-of-temporal-epilepsies-a-systematic-review
#26
JOURNAL ARTICLE
Daniela de Andrade Morange, Magali Teresópolis Reis Amaral, Martha Silvia Martinez-Silveira, Agnès Trébuchon
BACKGROUND:  Cognitive event-related potentials (ERPs) allow for lateralization of the epileptogenic zone (EZ) to estimate the reserve of memory in the contralateral non-epileptogenic hemisphere, and to investigate the prognosis of temporal lobe seizure control in unilateral temporal lobe epilepsy (TLE). OBJECTIVE:  To define the accuracy of cognitive evoked anterior mesial temporal lobe (AMTL-N400) and P600 potentials in detecting the epileptogenic zone in temporal lobe epilepsy (TLE), and second, to evaluate the possibility of using them as markers of cognitive outcome...
May 2023: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/37204159/the-ca2-hippocampal-subfield-in-humans-a-review
#27
REVIEW
Ricardo Insausti, Monica Muñoz-López, Ana Maria Insausti
CA2 is probably the most enigmatic of the hippocampal fields. It is small in size (in humans about 500 μm across the mediolateral axis), and yet, it is involved in important functions, such as in social memory and anxiety. This study offers a glimpse of several significant aspects of the anatomical organization of CA2. We present an overview of the anatomical structure of CA2, imbued in the general organization of the human hippocampal formation. The location and distinctiveness of CA2 is presented in relation with CA3 and CA1, based in a total of 23 human control cases serially sectioned throughout the whole longitudinal axis of the hippocampus, examined every 500 μm in Nissl-stained sections...
June 2023: Hippocampus
https://read.qxmd.com/read/37192585/multifocal-hypometabolic-correlates-to-deficits-of-verbal-memory-in-mesial-temporal-lobe-epilepsy
#28
JOURNAL ARTICLE
Racheal M Smetana, Prem P Batchala, Bern G Lee, Tamer Albataineh, Donna K Broshek, Nathan B Fountain, Salma Abbas, Mark Quigg
BACKGROUND AND OBJECTIVES: Neuropsychological research on mesial temporal lobe epilepsy (MTLE) often highlights material-specific memory deficits, but a lesion-focused model may not accurately reflect the underlying networks that support episodic memory in these patients. Our study evaluated the pathophysiology behind verbal learning/memory deficits as revealed by hypometabolism quantified through 18-fluorodeoxyglucose positron emission tomography (FDG-PET). METHODS: This retrospective study included thirty presurgical patients with intractable unilateral MTLE who underwent interictal FDG-PET and verbal memory assessment (12 females, mean age: 38...
May 14, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37037096/mesial-temporal-lobe-epilepsy-with-amygdalar-hamartoma-like-lesion-is-it-a-distinct-syndrome
#29
JOURNAL ARTICLE
Kiminobu Okayama, Naotaka Usui, Takashi Matsudaira, Akihiko Kondo, Yasukiyo Araki, Norihiko Kawaguchi, Kazumi Matsuda, Takayasu Tottori, Kiyohito Terada, Riki Matsumoto, Yukitoshi Takahashi
INTRODUCTION: We examined the clinical, semiological, scalp electroencephalographic (EEG), and neuropsychological features of patients with amygdalar hamartoma-like lesion (AHL) without hippocampal sclerosis (HS). METHODS: This retrospective study included 9 patients with mesial temporal lobe epilepsy (MTLE) who had an amygdalar lesion on preoperative MRI; underwent mesial temporal resection; were diagnosed with amygdalar hamartoma-like lesion (AHL) without hippocampal sclerosis (HS); were followed up for at least 2 years after surgery; and had a favourable postoperative seizure outcome (Engel Class I)...
May 2023: Epilepsy Research
https://read.qxmd.com/read/37032630/memory-characteristics-in-mesial-temporal-lobe-epilepsy-insights-from-an-eye-tracking-memory-game-and-neuropsychological-assessments
#30
JOURNAL ARTICLE
Ling Xiao, Guangpu Zhu, Kailing Huang, Shirui Wen, Li Feng, Beibin Li, Bo Xiao, Ding Liu, Quan Wang
AIMS: To compare different patterns of memory impairment in patients with two subtypes of mesial temporal lobe epilepsy (MTLE) and healthy controls. METHODS: Thirty-five healthy controls and 41 patients with MTLE were recruited, of which 25 patients were diagnosed as hippocampal sclerosis (HS-MTLE), and the rest 16 patients were lesion-negative (MRI-neg MTLE). Participants completed the Wechsler memory assessment and a short-term memory game on an automated computer-based memory assessment platform with an eye tracker...
