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Mesial temporal lobe epilepsy and memory

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https://www.readbyqxmd.com/read/27816897/epileptic-networks-in-patients-with-bitemporal-epilepsy-the-role-of-seeg-for-the-selection-of-good-surgical-candidates
#1
REVIEW
L Di Vito, F Mauguière, H Catenoix, S Rheims, P Bourdillon, A Montavont, J Isnard
OBJECTIVE: In this study we investigated the electrical characteristics of seizures recorded by stereo-EEG (SEEG) in a cohort of patients with bitemporal lobe epilepsy (BTLE), in the attempt to verify the presence/absence of different seizure patterns and to identify good surgical candidates. METHODS: We retrospectively reviewed 14 consecutive patients with medically refractory BTLE confirmed by scalp video-EEG (VEEG) recording of bitemporal independent or non-lateralizing seizure onset...
October 24, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27756511/why-epilepsy-challenges-social-life
#2
Bettina K Steiger, Hennric Jokeit
Social bonds are at the center of our daily living and are an essential determinant of our quality of life. In people with epilepsy, numerous factors can impede cognitive and affective functions necessary for smooth social interactions. Psychological and psychiatric complications are common in epilepsy and may hinder the processing of social information. In addition, neuropsychological deficits such as slowed processing speed, memory loss or attentional difficulties may interfere with enjoyable reciprocity of social interactions...
October 11, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27736656/declarative-long-term-memory-and-the-mesial-temporal-lobe-insights-from-a-5-year-postsurgery-follow-up-study-on-refractory-temporal-lobe-epilepsy
#3
Gerardo Salvato, Pina Scarpa, Stefano Francione, Roberto Mai, Laura Tassi, Elisa Scarano, Giorgio Lo Russo, Gabriella Bottini
It is largely recognized that the mesial temporal lobe and its substructure support declarative long-term memory (LTM). So far, different theories have been suggested, and the organization of declarative verbal LTM in the brain is still a matter of debate. In the current study, we retrospectively selected 151 right-handed patients with temporal lobe epilepsy with and without hippocampal sclerosis, with a homogeneous (seizure-free) clinical outcome. We analyzed verbal memory performance within a normalized scores context, by means of prose recall and word paired-associate learning tasks...
November 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27688159/safety-and-seizure-control-in-patients-with-mesial-temporal-lobe-epilepsy-treated-with-regional-superselective-intra-arterial-injection-of-autologous-bone-marrow-mononuclear-cells
#4
Jaderson C DaCosta, Mirna W Portuguez, Daniel R Marinowic, Lucas P Schilling, Carolina M Torres, Danielle I DaCosta, Maria Júlia M Carrion, Eduardo F Raupp, Denise C Machado, Ricardo B Soder, Silvia L Lardi, Bernardo Garicochea
Temporal lobe epilepsy (TLE) is a highly prevalent syndrome among people with epilepsy, and is usually refractory to drug treatment. Structural and physiological changes, such as hippocampal sclerosis, are often present in TLE patients. The objective of this study is to evaluate the feasibility and safety of intra-arterial infusion of autologous bone marrow mononuclear cells (BMMC) in adults with medically refractory mesial temporal lobe epilepsy (MTLE) and unilateral hippocampal sclerosis (MTLE-HS). We enrolled 20 patients that had been diagnosed with MTLE-HS and refractory to medical treatment...
September 29, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27601154/seizure-freedom-after-limited-hippocampal-radiofrequency-thermocoagulation
#5
Han-Tao Li, Ching-Yi Lee, Siew-Na Lim, Chun-Wei Chang, Shih-Tseng Lee, Tony Wu
BACKGROUND: Surgical interventions are often used for freedom from seizure in patients with drug-resistant mesial temporal lobe epilepsy. A patient with seizure foci in the left mesiotemporal region underwent limited-size stereotactic radiofrequency thermocoagulation (RF-TC) over the left hippocampus. CASE DESCRIPTION: A 37-year-old woman with febrile convulsion in her childhood was admitted to our neurologic department with complex partial seizure with secondary generalization...
