keyword
MENU ▼
Read by QxMD icon Read
search

Alejandro

keyword
https://www.readbyqxmd.com/read/27933649/using-chiral-peptide-substitutions-to-probe-the-structure-function-relationship-of-a-key-residue-of-a%C3%AE-42
#1
Christopher J A Warner, Subrata Dutta, Alejandro R Foley, Eefei Chen, David S Kliger, Jevgenij A Raskatov
Amyloid beta-protein 42 plays an important role in the onset and progression of Alzheimer's disease. Familial mutations have identified the glutamate residue 22 as a hotspot with regard to peptide neurotoxicity. We introduce an approach to study the influence of systematic sidechain modification at this residue, employing chirality as a structural probe. Circular dichroism experiments reveal that charge-preserving alterations of the amino acid sidechain attenuate the characteristic random coil to β-sheet transition associated with the wildtype peptide...
December 8, 2016: Chirality
https://www.readbyqxmd.com/read/27933457/pristine-but-metal-rich-r%C3%A3-o-sucio-dirty-river-is-dominated-by-gallionella-and-other-iron-sulfur-oxidizing-microbes
#2
Alejandro Arce-Rodríguez, Fernando Puente-Sánchez, Roberto Avendaño, Eduardo Libby, Leonardo Rojas, Juan Carlos Cambronero, Dietmar H Pieper, Kenneth N Timmis, Max Chavarría
Whether the extreme conditions of acidity and heavy metal pollution of streams and rivers originating in pyritic formations are caused primarily by mining activities or by natural activities of metal-oxidizing microbes living within the geological formations is a subject of considerable controversy. Most microbiological studies of such waters have so far focused on acid mine drainage sites, which are heavily human-impacted environments, so it has been problematic to eliminate the human factor in the question of the origin of the key metal compounds...
December 8, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27933067/peptide-idr-1002-inhibits-nf-%C3%AE%C2%BAb-nuclear-translocation-by-inhibition-of-i%C3%AE%C2%BAb%C3%AE-degradation-and-activates-p38-erk1-2-msk1-dependent-creb-phosphorylation-in-macrophages-stimulated-with-lipopolysaccharide
#3
Alejandro Huante-Mendoza, Octavio Silva-García, Javier Oviedo-Boyso, Robert E W Hancock, Víctor M Baizabal-Aguirre
The inflammatory response is a critical molecular defense mechanism of the innate immune system that mediates the elimination of disease-causing bacteria. Repair of the damaged tissue, and the reestablishment of homeostasis, must be accomplished after elimination of the pathogen. The innate defense regulators (IDRs) are short cationic peptides that mimic natural host defense peptides and are effective in eliminating pathogens by enhancing the activity of the immune system while controlling the inflammatory response...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27932976/melatonin-and-nitrones-as-potential-therapeutic-agents-for-stroke
#4
Alejandro Romero, Eva Ramos, Paloma Patiño, Maria J Oset-Gasque, Francisco López-Muñoz, José Marco-Contelles
Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27931927/owned-dog-ecology-and-demography-in-villa-de-tezontepec-hidalgo-mexico
#5
Luz Maria Kisiel, Andria Jones-Bitton, Jan M Sargeant, Jason B Coe, D T Tyler Flockhart, Alejandro Reynoso Palomar, Erick J Canales Vargas, Amy L Greer
Dog overpopulation in developing countries has negative implications for the health and safety of people, including the transmission of zoonotic diseases, physical attacks and intimidation to humans and animals, as well as impacts on canine welfare. Understanding the ecology and demographic characteristics of a dog population can help in the planning and monitoring of canine population control programs. Little data exist regarding demography and dynamics of domestic dog populations in semi-urban areas in Mexico...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931012/impact-of-thrombophilia-screening-on-venous-thromboembolism-management-practices
#6
Alejandro Garcia-Horton, Michael J Kovacs, Jameel Abdulrehman, Jay E Taylor, Shobha Sharma, Alejandro Lazo-Langner
BACKGROUND: It is unclear whether thrombophilia testing provides any further information on risk of recurrence or guidance in management of patients with a first episode of idiopathic venous thromboembolism (VTE). Furthermore, after the introduction to clinical practice of clinical prediction rules, thrombophilia screening could be less relevant in anticoagulation decision making. We assessed the potential impact of thrombophilia screening on the decision of maintaining anticoagulation beyond the initially planned anticoagulation period in patients with an unprovoked VTE, before and after the introduction of a clinical prediction rule into practice...
