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https://www.readbyqxmd.com/read/28231635/in-vivo-structural-imaging-in-rats-reveals-neuroanatomical-correlates-of-behavioral-sub-dimensions-of-cocaine-addiction
#1
Nazzareno Cannella, Alejandro Cosa-Linan, Elena Büchler, Claudia Falfan-Melgoza, Wolfgang Weber-Fahr, Rainer Spanagel
Cocaine addiction is a multi-dimensional behavioral disorder characterized by a loss of control over cocaine taking despite of detrimental consequences. Structural MRI studies have revealed association between cocaine consumption and gray matter volume (GMV) in cocaine-addicted patients. However, the behavioral correlates of GMV in cocaine addiction are poorly understood. Here, we used a DSM-IV-based rat model of cocaine addiction with high face validity for structural imaging. According to three behavioral sub-dimensions of addiction, rats were separated into two groups showing either addict-like or non-addict-like behavior...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28231435/impact-of-a-competition-with-two-consecutive-matches-in-a-day-on-physical-performance-in-young-tennis-players
#2
Cesar Gallo-Salazar, Juan Del Coso, David Barbado, Alejandro Lopez-Valenciano, Francisco Javier Santos-Rosa, David Sanz-Rivas, Manuel Moya, Jaime Fernandez-Fernandez
The purpose of this study was to analyze the effects of playing two tennis matches on the same day on physical performance in young tennis players. Twelve well-trained young tennis players took part in a simulated tennis competition consisting of two tennis matches on the same day (morning and afternoon sessions). Before and the day after the competition, physical performance was measured using a battery of countermovement jumps (CMJ), a 10-m sprint, the 5-0-5 agility test, hip, grip and shoulder maximal isometric strength, shoulder range of motion (ROM) and a serve velocity test...
February 23, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28230082/tubz-filament-assembly-dynamics-requires-the-flexible-c-terminal-tail
#3
Maria E Fuentes-Pérez, Rafael Núñez-Ramírez, Alejandro Martín-González, David Juan-Rodríguez, Oscar Llorca, Fernando Moreno-Herrero, Maria A Oliva
Cytomotive filaments are essential for the spatial organization in cells, showing a dynamic behavior based on nucleotide hydrolysis. TubZ is a tubulin-like protein that functions in extrachromosomal DNA movement within bacteria. TubZ filaments grow in a helical fashion following treadmilling or dynamic instability, although the underlying mechanism is unclear. We have unraveled the molecular basis for filament assembly and dynamics combining electron and atomic force microscopy and biochemical analyses. Our findings suggest that GTP caps retain the filament helical structure and hydrolysis triggers filament stiffening upon disassembly...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230069/consistent-role-of-quaternary-climate-change-in-shaping-current-plant-functional-diversity-patterns-across-european-plant-orders
#4
Alejandro Ordonez, Jens-Christian Svenning
Current and historical environmental conditions are known to determine jointly contemporary species distributions and richness patterns. However, whether historical dynamics in species distributions and richness translate to functional diversity patterns remains, for the most part, unknown. The geographic patterns of plant functional space size (richness) and packing (dispersion) for six widely distributed orders of European angiosperms were estimated using atlas distribution data and trait information. Then the relative importance of late-Quaternary glacial-interglacial climate change and contemporary environmental factors (climate, productivity, and topography) as determinants of functional diversity of evaluated orders was assesed...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229608/usefulness-of-an-intra-gastric-balloon-before-bariatric-surgery
#5
Cristina Vicente, Luis Ramón Rábago, Alejandro Ortega, Marisa Arias, Jaime Vázquez Echarri
INTRODUCTION: There are only few reports regarding the use of intragastric-balloons (IGB®) to achieve weight loss and subsequently decrease surgical complications. In this study, we try to assess whether presurgery weight loss using IGB decreases the postsurgical mortality after bariatric surgery. METHODS: This is a prospective case-control study. We matched 1:1 by gender, age (± 10 y-o) and type of surgery (sleeve resection [LSG] or gastric bypass [LGBP]), matching cases (A) and controls (H, from a historic cohort)...