September 4, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27554793/regional-and-global-connectivity-disturbances-in-focal-epilepsy-related-neurocognitive-sequelae-and-potential-mechanistic-underpinnings
#6
REVIEW
Dario J Englot, Peter E Konrad, Victoria L Morgan
Epilepsy is among the most common brain network disorders, and it is associated with substantial morbidity and increased mortality. Although focal epilepsy was traditionally considered a regional brain disorder, growing evidence has demonstrated widespread network alterations in this disorder that extend beyond the epileptogenic zone from which seizures originate. The goal of this review is to summarize recent investigations examining functional and structural connectivity alterations in focal epilepsy, including neuroimaging and electrophysiologic studies utilizing model-based or data-driven analytic methods...
October 2016: Epilepsia
https://www.readbyqxmd.com/read/27551668/cortical-and-subcortical-brain-alterations-in-juvenile-absence-epilepsy
#7
Manuela Tondelli, Anna Elisabetta Vaudano, Andrea Ruggieri, Stefano Meletti
Despite the common assumption that genetic generalized epilepsies are characterized by a macroscopically normal brain on magnetic resonance imaging, subtle structural brain alterations have been detected by advanced neuroimaging techniques in Childhood Absence Epilepsy syndrome. We applied quantitative structural MRI analysis to a group of adolescents and adults with Juvenile Absence Epilepsy (JAE) in order to investigate micro-structural brain changes using different brain measures. We examined grey matter volumes, cortical thickness, surface areas, and subcortical volumes in 24 patients with JAE compared to 24 healthy controls; whole-brain voxel-based morphometry (VBM) and Freesurfer analyses were used...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27399486/207%C3%A2-aberrant-preoperative-hippocampal-interconnectivity-predicts-verbal-memory-improvement-following-anterior-temporal-lobectomy
#8
Philip Lee, Ahmad Alhourani, Robert Mark Richardson
INTRODUCTION: Changes in connectivity have been found surrounding epileptic foci during resting state magnetoencephalography (MEG). One manifestation of these changes is disorganization manifested by increased interconnectivity within a region. This abnormal interconnectivity indicates a decrease in efficiency, because efficient function within a system requires communication across brain regions. Surgical resection of seizure foci may attenuate these aberrant patterns of connectivity...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27250575/verbal-dominant-memory-impairment-and-low-risk-for-post-operative-memory-worsening-in-both-left-and-right-temporal-lobe-epilepsy-associated-with-hippocampal-sclerosis
#9
Amr Farid Khalil, Masaki Iwasaki, Yoshiyuki Nishio, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga
Post-operative memory changes after temporal lobe surgery have been established mainly by group analysis of cognitive outcome. This study investigated individual patient-based memory outcome in surgically-treated patients with mesial temporal lobe epilepsy (TLE). This study included 84 consecutive patients with intractable TLE caused by unilateral hippocampal sclerosis (HS) who underwent epilepsy surgery (47 females, 41 left [Lt] TLE). Memory functions were evaluated with the Wechsler Memory Scale-Revised before and at 1 year after surgery...
November 15, 2016: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27171178/gray-matter-abnormalities-in-temporal-lobe-epilepsy-relationships-with-resting-state-functional-connectivity-and-episodic-memory-performance
#10
Gaelle E Doucet, Xiaosong He, Michael Sperling, Ashwini Sharan, Joseph I Tracy
Temporal lobe epilepsy (TLE) affects multiple brain regions through evidence from both structural (gray matter; GM) and functional connectivity (FC) studies. We tested whether these structural abnormalities were associated with FC abnormalities, and assessed the ability of these measures to explain episodic memory impairments in this population. A resting-state and T1 sequences were acquired on 94 (45 with mesial temporal pathology) TLE patients and 50 controls, using magnetic resonance imaging (MRI) technique...