December 1, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27930835/effect-of-antibiotics-on-biofilm-inhibition-and-induction-measured-by-real-time-cell-analysis
#7
Maria D Ferrer, Juan C Rodriguez, Ledicia Álvarez, Alejandro Artacho, Gloria Royo, Alex Mira
AIMS: The purpose of the current work was to study the pattern and dynamics of biofilm formation in clinical isolates of Staphylococcus aureus and S. epidermidis in the presence of 10 antibiotics with different action mechanisms. METHODS AND RESULTS: By using impedance measurements in microtiter plates with gold electrodes we have assessed the antibiotic effect on bacterial biofilm growth in real time. The impedance measurements appear to combine both cellular growth and matrix production, representing a measurement of total biofilm mass...
December 8, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27927958/coding-of-event-nodes-and-narrative-context-in-the-hippocampus
#8
Branka Milivojevic, Meryl Varadinov, Alejandro Vicente Grabovetsky, Silvy H P Collin, Christian F Doeller
: Narratives may provide a general context, unrestricted by space and time, which can be used to organize episodic memories into networks of related events. However, it is not clear how narrative contexts are represented in the brain. Here we test the novel hypothesis that the formation of narrative-based contextual representations in humans relies on the same hippocampal mechanisms that enable formation of spatiotemporal contexts in rodents. Participants watched a movie consisting of two interleaved narratives while we monitored their brain activity using fMRI...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27927103/mechanism-of-action-of-relaxant-effect-of-agastache-mexicana-ssp-mexicana-essential-oil-in-guinea-pig-trachea-smooth-muscle
#9
Andrés Navarrete, Natalia Ávila-Rosas, Mateo Majín-León, José Luis Balderas-López, Alejandro Alfaro-Romero, José Carlos Tavares-Carvalho
CONTEXT: Agastache mexicana ssp. mexicana (Kunth) Lint & Epling (Lamiaceae), popularly known as 'toronjil morado', is used in Mexican traditional medicine for the treatment of several diseases such as hypertension, anxiety and respiratory disorders. OBJECTIVE: This study investigates the relaxant action mechanism of A. mexicana ssp. mexicana essential oil (AMEO) in guinea-pig isolated trachea model. MATERIALS AND METHOD: AMEO was analyzed by GC/MS...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27926992/inherited-diseases-caused-by-mutations-in-cathepsin-protease-genes
#10
REVIEW
Stephanie Ketterer, Alejandro Gomez-Auli, Larissa E Hillebrand, Agnese Petrera, Anett Ketscher, Thomas Reinheckel
Lysosomal cathepsins are proteolytic enzymes increasingly recognized as prognostic markers and potential therapeutic targets in a variety of diseases. In those conditions the cathepsins are mostly overexpressed, thereby driving the respective pathogenic processes. Although less known, there are also diseases with a genetic deficiency of cathepsins. In fact, nowadays six out of the fifteen human proteases called "cathepsins" have been linked to inherited syndromes. However, only three of these syndromes are typical lysosomal storage diseases, while the others are apparently caused by defective cleavage of specific protein substrates...
