keyword
https://read.qxmd.com/read/38542109/differential-impact-of-cd43-and-cd28-on-t-cell-differentiation-depending-on-the-order-of-engagement-with-the-tcr
#21
JOURNAL ARTICLE
Monserrat Alba Sandoval-Hernández, Nora Alma Fierro, José Ignacio Veytia-Bucheli, Den Alejandro Alvarado-Velázquez, Estefanía Alemán-Navarro, Erika Melchy-Pérez, Constance Auvynet, Iván Imaz-Rosshandler, Jorge Carneiro, Ernesto Perez-Rueda, Yvonne Rosenstein
The combination of signals from the T-cell receptor (TCR) and co-stimulatory molecules triggers transcriptional programs that lead to proliferation, cytokine secretion, and effector functions. We compared the impact of engaging the TCR with CD28 and/or CD43 at different time points relative to TCR engagement on T-cell function. TCR and CD43 simultaneous engagement resulted in higher CD69 and PD-1 expression levels than in TCR and CD28-stimulated cells, with a cytokine signature of mostly effector, inflammatory, and regulatory cytokines, while TCR and CD28-activated cells secreted all categories of cytokines, including stimulatory cytokines...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541710/primary-cutaneous-cd4-small-medium-t-cell-lymphoproliferative-disorder-following-covid-19-vaccination-what-do-we-know-about-lymphoproliferative-disorders-and-cutaneous-lymphomas-after-covid-19-vaccination-a-report-of-an-atypical-case-and-a-review-of-the-literature
#22
JOURNAL ARTICLE
Francisco Javier De la Torre-Gomar, Jose María Llamas-Molina, Maria Dolores Pegalajar-García, Carmen Pérez-Valencia, Alejandro Carrero-Castaño, Ricardo Ruiz-Villaverde
The association between Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSM-TCLPD) and COVID-19 immunization has been sparsely documented in the medical literature. Reviewing the literature, albeit infrequently, we can find cases of the recurrence and new onset of lymphoproliferative processes and cutaneous lymphomas following the COVID-19 vaccine. Many of the entities we encounter are classified as cutaneous lymphoproliferative disorders. The prevailing hypothesis suggests that the predominant cutaneous reactions to SARS-CoV-2 vaccines may stem from T-cell-mediated immune activation responses to vaccine components, notably messenger RNA (mRNA)...
March 14, 2024: Life
https://read.qxmd.com/read/38541130/comparative-analysis-of-psychophysiological-responses-in-fibromyalgia-patients-evaluating-neuromodulation-alone-neuromodulation-combined-with-virtual-reality-and-exercise-interventions
#23
JOURNAL ARTICLE
Alejandro Rubio-Zarapuz, María Dolores Apolo-Arenas, Pablo Tomas-Carus, José Francisco Tornero-Aguilera, Vicente Javier Clemente-Suárez, Jose A Parraca
BACKGROUND AND OBJECTIVES: Fibromyalgia, a chronic condition, manifests as widespread musculoskeletal pain, fatigue, sleep disturbances, autonomic and cognitive dysfunction, hypersensitivity to stimuli, and various somatic and psychiatric symptoms. This study, a controlled and randomized experiment, aimed to evaluate and compare the immediate effects of different treatments on fibromyalgia patients. MATERIALS AND METHODS: The treatments included the EXOPULSE Mollii suit, a combination of the EXOPULSE Mollii suit with a virtual reality (VR) protocol, and a physical exercise regimen...
February 27, 2024: Medicina
https://read.qxmd.com/read/38540648/exploring-the-impact-of-web-based-vs-in-person-exercise-training-on-benefits-and-adherence-in-substance-use-disorder-interventions-a-pilot-study
#24
JOURNAL ARTICLE
Roberto Montón-Martínez, Juan Arturo Ballester-Ferrer, Sabina Baladzhaeva, Noemí Sempere-Ruiz, Antonio Casanova-Lizón, Alba Roldan, Diego Pastor, José Manuel Sarabia, Alejandro Javaloyes, Iván Peña-González, Manuel Moya-Ramón
BACKGROUND: Substance use disorders pose unique challenges, affecting individuals physiologically and socially. This study addresses the fundamental question of how adherence to exercise programs impacts those with substance use disorders, examining both in-person and online interventions. METHODS: A 12-week analysis involving 26 participants assessed physical fitness, strength, and quality of life. Participants were categorized into in-person and online exercise groups, with their adherence tracked through attendance and a dedicated app...