2016: PloS One
https://www.readbyqxmd.com/read/27080062/long-term-outcome-and-neuroradiologic-changes-after-multiple-hippocampal-transection-combined-with-multiple-subpial-transection-or-lesionectomy-for-temporal-lobe-epilepsy
#11
Kenichi Usami, Mayumi Kubota, Kensuke Kawai, Naoto Kunii, Takeshi Matsuo, Kenji Ibayashi, Miwako Takahashi, Kyousuke Kamada, Toshimitsu Momose, Shigeki Aoki, Nobuhito Saito
OBJECTIVE: Multiple hippocampal transection (MHT) is a surgical procedure developed to avoid postoperative memory decline. Its efficacy has been documented in only a few small series with relatively short observation periods. We prospectively evaluated the long-term seizure and cognitive outcomes of MHT combined with multiple subpial transection or lesionectomy (MHT + MST/L). Moreover, we quantitatively evaluated the structural and metabolic neuroradiologic changes after the procedure to elucidate the anatomofunctional correlates of memory preservation...
June 2016: Epilepsia
https://www.readbyqxmd.com/read/26921578/neuropsychological-results-after-gamma-knife-radiosurgery-for-mesial-temporal-lobe-epilepsy
#12
Zdeněk Vojtěch, Lenka Krámská, Hana Malíková, Michaela Stará, Roman Liščák
OBJECTIVES: The aim of this study is to summarize our experience with neuropsychological changes after radiosurgical treatment for mesial temporal lobe epilepsy and subsequent surgery due to insufficient seizure control. METHODS: Between November 1995 and May 1999, 14 patients underwent radiosurgical entorhinoamygdalohippocampectomy with a marginal dose of 18, 20 or 25 Gy to the 50% isodose. 9 of these patients subsequently underwent surgery. We compared Memory Quotients and Intelligence Quotients before and after the interventions...
2015: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/26846702/stereotactic-radiosurgery-for-the-treatment-of-mesial-temporal-lobe-epilepsy
#13
E-S Feng, C-B Sui, T-X Wang, G-L Sun
OBJECTIVES: Stereotactic radiosurgery (RS) is a potential option for some patients with temporal lobe epilepsy (TLE). The aim of this meta-analysis was to determine the pooled seizure-free rate and the time interval to seizure cessation in patients with lesions in the mesial temporal lobe, and who were eligible for either stereotactic or gamma knife RS. MATERIALS & METHODS: We searched the Medline, Cochrane, EMBASE, and Google Scholar databases using combinations of the following terms: RS, stereotactic radiosurgery, gamma knife, and TLE...
February 4, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/26828690/neurocognitive-outcome-following-stereotactic-laser-ablation-in-two-patients-with-mri-pet-mtle
#14
Brynn K Dredla, John A Lucas, Rober E Wharen, William O Tatum
The most effective treatment for drug-resistant seizures associated with mesial temporal lobe epilepsy (mTLE) is surgical resection. Neurocognitive sequelae may occur and are especially likely to occur after left temporal lobectomy. Smaller resections observed with selective amygdalohippocampectomy have resulted in a more favorable neurocognitive outcome in some cases when compared to standard anterior temporal lobectomy. Specifically, MRI-guided interstitial laser thermal ablation (MRgLITT) uses a superselective stereotactic amygdalohippocampotomy that has been reported to preserve object recognition and naming abilities compared with standard temporal lobe resection...
March 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26709879/temporal-lobe-volume-predicts-wada-memory-test-performance-in-patients-with-mesial-temporal-sclerosis
#15
Kan Ding, Yunhua Gong, Pradeep N Modur, Ramon Diaz-Arrastia, Mark Agostini, Puneet Gupta, Roderick McColl, Ryan Hays, Paul Van Ness
The Wada test is widely used in the presurgical evaluation of potential temporal lobectomy patients to predict postoperative memory function. Expected asymmetry (EA), defined as Wada memory lateralized to the nonsurgical hemisphere, or a higher score after injection of the surgical hemisphere would be considered favorable in terms of postoperative memory outcome. However, in some cases, nonlateralized memory (NM) results, with no appreciable asymmetry, may occur because of impaired scores after both injections, often leading to denial of surgery...
