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JOURNAL ARTICLE
María Ángeles Bernal-Jiménez, German Calle, Alejandro Gutiérrez Barrios, Livia Luciana Gheorghe, Celia Cruz-Cobo, Nuria Trujillo-Garrido, Amelia Rodríguez-Martín, Josep A Tur, Rafael Vázquez-García, María José Santi-Cano
BACKGROUND: Coronary heart disease is one of the leading causes of mortality worldwide. Secondary prevention is essential, as it reduces the risk of further coronary events. Mobile health (mHealth) technology could become a useful tool to improve lifestyles. OBJECTIVE: This study aimed to evaluate the effect of an mHealth intervention on people with coronary heart disease who received percutaneous coronary intervention. Improvements in lifestyle regarding diet, physical activity, and smoking; level of knowledge of a healthy lifestyle and the control of cardiovascular risk factors (CVRFs); and therapeutic adherence and quality of life were analyzed...
April 22, 2024: JMIR MHealth and UHealth
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JOURNAL ARTICLE
Temidayo James Aransiola, Daniella Cavalcanti, José Alejandro Ordoñez, Philipp Hessel, Ana L Moncayo, Carlos Chivardi, Alberto Sironi, Renato Tasca, Tereza Campello, Rômulo Paes-Sousa, Gulnar Azevedo E Silva, Felipe Alves Rubio, Luis Eugenio de Souza, James Macinko, Davide Rasella
IMPORTANCE: The health outcomes of increased poverty and inequalities in low- and middle-income countries (LMICs) have been substantially amplified as a consequence of converging multiple crises. Brazil has some of the world's largest conditional cash transfer (Programa Bolsa Família [PBF]), social pension (Beneficio de Prestacão Continuada [BPC]), and primary health care (Estratégia de Saúde da Família [ESF]) programs that could act as mitigating interventions during the current polycrisis era of increasing poverty, slow or contracting economic growth, and conflicts...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Haneen Salah, Juanita Duran, Mark A Russell, Alejandro A Gru
Apocrine hidrocystomas are benign, cystic neoplastic lesions resulting from the apocrine secretory component of the sweat gland. They most commonly occur on the head and neck, with predilection to the periorbital area. Less frequent sites include the axilla, nipple, external auditory canal, foreskin, conjunctiva, lower lip, and fingers, among others. The authors report a unique case of a nail bed hidrocystoma in a 55-year-old woman, a site not previously described.
April 23, 2024: American Journal of Dermatopathology
#4
JOURNAL ARTICLE
Paolo Palatini, Anastasios Kollias, Francesca Saladini, Roland Asmar, Grzegorz Bilo, Konstantinos G Kyriakoulis, Gianfranco Parati, George S Stergiou, Guido Grassi, Reinhold Kreutz, Giuseppe Mancia, Jens Jordan, Italo Biaggioni, Alejandro de la Sierra
Recent evidence suggests that an exaggerated blood pressure (BP) response to standing (ERTS) is associated with an increased risk of adverse outcomes, both in young and old individuals. In addition, ERTS has been shown to be an independent predictor of masked hypertension. In the vast majority of studies reporting on the prognostic value of orthostatic hypertension (OHT), the definition was based only on systolic office BP measurements. This consensus statement provides recommendations on the assessment and management of individuals with ERTS and/or OHT...
March 4, 2024: Journal of Hypertension
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REVIEW
Yangmeihui Song, Jianhua Zou, E Alejandro Castellanos, Naomi Matsuura, John A Ronald, Adam Shuhendler, Wolfgang A Weber, Assaf A Gilad, Cristina Müller, Timothy H Witney, Xiaoyuan Chen
Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade...