March 19, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540616/evidence-based-recommendations-in-primary-tracheoesophageal-puncture-for-voice-prosthesis-rehabilitation
#25
REVIEW
Miguel Mayo-Yáñez, Alejandro Klein-Rodríguez, Aldán López-Eiroa, Irma Cabo-Varela, Raquel Rivera-Rivera, Pablo Parente-Arias
Head and neck cancer, the seventh most common cancer worldwide, often affects the larynx, with a higher incidence in men. Total laryngectomy, a common treatment, results in the loss of phonation, and tracheoesophageal voice rehabilitation is the current rehabilitation method of choice. Despite ongoing debates regarding the timing of tracheoesophageal puncture (TEP), a crucial procedure for voice prosthesis placement, the secondary puncture continues to be the preferred choice in the majority of cases. This underscores the persistent controversy and the absence of consensus in this field...
March 14, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540215/association-of-the-rs1966265-and-rs351855-fgfr4-variants-with-colorectal-cancer-in-a-mexican-population-and-their-analysis-in-silico
#26
JOURNAL ARTICLE
Irving Alejandro Carrillo-Dávila, Asbiel Felipe Garibaldi-Ríos, Luis E Figuera, Belinda Claudia Gómez-Meda, Guillermo M Zúñiga-González, Ana María Puebla-Pérez, Patricia Montserrat García-Verdín, Paola Beatriz Castro-García, Itzae Adonai Gutiérrez-Hurtado, Blanca Miriam Torres-Mendoza, Martha Patricia Gallegos-Arreola
The aim of this study was to associate FGFR4 rs1966265 and rs351855 variants with colorectal cancer (CRC) in a Mexican population and to perform in silico analysis. Genomic DNA from 412 healthy individuals and 475 CRC patients was analyzed. In silico analysis was performed using the PolyPhen-V2, GEPIA, GTEx, and Cytoscape platforms. The GA genotype dominant model (GAAA) of rs1966265 and the AA genotype dominant and recessive models of rs351855 were identified as CRC risk factors ( p < 0.05). CRC patients aged ≥ 50 years at diagnosis who consumed alcohol had a higher incidence of the rs351855 GA genotype than the control group ( p < 0...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38539980/infrared-thermography-of-teat-in-french-dairy-alpine-goats-a-promising-tool-to-study-animal-machine-interaction-during-milking-but-not-to-detect-mastitis
#27
JOURNAL ARTICLE
Pierre-Guy Marnet, Alejandro B Velasquez, Alen Dzidic
There is a need to develop tools for mastitis management in goats and to measure the effects of milking machines on teats. Infrared thermography (IRT), as shown in cows, was a good candidate for early mastitis detection and focusing on milking equipment and settings implicated in potential problems. The aim of this study was to test IRT to detect udder inflammation and the effects of mechanical milking on teats in relation to inflammation status, udder balance, and teat shape in Alpine goats. IRT spectra were compared before and after milking in 551 goats from three commercial herds compared to their individual SCC (somatic cell count)...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539956/a-cadaveric-study-using-anatomical-cross-section-and-computed-tomography-for-the-coelomic-cavity-in-juvenile-cory-s-shearwater-aves-procellariidae-calonectris-borealis
#28
JOURNAL ARTICLE
Alejandro Morales Espino, Soraya Déniz, Marcos Fumero-Hernández, Mario Encinoso, Pascual Calabuig, Magnolia Conde-Felipe, José Raduan Jaber
Birds play a crucial role in ecosystems, engaging in key functions such as pollination, pest control, and seed dispersal. The anatomical understanding of these species is essential to addressing emerging challenges, including climate change and habitat loss, which directly impact their survival. Detailed knowledge of avian anatomy is fundamental for research across various disciplines, ranging from ornithology to veterinary medicine. Therefore, this study aims to disseminate the understanding of avian anatomy and the application of computed tomography (CT) for visualizing the coelomic cavity in Cory's Shearwater ( Calonectris borealis )...
March 11, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539928/assessing-ecogeographic-rules-in-two-sigmodontine-rodents-along-an-elevational-gradient-in-central-chile
#29
JOURNAL ARTICLE
Alejandro Valladares-Gómez, Fernando Torres-Pérez, R Eduardo Palma
Bergmann's and Allen's rules are two classic ecogeographic rules concerning the physiological mechanisms employed by endotherm vertebrates for heat conservation in cold environments, which correlate with adaptive morphological changes. Thus, larger body sizes (Bergmann's rule) and shorter appendages and limbs (Allen's rule) are expected in mammals inhabiting cold environments (higher latitudes). Both rules may also apply to elevational gradients, due to the decrease in external temperature as elevation increases...
