Laura Fischbach, Tobias Bauer, Kersten Diers, Juri-Alexander Witt, Mar Brugues, Valeri Borger, Martin Schidlowski, Attila Rácz, Tobias Baumgartner, Randi von Wrede, Daniel Paech, Bernd Weber, Alexander Radbruch, Hartmut Vatter, Albert J Becker, Hans-Jürgen Huppertz, Christoph Helmstaedter, Rainer Surges, Martin Reuter, Theodor Rüber
Hippocampal volumetry is an essential tool in researching and diagnosing mesial temporal lobe epilepsy (mTLE). However, it has a limited ability to detect subtle alterations in hippocampal morphometry. Here, we establish and apply a novel geometry-based tool that enables point-wise morphometric analysis based on an intrinsic coordinate system of the hippocampus. We hypothesized that this point-wise analysis uncovers structural alterations not measurable by volumetry, but associated with histological underpinnings and the neuropsychological profile of mTLE...
June 22, 2023: Human Brain Mapping