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Mesial temporal lobe epilepsy and memory

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https://www.readbyqxmd.com/read/29893987/laser-ablation-for-mesial-temporal-lobe-epilepsy-surgical-and-cognitive-outcomes-with-and-without-mesial-temporal-sclerosis
#1
Cristian Donos, Joshua Breier, Elliott Friedman, Patrick Rollo, Jessica Johnson, Lauren Moss, Stephen Thompson, Melissa Thomas, Omotola Hope, Jeremy Slater, Nitin Tandon
OBJECTIVES: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT is that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) epilepsy. To evaluate this, as well as to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and surgical or cognitive outcomes in 43 consecutive patients undergoing LITT for MTL epilepsy...
June 12, 2018: Epilepsia
https://www.readbyqxmd.com/read/29873197/hippocampal-involvement-in-nonpathological-d%C3%A3-j%C3%A3-vu-subfield-vulnerability-rather-than-temporal-lobe-epilepsy-equivalent
#2
Eva Pešlová, Radek Mareček, Daniel J Shaw, Tomáš Kašpárek, Martin Pail, Milan Brázdil
INTRODUCTION: Morphological correlates of nonpathological déjà vu (DV) have been identified recently within the human brain. Significantly reduced gray matter volume (GMV) within a set of cortical and subcortical regions reported in subjects experiencing DV seems to mirror the distribution of GMV reduction in mesial temporal lobe epilepsy (MTLE) patients but vary in terms of the hippocampus. Another condition associated with hippocampal GMV reduction and DV alike disturbance in memory processing is schizophrenia (SCH)...
June 5, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29859335/hippocampal-activations-in-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-an-observational-study-on-intramural-encoding-delayed-recall-paradigms-using-task-based-memory-fmri
#3
Rajesh Pg, Thomas Bejoy, Chandrasekhar Pammi Vs, Kesavadas Chandrasekharan, Radhakrishnan Ashalatha, Alexander Aley, Thomas Sanjeev V, Menon Ramshekhar N
OBJECTIVES: To validate concurrent utility of within-scanner encoding and delayed recognition-memory paradigms to ascertain hippocampal activations during task-based memory fMRI. METHODS: Memory paradigms were designed for faces, word-pairs and abstract designs. A deep-encoding task was designed comprising of a total of 9 cycles run within a 1.5T MRI scanner. A recall session was performed after 1 h within the scanner using an event-related design. Group analysis was done with 'correct-incorrect' responses applied as parametric modulators in Statistical Parametric Mapping version 8 using boot-strap method to enable estimation of laterality indices (LI) using custom anatomical masks involving the medio-basal temporal structures...
May 26, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29600809/radiosurgery-versus-open-surgery-for-mesial-temporal-lobe-epilepsy-the-randomized-controlled-rose-trial
#4
Nicholas M Barbaro, Mark Quigg, Mariann M Ward, Edward F Chang, Donna K Broshek, John T Langfitt, Guofen Yan, Kenneth D Laxer, Andrew J Cole, Penny K Sneed, Christopher P Hess, Wei Yu, Manjari Tripathi, Christianne N Heck, John W Miller, Paul A Garcia, Andrew McEvoy, Nathan B Fountain, Vincenta Salanova, Robert C Knowlton, Anto Bagić, Thomas Henry, Siddharth Kapoor, Guy McKhann, Adriana E Palade, Markus Reuber, Evelyn Tecoma
OBJECTIVE: To compare stereotactic radiosurgery (SRS) versus anterior temporal lobectomy (ATL) for patients with pharmacoresistant unilateral mesial temporal lobe epilepsy (MTLE). METHODS: This randomized, single-blinded, controlled trial recruited adults eligible for open surgery among 14 centers in the USA, UK, and India. Treatment was either SRS at 24 Gy to the 50% isodose targeting mesial structures, or standardized ATL. Outcomes were seizure remission (absence of disabling seizures between 25 and 36 months), verbal memory (VM), and quality of life (QOL) at 36-month follow-up...