March 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539920/correlation-of-blood-hemoglobin-values-with-non-invasive-co-oximetry-measurement-of-sphb-in-dogs-undergoing-elective-ovariohysterectomy
#30
JOURNAL ARTICLE
María Fernanda Espinosa-Morales, Agatha Elisa Miranda-Cortés, Daniel Mota-Rojas, Alejandro Casas-Alvarado, Alejandro Jiménez-Yedra, Alicia Pamela Pérez-Sánchez, Ismael Hernández-Ávalos
Cardiovascular function monitoring has been suggested as a key parameter to determine patient stability during the anesthetic process. However, the use of pulse co-oximetry has been suggested as a technology to complement the monitoring of this system as a direct way to assess hemoglobin (Hb) blood concentration. Therefore, this study aimed to correlate and determine the measurement bias between Hb blood levels with continuously determined blood hemoglobin concentration (SpHb) and arterial oxygen content values (SpOC), both obtained by noninvasive co-oximetry in dogs undergoing elective ovariohysterectomy (OVH)...
March 7, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539770/differential-entropy-based-fault-detection-mechanism-for-power-constrained-networked-control-systems
#31
JOURNAL ARTICLE
Alejandro J Rojas
In this work, we consider the design of power-constrained networked control systems (NCSs) and a differential entropy-based fault-detection mechanism. For the NCS design of the control loop, we consider faults in the plant gain and unstable plant pole locations, either due to natural causes or malicious intent. Since the power-constrained approach utilized in the NCS design is a stationary approach, we then discuss the finite-time approximation of the power constraints for the relevant control loop signals...
March 14, 2024: Entropy
https://read.qxmd.com/read/38539563/treatment-strategies-for-glioblastoma-in-the-elderly-what-should-we-focus-on-compared-to-younger-patients
#32
JOURNAL ARTICLE
Hanah Hadice Gull, Antonia Carlotta Von Riegen, Greta Theresa Beckmann, Pikria Ketelauri, Sebastian Walbrodt, Alejandro N Santos, Christoph Oster, Teresa Schmidt, Martin Glas, Ramazan Jabbarli, Neriman Özkan, Philipp Dammann, Björn Scheffler, Ulrich Sure, Yahya Ahmadipour
(1) Background: Although the incidence of glioblastoma (GB) has a peak in patients aged 75-84 years, no standard treatment regimen for elderly patients has been established so far. The goal of this study was to analyze the outcome of GB patients ≥ 65 years to detect predictors with relevant impacts on overall survival (OS) and progression-free survival (PFS). (2) Methods: Medical records referred to our institution from 2006 to 2020 were analyzed. Adult GB patients with clinical data, postoperative MRI data, and ≥1 follow-up investigation after surgical resection were included...
March 21, 2024: Cancers
https://read.qxmd.com/read/38539341/executive-functioning-and-language-in-a-pediatric-population-with-autism-spectrum-disorders-and-epilepsy-a-comparative-study
#33
JOURNAL ARTICLE
Alejandro Cano-Villagrasa, Nadia Porcar-Gozalbo, Isabel López-Chicheri, Miguel López-Zamora
In recent years, there has been an increase in the prevalence of comorbidity between ASD and epilepsy in the pediatric population. Children with ASD and epilepsy often exhibit greater impairments in executive functions such as cognitive flexibility, planning, inhibition, and emotional control, as well as in language dimensions such as phonology, semantics, morphosyntax, and pragmatics. These impairments can significantly impact their maturation and development. The aim of this study was to assess and compare the executive functioning and language skills of 150 participants, divided into three groups: one with ASD only, another with epilepsy only, and the third group with both ASD and epilepsy...
March 5, 2024: Children
https://read.qxmd.com/read/38539270/editorial-for-evaluation-of-4d-flow-mri-derived-relative-residence-time-as-a-marker-for-cirrhosis-associated-portal-vein-thrombosis
#34
EDITORIAL
Alejandro Roldán-Alzate, Scott B Reeder
No abstract text is available yet for this article.