April 10, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/36921552/epilepsy-surgery-for-dominant-side-mesial-temporal-lobe-epilepsy-without-hippocampal-sclerosis
#31
JOURNAL ARTICLE
Daisu Abe, Motoki Inaji, Satoka Hashimoto, Shunsuke Takagi, Taketoshi Maehara
Although anterior temporal lobectomy (ATL) is an established surgery for medically intractable mesial temporal lobe epilepsy (MTLE), it can harm memory function, especially in dominant-side MTLE patients without hippocampal sclerosis (HS). To avoid this complication, multiple hippocampal transection (MHT) was developed, but its efficacy has not been fully elucidated. We report the detailed treatment results of MHT compared with that of ATL. We retrospectively analysed the records of 30 patients who underwent surgery for dominant-side MTLE...
March 13, 2023: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/36867249/burr-hole-microsurgical-subtemporal-selective-amygdalohippocampectomy
#32
JOURNAL ARTICLE
David Pitskhelauri, Elina Kudieva, Pavel Vlasov, Natalya Eliseeva, Oleg Zaitsev, Maria Kamenetskaya, Antonina Kozlova, Ludmila Shishkina, Gleb Danilov, Alexander Sanikidze, Tekla Kuprava, Ruslan Ishkinin, Armen Melikyan
INTRODUCTION: At present, selective amygdalohippocampectomy (SAH) has become popular in the treatment of drug-resistant mesial temporal lobe epilepsy (TLE). However, there is still an ongoing discussion about the advantages and disadvantages of this approach. METHODS: The study included a consecutive series of 43 adult patients with drug-resistant TLE, involving 24 women and 19 men (1.8/1). Surgeries were performed at the Burdenko Neurosurgery Center from 2016 to 2019...
May 2023: Acta Neurochirurgica
https://read.qxmd.com/read/36864916/morphometric-and-microstructural-characteristics-of-hippocampal-subfields-in-mesial-temporal-lobe-epilepsy-and-their-correlates-with-mnemonic-discrimination
#33
JOURNAL ARTICLE
Alicia Comino Garcia-Munoz, Yasser Alemán-Gómez, Rafael Toledano, Claudia Poch, Irene García-Morales, Ángel Aledo-Serrano, Antonio Gil-Nagel, Pablo Campo
INTRODUCTION: Pattern separation (PS) is a fundamental aspect of memory creation that defines the ability to transform similar memory representations into distinct ones, so they do not overlap when storing and retrieving them. Experimental evidence in animal models and the study of other human pathologies have demonstrated the role of the hippocampus in PS, in particular of the dentate gyrus (DG) and CA3. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HE) commonly report mnemonic deficits that have been associated with failures in PS...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36861271/memory-functioning-after-hippocampal-removal-does-side-matter
#34
JOURNAL ARTICLE
Virginie Lambrecq, Irene Alonso, Dominique Hasboun, Vera Dinkelacker, Lila Davachi, Séverine Samson, Sophie Dupont
To address the memory functioning after medial temporal lobe (MTL) surgery for refractory epilepsy and relationships with the side of the hippocampal removal, 22 patients with pharmaco-resistant epilepsy who had undergone MTL resection (10 right/12 left) at the Salpêtrière Hospital were compared with 21 matched healthy controls. We designed a specific neuropsychological binding memory test that specifically addressed hippocampal cortex functioning, and left-right material-specific lateralization. Our results showed that both left and right mesial temporal lobe removal cause a severe memory impairment, for both verbal and visual material...
March 1, 2023: Journal of Neuropsychology
https://read.qxmd.com/read/36816567/cerebellar-functional-disruption-and-compensation-in-mesial-temporal-lobe-epilepsy
#35
JOURNAL ARTICLE
Yiqian Peng, Kangrun Wang, Chaorong Liu, Langzi Tan, Min Zhang, Jialinzi He, Yuwei Dai, Ge Wang, Xianghe Liu, Bo Xiao, Fangfang Xie, Lili Long
BACKGROUND: Cerebellar functional alterations are common in patients with mesial temporal lobe epilepsy (MTLE), which contribute to cognitive decline. This study aimed to deepen our knowledge of cerebellar functional alterations in patients with MTLE. METHODS: In this study, participants were recruited from an ongoing prospective cohort of 13 patients with left TLE (LTLE), 17 patients with right TLE (RTLE), and 30 healthy controls (HCs). Functional magnetic resonance imaging data were collected during a Chinese verbal fluency task...
