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Syphilis immune

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https://www.readbyqxmd.com/read/28871259/syphilis-infection-differentially-regulates-the-phenotype-and-function-of-%C3%AE-%C3%AE-t-cells-in-hiv-1-infected-patients-depends-on-the-hiv-1-disease-stage
#1
Zhen Li, Xiaofan Lu, Zhiliang Hu, Zhenwu Luo, Wei Jiang, Hao Wu, Yanqing Gao, Junling Yan, Qiuyue Zhang, Aixin Song, Xiaojie Huang, Danlei Mou, Bin Su, Tong Zhang
A rapidly escalating outbreak of syphilis infection has been affected men who have sex with men, particularly those with HIV-1 infection. γδ T cells are unconventional immune cells with two main subsets, Vδ1 T cells and Vδ2 T cells, which possess a combination of innate and adaptive immune features allowing them against HIV-1. However, whether syphilis infection affects the phenotype and function of γδ T cells in HIV-1-infected patients remains unclear, especially in acute HIV-1 infection (AHI). In this study, we enrolled 57 HIV-1-infected patients (24 with HIV-1 infection only and 33 coinfected with syphilis) from an acute HIV-1-infected cohort in Beijing (PRIMO)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28768983/longitudinally-extensive-transverse-myelitis-and-optic-neuropathy-associated-with-syphilitic-meningomyelitis-and-human-immunodeficiency-virus-infection-a-case-report-and-review-of-the-literature
#2
Rie Tohge, Yuya Shinoto, Makio Takahashi
The incidence of co-infection with Treponema pallidum and human immunodeficiency virus (HIV) is increasing in developing and developed countries. The neurological complications of both infections occasionally occur simultaneously during a clinical course. We herein report the case of an HIV carrier with syphilitic meningomyelitis and subclinical optic neuropathy. The patient presumably had latent syphilis and slowly developed longitudinally extensive transverse myelitis (LETM). A cerebrospinal fluid examination confirmed the diagnosis of active neurosyphilis based on an elevated T...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28607411/an-immunization-strategy-for-hidden-populations
#3
Saran Chen, Xin Lu
Hidden populations, such as injecting drug users (IDUs), sex workers (SWs) and men who have sex with men (MSM), are considered at high risk of contracting and transmitting infectious diseases such as AIDS, gonorrhea, syphilis etc. However, public health interventions to such groups are prohibited due to strong privacy concerns and lack of global information, which is a necessity for traditional strategies such as targeted immunization and acquaintance immunization. In this study, we introduce an innovative intervention strategy to be used in combination with a sampling approach that is widely used for hidden populations, Respondent-driven Sampling (RDS)...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606185/non-malarial-infectious-diseases-of-antenatal-care-in-pregnant-women-in-franceville-gabon
#4
Irene Pegha Moukandja, Edgard Brice Ngoungou, Guy Joseph Lemamy, Ulrick Bisvigou, Antoine Gessain, Fousseyni S Toure Ndouo, Mirdad Kazanji, Jean Bernard Lekana-Douki
BACKGROUND: In sub-tropical countries, infectious diseases remain one of the main causes of mortality. Because of their lack of active immunity, pregnant women and their unborn children represent the most susceptible people. In Gabon, data on infectious diseases of pregnant women such as syphilis and rubella are either scarce or very old. Few studies have assessed T. gondii infection during pregnancy in the country. Here, we evaluate seroprevalence of HIV, HTVL-1, syphilis and T. gondii and rubella infection during antenatal care among women living in Franceville, Gabon...
June 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28538901/sexually-transmitted-infections-and-pro-lives-based-on-a-clinical-report
#5
Paulo Eduardo Neves Ferreira Velho
Physicians are also responsible for the increase in sexually transmitted infections. We report a case of patient inadequately monitored, that shows the importance of physicians to take basic measures with any individual at risk of acquiring such infections. We propose the following mnemonic acrostic: PRO-LIVES (Protection: usual and proper codom use, Responsibility, Other orientations, Laboratory tests -HIV infection, syphilis and B and C hepatitis-, Immunization: B hepatitis vaccination, Various: at least two patients, Ensure: case history and physical examination, Single dose treatment: whenever possible)...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28484042/a-proteomic-signature-of-dormancy-in-the-actinobacterium-micrococcus-luteus
#6
Sujina Mali, Morgan Mitchell, Spencer Havis, Abiodun Bodunrin, Jonathan Rangel, Gabriella Olson, William R Widger, Steven J Bark
Dormancy is a protective state in which diverse bacteria, including Mycobacterium tuberculosis, Staphylococcus aureus, Treponema pallidum (syphilis), and Borrelia burgdorferi (Lyme disease), curtail metabolic activity to survive external stresses, including antibiotics. Evidence suggests dormancy consists of a continuum of interrelated states, including viable but nonculturable (VBNC) and persistence states. VBNC and persistence contribute to antibiotic tolerance, reemergence from latent infections, and even quorum sensing and biofilm formation...