23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229048/anaplasma-phagocytophilum-infection-subverts-carbohydrate-metabolic-pathways-in-the-tick-vector-ixodes-scapularis
#6
Alejandro Cabezas-Cruz, Pilar Alberdi, James J Valdés, Margarita Villar, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of human, equine, and canine granulocytic anaplasmosis and tick-borne fever (TBF) in ruminants. A. phagocytophilum has become an emerging tick-borne pathogen in the United States, Europe, Africa, and Asia, with increasing numbers of infected people and animals every year. It has been recognized that intracellular pathogens manipulate host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28228887/transarterial-embolization-of-a-hyperfunctioning-aldosteronoma-in-a-patient-with-bilateral-adrenal-nodules
#7
Jason T Salsamendi, Francisco J Gortes, Alejandro R Ayala, Juan D Palacios, Sanjit Tewari, Govindarajan Narayanan
Primary hyperaldosteronism often results in resistant hypertension and hypokalemia, which may lead to cardiovascular and cerebrovascular complications. Although surgery is first line treatment for unilateral functioning aldosteronomas, minimally invasive therapies may be first line for certain patients such as those who cannot tolerate surgery. We present a case of transarterial embolization (TAE) of an aldosteronoma. The patient presented with a cerebrovascular accident, and subsequently developed uncontrolled hypertension, hypokalemia, and a myocardial infarction...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28227858/compensation-of-pulsation-artifacts-during-optical-imaging-with-and-without-cranial-chamber
#8
Alejandro Romero-Santiago, Philipp Flotho, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Alejandro Romero-Santiago, Philipp Flotho, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Daniel J Strauss, Alejandro Romero-Santiago, Jacek Szczygielski, Karsten Schwerdtfeger, Philipp Flotho, Lars Haab, Matthias Hulser
Functional Optical Imaging (OI) through the opened skull forms a group of Neuroimaging techniques characterized by a high temporal and spatial resolution on a meso-to macroscopic scale. State of the art OI experiments are generally difficult to execute, with a very timely surgical preparation preceding the experiment, that requires a skilled surgeon to mount a sealed imaging chamber onto the skull. The chamber reduces brain pulsation artifacts and swelling of the brain through movement restriction. In this work, we present preliminary results of a novel approach that does not rely on the usage of an imaging chamber with the goal to facilitate heavily the surgical animal preparation and to allow straightforward joint Electroencephalography - Optical Imaging recordings in the future...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227739/cortical-responses-following-simultaneous-and-sequential-retinal-neurostimulation-with-different-return-configurations
#9
Alejandro Barriga-Rivera, John W Morley, Nigel H Lovell, Gregg J Suaning, Alejandro Barriga-Rivera, John W Morley, Nigel H Lovell, Gregg J Suaning, Alejandro Barriga-Rivera, Gregg J Suaning, John W Morley, Nigel H Lovell
Researchers continue to develop visual prostheses towards safer and more efficacious systems. However limitations still exist in the number of stimulating channels that can be integrated. Therefore there is a need for spatial and time multiplexing techniques to provide improved performance of the current technology. In particular, bright and high-contrast visual scenes may require simultaneous activation of several electrodes. In this research, a 24-electrode array was suprachoroidally implanted in three normally-sighted cats...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227375/motion-invariant-contrast-enhancement-of-optical-imaging-data-in-the-gradient-domain
#10
Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Philipp Flotho, Alejandro Romero-Santiago, Karsten Schwerdtfeger, Jacek Szczygielski, Matthias Hulser, Lars Haab, Daniel J Strauss, Daniel J Strauss, Alejandro Romero-Santiago, Jacek Szczygielski, Karsten Schwerdtfeger, Philipp Flotho, Lars Haab
Functional optical imaging (OI) of intrinsic signals (like blood oxygenation coupled reflection changes) and of extrinsic properties of voltage sensitive probes (like voltage-sensitive dyes (VSD)) forms a group of neuroimaging techniques that possess up to date highest temporal and spatial resolution on a meso-to macroscopic scale. An inherent problem of OI is a very low signal to noise ratio (SNR), which restricts the recordings to be completely motionless and requires detailed knowledge of the properties of the different noise sources...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227108/analysis-of-spontaneous-eeg-activity-in-alzheimer-s-disease-using-cross-sample-entropy-and-graph-theory