March 30, 2018: Epilepsia
https://www.readbyqxmd.com/read/29499551/task-activation-and-functional-connectivity-show-concordant-memory-laterality-in-temporal-lobe-epilepsy
#5
Noah Sideman, Ganne Chaitanya, Xiaosong He, Gaelle Doucet, Na Young Kim, Michael R Sperling, Ashwini D Sharan, Joseph I Tracy
OBJECTIVE: In epilepsy, asymmetries in the organization of mesial temporal lobe (MTL) functions help determine the cognitive risk associated with procedures such as anterior temporal lobectomy. Past studies have investigated the change/shift in a visual episodic memory laterality index (LI) in mesial temporal lobe structures through functional magnetic resonance imaging (fMRI) task activations. Here, we examine whether underlying task-related functional connectivity (FC) is concordant with such standard fMRI laterality measures...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29473981/theta-frequency-decreases-throughout-the-hippocampal-formation-in-a-focal-epilepsy-model
#6
Antje Kilias, Ute Häussler, Katharina Heining, Ulrich P Froriep, Carola A Haas, Ulrich Egert
Mesial temporal lobe epilepsy is characterized by focal, recurrent spontaneous seizures, sclerosis and granule cell dispersion (GCD) in the hippocampal formation. Changes in theta rhythm properties have been correlated with the severity of hippocampal restructuring and were suggested as a cause of memory deficits accompanying epilepsy. For severe sclerosis, it has even been questioned whether theta band oscillations persist. We asked how theta oscillations change with graded restructuring along the longitudinal hippocampal axis and whether these changes correlate with the overall severity of temporal lobe epilepsy...
February 23, 2018: Hippocampus
https://www.readbyqxmd.com/read/29420840/stereotactic-laser-amygdalohippocampotomy-for-mesial-temporal-lobe-epilepsy
#7
Robert E Gross, Matthew A Stern, Jon T Willie, Rebecca E Fasano, Amit M Saindane, Bruno P Soares, Nigel P Pedersen, Daniel L Drane
OBJECTIVE: To evaluate the outcomes 1 year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a 5-year period since introduction of this novel technique. METHODS: Surgical outcomes of a consecutive series of 58 patients with mesial temporal lobe epilepsy who underwent the surgery at our institution with at least 12 months of follow-up were retrospectively evaluated. A subgroup analysis was performed comparing patients with and without mesial temporal sclerosis...
March 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29306849/verbal-learning-and-memory-outcome-in-selective-amygdalohippocampectomy-versus-temporal-lobe-resection-in-patients-with-hippocampal-sclerosis
#8
Mette Thrane Foged, Kirsten Vinter, Louise Stauning, Troels W Kjær, Brice Ozenne, Sándor Beniczky, Olaf B Paulson, Flemming Find Madsen, Lars H Pinborg
PURPOSE: With the advent of new very selective techniques like thermal laser ablation to treat drug-resistant focal epilepsy, the controversy of resection size in relation to seizure outcome versus cognitive deficits has gained new relevance. The purpose of this study was to test the influence of the selective amygdalohippocampectomy (SAH) versus nonselective temporal lobe resection (TLR) on seizure outcome and cognition in patients with mesial temporal lobe epilepsy (MTLE) and histopathological verified hippocampal sclerosis (HS)...
February 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29287217/association-of-white-matter-diffusion-characteristics-and-cognitive-deficits-in-temporal-lobe-epilepsy
#9
Raúl Rodríguez-Cruces, Leticia Velázquez-Pérez, Ildefonso Rodríguez-Leyva, Ana Luisa Velasco, David Trejo-Martínez, Héctor Manuel Barragán-Campos, Vicente Camacho-Téllez, Luis Concha
OBJECTIVE: The purpose of this study was to evaluate the relation between cognitive performance and white matter (WM) integrity in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS). METHODS: We included 26 patients with TLE (10 right, 16 left onset) as well as 24 healthy controls matched for age, gender, and years of education. In addition to quantitative hippocampal volume and transverse relaxation (T2) evaluation, whole-brain WM was analyzed using fractional anisotropy (FA) maps, derived from the diffusion tensor model...
February 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29273691/neuropsychological-outcome-after-subtemporal-versus-transsylvian-approach-for-selective-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy-a-randomised-prospective-clinical-trial
#10
Viola Lara Vogt, Daniel Delev, Alexander Grote, Johannes Schramm, Marec von Lehe, Christian Erich Elger, Juri-Alexander Witt, Christoph Helmstaedter
OBJECTIVE: To compare the effects of different surgical approaches for selective amygdalohippocampectomy in patients with pharmacoresistant mesial temporal lobe epilepsy with regard to the neuropsychological outcome and to replicate an earlier study employing a matched-pair design. METHOD: 47 patients were randomised to subtemporal versus transsylvian approaches. Memory, language, attentional and executive functions were assessed before and 1 year after surgery...