July 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28482131/incidence-of-acute-hepatitis-a-among-hiv-positive-patients-during-an-outbreak-among-msm-in-taiwan-impact-of-hav-vaccination
#7
Guan-Jhou Chen, Kuan-Yin Lin, Hsin-Yun Sun, Wang-Huei Sheng, Szu-Min Hsieh, Yi-Chia Huang, Aristine Cheng, Wen-Chun Liu, Chien-Ching Hung, Shan-Chwen Chang
BACKGROUND: An unprecedented outbreak of acute hepatitis A has occurred among MSM in Taiwan since June 2015. We aimed to describe the seroepidemiology of HAV infection and to investigate the relationship between HAV vaccination and the incidence of acute hepatitis A among HIV-positive patients at the largest designated hospital for HIV care during the outbreak. METHODS: Between 2012 and 2016, the HAV serostatus, vaccination history, and clinical characteristics of HIV-positive patients were retrospectively reviewed...
May 8, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28431845/infection-prevention-and-control-and-the-refugee-population-experiences-from-the-university-of-louisville-global-health-center
#8
Ruth M Carrico, Linda Goss, Timothy L Wiemken, Rahel S Bosson, Paula Peyrani, William A Mattingly, Allison Pauly, Rebecca A Ford, Stanley Kotey, Julio A Ramirez
BACKGROUND: During 2016, approximately 140,000 individuals entered the United States as part of the federal government refugee resettlement program and established themselves in communities in virtually every state. No national database regarding refugee health currently exists; therefore, little is known about existing infectious diseases, conditions, and cultural practices that impact successful acculturation. The objective of this report is to identify what is currently known about refugees and circumstances important to infection prevention and control with respect to their roles as new community members, employees, and consumers of health care...
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28399709/treponema-pallidum-ssp-pallidum-identification-by-real-time-pcr-targetting-the-pola-gene-in-paraffin-embedded-samples-positive-by-immunohistochemistry
#9
A Gama, E M Carrillo-Casas, R Hernández-Castro, V A Vázquez-Aceituno, S Toussaint-Caire, J Xicohtencatl-Cortes, R Fernández-Martínez, G Moreno-Coutiño
Syphilis is a systemic and sexually transmitted infection caused by Treponema pallidum ssp. pallidum. This spirochete causes different clinical and subclinical stages depending on the duration of infection and immune status of the host. Several tests have been developed for diagnosis, and are classified into direct and indirect methods. The first one includes dark field microscopy, direct fluorescent antibody test in fluids or tissue, and molecular biology techniques. In the indirect method (serologic), the routine tests are used, and are divided in two categories: non-treponemal and treponemal ones...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28369934/recurrent-donath-landsteiner-hemolytic-anemia-a-pediatric-case-report
#10
Sara D Prince, Lena E Winestone, Sandra J Nance, David F Friedman
BACKGROUND: Paroxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath-Landsteiner antibody (D-L antibody). In children, this is typically a transient immune-mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D-L antibody is very rare. CASE REPORT: We have reported a unique case of recurrent PCH in a 5-year-old boy with two acute episodes of hemolysis separated by 21 months of hematologic remission...
June 2017: Transfusion
https://www.readbyqxmd.com/read/28366895/syphilization-and-its-discontents-experimental-inoculation-against-syphilis-at-the-london-lock-hospital
#11
Anne Hanley
In 1867 James Lane and George Gascoyen, surgeons to the London Lock Hospital, compiled a report on their experiments with a new and controversial treatment. The procedure, known as "syphilization," saw patients be inoculated with infective matter taken from a primary syphilitic ulcer or the artificial sores produced in another patient. Each patient received between 102 and 468 inoculations to determine whether syphilization could cure syphilis and produce immunity against reinfection. This article examines the theory and practice of this experimental treatment...