2024: Theranostics
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JOURNAL ARTICLE
Jamie L Breunig, M Alejandro Valdes-Pena, Andrew W Ratchford, Joshua G Pierce
New antimicrobial scaffolds are scarce, and there is a great need for the development of novel therapeutics. In this study, we report a convergent 9-step synthesis of leopolic acid A and a series of targeted analogues. The designed compounds allowed for incorporation of non-natural ureido dipeptide moieties and 4- and 5-position substituents around the 2,3-pyrrolidinedione of leopolic acid A. Leopolic acid A displayed modest antimicrobial activity (32 μg/mL) against MRSA, while the most active analogues displayed slightly improved activity (8-16 μg/mL)...
April 17, 2024: ACS Bio Med Chem Au
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JOURNAL ARTICLE
Raquel Benavides, Ricardo Mejías, Alejandro Blanco, Luis Bermudez-Guzman
INTRODUCTION: Uveal melanoma is the most common primary intraocular malignancy in adults, affecting primarily the choroid of the eye. Plaque brachytherapy is the most common procedure for the treatment of small choroidal melanoma, especially in posteriorly located tumors. However, modern radiotherapy techniques, such as CyberKnife or Gamma knife stereotactic radiosurgery (SRS) and proton beam radiotherapy, have shown better results in tumor control and eye retention. Recent studies have indicated that SRS is a promising non-invasive, single-session treatment option, with most studies reporting the best outcomes when using ≥21-22 Gy...
April 2024: Ocular Oncology and Pathology
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JOURNAL ARTICLE
Ehab Kotb Elmahallawy, Ahmed Gareh, Marwa M I Ghallab, Pamela C Köster, Alejandro Dashti, Dina Aboelsoued, Nagwa Ibrahim Toaleb, Hind Alzaylaee, Moisés Gonzálvez, Amira A Saleh, Alaa S Alhegaili, Ahmed Fathy Eldehn, Carolina Hernández-Castro, Begoña Bailo, David González-Barrio, David Carmena
INTRODUCTION: Giardiosis remains one of the most prevalent enteric parasitic infections globally. Earlier molecular-based studies conducted in Egypt have primarily focused on paediatric clinical populations and most were based on single genotyping markers. As a result, there is limited information on the frequency and genetic diversity of G. duodenalis infections in individuals of all age groups. METHODS: Individual stool samples ( n = 460) from outpatients seeking medical care were collected during January-December 2021 in Kafr El-Sheikh governorate, northern Egypt...
2024: Frontiers in Public Health
#9
Frank Li, Xuan Zhang, Alejandro P Comellas, Eric A Hoffman, Michael M Graham, Ching-Long Lin
BACKGROUND: The objective of this study is to understand chronic obstructive pulmonary disease (COPD) phenotypes and their progressions by quantifying heterogeneities of lung ventilation from the single photon emission computed tomography (SPECT) images and establishing associations with the quantitative computed tomography (qCT) imaging-based clusters and variables. METHODS: Eight COPD patients completed a longitudinal study of three visits with intervals of about a year...
April 13, 2024: medRxiv
#10
JOURNAL ARTICLE
Long-term mandibular growth in patients with airway obstruction treated with mandibular distraction.
Maria Costanza Meazzini, Alejandro Piza, Novelli Giorgio, Davide Sozzi, Elena de Ponti, Fabio Mazzoleni
Congenital craniofacial malformations play an important role in upper airway obstruction. One of the main causes is mandibular hypoplasia which is present in the pierre robin sequence. Mandibular distraction osteogenesis (MDO) is one of the most commonly used treatments for the resolution of upper airway obstruction in patients that do not respond to a conservative treatment. We performed a long term follow up of syndromic and non-syndromic patients with pierre robin sequence where the lateral xrays were studied before surgery (T1), after MDO (T2) and long-term follow-up (T3, at least 5 years)...