December 22, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29229342/parahippocampectomy-as-a-new-surgical-approach-to-mesial-temporal-lobe-epilepsy-caused-by-hippocampal-sclerosis-a-pilot-randomized-comparative-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Mario Arturo Alonso-Vanegas, Iván D Freire Carlier, Daniel San-Juan, Alma Rosa Martínez, Carlos Trenado
BACKGROUND AND OBJECTIVE: The parahippocampal gyrus plays an important role in the epileptogenic pathways of mesial temporal lobe epilepsy caused by hippocampal sclerosis (mTLE-HS); its resection could prevent epileptic seizures with fewer complications. This study evaluates the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalohipppocampectomy (SAH), and parahippocampectomy (PHC) surgical approaches in mTLE-HS. METHODS: A randomized comparative pilot clinical trial (2008-2011) was performed that included patients with mTLE-HS who underwent ATL, trans-T3 SAH, and trans-T3 PHC...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29186594/resection-of-temporal-neocortex-during-multiple-hippocampal-transections-for-mesial-temporal-lobe-epilepsy-does-not-affect-seizure-or-memory-outcome
#12
Fady Girgis, Madeline E Greil, Philip S Fastenau, Jennifer Sweet, Hans Lüders, Jonathan P Miller
BACKGROUND: Multiple hippocampal transection (MHT) is a surgical treatment for mesial temporal lobe epilepsy associated with improved postoperative neuropsychological outcomes compared with lobectomy. OBJECTIVE: To determine whether resection of the amygdala and anterior temporal neocortex during MHT affects postoperative seizure/memory outcome. METHODS: Seventeen patients with normal magnetic resonance imaging and stereo-electroencephalogram-proven drug-resistant dominant mesial temporal lobe epilepsy were treated with MHT...
December 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29183959/stereotactic-eeg-guided-laser-interstitial-thermal-therapy-for-mesial-temporal-lobe-epilepsy
#13
James X Tao, Shasha Wu, Maureen Lacy, Sandra Rose, Naoum P Issa, Carina W Yang, Katherine E Dorociak, Maria Bruzzone, Jisoon Kim, Ahmad Daif, Jason Choi, Vernon L Towle, Peter C Warnke
OBJECTIVE: To determine the outcomes of combined stereo-electroencephalography-guided and MRI-guided stereotactic laser interstitial thermal therapy (LITT) in the treatment of patients with drug-resistant mesial temporal lobe epilepsy (mTLE). METHODS: We prospectively assessed the surgical and neuropsychological outcomes in 21 patients with medically refractory mTLE who underwent LITT at the University of Chicago Medical Center. We further compared the surgical outcomes in patients with and without mesial temporal sclerosis (MTS)...
May 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29175724/a-right-amygdalohippocampectomy-a-diagnostic-challenge
#14
Frank Jonker, Cees Jonker, Laura Bronzwaer, Erik Scherder
OBJECTIVE: Amygdalohippocampectomy (AHE) is the resective surgery for medically intractable mesial temporal lobe epilepsy. To date no study has investigated a wide range of neuropsychiatric symptoms in right AHE outpatients. PATIENTS AND METHODS: Three patients with right AHE participated in this study. The control group are patients with cognitive complaints with no history of epilepsy or neurological impairment and no structural abnormalities on the MRI/CT. We expected no difference in verbal memory compared to the controls...