2017: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/28327799/prevalence-and-factors-associated-with-syphilis-in-a-reference-center
#12
Natália Carolina Rodrigues Colombo Gomes, Denise Andrade Pereira Meier, Flávia Meneguetti Pieri, Elaine Alves, Silvia Paulino Ribeiro Albanese, Edvilson Cristiano Lentine, Ricardo Alexandre Arcêncio, Elma Mathias Dessunti
INTRODUCTION: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC). METHODS: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28274320/-circulating-levels-of-th1-and-th2-chemokines-increase-in-patients-with-early-syphilis
#13
Anyou Zhu, Chenchen Wang, Hong Sun, Hongfang Han, Fengchao Wang, Lunjun Zhang, Jianguo Hu
Objective To study the changes of plasma T helper type I (Th1)-and Th2-chemokine levels and analyze their roles in immune response and pathogenesis of early syphilis. Methods Heparin-anticoagulated peripheral blood was collected from 56 patients with early syphilis (primary syphilis, PS, n=22; secondary syphilis, SS, n=34) and healthy controls (HC, n=20). The levels of plasma Th1 chemokines including monokine induced by interferon-γ (MIG), interferon-γ inducible protein-10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC) and Th2 chemokines including thymus-and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) were examined using ELISA...
March 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28271555/immune-reconstitution-inflammatory-syndrome-presenting-as-secondary-syphilis-with-polymorphous-erythema-and-knee-arthritis
#14
LETTER
J Brochard, L Khatchatourian, P Woaye-Hune, C Biron, M Lefebvre, M Denis-Musquer, P Grange, N Dupin, F Raffi
No abstract text is available yet for this article.
March 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28192579/infectious-diseases-and-immunizations-in-international-adoption
#15
Emily Obringer, Linda Walsh
Children who are adopted internationally have an increased risk of infectious diseases due to endemic conditions and variable access to preventive health care, such as vaccines, in their country of origin. Pediatricians and other providers who care for children should be familiar with the recommended screening for newly arrived international adoptees. Testing for gastrointestinal pathogens, tuberculosis, hepatitis, syphilis, and HIV should be routinely performed. Other endemic diseases and common skin infections may need to be assessed...
February 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28161356/a-retrospective-cross-sectional-quantitative-molecular-approach-in-biological-samples-from-patients-with-syphilis
#16
Miguel Pinto, Minia Antelo, Rita Ferreira, Jacinta Azevedo, Irene Santo, Maria José Borrego, João Paulo Gomes
Syphilis is the sexually transmitted disease caused by Treponema pallidum, a pathogen highly adapted to the human host. As a multistage disease, syphilis presents distinct clinical manifestations that pose different implications for diagnosis. Nevertheless, the inherent factors leading to diverse disease progressions are still unknown. We aimed to assess the association between treponemal loads and dissimilar disease outcomes, to better understand syphilis. We retrospectively analyzed 309 DNA samples distinct anatomic sites associated with particular syphilis manifestations...
March 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28145405/a-defined-syphilis-vaccine-candidate-inhibits-dissemination-of-treponema-pallidum-subspecies-pallidum
#17
Karen V Lithgow, Rebecca Hof, Charmaine Wetherell, Drew Phillips, Simon Houston, Caroline E Cameron
Syphilis is a prominent disease in low- and middle-income countries, and a re-emerging public health threat in high-income countries. Syphilis elimination will require development of an effective vaccine that has thus far remained elusive. Here we assess the vaccine potential of Tp0751, a vascular adhesin from the causative agent of syphilis, Treponema pallidum subsp. pallidum. Tp0751-immunized animals exhibit a significantly reduced bacterial organ burden upon T. pallidum challenge compared with unimmunized animals...
February 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28143443/the-immunological-response-to-syphilis-differs-by-hiv-status-a-prospective-observational-cohort-study
#18
Chris Kenyon, Kara Krista Osbak, Tania Crucitti, Luc Kestens
BACKGROUND: It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals. METHODS: We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy. RESULTS: A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28128088/gestational-pityriasis-rosea-suggestions-for-approaching-affected-pregnant-women
#19
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28093460/a-double-edged-sword-does-highly-active-antiretroviral-therapy-contribute-to-syphilis-incidence-by-impairing-immunity-to-treponema-pallidum
#20
REVIEW
Michael L Rekart, Wilfred Ndifon, Robert C Brunham, Jonathan Dushoff, Sang Woo Park, Sanjana Rawat, Caroline E Cameron
BACKGROUND AND HYPOTHESIS: Recently, the world has experienced a rapidly escalating outbreak of infectious syphilis primarily affecting men who have sex with men (MSM); many are taking highly active antiretroviral therapy (HAART) for HIV-1 infection. The prevailing hypothesis is that HAART availability and effectiveness have led to the perception among both individuals who are HIV-1 infected and those who are uninfected that HIV-1 transmission has become much less likely, and the effects of HIV-1 infection less deadly...
August 2017: Sexually Transmitted Infections
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