keyword
MENU ▼
Read by QxMD icon Read
search

Alejandro

keyword
https://www.readbyqxmd.com/read/28548195/-qualitative-research-methodology-in-health-care
#1
Paula Bedregal, Carolina Besoain, Alejandro Reinoso, Tamara Zubarew
Health care research requires different methodological approaches such as qualitative and quantitative analyzes to understand the phenomena under study. Qualitative research is usually the least considered. Central elements of the qualitative method are that the object of study is constituted by perceptions, emotions and beliefs, non-random sampling by purpose, circular process of knowledge construction, and methodological rigor throughout the research process, from quality design to the consistency of results...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28548079/design-of-live-attenuated-bacterial-vaccines-based-on-d-glutamate-auxotrophy
#2
Maria P Cabral, Patricia García, Alejandro Beceiro, Carlos Rumbo, Astrid Pérez, Miriam Moscoso, Germán Bou
Vaccine development is a priority for global health due to the growing multidrug resistance in bacteria. D-glutamate synthesis is essential for bacterial cell wall formation. Here we present a strategy for generating effective bacterial whole-cell vaccines auxotrophic for D-glutamate. We apply this strategy to generate D-glutamate auxotrophic vaccines for three major pathogens, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus. These bacterial vaccines show virulence attenuation and self-limited growth in mice, and elicit functional and cross-reactive antibodies, and cellular immunity...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547529/toll-like-receptor-4-tlr4-and-triggering-receptor-expressed-on-myeloid-cells-2-trem-2-activation-balance-astrocyte-polarization-into-a-proinflammatory-phenotype
#3
Gerardo Rosciszewski, Vanesa Cadena, Veronica Murta, Jeronimo Lukin, Alejandro Villarreal, Thierry Roger, Alberto Javier Ramos
Astrocytes react to brain injury with a generic response known as reactive gliosis, which involves activation of multiple intracellular pathways including several that may be beneficial for neuronal survival. However, by unknown mechanisms, reactive astrocytes can polarize into a proinflammatory phenotype that induces neurodegeneration. In order to study reactive gliosis and astroglial polarization into a proinflammatory phenotype, we used cortical devascularization-induced brain ischemia in Wistar rats and primary astroglial cell cultures exposed to oxygen-glucose deprivation (OGD)...
May 25, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28547131/erratum-to-paraesophageal-hernia-and-reflux-prevention-is-one-fundoplication-better-than-the-other
#4
Ciro Andolfi, Alejandro Plana, Sara Furno, Piero Marco Fisichella
No abstract text is available yet for this article.
May 25, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28546574/corrigendum-a-study-of-allelic-diversity-underlying-flowering-time-adaptation-in-maize-landraces
#5
J Alberto Romero Navarro, Martha Wilcox, Juan Burgueño, Cinta Romay, Kelly Swarts, Samuel Trachsel, Ernesto Preciado, Arturo Terron, Humberto Vallejo Delgado, Victor Vidal, Alejandro Ortega, Armando Espinoza Banda, Noel Orlando Gómez Montiel, Ivan Ortiz-Monasterio, Félix San Vicente, Armando Guadarrama Espinoza, Gary Atlin, Peter Wenzl, Sarah Hearne, Edward S Buckler
No abstract text is available yet for this article.
May 26, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28546549/restimulation-induced-t-cell-death-through-ntb-a-sap-signaling-pathway-is-impaired-in-tuberculosis-patients-with-depressed-immune-responses
#6
Rodrigo E Hernández Del Pino, Joaquín M Pellegrini, Ana I Rovetta, Delfina Peña, Guadalupe I Álvarez, Agustín Rolandelli, Rosa M Musella, Domingo J Palmero, Alejandro Malbran, Virginia Pasquinelli, Verónica E García
Production of IFN-γ contributes to host defense against Mycobacterium tuberculosis (Mtb) infection. We previously demonstrated that Signaling lymphocytic activation molecule-associated protein (SAP) expression on cells from tuberculosis (TB) patients was inversely correlated with IFN-γ production. Here we first investigated the role of NK, T and B cell antigen (NTB-A)/SAP pathway in the regulation of Th1 response against Mtb. Upon antigen stimulation, NTB-A phosphorylation rapidly increases and afterwards modulates IFN-γ and IL-17 secretion...