March 31, 2024: Journal of Cranio-maxillo-facial Surgery
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JOURNAL ARTICLE
Pablo Bellosta-López, Rafael Giner-Nicolás, Alejandro Molina-Molina, Alberto Rubio-Peirotén, Luis Enrique Roche-Seruendo, Víctor Doménech-García
OBJECTIVES: This study aimed to analyze how spatiotemporal gait parameters, active knee extension range of motion, muscle activity, and self-perceived function change over a seven-day period in healthy individuals after exercise-induced muscle damage (EIMD) in the hamstrings. DESIGN: Longitudinal cohort study. METHODS: Twenty-four healthy males participated in four sessions before and after EIMD (pre-EIMD, 48 h, 96 h, and 168 h post-EIMD)...
April 6, 2024: Journal of Science and Medicine in Sport
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JOURNAL ARTICLE
Diana Marín, Xavier Basagaña, Ferney Amaya, Luis Miguel Aristizábal, Diego Alejandro Muñoz, Alan Domínguez, Francisco Molina, Carlos Daniel Ramos, Ricardo Morales-Betancourt, Roberto Hincapié, Laura Rodríguez-Villamizar, Yurley Rojas, Olga Morales, Martha Cuellar, Andrea Corredor, Milena Villamil-Osorio, María Alejandra Bejarano, Dolly Vidal, Diana M Narváez, Helena Groot, Juan José Builes, Lucelly López, Enrique Antonio Henao, Verónica Lopera, Luis Jorge Hernández, Shrikant I Bangdiwala, Beatriz Marín-Ochoa, Ana Isabel Oviedo, Oscar Eduardo Sánchez-García, María Victoria Toro, Will Riaño, Zulma Vanessa Rueda
Exposome studies are advancing in high-income countries to understand how multiple environmental exposures impact health. However, there is a significant research gap in low- and middle-income and tropical countries. We aimed to describe the spatiotemporal variation of the external exposome, its correlation structure between and within exposure groups, and its dimensionality. A one-year follow-up cohort study of 506 children under 5 in two cities in Colombia was conducted to evaluate asthma, acute respiratory infections, and DNA damage...
April 19, 2024: Environmental Research
#13
JOURNAL ARTICLE
Alejandro Oncina-Cánovas, Laura Torres-Collado, Manuela García-de-la-Hera, Laura María Compañ-Gabucio, Sandra González-Palacios, Antonio J Signes-Pastor, Jesús Vioque
PURPOSE: Pro-vegetarian (PVG) dietary patterns have shown health benefits, although the evidence concerning their association with mortality is scarce, particularly in older populations. We investigated the effect of three defined PVG patterns on all-cause, cardiovascular disease (CVD) and cancer mortality risk in an older Mediterranean population. METHODS: We analysed baseline data from 597 adults aged 65 and older who participated in a population-based cross-sectional study, and mortality during a 12-year period...
April 20, 2024: Journal of Nutrition, Health & Aging
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JOURNAL ARTICLE
Jon Jiménez, Samanta Gasco Cavero, Miguel Ángel Marazuela, Carlos Baquedano, Chrysi Laspidou, Juan C Santamarta, Alejandro García-Gil
Volcanic islands face unique challenges in protecting and managing their water resources due to their small size, limited freshwater availability, and vulnerability to natural hazards. The recent 2021 eruption of the Tajogaite volcano on La Palma Island in the Canary Islands, Spain, raised concerns regarding the potential impact on groundwater hydrochemistry. This work aimed to characterize and model the processes that lead to the measured hydrochemical impacts in the groundwater of La Palma as a consequence of the volcanic eruption...