December 7, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27924642/development-of-an-rt-qpcr-assay-for-the-specific-detection-of-a-distinct-genetic-lineage-of-the-infectious-bursal-disease-virus
#11
Gonzalo Tomás, Martín Hernández, Ana Marandino, Claudia Techera, Sofia Grecco, Diego Hernández, Alejandro Banda, Yanina Panzera, Ruben Pérez
The infectious bursal disease virus (IBDV) is a major health threat to the world's poultry industry despite intensive controls including proper biosafety practices and vaccination. IBDV (Avibirnavirus, Birnaviridae) is a non-enveloped virus with a bisegmented double-stranded RNA genome. The virus is traditionally classified into classic, variant and very virulent strains, each with different epidemiological relevance and clinical implications. Recently, a novel worldwide spread genetic lineage was described and denoted as distinct (d) IBDV...
December 7, 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/27924376/predicting-levator-avulsion-from-ics-pop-q-findings
#12
Alejandro Pattillo Garnham, Rodrigo Guzmán Rojas, Ka Lai Shek, Hans Peter Dietz
INTRODUCTION AND HYPOTHESIS: Levator avulsion is a common consequence of vaginal childbirth. It is associated with symptomatic female pelvic organ prolapse and is also a predictor of recurrence after surgical correction. Skills and hardware necessary for diagnosis by imaging are, however, not universally available. Diagnosis of avulsion may benefit from an elevated index of suspicion. The aim of this study was to examine the predictive value of the International Continence Society Pelvic Organ Prolapse Quantification (ICS POP-Q) for the diagnosis of levator avulsion by tomographic 4D translabial ultrasound...
December 6, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27923909/mating-system-of-caiman-yacare-reptilia-alligatoridae-described-from-microsatellite-genotypes
#13
Guillermo N Ojeda, Patricia S Amavet, Eva C Rueda, Pablo A Siroski, Alejandro Larriera
The yacare caiman (Caiman yacare) is a reptile from South America and 1 of the 2 crocodilian species present in Argentina. The degradation of their natural habitat and strong hunting pressure led to a sharp numerical decline of wild populations. Nowadays, C. yacare is included in Appendix II of CITES, and ranching practices in some areas in Argentina are helping hatching success. In this context, it is important to better understand the population structure and mating system of the species. To do this, we amplified 10 microsatellite markers (SSRs) in 148 individuals of 13 C...
December 6, 2016: Journal of Heredity
https://www.readbyqxmd.com/read/27923180/insight-into-the-structure-and-stability-of-tc-and-re-dmsa-complexes-a-computational-study
#14
Daniel Hernández-Valdés, Alejandro Blanco-González, Ariel García-Fleitas, Zalua Rodríguez-Riera, Giuseppe Meola, Roger Alberto, Ulises Jáuregui-Haza
Meso-2,3-dimercaptosuccinic acid (DMSA) is used in nuclear medicine as ligand for preparation of diagnostic and therapy radiopharmaceuticals. DMSA has been the subject of numerous investigations during the past three decades and new and significant information of the chemistry and pharmacology of DMSA complexes have emerged. In comparison to other ligands, the structure of some DMSA complexes is unclear up today. The structures and applications of DMSA complexes are strictly dependent on the chemical conditions of their preparation, especially pH and components ratio...
November 27, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/27920952/a-methodology-for-the-design-of-experiments-in-computational-intelligence-with-multiple-regression-models
#15
Carlos Fernandez-Lozano, Marcos Gestal, Cristian R Munteanu, Julian Dorado, Alejandro Pazos
The design of experiments and the validation of the results achieved with them are vital in any research study. This paper focuses on the use of different Machine Learning approaches for regression tasks in the field of Computational Intelligence and especially on a correct comparison between the different results provided for different methods, as those techniques are complex systems that require further study to be fully understood. A methodology commonly accepted in Computational intelligence is implemented in an R package called RRegrs...
2016: PeerJ
https://www.readbyqxmd.com/read/27919824/melatonin-s-role-as-a-co-adjuvant-treatment-in-colonic-diseases-a-review
#16
REVIEW
Eduardo Esteban-Zubero, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, Purificación Ochoa-Moneo, Celia Buisac-Ramón, Miguel Rivas-Jiménez, Silvia Castán-Ruiz, Ángel Antoñanzas-Lombarte, Dun-Xian Tan, José Joaquín García, Russel J Reiter
Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression...