May 26, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28546423/overexpression-of-kinase-dead-mtor-impairs-glucose-homeostasis-by-regulating-insulin-secretion-and-not-%C3%AE-cell-mass
#7
Emilyn U Alejandro, Nadejda Bozadjieva, Manuel Blandino-Rosano, Michelle Ann Wasan, Lynda Elghazi, Suryakiran Vadrevu, Leslie Satin, Ernesto Bernal-Mizrachi
Regulation of glucose homeostasis by insulin depends on β-cell growth and function. Nutrients and growth factors stimuli converge on the conserved protein kinase mechanistic target of rapamycin (mTOR), existing in two complexes mTORC1 and mTORC2. To understand the functional relevance of mTOR enzymatic activity in β-cell development and in glucose homeostasis, we generated mice overexpressing either one or two copies of a kinase-dead mTOR mutant (KD-mTOR) transgene exclusively in β-cells. We examined glucose homeostasis and β-cell function of these mice in control chow and in high-fat diet (HFD)...
May 25, 2017: Diabetes
https://www.readbyqxmd.com/read/28545752/emergency-department-as-a-first-contact-for-mental-health-problems-in-children-and-youth
#8
Peter J Gill, Natasha Saunders, Sima Gandhi, Alejandro Gonzalez, Paul Kurdyak, Simone Vigod, Astrid Guttmann
OBJECTIVE: To characterize youth who use the emergency department (ED) as a "first contact" for mental health (MH) problems. METHOD: This was a population-based cross-sectional cohort study using linked health and demographic administrative datasets of youth 10 to 24 years of age with an incident MH ED visit from April 1, 2010, to March 31, 2014, in Ontario, Canada. We modeled the association of demographic, clinical, and health service use characteristics with having no prior outpatient MH care in the preceding 2-year period ("first contact") using modified Poisson models...
June 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28545578/the-effect-of-a-mindfulness-based-intervention-in-cognitive-functions-and-psychological-well-being-applied-as-an-early-intervention-in-schizophrenia-and-high-risk-mental-state-in-a-chilean-sample-study-protocol-for-a-randomized-controlled-trial
#9
Álvaro I Langer, Carlos Schmidt, Rocío Mayol, Marcela Díaz, Javiera Lecaros, Edwin Krogh, Aída Pardow, Carolina Vergara, Guillermo Vergara, Bernardita Pérez-Herrera, María José Villar, Alejandro Maturana, Pablo A Gaspar
BACKGROUND: According to the projections of the World Health Organization, 15% of all disabilities will be associated with mental illnesses by 2020. One of the mental disorders with the largest social impacts due to high personal and family costs is psychosis. Among the most effective psychological approaches to treat schizophrenia and other psychotic disorders at the world level is cognitive behavioral therapy. Recently, cognitive behavioral therapy has introduced several tools and strategies that promote psychological processes based on acceptance and mindfulness...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28545191/%C3%A2-mate%C3%A2-intake-hormone-based-risk-factors-and-breast-cancer-a-case-control-study
#10
Alvaro L Ronco, Edison Espinosa, Juan M Calderon, Eduardo Lasalvia- Galante, Alejandro De Rosa, Gustavo Sanchez
Previous reports on the inverse association between ‘mate’ intake (infusion of Ilex Paraguariensis herb) and breast cancer (BC) risk led us to consider two main roles for the infusion: as a substantial antioxidant contributor and as a hormone regulator, particularly through anti-aromatase capacities. Since menstrual-reproductive risk factors for BC reflect women’s estrogenic exposure during the reproductive lifespan, and considering that ‘mate’ intake exerts putative stronger protection among high antioxidant contributors, we attempted to analyze interactions among the infusion, hormon-linked reproductive factors and BC risk, which have hitherto remained unexplored...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545090/neotropical-bats-that-co-habit-with-humans-function-as-dead-end-hosts-for-dengue-virus
#11
Amanda Vicente-Santos, Andres Moreira-Soto, Claudio Soto-Garita, Luis Guillermo Chaverri, Andrea Chaves, Jan Felix Drexler, Juan Alberto Morales, Alejandro Alfaro-Alarcón, Bernal Rodríguez-Herrera, Eugenia Corrales-Aguilar
Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim to elucidate the role of house-roosting bats in the DENV transmission cycle. Bats were sampled in households located in high and low dengue incidence regions during rainy and dry seasons in Costa Rica. We captured 318 bats from 12 different species in 29 households. Necropsies were performed in 205 bats to analyze virus presence in heart, lung, spleen, liver, intestine, kidney, and brain tissue...