February 2016: Epilepsy Research
https://www.readbyqxmd.com/read/26697969/laser-interstitial-thermal-therapy-for-medically-intractable-mesial-temporal-lobe-epilepsy
#16
Joon Y Kang, Chengyuan Wu, Joseph Tracy, Matthew Lorenzo, James Evans, Maromi Nei, Christopher Skidmore, Scott Mintzer, Ashwini D Sharan, Michael R Sperling
OBJECTIVE: To describe mesial temporal lobe ablated volumes, verbal memory, and surgical outcomes in patients with medically intractable mesial temporal lobe epilepsy (mTLE) treated with magnetic resonance imaging (MRI)-guided stereotactic laser interstitial thermal therapy (LiTT). METHODS: We prospectively tracked seizure outcome in 20 patients at Thomas Jefferson University Hospital with drug-resistant mTLE who underwent MRI-guided LiTT from December 2011 to December 2014...
February 2016: Epilepsia
https://www.readbyqxmd.com/read/26690840/anterior-temporal-lobectomy-versus-selective-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy
#17
COMPARATIVE STUDY
Fábio A Nascimento, Luana Antunes Maranha Gatto, Carlos Silvado, Maria Joana Mäder-Joaquim, Marlus Sidney Moro, Joao Candido Araujo
OBJECTIVE: To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). METHOD: This is a retrospective observational study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas - UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications...
January 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26689596/using-network-dynamic-fmri-for-detection-of-epileptogenic-foci
#18
Sanja Nedic, Steven M Stufflebeam, Carlo Rondinoni, Tonicarlo R Velasco, Antonio C dos Santos, Joao P Leite, Ana C Gargaro, Lilianne R Mujica-Parodi, Jaime S Ide
BACKGROUND: Epilepsy is one of the most prevalent neurological disorders. It remains medically intractable for about one-third of patients with focal epilepsy, for whom precise localization of the epileptogenic zone responsible for seizure initiation may be critical for successful surgery. Existing fMRI literature points to widespread network disturbances in functional connectivity. Per previous scalp and intracranial EEG studies and consistent with excessive local synchronization during interictal discharges, we hypothesized that, relative to same regions in healthy controls, epileptogenic foci would exhibit less chaotic dynamics, identifiable via entropic analyses of resting state fMRI time series...
2015: BMC Neurology
https://www.readbyqxmd.com/read/26654894/memory-outcomes-in-mesial-temporal-lobe-epilepsy-surgery
#19
Urvashi Shah, Aishani Desai, Sangeeta Ravat, Dattatraya Muzumdar, Yogesh Godge, Neena Sawant, Mayuri Jain, Neeraj Jain
INTRODUCTION: Decline in verbal memory after dominant mesial temporal lobe surgery is a concern. Outcomes primarily reported by group data analysis do not address issues of practice effects and measurement errors and also do not provide information about individual meaningful change after surgery. Reliable Change Indices (RCI's) are regarded to be robust statistical methods for reporting individual change and have not been hitherto derived in patient populations in India. AIM: Report memory outcomes for patients after surgery using group data as well as RCI score analyses using RCI scores derived in a control patient population...
November 30, 2015: International Journal of Surgery
https://www.readbyqxmd.com/read/26654176/neuropsychological-outcomes-of-subtemporal-selective-amygdalohippocampectomy-via-a-small-craniotomy
#20
Peng-Fan Yang, Hui-Jian Zhang, Jia-Sheng Pei, Qiao Lin, Zhen Mei, Zi-Qian Chen, Yan-Zeng Jia, Zhong-Hui Zhong, Zhi-Yong Zheng
OBJECT The objectives of this study were to describe a novel minimal-access subtemporal approach for selective resection of the amygdala and hippocampus in patients with medically refractory mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis, and to analyze the related outcomes. METHODS The authors analyzed data from all cases involving patients with unilateral MTLE due to hippocampal sclerosis who were treated with selective amygdalohippocampectomy via the posterior subtemporal approach through a relatively small craniotomy, without a neuronavigation system, at their institution during the period from September 2010 to September 2012...
July 2016: Journal of Neurosurgery
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