2023: Frontiers in Neurology
https://read.qxmd.com/read/36709527/hippocampal-resection-in-temporal-lobe-epilepsy-do-we-need-to-resect-the-tail
#36
JOURNAL ARTICLE
Debayan Dasgupta, Roisin Finn, Aswin Chari, Davide Giampiccolo, Jane de Tisi, Aidan G O'Keeffe, Anna Miserocchi, Andrew W McEvoy, Sjoerd B Vos, John S Duncan
INTRODUCTION: Anteromesial temporal lobe resection is the most common surgical technique used to treat drug-resistant mesial temporal lobe epilepsy, particularly when secondary to hippocampal sclerosis. Structural and functional imaging data suggest the importance of sparing the posterior hippocampus for minimising language and memory deficits. Recent work has challenged the view that maximal posterior hippocampal resection improves seizure outcome. This study was designed to assess whether resection of posterior hippocampal atrophy was associated with improved seizure outcome...
February 2023: Epilepsy Research
https://read.qxmd.com/read/36700444/-hippocampal-sclerosis-linked-to-epilepsy-clinical-consequences-histopathology-and-evolution-with-aging
#37
JOURNAL ARTICLE
Bastien Herlin
Hippocampal sclerosis is the most frequent etiology of patients with drug-resistant mesial temporal lobe epilepsy, which is the most frequent localization for focal epilepsy. Hippocampal sclerosis is the consequence of a cerebral aggression during early childhood, called the initial precipitating event, the most frequent of which are: febrile seizure, intracranial infection, hypoxia, or cranial trauma. The epilepsy onset usually occurs a few years after this event, with an association of focal temporal seizures and rarer secondarily generalized tonic-clonic seizures...
December 1, 2022: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://read.qxmd.com/read/36693618/long-term-outcome-of-seizure-control-and-neurologic-performance-after-limited-hippocampal-radiofrequency-thermocoagulation-for-mesial-temporal-lobe-epilepsy
#38
JOURNAL ARTICLE
Kuan-Hao Fu, Yu-Chi Wang, Siew-Na Lim, Mei-Yun Cheng, Tony Wu, Chun-Wei Chang, Bao-Luen Chang, Ching-Yi Lee, Chih-Hong Lee, Wei-En Johnny Tseng, Hsing-I Chiang, Ting-Wei Liao, Po-Hsun Tu
OBJECTIVE: Limited hippocampal radiofrequency thermocoagulation (RFTC) for patients with mesial temporal lobe epilepsy was associated with good short-term seizure control and few complications. We aimed to demonstrate the neuropsychologic outcomes and assess the prognostic factors of long-term seizure control in these patients. METHODS: We included all patients with mesial temporal lobe epilepsy who underwent limited hippocampal RFTC from January 2016 to December 2020...
May 2023: World Neurosurgery
https://read.qxmd.com/read/36682755/-surgical-treatment-of-mesial-temporal-lobe-epilepsy-focusing-on-anatomical-understanding
#39
JOURNAL ARTICLE
Takehiro Uda, Noritsugu Kunihiro, Yuta Tanoue, Yuichiro Kojima, Toshiyuki Kawashima, Ryoko Umaba, Hiroshi Uda, Saya Koh, Takeo Goto
Surgical treatment is an effective option for medically intractable epilepsy. Amygdalohippocampectomy for mesial temporal lobe epilepsy is a surgically remediable epileptic syndrome. It is a well-established surgery and various approaches to the mesial temporal lobe have been reported. To reduce the complication rate, surgeons should have sufficient knowledge of anatomy in the mesial temporal region. Here, we summarize the surgical treatments for mesial temporal lobe epilepsy, focusing on anatomical understanding...
January 2023: No Shinkei Geka. Neurological Surgery
https://read.qxmd.com/read/36648207/does-alzheimer-s-disease-with-mesial-temporal-lobe-epilepsy-represent-a-distinct-disease-subtype
#40
JOURNAL ARTICLE
Ifrah Zawar, Jaideep Kapur
Alzheimer's disease (AD) patients have a high risk of developing mesial temporal lobe epilepsy (MTLE) and subclinical epileptiform activity. MTLE in AD worsens outcomes. Therefore, we need to understand the overlap between these disease processes. We hypothesize that AD with MTLE represents a distinct subtype of AD, with the interplay between tau and epileptiform activity at its core. We discuss shared pathological features including histopathology, an initial mesial temporal lobe (MTL) hyperexcitability followed by MTL dysfunction and involvement of same networks in memory (AD) and seizures (MTLE)...
January 17, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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