April 18, 2024: Science of the Total Environment
#15
JOURNAL ARTICLE
Laura Álvarez-Álvarez, María Rubín-García, Facundo Vitelli-Storelli, Silvia García, Cristina Bouzas, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Mireia Malcampo, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, Lluís Serra-Majem, Aurora Bueno-Cavanillas, Camino García Fernández, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Ana García-Arellano, María Ángeles Martínez, José V Sorlí, María Dolores Zomeño, Antonio García-Rios, Sandra González-Palacios, Margalida Monserrat-Mesquida, Itziar Abete, Antoni Colom Fernández, Rosa Casas, Naomi Cano Ibañez, Lucía Ugarriza, M Rosa Bernal-López, Maira Bes-Rastrollo, Indira Paz-Graniel, Eva M Asensio, Montse Fitó, Antonio P Arenas Larriva, Alejandro Oncina-Cánovas, Zenaida Vázquez, María Fernández de la Puente, Alejandra Pérez-Vega, Josep A Tur, Vicente Martín-Sánchez
OBJECTIVE: To estimate the environmental impact of a dietary intervention based on an energy-reduced Mediterranean diet (MedDiet) after one year of follow-up. METHODS: Baseline and 1-year follow-up data were used for 5800 participants aged 55-75 years with metabolic syndrome in the PREDIMED-Plus study. Food intake was estimated through a validated semiquantitative food consumption frequency questionnaire, and adherence to the MedDiet was estimated through the Diet Score...
April 18, 2024: Science of the Total Environment
#16
JOURNAL ARTICLE
Yvan Baldera-Moreno, Camila Hernández, Aris Vargas, Alejandro Rojas-Palma, Rodrigo Morales-Vera, Rodrigo Andler
Plastic pollution is primarily caused by the accumulation of petroleum-derived plastics, as they tend to degrade slowly. Sustainable alternatives to these materials are bio-based and biodegradable plastics, such as polylactic acid (PLA). In this study, we assessed how turning aeration and the initial carbon/nitrogen (C/N) ratio impact PLA biodegradation. The study was carried out under controlled composting conditions, over 180 days, with the aim of decreasing the biodegradation time of the PLA. Apple pomace, rice husk, grape pomace compost, and PLA were used as substrates in the composting process...
April 18, 2024: International Journal of Biological Macromolecules
#17
JOURNAL ARTICLE
Agustín Pérez-Londoño, Alejandro Abello, Boris Gershman, Ruslan Korets
Holmium laser enucleation of the prostate (HoLEP) is considered a size-independent technique to treat benign prostatic hyperplasia. This safe and effective procedure is increasingly being adopted in urology training programs worldwide, yet limited teaching strategies have been described. Endoscopic handling during HoLEP allows for a simultaneous interaction between the surgeon and trainee, facilitating a guided teaching strategy with increasing difficulty as experience grows. In this article, we describe our stepwise approach for teaching HoLEP as part of a structured surgical training curriculum...
April 2024: Canadian Journal of Urology
#18
JOURNAL ARTICLE
Alejandro Liñan-Padilla, Alejandro Berlanga-Porras, Isidro Jiménez
The results of this study suggest that a decreased vascularization of the median nerve after releasing the carpal tunnel predicts an inferior clinical improvement assessed by the Boston Carpal Tunnel Questionnaire.
April 20, 2024: Journal of Hand Surgery, European Volume
#19
Alejandro Lapresta-Fernández, Alfonso Salinas-Castillo, Luis Fermín Capitán-Vallvey
No abstract text is available yet for this article.
April 19, 2024: Scientific Reports
#20
JOURNAL ARTICLE
Carolina Cifuentes-Jiménez, María Victoria Bolaños-Carmona, Tattiana Enrich-Essvein, Alejandro B Rodríguez-Navarro, Santiago González-López, Monica Yamauti, Pedro Álvarez-Lloret
This research aimed to synthesise and characterise chitosan/fluoride functionalised silver nanoparticles (AgNPs) reduced with white tea (Camellia sinensis, WT) and evaluate the effects of WT_AgNPs application on demineralised dentine. The WT_AgNPs were characterised to determine their molecular composition, organic matter content, crystallite size, and degree of aggregation. Forty human molars were randomly assigned to different control groups: sound dentine (SD) and demineralised dentine (DD), and experimental groups: WT_AgNPs, WT_AgNPs_NaF, and WT_AgNPs_CHS...
April 17, 2024: International Journal of Biological Macromolecules
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