March 27, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38538968/real-world-experience-with-pertuzumab-and-trastuzumab-combined-with-chemotherapy-in-neoadjuvant-treatment-for-patients-with-early-stage-her2-positive-breast-cancer-the-neopersur-study
#35
JOURNAL ARTICLE
Alejandro Falcón González, Josefina Cruz Jurado, Elisenda Llabrés Valenti, Rocío Urbano Cubero, Maria Carmen Álamo de la Gala, María Antonia Martínez Guisado, Rocío Álvarez Ambite, Carlos José Rodríguez González, Marta Amérigo Góngora, Lourdes Rodríguez Pérez, Pilar López Álvarez, Pedro Sánchez Rovira, Encarnación González Flores, Fernando Henao Carrasco, Juan Bayo Calero, María Valero Arbizu, Alicia Quílez Cutillas, Javier Salvador Boffil, Eloísa Rubio Pérez, Manuel Ruiz-Borrego
PURPOSE: HER2-targeted therapies have dramatically improved outcomes of patients with HER2-positive breast cancer (BC), as demonstrated in neoadjuvant trials. This study aims to provide real-world evidence on the use and effectiveness of combined pertuzumab, trastuzumab and chemotherapy (CT) in early-stage HER2-positive BC. METHODS: A retrospective, multicentre study was conducted on patients diagnosed with HER2-positive early BC treated with neoadjuvant pertuzumab and trastuzumab plus CT at 13 Spanish sites...
March 28, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38538918/semiautomated-approach-focused-on-new-genomic-information-results-in-time-and-effort-efficient-reannotation-of-negative-exome-data
#36
JOURNAL ARTICLE
Alejandro Ferrer, Patrick Duffy, Rory J Olson, Michael A Meiners, Laura Schultz-Rogers, Erica L Macke, Stephanie Safgren, Joel A Morales-Rosado, Margot A Cousin, Gavin R Oliver, David Rider, Megan Williams, Pavel N Pichurin, David R Deyle, Eva Morava, Ralitza H Gavrilova, Radhika Dhamija, Klass J Wierenga, Brendan C Lanpher, Dusica Babovic-Vuksanovic, Charu Kaiwar, Carolyn R Vitek, Tammy M McAllister, Myra J Wick, Lisa A Schimmenti, Konstantinos N Lazaridis, Filippo Pinto E Vairo, Eric W Klee
Most rare disease patients (75-50%) undergoing genomic sequencing remain unsolved, often due to lack of information about variants identified. Data review over time can leverage novel information regarding disease-causing variants and genes, increasing this diagnostic yield. However, time and resource constraints have limited reanalysis of genetic data in clinical laboratories setting. We developed RENEW, (REannotation of NEgative WES/WGS) an automated reannotation procedure that uses relevant new information in on-line genomic databases to enable rapid review of genomic findings...
March 27, 2024: Human Genetics
https://read.qxmd.com/read/38537928/spontaneous-intestinal-perforation-due-to-a-possible-infection-due-to-angiostrongylus-costaricensis-in-colombia
#37
JOURNAL ARTICLE
Paola Marsela Pérez-Camacho, Jaime A Patiño-Niño, Alejandro Restrepo Cedeño, Inés Elvira Gómez, Lina M Sandoval-Calle
No abstract text is available yet for this article.
March 25, 2024: Travel Medicine and Infectious Disease
https://read.qxmd.com/read/38537536/annotation-free-prediction-of-treatment-specific-tissue-outcome-from-4d-ct-perfusion-imaging-in-acute-ischemic-stroke
#38
JOURNAL ARTICLE
Alejandro Gutierrez, Kimberly Amador, Anthony Winder, Matthias Wilms, Jens Fiehler, Nils D Forkert
Acute ischemic stroke is a critical health condition that requires timely intervention. Following admission, clinicians typically use perfusion imaging to facilitate treatment decision-making. While deep learning models leveraging perfusion data have demonstrated the ability to predict post-treatment tissue infarction for individual patients, predictions are often represented as binary or probabilistic masks that are not straightforward to interpret or easy to obtain. Moreover, these models typically rely on large amounts of subjectively segmented data and non-standard perfusion analysis techniques...
March 23, 2024: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://read.qxmd.com/read/38537245/colorectal-endometriosis-a-proposal-of-complementary-classification-and-surgical-management-in-stages
#39
JOURNAL ARTICLE
Armando Cepeda-Silva, Harald Krentel, Oliver P Cruz-Orozco, Jorge L Vela-Cantorán, Edgar González-Macedo, Alejandro Rendón-Molina, José R Silvestri-Tomassoni
OBJECTIVE: To organize the experience and international knowledge in the surgical management and staging of colorectal endometriosis, with a management proposal in stages. METHOD: An extensive non-systematic review of the literature was carried to organize the disease in stages (limited, intermediate and advanced) according to a scoring system, which considers the characteristics of the endometrioma, the personal history and surgical findings. We tested the proposed staging in a retrospective group of patients...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537229/transcendence-of-scientific-research-dissemination-diffusion-and-impact-factor
#40
JOURNAL ARTICLE
Alejandro Navas-Pérez, Virgilio Lima-Gómez, Sergio Sobrino-Cossío
No abstract text is available yet for this article.
2024: Cirugia y Cirujanos
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