#11
Carlos Gomez, Jesus Poza, Javier Gomez-Pilar, Alejandro Bachiller, Celia Juan-Cruz, Miguel A Tola-Arribas, Alicia Carreres, Monica Cano, Roberto Hornero, Carlos Gomez, Jesus Poza, Javier Gomez-Pilar, Alejandro Bachiller, Celia Juan-Cruz, Miguel A Tola-Arribas, Alicia Carreres, Monica Cano, Roberto Hornero, Celia Juan-Cruz, Carlos Gomez, Alicia Carreres, Jesus Poza, Monica Cano, Roberto Hornero, Javier Gomez-Pilar, Alejandro Bachiller, Miguel A Tola-Arribas
The aim of this pilot study was to analyze spontaneous electroencephalography (EEG) activity in Alzheimer's disease (AD) by means of Cross-Sample Entropy (Cross-SampEn) and two local measures derived from graph theory: clustering coefficient (CC) and characteristic path length (PL). Five minutes of EEG activity were recorded from 37 patients with dementia due to AD and 29 elderly controls. Our results showed that Cross-SampEn values were lower in the AD group than in the control one for all the interactions among EEG channels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225766/marine-actinobacteria-as-a-source-of-compounds-for-phytopathogen-control-an-integrative-metabolic-profiling-bioactivity-and-taxonomical-approach
#12
Luz A Betancur, Sandra J Naranjo-Gaybor, Diana M Vinchira-Villarraga, Nubia C Moreno-Sarmiento, Luis A Maldonado, Zulma R Suarez-Moreno, Alejandro Acosta-González, Gillermo F Padilla-Gonzalez, Mónica Puyana, Leonardo Castellanos, Freddy A Ramos
Marine bacteria are considered as promising sources for the discovery of novel biologically active compounds. In this study, samples of sediment, invertebrate and algae were collected from the Providencia and Santa Catalina coral reef (Colombian Caribbean Sea) with the aim of isolating Actinobateria-like strain able to produce antimicrobial and quorum quenching compounds against pathogens. Several approaches were used to select actinobacterial isolates, obtaining 203 strains from all samples. According to their 16S rRNA gene sequencing, a total of 24 strains was classified within Actinobacteria represented by three genera: Streptomyces, Micromonospora, and Gordonia...
2017: PloS One
https://www.readbyqxmd.com/read/28225182/double-sequential-encrypted-targeting-sequence-a-new-concept-for-bone-cancer-treatment
#13
Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, Maria Vallet-Regi
The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuli-responsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells...
February 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28224622/slc2a3-single-nucleotide-polymorphism-and-duplication-influence-cognitive-processing-and-population-specific-risk-for-attention-deficit-hyperactivity-disorder
#14
Sören Merker, Andreas Reif, Georg C Ziegler, Heike Weber, Ute Mayer, Ann-Christine Ehlis, Annette Conzelmann, Stefan Johansson, Clemens Müller-Reible, Indrajit Nanda, Thomas Haaf, Reinhard Ullmann, Marcel Romanos, Andreas J Fallgatter, Paul Pauli, Tatyana Strekalova, Charline Jansch, Alejandro Arias Vasquez, Jan Haavik, Marta Ribasés, Josep Antoni Ramos-Quiroga, Jan K Buitelaar, Barbara Franke, Klaus-Peter Lesch
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder with profound cognitive, behavioral, and psychosocial impairments with persistence across the life cycle. Our initial genome-wide screening approach for copy number variants (CNVs) in ADHD implicated a duplication of SLC2A3, encoding glucose transporter-3 (GLUT3). GLUT3 plays a critical role in cerebral glucose metabolism, providing energy for the activity of neurons, which, in turn, moderates the excitatory-inhibitory balance impacting both brain development and activity-dependent neural plasticity...
February 22, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28224448/comparison-of-esc-and-acc-aha-guidelines-for-myocardial-revascularization
#15
Jim Stirrup, Alejandro Velasco, Fadi G Hage, Eliana Reyes
In 2014, the Task Force on Myocardial Revascularization of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery with the special contribution of the European Association of Percutaneous Cardiovascular Interventions published a comprehensive set of recommendations on myocardial revascularization in patients presenting with acute or chronic coronary artery disease. In the United States, pertinent guidance on this topic has been published by the American College of Cardiology, American Heart Association and other relevant societies in multiple guideline documents that have been published in recent years...