December 2, 2016: Life Sciences
https://www.readbyqxmd.com/read/27919512/effect-of-metronidazole-supplemented-with-hydroquinone-on-the-adhesion-of-lactobacillus-acidophilus-in-ovine-vaginal-cells
#17
Tamara L Coletti Zabala, María E Zerbatto, Elda B R Perotti, Ana M Smacchia, Adriana Ombrella, Alejandro R Pidello
This work demonstrates that the addition of metronidazole together with a ubiquitous quinone compound reduces adherence of Lactobacillus acidophilus to ovine vaginal cells. Spectrophotometric and voltammetric studies have shown that neoformed compounds were observed in these systems; there were also changes in their electroactive composition, and the oxidant status had a significantly higher value compared to the control (p<0.05). Based on reduction potential (E; mV), the distribution of electroactive compound concentrations suggests that the compounds with low reduction potential induce this behavior, which would indicate that the addition of metronidazole with a ubiquitous quinone compound to the vaginal system might increase the reductive capacity of these systems...
December 2, 2016: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/27918657/telomere-length-in-elite-athletes
#18
Carlos A Muniesa, Zoraida Verde, Germán Diaz-Ureña, Catalina Santiago, Fernando Gutiérrez, Enrique Díaz, Félix Gómez-Gallego, Helios Pareja-Galeano, Luisa Soares-Miranda, Alejandro Lucia
PURPOSE: Growing evidence suggests that regular, moderate-intensity physical activity is associated with an attenuation of leucocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads, such as those imposed by elite sports participation. METHODS: We have investigated LTL differences between young elite athletes (n=61, 54% men, aged [mean±SD] 27.2±4.9 years) and their healthy non-smoker, physically inactive controls (n=64, 52% men, 28...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918363/tip-fold-over-in-cochlear-implantation-case-series
#19
M Geraldine Zuniga, Alejandro Rivas, Andrea Hedley-Williams, Rene H Gifford, Robert Dwyer, Benoit M Dawant, Linsey W Sunderhaus, Kristen L Hovis, George B Wanna, Jack H Noble, Robert F Labadie
OBJECTIVE: To describe the incidence, clinical presentation, and performance of cochlear implant (CI) recipients with tip fold-over. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: CI recipients who underwent postoperative computed tomography (CT) scanning. INTERVENTION(S): Tip fold-over was identified tomographically using previously validated software that identifies the electrode array...
December 1, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27917891/modular-architecture-and-unique-teichoic-acid-recognition-features-of-choline-binding-protein-l-cbpl-contributing-to-pneumococcal-pathogenesis
#20
Javier Gutiérrez-Fernández, Malek Saleh, Martín Alcorlo, Alejandro Gómez-Mejía, David Pantoja-Uceda, Miguel A Treviño, Franziska Voß, Mohammed R Abdullah, Sergio Galán-Bartual, Jolien Seinen, Pedro A Sánchez-Murcia, Federico Gago, Marta Bruix, Sven Hammerschmidt, Juan A Hermoso
The human pathogen Streptococcus pneumoniae is decorated with a special class of surface-proteins known as choline-binding proteins (CBPs) attached to phosphorylcholine (PCho) moieties from cell-wall teichoic acids. By a combination of X-ray crystallography, NMR, molecular dynamics techniques and in vivo virulence and phagocytosis studies, we provide structural information of choline-binding protein L (CbpL) and demonstrate its impact on pneumococcal pathogenesis and immune evasion. CbpL is a very elongated three-module protein composed of (i) an Excalibur Ca(2+)-binding domain -reported in this work for the very first time-, (ii) an unprecedented anchorage module showing alternate disposition of canonical and non-canonical choline-binding sites that allows vine-like binding of fully-PCho-substituted teichoic acids (with two choline moieties per unit), and (iii) a Ltp_Lipoprotein domain...
December 5, 2016: Scientific Reports
keyword
keyword
24944
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"