January 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29163352/parahippocampal-involvement-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis-a-proof-of-concept-from-memory-guided-saccades
#15
Silvia Colnaghi, Giorgio Beltrami, Guy Poloni, Anna Pichiecchio, Stefano Bastianello, Carlo Andrea Galimberti, Maurizio Versino
Objective: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) may involve extrahippocampal areas of structural damage and dysfunction. The accuracy of medium-term spatial memory can be tested by memory-guided saccades (MGS) to evaluate a functional impairment of the parahippocampal cortex (PHC), while voxel-based morphometry (VBM) analysis can be used to detect a structural damage of the latter region. Methods: MGS with 3- and 30-s memorization delays were compared between 7 patients affected by right MTLE-HS (r-MTLE-HS), 6 patients affected by left MTLE-HS, and 13 healthy controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29105058/verbal-memory-decline-from-hippocampal-depth-electrodes-in-temporal-lobe-surgery-for-epilepsy
#16
Hanna Ljung, Arto Nordlund, Maria Strandberg, Johan Bengzon, Kristina Källén
OBJECTIVE: To explore whether patients with refractory mesial temporal lobe epilepsy risk aggravated verbal memory loss from intracranial electroencephalography (EEG) recording with longitudinal hippocampal electrodes in the language-dominant hemisphere. METHODS: A long-term neuropsychological follow-up (mean 61.5 months, range 22-111 months) was performed in 40 patients after ictal registration with left hippocampal depth electrodes (study group, n = 16) or no invasive EEG, only extracranial registration (reference group, n = 24)...
December 2017: Epilepsia
https://www.readbyqxmd.com/read/29094314/volumetric-changes-in-hippocampal-subregions-and-memory-performance-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#17
Caihong Ji, Lujia Zhu, Cong Chen, Shuang Wang, Leilei Zheng, Hong Li
In the present study we explored the different patterns of volumetric atrophy in hippocampal subregions of patients with left and right mesial temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Meanwhile, the memory impairment patterns in Chinese-speaking TLE-HS patients and potential influencing factors were also determined. TLE-HS patients (21 left and 17 right) and 21 healthy controls were recruited to complete T2-weighted imaging and verbal/nonverbal memory assessment. The results showed that both left and right TLE-HS patients had overall reduced hippocampal subregion volumes on the sclerotic side, and cornu ammonis sectors (CA1) exhibited maximum atrophy...
April 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29089238/-clinical-and-pathological-definition-of-temporal-medium-epilepsy-subtypes-with-hypocampic-sclerosis
#18
Gonzalo Olivares-Granados, Rosa María Ríos-Pelegrina, Jesús Ruiz-Giménez, Alberto Galdón-Castillo, Teresa Escobar-Delgado, Raimundo García Del Moral
BACKGROUND AND OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis is the most common cause of refractory epilepsy, and the most common indication for surgery. Although effective, surgery fails in up to 40% of patients. The objective of our study was to establish a correlation between the different histological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis and the prognosis, seizures control, side effects and anticonvulsivant drug withdrawal in patients with refractory epilepsy...
January 2018: Neurocirugía
https://www.readbyqxmd.com/read/29053037/possible-autoantibody-negative-limbic-encephalitis-after-anterior-temporal-lobectomy-for-hippocampal-sclerosis
#19
Sara Casciato, Alfredo D'Aniello, Addolorata Mascia, Pier Paolo Quarato, Marco De Risi, Liliana G Grammaldo, Vincenzo Esposito, Marco Zoccarato, Giancarlo Di Gennaro
PURPOSE: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. MATERIALS AND METHODS: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures...
May 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29040828/neuropsychological-functioning-and-brain-energetics-of-drug-resistant-mesial-temporal-lobe-epilepsy-patients
#20
Camila Moreira Osório, Alexandra Latini, Rodrigo Bainy Leal, Maria Emília Rodrigues de Oliveira Thais, Helena Dresch Vascouto, Aline Pertile Remor, Mark William Lopes, Marcelo Neves Linhares, Juliana Ben, Roberta de Paula Martins, Rui Daniel Prediger, Alexandre Ademar Hoeller, Hans Joachim Markowitsch, Peter Wolf, Kátia Lin, Roger Walz
Interictal hypometabolism is commonly measured by 18-fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) in the temporal lobe of patients with mesial temporal lobe epilepsy (MTLE-HS). Left temporal lobe interictal FDG-PET hypometabolism has been associated with verbal memory impairment, while right temporal lobe FDG-PET hypometabolism is associated with nonverbal memory impairment. The biochemical mechanisms involved in these findings remain unknown. In comparison to healthy controls (n=21), surgically treated patients with MTLE-HS (n=32, left side=17) had significant lower scores in the Rey Auditory Verbal Learning Test (RAVLT retention and delayed), Logical Memory II (LMII), Boston Naming test (BNT), Letter Fluency and Category Fluency...
October 12, 2017: Epilepsy Research
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