February 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28224161/f-element-metalated-dipyrrins-synthesis-and-characterization-of-a-family-of-uranyl-bis-dipyrrinate-complexes
#16
Duer Bolotaulo, Alejandro Metta-Magaña, Skye Fortier
Using an improved, chromatography-free dipyrrin synthesis, the α,β-unsubstituted dipyrrins [RC(C4H2N)2H] (2) (R = tolyl (2toly(l)), p-OMe-C6H4 (2anis), mesityl (2mes), ferrocenyl (2Fc)) were isolated in good to excellent yields. Deprotonation of 2 with Na[N(SiMe3)2] gives the alkali metal salts [Na(DME)n][RC(C4H2N)2] (3) which reacts with UO2Cl2(THF)3 to give the uranyl bis(dipyrrinates) UO2[RC(C4H2N)2]2(L) (L = THF (4R-THF); DMAP (4R-DMAP)) (R = tolyl, p-OMe-C6H4, mesityl, ferrocenyl). The THF adducts, 4R-THF, are unstable in aromatic and nonpolar solvents and rapidly decompose to 2 and an intractable uranium-containing solid...
February 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28223806/efficacy-of-a-short-cognitive-training-program-in-patients-with-multiple-sclerosis
#17
María Yaiza Pérez-Martín, Montserrat González-Platas, Pablo Eguía-Del Río, Cristina Croissier-Elías, Alejandro Jiménez Sosa
BACKGROUND: Cognitive impairment is a common feature in multiple sclerosis (MS) and may have a substantial impact on quality of life. Evidence about the effectiveness of neuropsychological rehabilitation is still limited, but current data suggest that computer-assisted cognitive training improves cognitive performance. OBJECTIVE: The objective of this study was to evaluate the efficacy of combined computer-assisted training supported by home-based neuropsychological training to improve attention, processing speed, memory and executive functions during 3 consecutive months...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28222071/combination-of-the-histone-deacetylase-inhibitor-vorinostat-with-bevacizumab-in-patients-with-clear-cell-renal-cell-carcinoma-a-multicentre-single-arm-phase-i-ii-clinical-trial
#18
Roberto Pili, Glenn Liu, Sreenivasulu Chintala, Hendrick Verheul, Shabnam Rehman, Kristopher Attwood, Martin A Lodge, Richard Wahl, James I Martin, Kiersten Marie Miles, Silvia Paesante, Remi Adelaiye, Alejandro Godoy, Serina King, James Zwiebel, Michael A Carducci
BACKGROUND: Class II histone deacetylase (HDAC) inhibitors induce hypoxia-inducible factor-1 and -2α degradation and have antitumour effects in combination with vascular endothelial growth factor (VEGF) inhibitors. In this study, we tested the safety and efficacy of the HDAC inhibitor vorinostat and the VEGF blocker bevacizumab in metastatic clear-cell renal cell carcinoma (ccRCC) patients previously treated with different drugs including sunitinib, sorafenib, axitinib, interleukin-2, interferon, and temsirolimus...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28221930/escherichia-albertii-inactivation-following-l-lactic-acid-exposure-or-cooking-in-ground-beef
#19
Amie M Jones-Ibarra, Kayley R Wall, Jennifer Vuia-Riser, Chris R Kerth, Alejandro Castillo, T Matthew Taylor
Escherichia albertii is an emerging foodborne pathogen recovered from young children and adults exhibiting symptoms of gastroenteritis via pathogenesis factors including attaching and effacing lesions, cytolethal distending toxin, and Shiga toxin variants. Study objectives were to determine E. albertii survival following (i) exposure to lactic acid as a function of solution pH and incubation period and (ii) cooking ground beef patties to different endpoint temperatures. E. albertii was incubated in phosphate buffer containing 3...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221906/tracing-surrogates-for-enteric-pathogens-inoculated-on-hide-through-the-beef-harvesting-process
#20
Mariana Villarreal-Silva, Daniel P Genho, Irfan Ilhak, Lisa M Lucia, James S Dickson, Kerri B Gehring, Jeffrey W Savell, Alejandro Castillo
Multiple antimicrobial interventions have been validated for use during the beef postharvesting process. However, little has been done to determine the impact of the postharvest environment on pathogen contamination. In this study, surrogate microorganisms were used to simulate pathogen cross-contamination through the postharvest environment at three different abattoirs. At each abattoir, the brisket areas of 13 hide-on carcasses were inoculated after stunning, with a gelatin slurry containing a cocktail (~7 log CFU/ml) of fluorescent Escherichia coli biotype I...
November 2016: Journal of Food Protection
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