May 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28545069/behavioral-alterations-are-associated-with-vitamin-b12-deficiency-in-the-transcobalamin-receptor-cd320-ko-mouse
#12
Kaveri Arora, Jeffrey M Sequeira, Alejandro I Hernández, Juan M Alarcon, Edward V Quadros
Vitamin B12 (cobalamin) deficiency is prevalent worldwide and causes megaloblastic anemia and neurologic deficits. While the anemia can be treated, the neurologic deficits can become refractive to treatment as the disease progresses. Therefore, timely intervention is critical for a favorable outcome. Moreover, the metabolic basis for the neuro-pathologic changes and the role of cobalamin deficiency in the pathology still remains unexplained. Using a transcobalamin receptor / CD320 knockout mouse that lacks the receptor for cellular uptake of transcobalamin bound cobalamin, we aimed to determine whether cobalamin deficiency in the central nervous system produced functional neurologic deficits in the mouse that would parallel those observed in humans...
2017: PloS One
https://www.readbyqxmd.com/read/28544388/healing-effect-of-controlled-anti-electromigration-on-conventional-and-high-tc-superconducting-nanowires
#13
Xavier D A Baumans, Joseph Lombardo, Jérémy Brisbois, Gorky Shaw, Vyacheslav S Zharinov, Ge He, Heshan Yu, Jie Yuan, Beiyi Zhu, Kui Jin, Roman B G Kramer, Joris Van de Vondel, Alejandro V Silhanek
The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ultimate resolution or, in the case of polyatomic compounds, to change the stoichiometry with the same atomic precision. As demonstrated here, a combination of electromigration and anti-electromigration can be used to reversibly displace atoms with a high degree of control. This enables a fine adjustment of the superconducting properties of Al weak links, whereas in Nb the diffusion of atoms leads to a more irreversible process...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28543880/the-role-of-the-co-activation-and-ligand-functionalization-in-neutral-methallyl-nickel-ii-catalysts-for-oligomerization-and-polymerization-of-ethylene
#14
Daniela E Ortega, Diego Cortés-Arriagada, Oleksandra S Trofymchuk, Diana Yepes, Soledad Gutierrez-Oliva, René S Rojas, Alejandro Toro-Labbe
It is presented a detailed quantum chemical study analyzing the mechanism of ethylene oligomerization and polymerization by means of a family of four neutral methallyl NiII catalysts. The role of the boron co-activators [BF₃ or B(C₆F₅)₃] and ligand functionalization (in ortho or para position of the N-arylcyano moiety of the catalysts) was investigated to explain the chain length of the obtained polymers. The chain initialization proceeds with higher activation barriers for the ortho functionalized complexes (19 kcal mol¯¹) compared to the para isomers (17-18 kcal mol¯¹)...
May 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28543774/spectral-signal-density-of-carotid-plaque-using-dual-energy-computed-tomography
#15
Exequiel Reynoso, Gastón A Rodriguez-Granillo, Carlos Capunay, Alejandro Deviggiano, Francisco Meli, Patricia Carrascosa
BACKGROUND AND PURPOSE: Plaque characterization using virtual monochromatic imaging derived from dual-energy computed tomography (CT) angiography requires the determination of normal signal density values of each plaque component. We sought to explore the signal density values of carotid plaque components using dual-energy compared to conventional single-energy CT angiography (CTA), and to establish the energy level with the largest differences between plaque components. METHODS: The present prospective study involved consecutive patients referred for carotid artery evaluation by CTA...
May 25, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28543421/foreign-relations
#16
Alejandro De La Hoz, Eduardo Díaz, Max Moses Feinstein
In a large Colombian teaching hospital, a fifty-five-year-old woman complaining of stomach pain is examined by a foreign-exchange medical student from the United States. Speaking in Spanish, the student elicits a medical history that suggests a possible recurrence of gallstones, but nothing further. Upon discussing the patient's case in private with the attending physician, the student is shocked to learn that the patient is suffering from terminal, metastatic gastric cancer but is unaware of her diagnosis...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28542655/-risk-factors-associated-with-postoperative-acute-renal-failure-in-pediatric-patients-undergoing-cardiopulmonary-bypass-surgery
#17
Elsa Nohemí Reyes-Flandes, Alejandro Herrera-Landero, Pascual Bobadilla-González, Juan Carlos Núñez-Enríquez
Acute renal failure (ARF) is a complication associated with cardiac surgery with cardiopulmonary bypass (CPB) with an impact on morbidity and mortality. OBJECTIVE: To identify risk factors associated with postoperative IRA according to pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease scale in children undergoing cardiac surgery with CPB. PATIENTS AND METHOD: A nested case-control study was conducted. We included children under 16 years of age attended postoperative for CBP in a pediatric intensive care unit over a period of 18 months...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542654/aspectos-legales-en-un-cambio-de-cultura-en-la-relaci%C3%A3-n-m%C3%A3-dico-paciente
#18
José Alejandro Inostroza Mandriaza
No abstract text is available yet for this article.
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542241/signification-of-distal-urinary-acidification-defects-in-hypocitraturic-patients
#19
Valentina Forni Ogna, Anne Blanchard, Rosa Vargas-Poussou, Adam Ogna, Stéphanie Baron, Jean-Philippe Bertocchio, Caroline Prot-Bertoye, Jérôme Nevoux, Julie Dubourg, Gérard Maruani, Margarida Mendes, Alejandro Garcia-Castaño, Cyrielle Treard, Nelly Lepottier, Pascal Houillier, Marie Courbebaisse
BACKGROUND AND OBJECTIVES: Hypocitraturia has been associated with metabolic acidosis and mineral disorders. The aim of this study was to investigate the occurrence of urinary acidification defects underlying hypocitraturia. MATERIALS AND METHODS: This retrospective observational study included 67 patients (32 men), aged 40.7±15.1 years with hypocitraturia (<1.67 mmol/24-h) and nephrolithiasis, nephrocalcinosis, and/or bone demineralization, referred to our center from 2000 to 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28541930/progress-in-artificial-vision-through-suprachoroidal-retinal-implants
#20
Lilach Bareket, Alejandro Barriga-Rivera, Marc Patrick Zapf, Nigel H Lovell, Gregg J Suaning
Retinal implants have proven their ability to restore visual sensation to people with degenerative retinopathy, characterized by photoreceptor cell death and the retina's inability to sense light. Retinal bionics operate by electrically stimulating the surviving neurons in the retina, thus triggering the transfer of visual sensory information to the brain. Suprachoroidal implants were first investigated in Australia in the 1950s. In this approach, the neuromodulation hardware is positioned between the sclera and the choroid, thus providing significant surgical and safety benefits for patients, with the potential to maintain residual vision combined with the artificial input from the device...
May 25, 2017: Journal of Neural Engineering
keyword
keyword
24944
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"